Contact Us | Overview
The Hur Laboratory studies various protein-nucleic acid interactions involved in the vertebrate immune system. The lab uses a combination of structural biology, biochemistry, and cell biology to understand molecule mechanisms of the following proteins.
1. Innate Immune Receptors
- RIG-I-like receptors and other dsRNA sensors
- Self vs. non-self nucleic acids discrimination mechanism
- Intracellular signal transduction mechanism
- Negative regulation (e.g. E3 ligases, Ub-proteasome/autophagy pathway)
- Development of small molecule modulators
2. Transcription Factors
- Key players in T cell tolerance (e.g. Aire and Foxp3)
- Target gene recognition mechanism
- Impact on transcriptional activity and chromatin structural reorganization
Applicants should have a strong background in protein or nucleic acid biochemistry, structural biology, cell biology, immunology or virology.
Please send a cover letter, CV, names, e-mail addresses and telephone numbers of three references to Sun Hur at sun.hur [at] crystal.harvard.edu.
Students in the Harvard graduate programs (BBS, Biophysics, Virology, and Immunology) are welcome to join our lab. Please contact Sun Hur at sun.hur [at] crystal.harvard.edu.
3 Blackfan Cir, Boston, MA 02115
sun.hur [at] crystal.harvard.edu