The Role of RNA Editing in the Immune Response

Ahmad, S., Mu, X., & Hur, S. (2021). Methods in molecular biology (Clifton, N.J.), 2181, 287–307.

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons

Gao, D., Ciancanelli, M. J., Zhang, P., Harschnitz, O., Bondet, V., Hasek, M., Chen, J., Mu, X., Itan, Y., Cobat, A., Sancho-Shimizu, V., Bigio, B., Lorenzo, L., Ciceri, G., McAlpine, J., Anguiano, E., Jouanguy, E., Chaussabel, D., Meyts, I., Diamond, M. S., Zhang, S. Y. (2021). The Journal of clinical investigation, 131(1), e134529.

Death domain fold proteins in immune signaling and transcriptional regulation

Huoh, Y. S., & Hur, S. (2021). The FEBS journal, 10.1111/febs.15901. Advance online publication.

DDX58(RIG-I)-related disease is associated with tissue-specific interferon pathway activation

Prasov, L., Bohnsack, B. L., El Husny, A. S., Tsoi, L. C., Guan, B., Kahlenberg, J. M., Almeida, E., Wang, H., Cowen, E. W., De Jesus, A. A., Jani, P., Billi, A. C., Moroi, S. E., Wasikowski, R., Almeida, I., Almeida, L. N., Kok, F., Garnai, S. J., Mian, S. I., Chen, M. Y., Gudjonsson, J. E. (2021). Journal of medical genetics, jmedgenet-2020-107447. Advance online publication.

Nonsegmented Negative-Sense RNA Viruses Utilize N6-Methyladenosine (m6A) as a Common Strategy To Evade Host Innate Immunity

Lu, M., Xue, M., Wang, H. T., Kairis, E. L., Ahmad, S., Wei, J., Zhang, Z., Liu, Q., Zhang, Y., Gao, Y., Garcin, D., Peeples, M. E., Sharma, A., Hur, S., He, C., & Li, J. (2021). Journal of virology, 95(9), e01939-20.


Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

Kato, K., Ahmad, S., Zhu, Z., Young, J. M., Mu, X., Park, S., Malik, H. S., & Hur, S. (2021).Molecular cell,81(3), 599–613.e8.PDF


Substrate recognition by TRIM and TRIM-like proteins in innate immunity

Wang, H. T., & Hur, S. (2020). Seminars in cell & developmental biology111, 76–85.  PDF 


Dual functions of Aire multimerization in the transcriptional regulation of T cell tolerance

Huoh, Y. S., Wu, B., Park, S., Yang, D., Bansal, K., Greenwald, E., Wong, W. P., Mathis, D., & Hur, S. (2020). (1), 1625.  PDF


Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Ablasser, A., & Hur, S. (2020). Nature immunology21(1), 17–29.  PDF 


  Genetic and phenotypic spectrum associated with IFIH1 gain-of-function

Rice, G. I., Park, S., Gavazzi, F., ..., Hur, S., Crow, Y. J. (2020). Human mutation41(4), 837–849.  PDF 



Filament-like assemblies of intracellular nucleic acid sensors: commonalities and differences 

Cadena C & Hur S, Mol. Cell, (2019), 76(2): 243-54 (review).  PDF 


N6-methyladenosine modification controls circular RNA immunity

Chen YG, Chen R, Ahmad S, Verma R, Kasturi S, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S and Chang HY, Mol.Cell  (2019).  PDF 


The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus

Jasenosky LD, Cadena C, Mire C, Haridas V, Ranjbar S, Borisevich V, Geisbert T, Hur S and Goldfeld A, iScience, Epub ahead of print (2019).  PDF 


Ubiquitin-dependent and -independent roles of E3 ligase RIPLET in innate immunity

Cadena C, Ahmad S, Xavier A, Willemsen J, Park S, Park JW, Oh SW, Fujita T, Hou F, Binder M, & Hur S, Cell, (2019), 177(5):1187-1200.  PDF 


