Principal Investigator, Gregory Lab
Professor, Department of Biological Chemistry and Molecular Pharmacology, and Department of Pediatrics, Harvard Medical School, Harvard Stem Cell Institute
|Esteban Orellana, PhD
Esteban joined the Gregory Laboratory in May 2018. He completed his graduate studies at Purdue University. His project involved ligand-mediated miRNA delivery and miRNA combinatorial therapeutics for cancer. Esteban's current research focuses on RNA methylation and its role in gene regulation and cancers including glioblastoma and sarcomas.
|Jia Cui, PhD
Jia received her PhD in 2018 from the University of Alabama at Birmingham, where she studied the post-transcriptional regulation of anti-apoptotic protein MCL1 in cancer. In August 2018 she joined the Gregory Lab as a postdoctoral fellow. She is interested in the field of RNA biology. Jia's current research focuses on RNA modifications and their roles in gene regulation and cancer.
|Jiazhi Li, PhD
Jiazhi received her PhD in 2018 from Institute of Biophysics, Chinese Academy of Sciences. Her doctoral program focused on the structural and mechanistic basis of the CRISPR-Cas system. She joined the Gregory Lab in April 2019 and started her research on investigating mechanisms of posttranscriptional gene regulation using a structural and functional combining method.
|Xin Yang, PhD
Xin received his PhD in 2018 from Beijing Institute of Genomics, Chinese Academy of Sciences. He studied the topology of mRNA m5C methylomes and the essential roles of m5C in mRNA export regulation. Xin also studied m6A and its role in the dynamic regulation of co-transcriptional R-loop formation and transcription termination. Xin joined the Gregory Lab in September 2019 and started his research on RNA modifications and their roles in gene regulation and cancer.
|Xushen Xiong, PhD
Xushen obtained his PhD degree in 2019 from Peking University in China, where he received training in chemical biology, specifically in the epitranscriptomics field. He then joined the Gregory Lab as a postdoc, co-supervised by Professor Manolis Kellis at MIT. Xushen is currently working on understanding the regulatory networks of RNA modification in diseases, by employing both computational and experimental approaches.
Julia Ramirez-Moya, PhD
Erdem Sendinc, PhD
After collaborating with the Gregory Lab on various projects, Erdem joined the lab in 2022. He is interested in investigating the roles of RNA modifications in RNA metabolism and cellular biology. He utilizes RNA mass spectrometry to characterize chemical modifications in RNA sequences. His current research focuses on mRNA and tRNA modifying enzymes in the context of regulation of gene expression.
Other Lab Members
Kaitlin received her Bachelor’s degree in 2022 from High Point University where she worked on a research project involving use of new technologies to advance novel compounds for Neurofibromatosis Type 1. She recently joined the Gregory Lab where she studies tRNA regulation and its role in cancer cells.
Lab Manager (2006-2013)
Current: Physician Assistant, New England Neurological Associates P.C.
Grad Student (2007-2011)
Current: Assistant Professor, Weill-Cornell Medical School
John P. Hagan
Current: Assistant Professor, University of Texas Health Sciences Center, Houston, TX
Current: Reseach Scientist, Alexion Pharmaceuticals Inc.
Current: Research Scientist, Twentyeight-seven Therapeutics
Grad Student (2009-2013)
Current: Senior Director of Business Development, Codiak BioSciences
Natalia J. Martinez
Current: Research Scientist, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH)
Current: Associate Professor, Shiga University of Medical Science, Japan
Current: Neurologist, Keio University School of Medicine, Japan
Current: Assistant Professor, Peking University, China
Current: Assistant Professor, Sun Yat-sen University, China
Current: Assistant Professor, Hanyang University, Korea
Lab Manager (2013-2020)
Current: Research Operations Manager, Broad Institute of MIT and Harvard
Current: Assistant Professor, Rutgers Medical School and Center for Advanced Biotechnology and Medicine
Current: Assistant Professor, Guangdong School of Agricultural Science
Research Assistant (2020-2022)
Current: Graduate Student, UNC Chapel Hill
Visiting Graduate Student (2021-2022)
Current: University of Utrecht Medical School