Current Environment:

Principal investigator

Frederick Alt, PhD

Frederick Alt, PhD
-Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
-Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
-Charles A. Janeway Professor of Pediatrics
-Professor of Genetics, Harvard Medical School

Assistant Professor

Ming Tian, PhD Ming Tian, PhD
Harvard University

I generate mouse models to test HIV-1 vaccine candidates.  The goal of HIV-1 vaccine development is to design immunization methods that can elicit broadly neutralizing antibodies against diverse viral strains.  Our mouse models express precursors of broadly neutralizing antibodies. Immunization of these mouse models can evaluate the ability of the vaccine candidate to mature the precursor antibody into broadly neutralizing antibodies.


Hongli Hu, PhD Hongli Hu, PhD
University of Chinese Academy of Sciences

My current research is focus on cohesion unloader Wapl's function in V(D)J recombination.


Zhuoyi Liang, PhD Zhuoyi Liang, PhD
Hong Kong University of Science and Technology

I am interested in DNA repair, recurrent DBS cluster (RDC) mapping and neural blastocyst complementation (NBC).

A man, Ye Yongxin, smiles at the camera for his headshot.

Yongxin Ye, PhD
Peking University, China

I work as a postdoctoral researcher, doing bioinformatic analysis, biostatistics testing and modeling for V(D)J recombination, somatic hypermutation and class switching recombination during B cell development, mainly based on high-throughput genome-wide translocation sequencing (HTGTS) and repertoire sequencing data.

Postdoctoral Fellows

Himanshu Batra headshot. Himanshu Batra

I am interested in generating mouse models for obtaining novel broadly neutralizing antibodies to COVID-19 and HIV. In addition to that, I am studying the regulatory mechanisms of immunoglobulin light chain isotypic exclusion in B cells.


changbin jin headshot. Changbin Jing

My research is focused on antibody class Switch recombination (CSR) and somatic hypermutation (SHM). I explore loop extrusion in SHM by deleting 3’RR enhancer or inserting CBE between 3’RR and V region.
Xiang Li headshot. Xiang Li

My research is focused on the mechanism of V(D)J recombination and IgH allelic exclusion in developing B cells
Chengxian Xu headshot. Chengxian Xu

My study is going to reveal the mechanisms of V(D)J recombination during B cell development.
File upload
A woman, Zhuo Yang, wears a graphic shirt and glasses in front of a desert rock as she plays with her hair and smiles at the camera. Zhuo Yang

My research is focused on elucidating the mechanism of chromatin loop extrusion-mediated class switch recombination.
Lijuan Zhao, PhD Lijuan Zhao, PhD
University of Chinese Academic Science

I have been using mouse modeling and high through put methods to elucidate the potentially complementary roles of the IgH locus intronic enhancer and the downstream IgH 3’ regulatory region enhancers in promoting V(D)J recombination and IgH variable region somatic hyper-mutation.

Graduate Students

Aseda Tena Aseda Tena
PhD student in Biological and Biomedical Sciences (BBS), Harvard University. 

I am interested in identifying mechanisms in brain neural progenitor cells that contribute to recurrent DNA breaks in a set of genes implicated in neuropsychiatric diseases and cancer. 


Yiwen Zhang Yiwen Zhang
PhD student in Biological and Biomedical Sciences (BBS), Harvard University

I am interested in studying the regulatory mechanisms of chromatin 3D structure in the context of IgH V(D)J recombination in progenitor B cells.


An asian woman, Hwei-Ling Cheng, has a closed-lip smile while looking at the camera for her headshot. Hwei-Ling Cheng
Lab Manager/Research Specialist III
A woman, Elyse Gaertner, has short brown hair wears a pink shirt as she smiles at the camera for her headshot. Kristen (Elyse) Gaertner
Research Assistant I
A blonde woman, Kerstin Johnson, smiles at the camera for her headshot. Kerstin Johnson
Research Assistant II
A woman, Xin Lin, gives the camera a serious look for her headshot. Xin Lin
Bioinformatic Research Assistant II
Judy Needham Judy Needham
Administrative Assistant




A man, Lucas Francisco, wears glasses and a red shirt as he stands outside and smiles at the camera. Lucas Vieira Francisco
Research Assistant II 
Aimee Williams Aimee Williams
Lead Research Technologist