Lab Members | Overview
|Frederick Alt, PhD
Director Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics Professor of Genetics Harvard Medical School
|Ming Tian, PhD
I generate mouse models to test HIV-1 vaccine candidates. The goal of HIV-1 vaccine development is to design immunization methods that can elicit broadly neutralizing antibodies against diverse viral strains. Our mouse models express precursors of broadly neutralizing antibodies. Immunization of these mouse models can evaluate the ability of the vaccine candidate to mature the precursor antibody into broadly neutralizing antibodies.
|Hongli Hu, PhD
University of Chinese Academy of Sciences
My current research is focus on cohesion unloader Wapl's function in V(D)J recombination.
|Zhuoyi Liang, PhD
Yongxin Ye, PhD
I work as a postdoctoral researcher, doing bioinformatic analysis, biostatistics testing and modeling for V(D)J recombination, somatic hypermutation and class switching recombination during B cell development, mainly based on high-throughput genome-wide translocation sequencing (HTGTS) and repertoire sequencing data.
I am interested in generating mouse models for obtaining novel broadly neutralizing antibodies to COVID-19 and HIV. In addition to that, I am studying the regulatory mechanisms of immunoglobulin light chain isotypic exclusion in B cells.
My research is focused on antibody class Switch recombination (CSR) and somatic hypermutation (SHM). I explore loop extrusion in SHM by deleting 3’RR enhancer or inserting CBE between 3’RR and V region.
My research is focused on the mechanism of V(D)J recombination and IgH allelic exclusion in developing B cells
My study is going to reveal the mechanisms of V(D)J recombination during B cell development.
My research is focused on elucidating the mechanism of chromatin loop extrusion-mediated class switch recombination.
|Lijuan Zhao, PhD
PhD student in Biological and Biomedical Sciences (BBS), Harvard University.
I am interested in identifying mechanisms in brain neural progenitor cells that contribute to recurrent DNA breaks in a set of genes implicated in neuropsychiatric diseases and cancer.
PhD student in Biological and Biomedical Sciences (BBS), Harvard University
I am interested in studying the regulatory mechanisms of chromatin 3D structure in the context of IgH V(D)J recombination in progenitor B cells.
Lab Manager/Research Specialist III
|Kristen (Elyse) Gaertner
Research Assistant I
Research Assistant II
Bioinformatic Research Assistant II
|Lucas Vieira Francisco
Research Assistant II
Lead Research Technologist