Double-stranded RNA sensors and modulators in innate immunity

Hur S,Annu. Rev. Immunol, (2019), 37:349-375.PDF

DDX58and Classic Singleton-Merten Syndrome

Ferreira C, Crow YJ, Gahl WA, Goldbach-Mansky R, Hur S, Almeida de Jesus A, Nehrebecky M, Park JW, and Briggs TA,J. of Clinical Immunol.(2019), 39(1):75-80.PDF



Autosomal dominant early-onset spastic paraparesis with brain calcification due to IFIH1 gain-of-function

Ruaud L, Rice GI, Cabrol C, Piard J, Rodero M, van Eyk L, Boucher-Brischoux E, Maertens de Noordhout A, Mare R, Scalais E, Pauly F, Debray FG, Dobyns W, Uggenti C, Park JW, Hur S, Livingston JH Crow YJ, Van Maldergem L, Human Mutation. (2018), 39: 1076-1080.  PDF 


An origin of the immunogenicity of in vitro transcribed RNA

Mu X, Greenwald E, Ahmad S and Hur S, Nucleic Acid Research, (2018), 46:5239-49.  PDF 


Breaching self-tolerance to Alu duplex RNA underlies MDA5-mediated inflammation

Ahmad S*, Mu X*, Yang F*, Greenwald E, Park JW, Jacob E, Zhang C-Z and Hur S., Cell, (2018) 172:797-810  --Highlighted in Cell (2018), 172:640-642.  PDF 



Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE).

Abbott JK*, Huoh YS*, Reynolds P, Yu L, Rewers M, Reddy M, Anderson MS, Hur S, Gelfand EW, J. of Autoimmunity. (2017) 17:30579-6.  PDF 


Antiviral immunity and Circular RNA: No End in Sight

Cadena C & Hur S, Molecular Cell, (2017) 67(2):163-164 (preview).  PDF 


Musculoskeletal disease in MDA5-related type I interferonopathy: A mendelian mimic of Jaccud’s Arthropathy

De Carvalho LM*, Ehmke N*, Park JW*, Ngoumou G, Deigendesch N, Kitabayashi N, Melki I, L Souza FF, Nogueira-Barbosa MH, Ferriani V, Louzada-Junior P, Marques Junior W, Lourenco CM, Horn D, Kallinich T, Stenzel W, Hur S, Rice GI, Crow YJ, Arthritis & Rheumatology. (2017) 69:2081-91.  PDF 



Filament assemblies in foreign nucleic acid sensors

Sohn J & Hur S, Curr Opin Struct Biol. (2016), 37:134-44 (Review).  PDF 


Endogenous retroelements and the host innate immune sensors

Mu X, Ahmad S & Hur S, Advances in Immunology, (2016), 132:47-69.  PDF 


Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors

Wu B, Houh Y & Hur S, Methods Molecular Biology (2016), Vol 1390, In Press, (Book Chapter).  PDF 



Unusual cutaneous features associated with a heterozygous gain‐of‐function mutation in IFIH1: overlap between Aicardi‐Goutières and Singleton‐Merten syndromes

Bursztejn AC, Briggs TA, Del Toro Duany Y, Anderson BH, O'Sullivan J, Williams SG, Bodemer C, Fraitag S, Gebhard F, Leheup B, Lemelle I, Oojageer A, Raffo E, Schmitt E, Rice GI, Hur S, Crow YJ., Br J Dermatol. (2015) 173:1505-13. 


Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

Xu J, Mercado-Lopez X, Grier JT, Kim WK, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M Jr, Raj A, Lopez CB. MBio.(2015) 6:e01265-15.  PDF 


Helicases in antiviral immunity: dual properties as sensors and effectors

Ahmad S and Hur S, Trends in Biochemical Sciences (2015) 40:576-85. (Review).  PDF 


How RIG-I like receptors activate MAVS

Wu B & Hur S, Curr. Opin. Virol. (2015)12:91-8.  PDF 


ATP-dependent effector-like functions of RIG-I like receptors

Yao H, Dittmann M, Peisley A, Hoffmann H-H, Gilmore RH, Schmidt T, Schmidt-Burgk J, Hornung V, Rice CM, and Hur S, Molecular Cell, (2015), 58:541-8. --Highlighted in Science Signaling (2015), 8:ec130.  PDF 


