Study Goals: We are interested in how the brains and nerves of people diagnosed with Complex Regional Pain Syndrome are affected by intensive rehabilitation. This information may lead to a better understanding of the neurological consequences of neuropathic pain, which in turn may lead to better treatment for the many patients who are affected.

Our Approach: We are using a variety of neuroimaging MRI techniques, including functional MRI and Diffusion Tensor Imaging, to examine the nerve and brain over time.

Eligibility to participate: 14 – 20 year olds with Complex Regional Pain Syndrome.  Healthy 14 – 20 year old individuals are also eligible to participate in the control group of the study.

Study Visit Overview:  The study will involve two study visits at our Waltham location and each visit will take up to 3 hours.

            1. Neurological evaluation (15 minutes)

            2. Pre-scan psychological questionnaires (30 minutes)

            3. Sensory Testing (10 minutes)

            4. Leg and Brain MRI scan (90 minutes)

Compensation: Participants will receive a $100 gift card for the first study session they participate in, as well as a CD with pictures of their brain to take home.

Funding Sources: This study is supported by the National Institutes of Health (NIH).

If you are interested in learning more, please contact the study coordinator, Tali, at 781-216-1199 or at .