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Shimamura Laboratory Research | Overview


Bone marrow failure, myelodysplastic syndrome, cancer genetics

Principal Investigator: Akiko Shimamura, MD, PhD

The Shimamura lab studies bone marrow failure, myelodysplastic syndromes, and genetic cancer predisposition with the goal of improving diagnosis, and developing better treatments.  We have identified new genes causing these disorders, elucidated molecular mechanisms causing these disorders and their complications, and expanded our understanding. of the broad clinical spectrum of these disorders. Our investigations span basic scientific mechanisms and clinical research. 

We welcome inquiries from talented and motivated scientists and clinical researchers interested in learning more about opportunities in our lab.

Decoding sickle cell disease

A recent Sankaran Lab study, which reveals how the fetal to adult hemoglobin switch is regulated, may open new possibilities for sickle cell patients.

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Probing a blood cancer’s genetic origins

When Meredith's headaches turn out to be caused by a rare blood cancer, the Sankaran Lab sets out to untangle the complicated genetics of myeloproliferative neoplasms.

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Fast tracking a novel gene therapy for DBA

The lack of a cure or a sustainable long-term solution for people with Diamond-Blackfan anemia, like Lindsay, is what inspired the Sankaran Lab to begin experimenting with potential treatments.

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