Publications

2021


The Role of RNA Editing in the Immune Response

Ahmad, S., Mu, X., & Hur, S. (2021). Methods in molecular biology (Clifton, N.J.), 2181, 287–307. https://doi.org/10.1007/978-1-0716-0787-9_17

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons

Gao, D., Ciancanelli, M. J., Zhang, P., Harschnitz, O., Bondet, V., Hasek, M., Chen, J., Mu, X., Itan, Y., Cobat, A., Sancho-Shimizu, V., Bigio, B., Lorenzo, L., Ciceri, G., McAlpine, J., Anguiano, E., Jouanguy, E., Chaussabel, D., Meyts, I., Diamond, M. S., Zhang, S. Y. (2021). The Journal of clinical investigation, 131(1), e134529. https://doi.org/10.1172/JCI134529

Death domain fold proteins in immune signaling and transcriptional regulation

Huoh, Y. S., & Hur, S. (2021). The FEBS journal, 10.1111/febs.15901. Advance online publication. https://doi.org/10.1111/febs.15901

DDX58(RIG-I)-related disease is associated with tissue-specific interferon pathway activation

Prasov, L., Bohnsack, B. L., El Husny, A. S., Tsoi, L. C., Guan, B., Kahlenberg, J. M., Almeida, E., Wang, H., Cowen, E. W., De Jesus, A. A., Jani, P., Billi, A. C., Moroi, S. E., Wasikowski, R., Almeida, I., Almeida, L. N., Kok, F., Garnai, S. J., Mian, S. I., Chen, M. Y., Gudjonsson, J. E. (2021). Journal of medical genetics, jmedgenet-2020-107447. Advance online publication.
https://doi.org/10.1136/jmedgenet-2020-107447

Nonsegmented Negative-Sense RNA Viruses Utilize N6-Methyladenosine (m6A) as a Common Strategy To Evade Host Innate Immunity

Lu, M., Xue, M., Wang, H. T., Kairis, E. L., Ahmad, S., Wei, J., Zhang, Z., Liu, Q., Zhang, Y., Gao, Y., Garcin, D., Peeples, M. E., Sharma, A., Hur, S., He, C., & Li, J. (2021). Journal of virology, 95(9), e01939-20. https://doi.org/10.1128/JVI.01939-20

2020



Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

Kato, K., Ahmad, S., Zhu, Z., Young, J. M., Mu, X., Park, S., Malik, H. S., & Hur, S. (2021).Molecular cell,81(3), 599–613.e8.PDF

 


Substrate recognition by TRIM and TRIM-like proteins in innate immunity

Wang, H. T., & Hur, S. (2020). Seminars in cell & developmental biology111, 76–85.  PDF 

 

Dual functions of Aire multimerization in the transcriptional regulation of T cell tolerance

Huoh, Y. S., Wu, B., Park, S., Yang, D., Bansal, K., Greenwald, E., Wong, W. P., Mathis, D., & Hur, S. (2020). (1), 1625.  PDF

 

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Ablasser, A., & Hur, S. (2020). Nature immunology21(1), 17–29.  PDF 

 

  Genetic and phenotypic spectrum associated with IFIH1 gain-of-function

Rice, G. I., Park, S., Gavazzi, F., ..., Hur, S., Crow, Y. J. (2020). Human mutation41(4), 837–849.  PDF 

 


2019


Filament-like assemblies of intracellular nucleic acid sensors: commonalities and differences 

Cadena C & Hur S, Mol. Cell, (2019), 76(2): 243-54 (review).  PDF 

 

N6-methyladenosine modification controls circular RNA immunity

Chen YG, Chen R, Ahmad S, Verma R, Kasturi S, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S and Chang HY, Mol.Cell  (2019).  PDF 

 

The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus

Jasenosky LD, Cadena C, Mire C, Haridas V, Ranjbar S, Borisevich V, Geisbert T, Hur S and Goldfeld A, iScience, Epub ahead of print (2019).  PDF 

 

Ubiquitin-dependent and -independent roles of E3 ligase RIPLET in innate immunity

Cadena C, Ahmad S, Xavier A, Willemsen J, Park S, Park JW, Oh SW, Fujita T, Hou F, Binder M, & Hur S, Cell, (2019), 177(5):1187-1200.  PDF 

