Silberstein Laboratory | Current Lab Members

Current Lab Members

Shin-Young Park, PhD Instructor in Pediatrics
Lab Manager
Cesar Nombela-Arrieta, PhD Research Fellow
Geqiang Li, PhD Research Fellow
Yan Sun, PhD Research Fellow
Kimberly Canty Research Technician



Shin-Young Park, Ph.D. - Instructor of Pediatrics, Lab Manager 


1997 Ph.D. State University of New York, Buffalo/RPCI
Microbiology and Molecular Immunology
1989 M.S. Seoul National University
Department of Microbiology
1987 B.S. Seoul National University
Department of Microbiology


  • Park S-Y, Avraham H, Avraham S. (2000) Characterization of the Tyrosine Kinases RAFTK/Pyk2 and FAK in NGF-induced Neuronal Differentiation. J. Biol. Chem. 275(26):19768-77.
  • Avraham H, Park S-Y, Schinkmann K, Avraham S. (2000) RAFTK/Pyk2-mediated Cellular Signalling. Cell Signalling. 12:123-33.
  • Koziak K, Kaczmarek E, Park S-Y, Fu Y, Avraham S, Avraham H. (2001) RAFTK/Pyk2 Involvement in Platelet Activation is Mediated by Phosphoinositide 3-Kinase. British Journal of Haematology. 114(1):134-40. 2001.
  • Park S-Y, Avraham H, Avraham S. (2002) Functional Aspects of RAFTK/Pyk2 in the Nervous System. Recent Res. Devel. Neurochem. 5:125-42.
  • McShan G, Zagozdzon R, Park S-Y, Zrihan-Licht S, Fu Y, Avraham S, Avraham H. (2002) Csk-homology Kinase (CHK) Negatively Regulates RAFTK/Pyk2 and Inhibits Migration of Breast Cancer Cells. International Journal of Oncology. 21(1):197-205.
  • Park S-Y, Avraham H, Avraham S. (2004) RAFTK/Pyk2 Activation is Mediated by Trans-acting Autophosporylation in a Src-Independent Manner. J. Biol. Chem. 279(32):33315-22.
  • Jiang S, Avraham H, Park S-Y, Kim T, Bu X, Seng S, Avraham S. (2005) Process Elongation of Oligodendrocytes is promoted by the Kelch-Related Protein Mayven. J. of Neurochemistry. 92(5):1191-1203.
  • Park S-Y, Schinkmann K, Avraham S. (2006) RAFTK/Pyk2 Mediates LPA-Induced Cell Migration in a Ras-Dependent Manner. Cell Signalling. 18(7):1063-1071.
  • Park S-Y, Li H, Avraham S. (2006) RAFTK/Pyk2 Regulates EGF-Induced PC12 Cell Spreading and Movement. Cell Signalling. In Press.

Cesar Nombela-Arrieta, Ph.D. - Research Fellow


2006 Ph.D. Theodor Kocher Institute (TKI)
University of Bern, Switzerland
2003 Ph.D. Student National Center for Biotechnology (CNB/CSIC), Madrid
Department of Immunology
2006 Diploma in Microbiology & Immunology Faculty of Pharmacy
Universidad Complutense de Madrid (UCM)
1999 Diploma in Pharmacy Universidad Complutense de Madrid


  • Stein JV, Fernandez-Soriano S, M'Rini C, Nombela-Arrieta C, Gonzalez de Buitrago G, Rodriguez-Frade JM, Mellado M, Girard JP, Martinez-A C. (2003) CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. Blood. Jan 1;101(1):38-40.
  • Nombela-Arrieta C, Lacalle AR, Montoya MC, Megias D, Marques M, Carrera A-C, Manes S, Fukui Y, Martinez-A C, Stein JV. (2004) Differential requirements for DOCK2 and phosphoinositide-3-kinase y during T and B lymphocyte homing. Immunity. Sep;21(3):429-441.
  • Garcia-Bernal D, Wright N, Sotillo-Mallo E, Nombela-Arrieta C, Stein JV, Bustelo XR, Teixido J. (2005) Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1. Mol Biol Cell. Jul;16(7):3223-3235.
  • Stein JV, Nombela-Arrieta C. (2005) Chemokine control of lymphocyte trafficking: a general overview. Immunology. Sep;116(1):1-12. Review.
  • Garcia-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, Fukui Y, Stein JV, Teixido J. (2006) DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1. Journal of Immunology. Oct 15;177(8):5215-5225.
  • Nombela-Arrieta C, Mempel TR, Fernandez-Soriano S, Mazo I, Wymann MP, Hirsch E, Martinez-A C, Fukui Y, von Andrian UH, Stein JV. (2007) The roles of DOCK2 and phosphoinositide-3 kinase y during interstitial lymphocyte motility, dwelling time in peripheral lymph nodes and sphingosine-1-phosphate receptor 1-mediated signaling. J Exp Med. Mar 19;204(3):497-510. Epub 2007 Feb 26.

Geqiang Li, PhD


2004 PhD

Case Western Reserve University

Department of Cancer Biology


Chinese Academy of Science


Wuhan University

Department of Biochemistry


  • Li G, et al. STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. Blood, 2010 Feb 18;115(7):1416-24
  • Li G, et al. Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin. Leukemia.2010 Aug;24(8):1397-405
  • Li G,et al. Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5. Plos One  2010 Feb 10;5(2):e9153
  • Li G,   et al STAT5 requires the N-domain to maintain hematopoietic stem cellrepopulating function and appropriate lymphoid-myeloid lineage output. Experimental Hematology 2007 Nov; 35(11):1684-94
  • Li G, et al. An apoptotic signaling pathway in the interferonantiviral response mediated by RNase L and c-Jun NH2-terminal kinase. J Biol. Chem. 2004 Jan 9; 279(2):1123-31.
  • Wang Z, Li G,  and Kevin D. Bunting. Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient non-ablative stem cell replacement. Blood. 2009 May 14;113(20):4856-65
  • Zhang Y, Diaz-Flores E, Li G, et al. Abnormal hematopoiesis in Gab2 mutant mice. Blood. 2007 Jul 1;110(1):116-24;
  • Friedbichler K, Kerenyi MA, Kovacic B, Li G, et al Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation. Blood  2010, May 27
  • Barnstein  BO, Li G, et al. Stat5 expression is required for IgE-mediated mast cell function. J Immunol. 2006 Sep 1;177(5):3421-6.
  • Chan ER, Lavender H, Li G, et al. An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance. Experimental Hematology. 2009, 37: 276–284.