MDA5-filament, dynamics and disease

Del Toro Duany Y, Wu B and Hur S, Curr. Opin. Virol. (2015), 12:20-5 (Review).  PDF 



Molecular imprinting as a signal activation mechanism of the viral RNA sensor RIG-I

Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor, KE, Walz T, Penczek PA and Hur S, Molecular Cell, (2014), 55: 511-23. --Highlighted in Molecular Cell (2014), 55:505-7.  PDF 


Gain of function mutations in IFIH1 (MDA5) cause a spectrum of human disease phenotypes associated with an upregulation of type I interferon signaling

Rice GI*, del Toro Duany Y*, Jenkinson EM, Forte GMA, Anderson BH, Ariaudo G, Bader-Meunier B, Baildam EM, Battini R, Beresford MW, Casarano M, Chouchane M, Cimaz R, Collins AE, Cordeiro NJV, Dale RC, Davidson JE, De Waele L, Desguerre I, Faivre L, Fazzi E, Isidor B, Lagae L, Latchman AR, Lebon P, Li C, Livingston JH, Lourenco CM, Mancardi MM, Masurel-Paulet A, McInnes IB, Menezes MP, Mignot C, O’Sullivan J, Orcesi S, Picco PP, Riva E, Robinson RA, Rodrigues D, Salvatici E, Scott C, Szybowska M, Tolmie JL, Vanderver A, Vanhulle C, Vieira JP, Webb K, Whitney RN, Williams SG, Wolfe LA, Zuberi SM,  Hur S**, Crow YJ**. Nature Genetics, (2014), 46:503-9, (* co-first authors, ** co-corresponding authors). --Highlighted in Nature Genetics (2014), 84:1551-61.  PDF 


Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I.

Peisley A, Wu B, Xu H, Chen ZJ & Hur S. Nature, (2014), 509:110-4  -- Highlighted in Cell Research (2014), 24:645-6.  PDF 



RIG-I forms signaling-competent filaments in an ATP-dependent and ubiquitin-independent manner

Peisley A*, Wu B*, Yao H, Walz T & Hur S. Molecular Cell, (2013), 51, 573-83, PMID: 23993742 (* equal contribution) -- Highlighted in Faculty1000Prime.  PDF 


Viral counterattack against the host innate immune system

Wu B and Hur S. Cell Research, (2013), 23, 735-6, PMID:23478300 (Review).  PDF 


Structural Basis for dsRNA recognition, filament formation and antiviral signaling by MDA5

Wu B, Peisley A, Richards C, Yao H, Zeng Z, Lin C, Chu F, Walz T & Hur S. Cell, (2013) 152, 276-89,  PMID: 23273991 -- Highlighted in Nat. Rev. Immunol. (2013), 13:153.  PDF 


Multi-level regulation of cellular recognition of viral dsRNA

Peisley A & Hur S. Cell Mol. Life Sci. (2013), 70, 1949-63, PMID:22960755 (Review).  PDF 


2011 - 2012

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells

Feng Q, Hato SV, Langereis MA, Zoll J, Virgen-Slane R, Peisley A, Hur S, Semler BL, van Rij R & van Kuppeveld FJM. Cell Reports, (2012), 2, 1187-96, PMID:23142662.  PDF 


Kinetic Mechanism for Viral dsRNA Length Discrimination by MDA5 filament

Peisley A*, Jo MH*, Lin C, Wu B, Orme-Johnson M, Walz T, Hohng S & Hur S. Proc. Natl. Acad. Sci. U.S.A. (2012), 109, E3340-9, PMID:23129641 (* equal contribution).  PDF  


Cooperative Assembly and Dynamic Disassembly of MDA5 Filaments for Viral dsRNA Recognition

Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, Walz T & Hur S. Proc. Natl. Acad. Sci. U.S.A. (2011), 108, 21010-5. PDF