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Biostatistics Research Design | Overview

Mission

The mission of the BARD Center is to promote excellence in the design and analysis of research studies at Boston Children’s Hospital. The ICCTR BARD Center provides biostatistical and methodological expertise, as well as scientific leadership through collaborative relationships with Boston Children’s investigators. The Center also provides educational offerings in a variety of areas.

Our group includes PhD and masters-level staff with experience in the design and analysis of a wide range of research studies, including pre-clinical experiments, observational and randomized studies, health econometrics and survey research, qualitative evaluations, and high dimensional functional neuroimaging studies. 

BARD services include:

  • Full biostatistical project support, tailored to your study and resources
  • Long-term collaborations with our faculty researchers
  • Study design and grant preparation
  • Short term consultations with our staff

For further information, please contact:

Dr. Edie Weller, Center Director
Dr. Michael Monuteaux, Center Assistant Director

Biostatistics Announcement image.

The ICCTR BARD Center congratulates the following members on their promotions:

Kim Greco, MPH, on her promotion to Biostatistician II
Carly Milliren, MPH, on her promotion to Biostatistician IV
Bo Zhang, PhD, on his promotion to Associate Professor of Neurology

Congratulations Kim, Carly and Bo!

BARD Services

The Biostatistics and Research Design (BARD) Center faculty and staff can collaborate with investigators on: 

green check mark.Protocol development/Grant preparation

We can ensure that the study objectives, specific aims, and endpoints are well defined, measurable and feasible and advise on appropriate design and methods.  Members can write sections related to research aims, data collection and data management methods, registration and randomization, sample size and power, statistical analysis methods and interim monitoring.

green check mark.Study Design and Planning

We provide advice on the most efficient, valid, and feasible study design (eg., cohort, case control, prospective, retrospective, cross sectional, randomized clinical trial, etc.) as well as advice on:

  • appropriate selection of the sample from the target population
  • choice of control group(s)
  • strategies for recruitment and retention
  • data collection methods
  • database design

In addition, we provide guidance on design issues that are unique to the following methodologies:

  • qualitative studies (use of focus groups, semi-structured or cognitive interviews)
  • survey research, including instrument creation/validation and sampling and data collection methods (e.g., in-person or telephone interviews, mail surveys, web surveys)
  • health econometrics (e.g., cost impact, cost-effectiveness, cost-benefit evaluations)

green check mark.Randomization

We generate randomization schemes and assignments for single- and double-blind studies. Members work in conjunction with the Research Pharmacy for the implementation of investigator-initiated randomized trials.

green check mark.Data analysis

We analyze study data, provide interpretation of statistical analysis results, including interpretation of previously published results as well as results of ongoing analyses. This includes guidance on and development of:

  • statistical graphics and tabular displays of data
  • interim or final data analyses
  • data and safety monitoring board reports

In addition, we provide support for analysis issues that are unique to:

  • qualitative studies (advice on how to analyze qualitative data including transcribing and coding of focus groups and interviews)
  • survey research (data analysis from complex survey design, including the use of post-survey adjustments and post-stratification weights)
  • econometrics research (advice on cost impact, cost-effectiveness, cost-benefit analysis and other types of economic evaluations)

green check mark.Manuscript preparation

We can contribute to the writing of manuscripts for submission to peer-reviewed scientific journals and prepare abstracts and presentations for scientific meetings.

Education

The Biostatistics and Research Design (BARD) Center offers educational opportunities for Boston Children's researchers on statistical design and analysis considerations for research studies. We also offer workshops on the use of statistical packages for data management and reporting. The objective of the BARD Educational Program is to impart a practical, conceptual understanding of the content we teach. Specifically, in each course we strive to achieve the following learning objectives:

  • an understanding of the purpose/intent of the method
  • an understanding of when/under what circumstances the method is applicable
  • an ability to interpret the method’s results, in context
  • an ability to critically evaluate the scientific literature where the method is used
  • an ability to use the method with guidance from a biostatistician, when appropriate 

Spring 2022 course schedule

View the Spring 2022 BARD Course schedule, and select a course to register.

