Scott Pomeroy, MD, PhD
Neurologist-in-Chief, Emeritus; Chair Emeritus, Department of Neurology
Bronson Crothers Professor of Neurology, Harvard Medical School
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Scott Pomeroy, MD, PhD
Neurologist-in-Chief, Emeritus; Chair Emeritus, Department of Neurology
Bronson Crothers Professor of Neurology, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Miami University
1975
Oxford
OH
Graduate School
University of Cincinnati
1982
Cincinnati
OH
Medical School
University of Cincinnati College of Medicine
1982
Cincinnati
OH
Internship
Pediatrics
Boston Children's Hospital
1984
Boston
MA
Residency
Child Neurology
Washington University/Children’s Hospital
1987
St. Louis
MO
Fellowship
Neurobiology
Washington University
1990
St. Louis
MO
Media
Innovation Summit
Closing the Gap from Discovery to Treatment
Research
(L-R) Drs. Scott Pomeroy, David DeMaso, and R. Michael Scott
Certifications
American Board of Psychiatry and Neurology (Child and Adolescent Neurology)
Professional History
Dr. Pomeroy is the Bronson Crothers Professor of Neurology at Harvard Medical School. He graduated with MD and PhD degrees from the University of Cincinnati, trained in Pediatrics at Boston Children's Hospital and in Child Neurology at Washington University in St. Louis. He joined the faculty of Boston Children's Hospital and Harvard Medical School in 1991. In 2005, he was appointed as Neurologist-in-Chief of Boston Children's Hospital and Chair of the Department of Neurology at Harvard Medical School.
Approach to Care
Throughout my career, I have strived to integrate cutting edge science into the practice of medicine and provide holistic care to children with nervous system disorders. My clinical practice and research focus on brain tumors. I served as Chair of the Department of Neurology and Neurologist-in-Chief for more than 19 years ending in October 2024. During my tenure as Chief of Neurology, great emphasis was placed on building world class programs in basic and clinical science, focused clinical practice and translation of scientific discoveries into impactful therapies.
Publications
An Approach to Successful Development of Clinician-Scientists in Neurology: The NINDS R25 Experience. View Abstract
WNT signalling control by KDM5C during development affects cognition. View Abstract
Developmental basis of SHH medulloblastoma heterogeneity. View Abstract
Clinical variants paired with phenotype: A rich resource for brain gene curation. View Abstract
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. View Abstract
Recognizing and Responding to the Needs of Future Child and Adult Neurology Care Through the Evolution of Residency Training. View Abstract
Global neurology: It's time to take notice. View Abstract
Validation of a computational phenotype for finding patients eligible for genetic testing for pathogenic PTEN variants across three centers. View Abstract
SEQing to find hidden medulloblastoma cells. View Abstract
Children's Oncology Group Phase III Trial of Reduced-Dose and Reduced-Volume Radiotherapy With Chemotherapy for Newly Diagnosed Average-Risk Medulloblastoma. View Abstract
TORC1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of MYC-driven medulloblastoma. View Abstract
Loss of Consciousness in the Young Child. View Abstract
Crisis Standard of Care: Management of Infantile Spasms during COVID-19. View Abstract
Epigenetics and survivorship in pediatric brain tumor patients. View Abstract
Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study. View Abstract
Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. View Abstract
Intellectual and developmental disabilities research centers: Fifty years of scientific accomplishments. View Abstract
Resolving medulloblastoma cellular architecture by single-cell genomics. View Abstract
Medulloblastoma. View Abstract
Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups. View Abstract
Rapid discrimination of pediatric brain tumors by mass spectrometry imaging. View Abstract
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. View Abstract
Brain cancer genomics and epigenomics. View Abstract
The whole-genome landscape of medulloblastoma subtypes. View Abstract
MicroRNA-1301 suppresses tumor cell migration and invasion by targeting the p53/UBE4B pathway in multiple human cancer cells. View Abstract
The evolution of medulloblastoma therapy to personalized medicine. View Abstract
Medulloblastoma: Molecular Classification-Based Personal Therapeutics. View Abstract
OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma. View Abstract
Tracking the Fate of Cells in Health and Disease. View Abstract
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation. View Abstract
The Evolution of Child Neurology Training. View Abstract
First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. View Abstract
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus. View Abstract
DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets. View Abstract
A clinic devoted to peer victimization in special needs children. View Abstract
Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. View Abstract
Defining the molecular landscape of ependymomas. View Abstract
WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. View Abstract
The G protein a subunit Gas is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. View Abstract
Could a5-GABA-A receptor activation be used as a target for managing medulloblastomas? View Abstract
Modelling high myc medulloblastoma and other brain tumors using human neural stem cells. View Abstract
CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. View Abstract
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. View Abstract
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. View Abstract
Cytogenetic prognostication within medulloblastoma subgroups. View Abstract
A developmental program drives aggressive embryonal brain tumors. View Abstract
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. View Abstract
a5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. View Abstract
Inactivation of the tumor suppressor WTX in a subset of pediatric tumors. View Abstract
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. View Abstract
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. View Abstract
Message from the incoming editor. View Abstract
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma. View Abstract
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. View Abstract
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. View Abstract
Clinical practice guidelines and practice parameters for the child neurologist. View Abstract
Activation of ß-catenin/TCF targets following loss of the tumor suppressor SNF5. View Abstract
A novel syndrome caused by the E410K amino acid substitution in the neuronal ß-tubulin isotype 3. View Abstract
Sport-related concussion: time to take notice. View Abstract
Medulloblastomics: the end of the beginning. View Abstract
Medulloblastoma biology in the post-genomic era. View Abstract
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. View Abstract
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. View Abstract
Dissecting the genomic complexity underlying medulloblastoma. View Abstract
Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis. View Abstract
Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors. View Abstract
Sleep dysfunction in long term survivors of craniopharyngioma. View Abstract
Hedgehog-GLI pathway in medulloblastoma. View Abstract
Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma. View Abstract
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. View Abstract
Molecular subgroups of medulloblastoma: the current consensus. View Abstract
MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma. View Abstract
Recent advances in autism spectrum disorders. View Abstract
Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples. View Abstract
Posterior fossa ependymomas: a tale of two subtypes. View Abstract
Neuro-oncology training for the child neurology resident. View Abstract
Training the next generation of child neurologists - a neuroscience based approach. View Abstract
Molecular fingerprints of medulloblastoma and their application to clinical practice. View Abstract
Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features. View Abstract
UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. View Abstract
Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. View Abstract
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma. View Abstract
Long-term clinical outcomes following treatment of childhood craniopharyngioma. View Abstract
Growing spectrum and relevance of pediatric neuro-immunology. View Abstract
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. View Abstract
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. View Abstract
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. View Abstract
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma. View Abstract
The landscape of somatic copy-number alteration across human cancers. View Abstract
Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. View Abstract
Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. View Abstract
Pathologic intracellular signaling in childhood pilocytic astrocytomas. View Abstract
Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. View Abstract
Pediatric sleep medicine in 2008: state-of-the-art. View Abstract
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability. View Abstract
Cardiac risk after craniopharyngioma therapy. View Abstract
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. View Abstract
Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. View Abstract
Introduction: survivors of childhood cancer: the new face of developmental disabilities. View Abstract
Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma. View Abstract
Moyamoya following cranial irradiation for primary brain tumors in children. View Abstract
Overlay analysis of the oligonucleotide array gene expression profiles and copy number abnormalities as determined by array comparative genomic hybridization in medulloblastomas. View Abstract
Molecular genetics of pediatric central nervous system tumors. View Abstract
Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. View Abstract
Transverse myelitis after therapy for primitive neuroectodermal tumors. View Abstract