 

Double-stranded RNA sensors and modulators in innate immunity

Hur S,Annu. Rev. Immunol, (2019), 37:349-375.PDF


DDX58and Classic Singleton-Merten Syndrome

Ferreira C, Crow YJ, Gahl WA, Goldbach-Mansky R, Hur S, Almeida de Jesus A, Nehrebecky M, Park JW, and Briggs TA,J. of Clinical Immunol.(2019), 39(1):75-80.PDF

 

2018


Autosomal dominant early-onset spastic paraparesis with brain calcification due to IFIH1 gain-of-function

Ruaud L, Rice GI, Cabrol C, Piard J, Rodero M, van Eyk L, Boucher-Brischoux E, Maertens de Noordhout A, Mare R, Scalais E, Pauly F, Debray FG, Dobyns W, Uggenti C, Park JW, Hur S, Livingston JH Crow YJ, Van Maldergem L, Human Mutation. (2018), 39: 1076-1080.  PDF 

 

An origin of the immunogenicity of in vitro transcribed RNA

Mu X, Greenwald E, Ahmad S and Hur S, Nucleic Acid Research, (2018), 46:5239-49.  PDF 

 

Breaching self-tolerance to Alu duplex RNA underlies MDA5-mediated inflammation

Ahmad S*, Mu X*, Yang F*, Greenwald E, Park JW, Jacob E, Zhang C-Z and Hur S., Cell, (2018) 172:797-810  --Highlighted in Cell (2018), 172:640-642.  PDF 

 

2017


Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE).

Abbott JK*, Huoh YS*, Reynolds P, Yu L, Rewers M, Reddy M, Anderson MS, Hur S, Gelfand EW, J. of Autoimmunity. (2017) 17:30579-6.  PDF 

 

Antiviral immunity and Circular RNA: No End in Sight

Cadena C & Hur S, Molecular Cell, (2017) 67(2):163-164 (preview).  PDF 

 

Musculoskeletal disease in MDA5-related type I interferonopathy: A mendelian mimic of Jaccud’s Arthropathy

De Carvalho LM*, Ehmke N*, Park JW*, Ngoumou G, Deigendesch N, Kitabayashi N, Melki I, L Souza FF, Nogueira-Barbosa MH, Ferriani V, Louzada-Junior P, Marques Junior W, Lourenco CM, Horn D, Kallinich T, Stenzel W, Hur S, Rice GI, Crow YJ, Arthritis & Rheumatology. (2017) 69:2081-91.  PDF 

 

2016


Filament assemblies in foreign nucleic acid sensors

Sohn J & Hur S, Curr Opin Struct Biol. (2016), 37:134-44 (Review).  PDF 

 

Endogenous retroelements and the host innate immune sensors

Mu X, Ahmad S & Hur S, Advances in Immunology, (2016), 132:47-69.  PDF 

 

Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors

Wu B, Houh Y & Hur S, Methods Molecular Biology (2016), Vol 1390, In Press, (Book Chapter).  PDF 

 

2015


Unusual cutaneous features associated with a heterozygous gain‐of‐function mutation in IFIH1: overlap between Aicardi‐Goutières and Singleton‐Merten syndromes

Bursztejn AC, Briggs TA, Del Toro Duany Y, Anderson BH, O'Sullivan J, Williams SG, Bodemer C, Fraitag S, Gebhard F, Leheup B, Lemelle I, Oojageer A, Raffo E, Schmitt E, Rice GI, Hur S, Crow YJ., Br J Dermatol. (2015) 173:1505-13. 
 