Educational program offerings

The following table provides a description of the BARD Educational Offerings. Please register for a course. We also encourage researchers to also explore the Harvard Catalyst educational opportunities. Contact icctr-education@childrens.harvard.edu with any questions.

Course Title Course Description Supporting Materials 
General  
How to Work with a Biostatistician Basic principles of working with a biostatistician.  
Design Series  
Case Series and Case-Control Studies Design and implementation of case series and case-control studies in the context of specific biomedical examples.  
Clinical Trials In this course, an introduction to clinical trials will be offered in 3 parts dedicated to discussing the statistical aspects of phase I, II and III trials. Session 1/Phase I Trials
Session 2/Phase II Trials 
Session 3/Phase III Trials 
Cross-Sectional and Cohort Studies Practical overview of cross-sectional and cohort study designs using examples drawn from pediatric clinical research video & slides
Design Makes a Difference: Choosing the Right Design for Your Research Question Concepts essential for writing a grant proposal/protocol; communicating results; and appraising others’ work. video & slides
Power and How to Get It: Sample Size and Detectable Effects Justifying the design and sample size for grants/protocols; assessing power and communicating key issues. video & slides
Survey Research: Design, Implementation and Analysis Design, implementation, and analysis of survey research in pediatrics. Session 1 and 2: video & slides
Session 3: video & slides
Session 4: video & slides
Analysis Series  
Data Visualization and Basic Statistical Testing Basic principles of biostatistics. Related course -Data Management and Reporting in SPSS. Session 1: video & slides
Session 2: video & slides
Session 3: video & slides
Session 4: video & slides
Linear Regression Concepts and examples of linear regression analysis. video & slides
Logistic Regression Examples and interpretation of logistic regression analysis. video & slides
Longitudinal Analysis Examples  and interpretation of  longitudinal analysis.  video & slides
Survival Analysis Survival analysis - what is it and why is it different? Session 1: video & slides
Session 2: video & slides
Special Topics  
Data management and reporting in SPSS Introduction to the statistical software package SPSS. Related course- Data Visualization and Basic Statistical Testing. Session 1: video & slides
Session 2: video & slides
Session 3: video & slides
Session 4: video & slides
Economic Evaluation Methods  Principles of economic evaluations of health care interventions; measurement/ analysis of economic outcomes. video & slides
Inter-rater Reliability Studies Analysis of studies with multiple raters to determine reliability. video & slides
Introduction to STATA Introduction to the statistical software package STATA and how it can be used in clinical research video
Qualitative Methods Introduction to qualitative research for use in pediatrics research. video & slides
Statistical Considerations for Laboratory Researchers Design and analysis issues relevant for pre-clinical research (for example, cell lines, in-vitro, in-vivo)  
Survey Validation Methodology Item development, instrument and scale construction and the psychometric properties of a survey instrument. video & slides
The Fuss About P Values P-values and hypothesis testing, the go-to technique for statistical inference in all branches of science for nearly a century, have nonetheless been under constant attack ever since they were introduced. The controversy is as hot as ever today. This single-session course will review the issues, survey alternatives, and provide guidance for everyday practice. video & slides 
Image
A man faces a dark blue board and writes math equations in white marker.

Careers: Senior Biostatistician

The BARD Center at Boston Children's Hospital seeks a PhD biostatistician to collaborate with investigators on basic and clinical research.

Learn more

Frequently asked questions

Who can request help?

Any faculty or trainee at BCH is eligible to request our help.  Clinical, preclinical, or translation research studies are all eligible.

When should I consult with a biostatistician?

As early in the planning stages of your study as possible!

How can I access services?

Use the following flow chart to determine how to access services or fill out an online support request.

How does 'funded support' work?

Image
BARD access flowchart.
  • "Funded support" is required if the investigator needs more help than a one-hour consult can provide.
  • A BARD Center team member and Investigator determine the number of hours/effort needed.
  • Budget and scope of work are created and approved by ICCTR and Investigator.

