Xi He - Principle Investigator

Xi He, PhD

Principle Investigator

Xi He received his PhD in 1992 from the University of California, San Diego, where he worked in the laboratory of Michael G. Rosenfeld. He completed a postdoctoral fellowship in 1996 at the National Institutes of Health, under the supervision of Harold E. Varmus. He was a Pew Scholar in Biomedical Sciences, a Klingenstein Fellow in Neuroscience, a Keck Foundation Distinguished Young Scholar in Medical Research and a Leukemia and Lymphoma Society Scholar. He is a Chang Jiang Guest Professor at the School of Life Science and Technology, Huazhong University of Science and Technology in Wuhan, China, inducted by the Ministry of Education of China.

Xi He is a member of the executive board of the Stem Cell Program at Boston Children's Hospital and a member of the editorial boards of Journal of Biological Chemistry, Journal of Genetics and Genomics and Protein & Cell. He has served and is serving on the Scientific Advisory Boards of institutes of the Chinese Academy of Sciences and of biotechnology companies in the United States, China and Europe.

Selective Publications:

  • Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S. FoxM1 promotes b-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 2011; 20:427-42
  • Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY. Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Dev Cell 2011; 21:848-61
  • MacDonald B, Tamai K, and He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009; 17:9-26.
  • Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J and He X. A dual-kinase mechanism for Wnt coreceptor phosphorylation and activation. Nature 2005; 438:873-77.
  • Tamai K, Zeng X, Chunming L, Zhang X, Harada Y, Chang Z, He X. A mechanism for Wnt coreceptor activation. Molecular Cell 2004; 13:149-56.
  • Liu C, Li Y, Semenov M, Baeg G-H, Han C, Tan Y, Zhang Z, Lin X, He X. Control of beta-catenin phosphorylation-degradation by a dual-kinase mechanism. Cell 2002; 108:837-47.
  • Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X. The Wnt antagonist Dickkopf 1 is a ligand for low density lipoprotein receptor related proteins. Curr Biol 2001; 26:951-61.
  • Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet J-P, He X. LDL receptor-related proteins in Wnt signal transduction. Nature 2000; 407: 530-35.

For a complete list of publications on PubMed, click here