Another lab focus is to discover new antigens expressed by muscle stem cells and their role in normal and diseased tissue. Few cell surface antigens are known for prospective isolation of muscle stem cells from human muscle, especially from dystrophic muscle where inherent deficiencies, such as protein glycosylation might alter expression of proteins at the cell surface. We identify new prospective markers and study their function in normal and diseased tissue. Purified myogenic cells are tested for efficacy in cell transplantation in a mouse model for muscular dystrophy.
Gussoni Laboratory job opportunities
Postdoctoral Fellow position available to work on tetraspanin CD82 and its role in normal and dystrophic muscle cells.