Scott B. Snapper, MD, PhD
Chief, Division of Gastroenterology, Hepatology and Nutrition; Director, Inflammatory Bowel Disease Center
Professor of Medicine and Pediatrics, Harvard Medical School
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Scott B. Snapper, MD, PhD
Chief, Division of Gastroenterology, Hepatology and Nutrition; Director, Inflammatory Bowel Disease Center
Professor of Medicine and Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Tufts University
Boston
MA
Graduate School
Albert Einstein College of Medicine
New York
NY
Medical School
Albert Einstein College of Medicine
New York
NY
Residency
Brigham and Women's Hospital
Boston
MA
Fellowship
Massachusetts General Hospital/Harvard Medical School
Boston
MA
Media
Caregiver Profile
Meet Dr. Scott Snapper
Certifications
American Board of Internal Medicine (Gastroenterology)
Professional History
Dr. Snapper serves as an expert for the Department of Gastroenterology for Boston Children's Hospital Precision Medicine Service. For more information about the Precision Medicine Service please visit bostonchildrens.org/precisionmed.
Publications
Expert recommendations to standardize transcriptomic analysis in inflammatory bowel disease clinical trials. View Abstract
Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort. View Abstract
Epstein-Barr Virus Exposure Precedes Crohn`s Disease Development. View Abstract
Human colon stem cells are the principal epithelial responders to bacterial antigens. View Abstract
Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. View Abstract
Comprehensive evaluation and practical guideline of gating methods for high-dimensional cytometry data: manual gating, unsupervised clustering, and auto-gating. View Abstract
Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis. View Abstract
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. View Abstract
Spatiotemporal coordination of actin regulators generates invasive protrusions in cell-cell fusion. View Abstract
Early Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease. View Abstract
Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during skeletal muscle regeneration. View Abstract
Efficacy and Safety of Anti-Tumor Necrosis Factor Alpha in Very Early Onset Inflammatory Bowel Disease. View Abstract
Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis. View Abstract
Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort. View Abstract
Surgery for Crohn's Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts. View Abstract
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. View Abstract
Response to Letter to the Editor: "Failure Rate of Antitumor Necrosis Factor Alpha Biologics in Very Early Onset Inflammatory Bowel Disease". View Abstract
Catalyzing change: Implementing standardised reporting in monogenic inflammatory bowel disease research. View Abstract
Anti-infliximab antibodies and low infliximab levels correlate with drug discontinuation in pediatric inflammatory bowel disease. View Abstract
Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome. View Abstract
Progression of Pediatric Crohn's Disease Is Associated With Anti-Tumor Necrosis Factor Timing and Body Mass Index Z-Score Normalization. View Abstract
Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards. View Abstract
Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease. View Abstract
Clinical Remission of Severe Crohn's Disease with Empagliflozin Monotherapy in a Pediatric Patient with Glycogen Storage Disease Type 1b. View Abstract
Editorial: Inborn errors of immunity and mucosal immunity. View Abstract
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. View Abstract
Low-Dose Interleukin 2 for the Treatment of Moderate to Severe Ulcerative Colitis. View Abstract
The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis. View Abstract
Vertebral Compression Fractures in Very Early Onset Inflammatory Bowel Disease. View Abstract
Human MD2 deficiency-an inborn error of immunity with pleiotropic features. View Abstract
RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing features. View Abstract
Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications. View Abstract
Identification of environmental factors that promote intestinal inflammation. View Abstract
Clinical Phenotypes and Outcomes in Monogenic Versus Non-monogenic Very Early Onset Inflammatory Bowel Disease. View Abstract
Inflammatory Bowel Disease and Cardiovascular Diseases. View Abstract
Cytotoxic T Lymphocyte Antigen 4 Haploinsufficiency Presenting As Refractory Celiac-Like Disease: Case Report. View Abstract
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease. View Abstract
Bone marrow adiposity in pediatric Crohn's disease. View Abstract
Targeted RNAseq Improves Clinical Diagnosis of Very Early-Onset Pediatric Immune Dysregulation. View Abstract
Utilization of Antitumor Necrosis Factor Biologics in Very Early Onset Inflammatory Bowel Disease: A Multicenter Retrospective Cohort Study From North America. View Abstract
Mucus sialylation determines intestinal host-commensal homeostasis. View Abstract
Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses. View Abstract
Author Correction: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. View Abstract
The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD). View Abstract
Efficacy and Safety of High-dose Cholecalciferol in Patients With Inflammatory Bowel Disease Receiving Infliximab. View Abstract
CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor. View Abstract
Pediatric Gastrointestinal Histopathology in Patients With Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A Rare Condition Leading to Multiple Intestinal Atresias, Severe Combined Immunodeficiency, and Congenital Enteropathy. View Abstract
Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive. View Abstract
An Integrated Taxonomy for Monogenic Inflammatory Bowel Disease. View Abstract
Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. View Abstract
Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation. View Abstract
Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease. View Abstract
Restored Macrophage Function Ameliorates Disease Pathophysiology in a Mouse Model for IL10 Receptor-deficient Very Early Onset Inflammatory Bowel Disease. View Abstract
Publisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes. View Abstract
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes. View Abstract
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion. View Abstract
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants. View Abstract
Therapeutic options for CTLA-4 insufficiency. View Abstract
Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia. View Abstract
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. View Abstract
Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells. View Abstract
A Systematic Review of Monogenic Inflammatory Bowel Disease. View Abstract
Novel CARMIL2 loss-of-function variants are associated with pediatric inflammatory bowel disease. View Abstract
Clinical Genomics for the Diagnosis of Monogenic Forms of Inflammatory Bowel Disease: A Position Paper From the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition. View Abstract
Natural History of? Very Early Onset Inflammatory Bowel Disease in North America: A Retrospective Cohort Study. View Abstract
Predictive Prenatal Diagnosis for Infantile-onset Inflammatory Bowel Disease Because of Interleukin-10 Signalling Defects. View Abstract
Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort. View Abstract
In utero human intestine harbors unique metabolome, including bacterial metabolites. View Abstract