PDF 

 

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

Xu J, Mercado-Lopez X, Grier JT, Kim WK, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M Jr, Raj A, Lopez CB. MBio.(2015) 6:e01265-15.  PDF 

 

Helicases in antiviral immunity: dual properties as sensors and effectors

Ahmad S and Hur S, Trends in Biochemical Sciences (2015) 40:576-85. (Review).  PDF 

 

How RIG-I like receptors activate MAVS

Wu B & Hur S, Curr. Opin. Virol. (2015)12:91-8.  PDF 

 

ATP-dependent effector-like functions of RIG-I like receptors

Yao H, Dittmann M, Peisley A, Hoffmann H-H, Gilmore RH, Schmidt T, Schmidt-Burgk J, Hornung V, Rice CM, and Hur S, Molecular Cell, (2015), 58:541-8. --Highlighted in Science Signaling (2015), 8:ec130.  PDF 

 

MDA5-filament, dynamics and disease

Del Toro Duany Y, Wu B and Hur S, Curr. Opin. Virol. (2015), 12:20-5 (Review).  PDF 

 

2014


Molecular imprinting as a signal activation mechanism of the viral RNA sensor RIG-I

Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor, KE, Walz T, Penczek PA and Hur S, Molecular Cell, (2014), 55: 511-23. --Highlighted in Molecular Cell (2014), 55:505-7.  PDF 

 

Gain of function mutations in IFIH1 (MDA5) cause a spectrum of human disease phenotypes associated with an upregulation of type I interferon signaling

Rice GI*, del Toro Duany Y*, Jenkinson EM, Forte GMA, Anderson BH, Ariaudo G, Bader-Meunier B, Baildam EM, Battini R, Beresford MW, Casarano M, Chouchane M, Cimaz R, Collins AE, Cordeiro NJV, Dale RC, Davidson JE, De Waele L, Desguerre I, Faivre L, Fazzi E, Isidor B, Lagae L, Latchman AR, Lebon P, Li C, Livingston JH, Lourenco CM, Mancardi MM, Masurel-Paulet A, McInnes IB, Menezes MP, Mignot C, O’Sullivan J, Orcesi S, Picco PP, Riva E, Robinson RA, Rodrigues D, Salvatici E, Scott C, Szybowska M, Tolmie JL, Vanderver A, Vanhulle C, Vieira JP, Webb K, Whitney RN, Williams SG, Wolfe LA, Zuberi SM,  Hur S**, Crow YJ**. Nature Genetics, (2014), 46:503-9, (* co-first authors, ** co-corresponding authors). --Highlighted in Nature Genetics (2014), 84:1551-61.  PDF 

 

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I.

Peisley A, Wu B, Xu H, Chen ZJ & Hur S. Nature, (2014), 509:110-4  -- Highlighted in Cell Research (2014), 24:645-6.  PDF 

 

2013


RIG-I forms signaling-competent filaments in an ATP-dependent and ubiquitin-independent manner

Peisley A*, Wu B*, Yao H, Walz T & Hur S. Molecular Cell, (2013), 51, 573-83, PMID: 23993742 (* equal contribution) -- Highlighted in Faculty1000Prime.  PDF 

 

Viral counterattack against the host innate immune system

Wu B and Hur S. Cell Research, (2013), 23, 735-6, PMID:23478300 (Review).  PDF 

 

Structural Basis for dsRNA recognition, filament formation and antiviral signaling by MDA5

Wu B, Peisley A, Richards C, Yao H, Zeng Z, Lin C, Chu F, Walz T & Hur S. Cell, (2013) 152, 276-89,  PMID: 23273991 -- Highlighted in Nat. Rev. Immunol. (2013), 13:153.  PDF 

 

Multi-level regulation of cellular recognition of viral dsRNA

Peisley A & Hur S. Cell Mol. Life Sci. (2013), 70, 1949-63, PMID:22960755 (Review).  PDF 

 

2011 - 2012


MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells

Feng Q, Hato SV, Langereis MA, Zoll J, Virgen-Slane R, Peisley A, Hur S, Semler BL, van Rij R & van Kuppeveld FJM. Cell Reports, (2012), 2, 1187-96, PMID:23142662.  PDF 

 

Kinetic Mechanism for Viral dsRNA Length Discrimination by MDA5 filament

Peisley A*, Jo MH*, Lin C, Wu B, Orme-Johnson M, Walz T, Hohng S & Hur S. Proc. Natl. Acad. Sci. U.S.A. (2012), 109, E3340-9, PMID:23129641 (* equal contribution).  PDF  

 

Cooperative Assembly and Dynamic Disassembly of MDA5 Filaments for Viral dsRNA Recognition

Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, Walz T & Hur S. Proc. Natl. Acad. Sci. U.S.A. (2011), 108, 21010-5. PDF