Current Environment:

Lab Members | Overview

Principal investigator

Frederick Alt, PhD Frederick Alt, PhD

Director Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics Professor of Genetics Harvard Medical School


Assistant Professor

Ming Tian, PhD Ming Tian, PhD
Harvard University

I generate mouse models to test HIV-1 vaccine candidates.  The goal of HIV-1 vaccine development is to design immunization methods that can elicit broadly neutralizing antibodies against diverse viral strains.  Our mouse models express precursors of broadly neutralizing antibodies. Immunization of these mouse models can evaluate the ability of the vaccine candidate to mature the precursor antibody into broadly neutralizing antibodies.



Hongli Hu, PhD Hongli Hu, PhD
University of Chinese Academy of Sciences

My current research is focus on cohesion unloader Wapl's function in V(D)J recombination.


Zhuoyi Liang, PhD Zhuoyi Liang, PhD
Hong Kong University of Science and Technology

I am interested in DNA repair, recurrent DBS cluster (RDC) mapping and neural blastocyst complementation (NBC).

Sai Luo, PhD Sai Luo, PhD
Tsinghua University, China

The objective of my research is to generate novel and effective humanized mouse models to test and optimize HIV immunization strategies for eliciting the potent VRC01 class of broadly neutralizing antibodies (bnAbs).

A man, Ye Yongxin, smiles at the camera for his headshot.

Yongxin Ye, PhD
Peking University, China

I work as a postdoctoral researcher, doing bioinformatic analysis, biostatistics testing and modeling for V(D)J recombination, somatic hypermutation and class switching recombination during B cell development, mainly based on high-throughput genome-wide translocation sequencing (HTGTS) and repertoire sequencing data.

A man, Yuxiang Zhang, has short dark hair and a serious expression on his face as he looks at the camera for his headshot.

Yuxiang Zhang, MD, PHD
Zhejiang University (MD); University of Pennsylvania (PhD)

I study mechanisms of genome instability in neural progenitor cells, B cell V(D)J rearrangement repertoire in various lymphoid tissues.  


Postdoctoral Fellows

Himanshu Batra headshot. Himanshu Batra

I am interested in generating mouse models for obtaining novel broadly neutralizing antibodies to COVID-19 and HIV. In addition to that, I am studying the regulatory mechanisms of immunoglobulin light chain isotypic exclusion in B cells.


changbin jin headshot. Changbin Jing

My research is focused on antibody class Switch recombination (CSR) and somatic hypermutation (SHM). I explore loop extrusion in SHM by deleting 3’RR enhancer or inserting CBE between 3’RR and V region.
Xiang Li headshot. Xiang Li

My research is focused on the mechanism of V(D)J recombination and IgH allelic exclusion in developing B cells
Chengxian Xu headshot. Chengxian Xu

My study is going to reveal the mechanisms of V(D)J recombination during B cell development.
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A woman, Zhuo Yang, wears a graphic shirt and glasses in front of a desert rock as she plays with her hair and smiles at the camera. Zhuo Yang

My research is focused on elucidating the mechanism of chromatin loop extrusion-mediated class switch recombination.
Lijuan Zhao, PhD Lijuan Zhao, PhD
University of Chinese Academic Science

I have been using mouse modeling and high through put methods to elucidate the potentially complementary roles of the IgH locus intronic enhancer and the downstream IgH 3’ regulatory region enhancers in promoting V(D)J recombination and IgH variable region somatic hyper-mutation.


Graduate Students

Aseda Tena Aseda Tena
PhD student in Biological and Biomedical Sciences (BBS), Harvard University. 

I am interested in identifying mechanisms in brain neural progenitor cells that contribute to recurrent DNA breaks in a set of genes implicated in neuropsychiatric diseases and cancer. 


Yiwen Zhang Yiwen Zhang
PhD student in Biological and Biomedical Sciences (BBS), Harvard University

I am interested in studying the regulatory mechanisms of chromatin 3D structure in the context of IgH V(D)J recombination in progenitor B cells.



An asian woman, Hwei-Ling Cheng, has a closed-lip smile while looking at the camera for her headshot. Hwei-Ling Cheng
Lab Manager/Research Specialist III
Headshot Jillian Davis of a young blonde woman with curled hair, smiling at the camera for her headshot. Jillian Davis
Research Assistant I
A woman, Elyse Gaertner, has short brown hair wears a pink shirt as she smiles at the camera for her headshot. Kristen (Elyse) Gaertner
Research Assistant I
An asian man, Jianquiao (Lawrence) Hu, wears a black shirt and looks at the camera for his headshot. Jianquiao (Lawrence) Hu
Bioinformatic Research Assistant
A blonde woman, Kerstin Johnson, smiles at the camera for her headshot. Kerstin Johnson
Research Assistant II
A woman, Xin Lin, gives the camera a serious look for her headshot. Xin Lin
Bioinformatic Research Assistant II
Judy Needham Judy Needham
Administrative Assistant




A man, Lucas Francisco, wears glasses and a red shirt as he stands outside and smiles at the camera. Lucas Vieira Francisco
Research Assistant II 
Aimee Williams Aimee Williams
Lead Research Technologist