Medulloblastoma Subtypes Defined by Gene Expression Analysis 864. View Abstract
Everyday cognitive function after craniopharyngioma in childhood. View Abstract
Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation. View Abstract
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. View Abstract
Ataxia and shaking in a 2-year-old girl: acute marijuana intoxication presenting as seizure. View Abstract
A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death. View Abstract
Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance. View Abstract
INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma. View Abstract
Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor. View Abstract
Stereotactic radiotherapy for localized low-grade gliomas in children: final results of a prospective trial. View Abstract
Craniopharyngioma therapy: long-term effects on hypothalamic function. View Abstract
Intracerebral abscess in children: historical trends at Children's Hospital Boston. View Abstract
Neural development and the ontogeny of central nervous system tumors. View Abstract
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. View Abstract
Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas. View Abstract
Molecular biology of medulloblastoma therapy. View Abstract
Pediatric brain tumors. View Abstract
Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. View Abstract
Progressive myoclonus in a child with a deep cerebellar mass. View Abstract
Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation. View Abstract
Neuropsychological functioning after surgery in children treated for brain tumor. View Abstract
Magnetic resonance imaging of patched heterozygous and xenografted mouse brain tumors. View Abstract
Application of microarrays to neurological disease. View Abstract
A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma. View Abstract
Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. View Abstract
Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences. View Abstract
High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. View Abstract
Focus on central nervous system neoplasia. View Abstract
Prediction of central nervous system embryonal tumour outcome based on gene expression. View Abstract
Memory deficits among children with craniopharyngiomas. View Abstract
Psychometric testing in bacterial meningitis: results of a long-term prospective study of infants and children treated between 1973 and 1977. View Abstract
Children with headache suspected of having a brain tumor: a cost-effectiveness analysis of diagnostic strategies. View Abstract
Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas. View Abstract
Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. View Abstract
Identification of PATCHED mutations in medulloblastomas by direct sequencing. View Abstract
Neurological dysfunction associated with postoperative cerebellar mutism. View Abstract
A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. View Abstract
Biology and pathobiology of neuronal development. View Abstract
Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. View Abstract
Basal ganglia germinoma with progressive cerebral hemiatrophy. View Abstract
Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. View Abstract
Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. View Abstract
Human immunodeficiency virus type 1 long terminal repeat quasispecies differ in basal transcription and nuclear factor recruitment in human glial cells and lymphocytes. View Abstract
Neurotrophins in cerebellar granule cell development and medulloblastoma. View Abstract
Activation of ErbB2 during wallerian degeneration of sciatic nerve. View Abstract
Trk receptors function as rapid retrograde signal carriers in the adult nervous system. View Abstract
Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterning. View Abstract
Postnatal addition of satellite cells to parasympathetic neurons. View Abstract
Magnetic resonance imaging changes after stereotactic radiation therapy for childhood low grade astrocytoma. View Abstract
Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. View Abstract
Neurobehavioral and neurologic outcome in long-term survivors of posterior fossa brain tumors: role of age and perioperative factors. View Abstract
Hemorrhagic vasculopathy after treatment of central nervous system neoplasia in childhood: diagnosis and follow-up. View Abstract
Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. View Abstract
The p53 tumor suppressor gene and pediatric brain tumors. View Abstract
Stereotactic radiotherapy for pediatric and adult brain tumors: preliminary report. View Abstract
Advances in radiation therapy for craniopharyngiomas. View Abstract
Vital imaging of glomeruli in the mouse olfactory bulb. View Abstract
Seizures and other neurologic sequelae of bacterial meningitis in children. View Abstract
Postnatal construction of neural circuitry in the mouse olfactory bulb. View Abstract
Neuron/glia relationships observed over intervals of several months in living mice. View Abstract
Effect of morphine injectedin periadueductal gray on the activity of single units in nucleus raphe magnus of the rat. View Abstract
Locations