Current Environment:

Lab Members | Overview

Principal investigator

Frederick Alt, PhD Frederick Alt, PhD

Director Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics Professor of Genetics Harvard Medical School

 

Assistant Professor

Ming Tian, PhD Ming Tian, PhD
Harvard University

I generate mouse models to test HIV-1 vaccine candidates.  The goal of HIV-1 vaccine development is to design immunization methods that can elicit broadly neutralizing antibodies against diverse viral strains.  Our mouse models express precursors of broadly neutralizing antibodies. Immunization of these mouse models can evaluate the ability of the vaccine candidate to mature the precursor antibody into broadly neutralizing antibodies.

 

Instructors

Hongli Hu, PhD Hongli Hu, PhD
University of Chinese Academy of Sciences

My current research is focus on cohesion unloader Wapl's function in V(D)J recombination.

 

Zhuoyi Liang, PhD Zhuoyi Liang, PhD
Hong Kong University of Science and Technology

I am interested in DNA repair, recurrent DBS cluster (RDC) mapping and neural blastocyst complementation (NBC).
 

Sai Luo, PhD Sai Luo, PhD
Tsinghua University, China

The objective of my research is to generate novel and effective humanized mouse models to test and optimize HIV immunization strategies for eliciting the potent VRC01 class of broadly neutralizing antibodies (bnAbs).
 

Yuxiang Zhang, MD, PHD Yuxiang Zhang, MD, PHD
Zhejiang University (MD); University of Pennsylvania (PhD)

I study mechanisms of genome instability in neural progenitor cells, B cell V(D)J rearrangement repertoire in various lymphoid tissues.  
 

Headshot of a man, Yongxin Ye, who has short black hair and a smile as he looks at the camera. Yongxin Ye, PhD
Peking University, China

I work as a postdoctoral researcher, doing bioinformatic analysis, biostatistics testing and modeling for V(D)J recombination, somatic hypermutation and class switching recombination during B cell development, mainly based on high-throughput genome-wide translocation sequencing (HTGTS) and repertoire sequencing data.

 

Postdoctoral Fellows

Himanshu Batra headshot. Himanshu Batra

I am interested in generating mouse models for obtaining novel broadly neutralizing antibodies to COVID-19 and HIV. In addition to that, I am studying the regulatory mechanisms of immunoglobulin light chain isotypic exclusion in B cells.

 

changbin jin headshot. Changbin Jing

My research is focused on antibody class Switch recombination (CSR) and somatic hypermutation (SHM). I explore loop extrusion in SHM by deleting 3’RR enhancer or inserting CBE between 3’RR and V region.
Xiang Li headshot. Xiang Li

My research is focused on the mechanism of V(D)J recombination and IgH allelic exclusion in developing B cells
Chengxian Xu headshot. Chengxian Xu

My study is going to reveal the mechanisms of V(D)J recombination during B cell development.
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Lijuan Zhao, PhD Lijuan Zhao, PhD
University of Chinese Academic Science

I have been using mouse modeling and high through put methods to elucidate the potentially complementary roles of the IgH locus intronic enhancer and the downstream IgH 3’ regulatory region enhancers in promoting V(D)J recombination and IgH variable region somatic hyper-mutation.

Zhuo Yang headshot. Zhuo Yang

My research is focused on elucidating the mechanism of chromatin loop extrusion-mediated class switch recombination.

 

Graduate Students

Aseda Tena Aseda Tena
PhD student in Biological and Biomedical Sciences (BBS), Harvard University. 

I am interested in identifying mechanisms in brain neural progenitor cells that contribute to recurrent DNA breaks in a set of genes implicated in neuropsychiatric diseases and cancer. 

 

Yiwen Zhang Yiwen Zhang
PhD student in Biological and Biomedical Sciences (BBS), Harvard University

I am interested in studying the regulatory mechanisms of chromatin 3D structure in the context of IgH V(D)J recombination in progenitor B cells.

 

Staff

A blue outline shadow of a woman. Jillian Davis
Research Assistant I
A woman, Elyse Gaertner, has short brown hair wears a pink shirt as she smiles at the camera for her headshot. Kristen (Elyse) Gaertner
Research Assistant I
A man, Vieira Francisco, wears a read shirt as he looks at the camera for his headshot. Lucas Vieira Francisco
Research Assistant II 
Hwei-Ling Cheng Hwei-Ling Cheng

Lab Manager/Research Specialist III

 

 

 

Jianquiao (Lawrence) Hu Jianquiao (Lawrence) Hu

Bioinformatic Research Assistant

 

 

 

Blue outline of a woman in a blue box. Xin Lin
Bioinformatic Research Assistant II
Judy Needham Judy Needham

Administrative Assistant

 

 

 

Aimee Williams Aimee Williams

Lead Research Technologist

 

 

 

Kerstin Johnson Kerstin Johnson

Research Assistant II