Research | Overview
Open Post-Doc Position
We are looking for a highly motivated, energetic and goal-oriented fellow to join the lab. Our lab is located at Joslin Diabetes Center. A new fellow would be co-mentored by myself and C. Ronald Kahn, combining the strengths of a new investigator who is hungry for success and an experienced investigator who has trained more than 180 post-docs at Harvard Medical School. The project would build on our findings published in JCI (Softic, JCI. 2017) and on our manuscript under review at Cell Metab.
A new post-doc would work on:
- Studying cell-specific metabolic outcomes following knockout or overexpression of ketohexokinase (KHK), the first enzyme in fructose metabolism pathway.
- Understanding how four newly identified acetylation sites on CPT1a induced by fructose feedings affect its enzymatic activity and mitochondrial fatty acid oxidation.
- Identify the mechanism by which insulin leads to alternative splicing of KHK-C versus KHK-A isoforms, to enhance fructose metabolism in hyperinsulinemic states.