Current Environment:

Selected Publications

2021

  • Timothy Klouda, Yuan Hao, Hyunbum Kim, Jiwon Kim, Judith Olejnik, Adam J. Hume, Sowntharya Ayyappan, Xuechong Hong, Juan Melero-Martin, Yinshan Fang, Qiong Wang, Xiaobo Zhou, Elke Mühlberger, Hongpeng Jia, Robert F. Padera Jr., Benjamin A. Raby & Ke Yuan*. Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2, Angiogenesis (IF:9.6) (2021) DOI. https://doi.org/10.1007/s10456-021-09823-4 * correspondence author. View on PubMed 

  • Yuan K, Agarwal S, Chakraborty A, Condon DF, Patel H, Zhang S, Huang F, Mello SA, Kirk OI, Vasquez R, de Jesus Perez VA. Lung Pericytes in Pulmonary Vascular Physiology and Pathophysiology. Comprehensive Physiology (IF: 8.6) 2021 06 30; 11(3):2227-2247. PMID: 34190345. View on PubMed

​Pre-2021

  • Yuan K. Shamskhou EA, Mark E. Orcholski ME, Reddy S, Honda H, Mani V, Demirci U, Nicolls M and Perez V de Jesus, Loss of endothelial-derived Wnt5a is associated with reduced pericyte recruitment and small vessel loss in PAH, Circulation (IF:29.7), 2018, Dec 11, View on PubMed

  • de Jesus Perez VA*, Yuan K*, Lyuksyutova MA, Dewey F, Orcholski ME, Shuffle EM, Mathur M, Yancy Jr L, Rojas V, Li CG: Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension, American journal of respiratory and critical care medicine (IF:21.4) 2014, 189:1260-1272. *co-first author, Cover Story. View on PubMed

  • Yuan K*, Liu Y, Zhang Y, Nathan A, Yu J, Condon D, Perez V de Jesus. Mural Cell SDF1 Signaling is Associated with the Pathogenesis of Pulmonary Arterial Hypertension,  American journal of respiratory cell and molecular biology (IF:6.9) , June 2020.PMID: 32084325 * first and co-correspondence author View on PubMed

  • Nickel N, Shamskhou E, Razeen M, Louro L, Dubra A, Liao YJ, Zamanian R, Yuan K*, Perez V de Jesus*. Anatomic genetic and functional properties of the retinal circulation in pulmonary hypertension. Pulmonary Circulation, 2020.*co-correspondence author View on PubMed

  • Klouda T, Kim H, Kim J, Visner G, Yuan K*. Precision Cut Lung Slices as an Efficient Tool for Ex vivo Pulmonary Vessel Structure and Contractility Studies. J Vis Exp. 2021 05 24; (171). PMID: 34096923.* correspondence author. View on PubMed 

  • Klouda T, Condon D, Hao Y, Tian W, Lvova M, Chakraborty A,  Nicolls MR, Zhou X,  Raby B, Yuan K*. From 2D to 3D: Promising Advances in Imaging Lung Structure. 16 July 2020. Frontier Medicine. 2020 Jul 16;7:343. doi: 10.3389/fmed.2020.00343. PMID: 32766264; PMCID: PMC7381109. * correspondence author. View on PubMed

  • Yuan K, N Shao, Hennigs, M Discipulo1, M Orcholski, A Richter, J C. Wu and V de Jesus Perez., Increased pyruvate dehydrogenase kinase 4 expression in lung pericytes is associated with reduced endothelial-pericyte interactions and small vessel loss in pulmonary arterial, The American Journal of Pathology, 2016, July 22. View on PubMed

  • Yuan K, Orcholski M, Panaroni C, Huang N, Jiang X, Shuffle E, Tian W, Desai T, Vladar E, Nicolls M, Wu J, de Jesus Perez VA. Activation of the Wnt/planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. The American Journal of Pathology, 2014, Nov 06, View on PubMed

  • Yuan K, Lian Z, Sun B, Clayton MM, Ng IO, Feitelson MA: Role of miR-148a in hepatitis B associated hepatocellular carcinoma, PLoS One 2012, 7:e35331 View on PubMed

  • Zehendner C, Thal S, Valasarajan C, Werner A, Boeckel J, Bischoff F, John D, Weirick T, Glaser S, Rossbach O, Jaé N, Demolli S, Hummel R, Kreitner K, Möllmann C, Yuan K, de Jesus Perez V, Michalik K, Chen W, Seeger W, Pullamsetti S, Dimmeler S. LncRNA TYKRIL controls pericyte function in health and human disease by modulating PDGF signaling and p53 activity, American journal of respiratory and critical care medicine (IF:21.4) 2020 Nov 15; 202(10): 1445–1457.View on PubMed

  • Nickel N, Yuan K, Dorfmuller P, Lai C, Austin E, de Jesus Perez VA. Beyond the lung: Systemic manifestations of pulmonary arterial hypertension. American journal of respiratory and critical care medicine (IF:21.4) 2019 Sep 12. View on PubMed

  • Yuan K, Orcholski M, Tian X, Liao X, de Jesus Perez VA: MicroRNAs: promising therapeutic targets for the treatment of pulmonary arterial hypertension, Expert opinion on therapeutic targets 2013, 17:557-564

  • Sung Y*, Yuan K.* and V de Jesus Perez, Novel approaches to pulmonary arterial hypertension drug discovery, Expert Opinion on Drug Discovery, 2016;11(4):407-14, *co-first author View on PubMed

  • Yuan K., Orcholski M, Huang NF and V de Jesus Perez, In Vivo Study Of Human Endothelial–Pericyte Interactions by Implantation Of Matrigel Plugs In SCID Mice, JOVE, 12/19/2016, Issue 118; View on PubMed