Please note:

  • Rates vary according to expertise and experience.
  • Funding is not required if the work is for an extramural grant application that budgets support for the BARD staff member (as co-investigator, or key personnel).
  • Trainees (e.g. residents and fellows) with research scholarship requirements can receive 20 hours of support for a discounted rate if BARD Center Members have availability.

How to do I prepare for a consult with a BARD Center member?

  • Have your study aims/hypotheses finalized.
  • If possible, explore funding resources in case you require additional support beyond the consult.
  • Consider whether the degree of collaboration you require with the BARD Center member may entail authorship on the resulting academic product.

How soon after I submit a request can I expect a response?

Someone from the BARD Center will contact you within 10 business days to discuss your request.

Team

Leadership

             Edie Weller, PhDEdie Weller, PhD

 

Director of ICCTR Biostatistics and Research Design Center

             Michael Monuteaux, ScDMichael Monuteaux, ScD

 

Associate Director of ICCTR Biostatistics and Research Design Center, Senior Epidemiologist and Biostatistician

 

Faculty

Suzanne Dahlberg Suzanne Dahlberg, PhD

 

Assistant Director, Clinical Trial Biostatistics and Data Management

  Henry FeldmanHenry Feldman, PhD

 

Principal Biostatistician, Institutional Centers for Clinical and Translational Research (ICCTR)

  Kosuke KawaiKosuke Kawai, ScD

 

Senior Biostatistician and Epidemiologist, Biostatistics and Research Design (BARD)Assistant

            
  Enju LiuEnju Liu, MD, PhD

 

Senior BiostatisticianAssistant

            

Faceless Female AvatarTanya Logvineko, PhD

Senior BiostatisticianAssistant

Faceless Female AvatarMihail Samnaliev, PhD

Health EconomistAssistant

Georgios Sideridis, PhDGeorgios Sideridis, PhD

Senior Survey Methodologist

Caterina Stamoulis, PhDCaterina Stamoulis, PhD

Principal Investigator, Computational Neuroscience Laboratory

David N. Williams, PhDDavid N. Williams, PhD

Senior Biostatistician, Orthopedic Surgery

Bo Zhang, PhDBo Zhang, PhD

Scientist, Department of Neurology, ICCTR Biostatistics and Research Design Center

 

Masters

          

Laura Berbert, MSLaura Berbert, MS

Biostatitician II, Institutional Centers for Clinical and Translational Research (ICCTR)

            
 

Gabrielle D'Ambrosi, MPHGabrielle D'Ambrosi, MPH

Biostatitician I, Institutional Centers for Clinical and Translational Research (ICCTR)

            
 

Kimberly Greco, MPHKimberly Greco, MPH

Biostatitician II, Institutional Centers for Clinical and Translational Research (ICCTR)

         

 

Jie He, MSJie He, MS

Biostatitician I, Institutional Centers for Clinical and Translational Research (ICCTR)

            
Jessica Liu

Jessica Liu, MPH, MBA

Biostatitician II, Institutional Centers for Clinical and Translational Research (ICCTR)

Shanshan Liu, MS, MPH

Shanshan Liu, MS

Biostatitician II, Institutional Centers for Clinical and Translational Research (ICCTR)

Faceless Female Avatar

Carly Milliren, MPH

Biostatitician II, Institutional Centers for Clinical and Translational Research (ICCTR)

 

Paul Mitchell, MS

Paul Mitchell,  MS

Senior Biostatitician, Institutional Centers for Clinical and Translational Research (ICCTR)

Carter Petty, MA

Carter Petty, MA

Senior Biostatitician, Institutional Centers for Clinical and Translational Research (ICCTR)

Morgan Ryan, MS

Morgan Ryan, MS

Biostatitician I, Institutional Centers for Clinical and Translational Research (ICCTR)

Kathryn Williams, MS

Kathryn Williams, MS

Biostatitician IV, Institutional Centers for Clinical and Translational Research (ICCTR)