Current Environment:

Lab Members | Overview

Staff

Simona Stella

 

Simona Stella | Email
Lab Administrator

 

Hailey Heston

Hailey Heston | Email
Research Associate

I am interested in the use of novel PET-tracer constructs for examining the prognostic and mechanistic elements of cancer and infectious disease.

 

Frederique van den Haak

Frederique van den Haak
Research Associate

My interest is in determining the mechanism of action of novel neutralizing nanobodies against the Ebola virus glycoprotein.

 

Postdoctoral Fellows

Ryan Alexander, PhD

Ryan Alexander, PhD | Email
PhD in Biological and Biomedical Sciences, Harvard Medical School

My research interests include the use of nanobodies in cancer immunotherapy, including their use as antigen recognition components in chimeric antigen receptor T cells targeting pancreatic cancer.

 

Thomas Balligand, MD, PhD

Thomas Balligand, MD, PhD | Email
MD Université Catholique de Louvain, Belgium
PhD in Biomedical and Pharmaceutical Sciences, Université Catholique de Louvain, Belgium

I am interested in developing nanobody-based immunotherapeutic strategies to treat myeloproliferative neoplasms driven by mutations of the CALR gene, as well as precising the role and biodistribution of circulating CALR oncoproteins in these diseases. I am using a combination of several approaches, including nanobody production, linking of small molecules/peptides to nanobodies through endopeptidase-mediated reactions and immuno-PET.

 

Thibault Harmand, PhD

Thibault Harmand, PhD | Email
PhD in Organic Chemistry, ETH Zürich, Switzerland

I am currently working on the development of new chemical and enzymatic tools to prepare complex bioconjugates for medical applications.

 

Nicholas McCaul, PhD

Nicholas McCaul, PhD | Email
PhD in Biochemistry, Utrecht University, The Netherlands

I am studying the ways in which aspects of protein quality control such as the unfolded protein response (UPR) and ER-associated degradation (ERAD) contribute to cell homeostasis and the response to proteotoxic insult.

 

Novalla Pishesha, PhD

Novalla Pishesha, PhD | Email
PhD in Biological Engineering, Massachusetts Institute of Technology, Cambridge

I am interested in developing protein and cell-based therapeutics to tackle autoimmunity and infectious diseases.

 

Xin Liu, PhD

Xin Liu, PhD | Email
PhD in Chemistry, Purdue University, Indiana

My research interests are "targeted imaging and therapeutic agents, influenza research."

 

Graduate Students

Lotte Wijne

Lotte Wijne | Email
PhD candidate in cell biology, University of Leiden, The Netherlands

I am interested in deciphering the complex roles of E2 enzymes, an important group of enzymes involved in ubiquitin conjugation. Ubiquitination is an important post-translational modification within the cell and plays many key roles in cellular functioning. Having the ability to study and manipulate them with nanobodies will greatly help in our understanding of these enzymes and how they contribute to health and disease.

Elisha Verhaar

Elisha Verhaar | Email
PhD Candidate

My interest is in cancer and immunology. Project: using nanobodies to target mutated KRAS in pancreatic cancer.

Alumni

Post-doctoral Fellows

2020 Md Ashraful Islam  Post-doctoral Fellow, University of Tromsø, Norway
2020 Ross Cheloha Investigator, National Institutes of Health, Bethesda
2020 Andrew Woodham Senior Research Scientist, BioNTech, Cambridge
2019 Tao Fang Senior Research Scientist
2019 Mohammad Rashidian Assistant Professor, Dana-Farber Cancer Institute, Boston
2018 Matthias Truttmann  Assistant Professor, University of Michigan Medical School, Ann Arbor

Graduate Students

2019 Djenet Bousbaine Research Fellow, Stanford University
2019 Jason Nguyen Patent Agent, Wilson Sonsini Goodrich
2019 Yushu (Joy) Xie Research Scientist, Bluebird Bio
2018 Ella Zeyang Li IP Practice Specialist, Jones Day
2018 Jingjing Ling Research Fellow, Singapore Immunology Network

Other Lab Members

2020 William Pinney (Research Assistant) Fulbright Scholar, Munich, Germany
2020 Stephen Kolifrath (Lab Supervisor) Laboratory Manager, Pandemic Response Lab, New York City
2019 Robert Miller (Lab Manager) retired
2018 Harun Sugito (Research Technician) MD student, Dartmouth College
2018 Rhogerry Deshycka (Research Assistant) PhD student, UCSF