  • Yuan K., Cai L, Ngok SP, Ma L, Botham CM. Ten Simple Rules for Writing a Postdoctoral Fellowship. PLoS Computational Biology, 2016, 12(7): e1004934. View on PubMed

  • Tian W, Jiang X, Sung YK, Qian J, Yuan K, Nicolls MR: Leukotrienes in pulmonary arterial hypertension, Immunologic research 2014, 58:387-393 View on PubMed

  • Perez VdJ, Yuan K, Alastalo T-P, Spiekerkoetter E, Rabinovitch M: Targeting the Wnt signaling pathways in pulmonary arterial hypertension, Drug discovery today 2014,19:1270-1276 View on PubMed

  • Li M, Vattulainen S, Aho J, Orcholski M, Rojas V, Yuan K, Helenius M, Taimen P, Myllykangas S, De Jesus Perez V: Loss of Bone Morphogenetic Protein Receptor 2 Is Associated with Abnormal DNA Repair in Pulmonary Arterial Hypertension, American journal of respiratory cell and molecular biology 2014, 50:1118-1128 View on PubMed

  • Brunner N, de Jesus Perez VA, Richter A, Haddad F, Denault A, Rojas V, Yuan K, Orcholski M, Liao X: Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery, Pulmonary Circulation 2014, 4:10-24 View on PubMed

  • Liao X-B, Zhang Z-Y, Yuan K, Liu Y, Feng X, Cui R-R, Hu Y-R, Yuan Z-S, Gu L, Li S-J: MiR-133a modulates osteogenic differentiation of vascular smooth muscle cells, Endocrinology 2013, 154:3344-3352 View on PubMed

  • Jiang X, Hsu JL, Tian W, Yuan K, Olcholski M, de Jesus Perez V, Semenza GL, Nicolls MR: Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus, Journal of Molecular Medicine 2013, 91:1081-1093 View on PubMed

  • Chen H-M, Hu Z-K, Zheng X-L, Yuan Z-S, Xu Z-B, Yuan L-Q, Perez VADJ, Yuan K, Orcholski M, Liao X-B: Effectiveness of YouTube as a source of medical information on heart transplantation, Interactive journal of medical research 2013, 2: View on PubMed

  • de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E: Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans, Circulation research 2012, 111:1551-1564 View on PubMed

  • Ali ZA, de Jesus Perez VA, Yuan K, Orcholski M, Pan S, Raiesdana A, Leeper NJ, Qu X, Rivera KZ, Oguri M, Kato K, Yamada Y, Channon K,Rabinovitch M, Charest A, Quertermous T, Ashley EA. Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1, Journal of Clinical Investigation, doi:10.1172/JCI77484. View on PubMed

  • Jiang X, Tian W, Nyugen T, Sung Y, Yuan K, Qian J, Rajadaus J, Rabinovitch M and Nicolls M. Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection. The American Journal of Transplantation. 27 Feb 2015 View on PubMed

  • Chang Y, Tseng C, Tannenberg P, Yuan K, de Jesus Perez V, Lundberg J, Botusan I, Tran P, Lundmark K. Perlecan Heparan Sulfate Deficiency Impairs Pulmonary Vascular Development and Attenuates Hypoxic Pulmonary Hypertension. Cardiovascular Research, 2015 May 6. pii: cvv143. View on PubMed

  • Zamanian R., Brunner N, Ikeno F, Connolly A, Shuffle E, Yuan K et al. Assessment Of Pulmonary Arterial Wall Anatomy In Healthy Human Lungs And Pig (Sus Scrofa) Using Optical Coherence Tomography: A Technical Case Report. Comparative Medicine, June 2015, View on PubMed

  • Takahashi J, Orcholski M, Yuan K, de Jesus Perez V. Pdgf-dependent b-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension. FEBS Letters. 2016 Jan, Volume 590, Issue 1, pages 101–109. View on PubMed

  • Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K,.et al, Loss of PPARγ in endothelial cells leads to impaired angiogenesis. J Cell Sci. 2016 Jan 7. View on PubMed

  • Orcholski M, Khurshudyan A, Shamskhou E, Yuan K et al. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension AJP- Lung Cellular and Molecular Physiology, 4 May 2017 Vol. no. , View on PubMed

  • Orcholski, M. E., Yuan, K., Rajasingh, C., Tsai, H., Shamskhou, E. A., Dhillon, N. K., Voelkel, N. F., Zamanian, R. T., de Jesus Perez, V. Drug induced pulmonary arterial hypertension: a primer for clinicians and scientists. American journal of physiology Lung cellular and molecular physiology. 04 JUN 2018 View on PubMed

  • Shamskhou, E. A., Verghese, L., Yuan, K., De Jesus Perez, V. A., EMAPII: A Key Player in HIV-Nef Induced Pulmonary Vasculopathy. Am J Respir Cell Mol Biol. 2018 Oct 30. View on PubMed

  • Shamskhou E**, Kratochvil M**, Orcholski M, Yuan K, Nagy N, Kaber G, Steen E, Balaji S, Sundeep Keswani S, et al. Hydrogel-based delivery of il-10 improves treatment of bleomycin-induced lung fibrosis in mice, BioMaterial, Volume 203, May 2019, Pages 52-62 View on PubMed​

  • Peng S, Shevidi S, Yuan E, Yuan K, Lautman Z, Jeffrey S, Sledge G, de la Zerda A, Gold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for In Vivo Multiplexing Studies, Nano Letters, Oct 04 2019, View on PubMed

​View All publications at Harvard Catalyst