The E3 ubiquitin ligase UBR5 interacts with TTC7A and may be associated with very early onset inflammatory bowel disease. View Abstract
Monogenic Inflammatory Bowel Disease: It's Never Too Late to Make a Diagnosis. View Abstract
Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease. View Abstract
An RTEL1 Mutation Links to Infantile-Onset Ulcerative Colitis and Severe Immunodeficiency. View Abstract
NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency. View Abstract
Children's rare disease cohorts: an integrative research and clinical genomics initiative. View Abstract
Children's rare disease cohorts: an integrative research and clinical genomics initiative. View Abstract
Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease. View Abstract
Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies. View Abstract
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. View Abstract
16S rRNA sequencing analysis: the devil is in the details. View Abstract
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Evaluation and Management for Patients With Very Early-onset Inflammatory Bowel Disease. View Abstract
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease. View Abstract
Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated With Monogenic Variants, Identified by Whole-Exome Sequencing in 1000 Children at a Single Center. View Abstract
Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD. View Abstract
NASPGHAN Position Paper on The Evaluation and Management for Patients with Very Early-Onset Inflammatory Bowel Disease (VEO-IBD). View Abstract
A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. View Abstract
Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency. View Abstract
Treatment-Specific Composition of the Gut Microbiota Is Associated With Disease Remission in a Pediatric Crohn's Disease Cohort. View Abstract
CARMIL2 Deficiency Presenting as Very Early Onset Inflammatory Bowel Disease. View Abstract
Humanized mouse models of genetic immune disorders and hematological malignancies. View Abstract
Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. View Abstract
Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study. View Abstract
Immunologic Alterations Associated With Oral Delivery of Anti-CD3 (OKT3) Monoclonal Antibodies in Patients With Moderate-to-Severe Ulcerative Colitis. View Abstract
Aerodigestive sampling reveals altered microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function. View Abstract
Challenges in IBD Research: Preclinical Human IBD Mechanisms. View Abstract
A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant. View Abstract
Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model. View Abstract
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. View Abstract
The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. View Abstract
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity. View Abstract
Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. View Abstract
Risk-factors Associated with Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. View Abstract
Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases. View Abstract
Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. View Abstract
Mucosal Gene Expression in Pediatric and Adult Patients With Ulcerative Colitis Permits Modeling of Ideal Biopsy Collection Strategy for Transcriptomic Analysis. View Abstract
The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children. View Abstract
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency. View Abstract
Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. View Abstract
Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles. View Abstract
Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers. View Abstract
Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive. View Abstract
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. View Abstract
An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. View Abstract
Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. View Abstract
The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies. View Abstract
Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. View Abstract
The Impact of Combination Therapy on Infliximab Levels and Antibodies in Children and Young Adults With Inflammatory Bowel Disease. View Abstract
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. View Abstract
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. View Abstract
Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. View Abstract
A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease. View Abstract
Human TGF-ß1 deficiency causes severe inflammatory bowel disease and encephalopathy. View Abstract
Genetic and Structural Analysis of a SKIV2L Mutation Causing Tricho-hepato-enteric Syndrome. View Abstract
Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn's Disease. View Abstract
Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. View Abstract
An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. View Abstract
Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier. View Abstract
Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. View Abstract
Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells. View Abstract
Spontaneous food allergy in Was-/- mice occurs independent of FceRI-mediated mast cell activation. View Abstract
Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. View Abstract
CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis. View Abstract
ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice. View Abstract
Haematopoietic stem and progenitor cells from human pluripotent stem cells. View Abstract
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. View Abstract
Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. View Abstract
Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. View Abstract
O-003 The Brain as Extraintestinal IBD Manifestation: Are Brain and Cognitive Differences in Pediatric Crohn's Disease Associated with Immune Gene Expression? View Abstract
O-011 Low-dose IL-2 Administration Expands Human Regulatory T Cells in Patients with UC and Humanized Mice and Protects Against Experimental Colitis. View Abstract
Erratum to: Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing. View Abstract
P356 Treatment with anakinra induces T cell production of IL22 and GI mucosal healing in an IL-10RA mutation patient. View Abstract
DOP082 Enhanced TH17 responses in patients with IL10 receptor deficiency and history of infantile-onset IBD. View Abstract
Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice. View Abstract
Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakin Treatment Suggests Further Mechanism for Mucosal Healing. View Abstract
IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. View Abstract
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. View Abstract
CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. View Abstract
Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. View Abstract
FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. View Abstract
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells. View Abstract
Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion. View Abstract
Large B-Cell Lymphoma in an Adolescent Patient With Interleukin-10 Receptor Deficiency and History of Infantile Inflammatory Bowel Disease. View Abstract
Neuronal Wiskott-Aldrich syndrome protein regulates TGF-ß1-mediated lung vascular permeability. View Abstract
O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD. View Abstract
O-008 Aberrant Anti-inflammatory Macrophage Function and Differentiation in Wiskott-Aldrich Syndrome Protein-Deficient Mice and Humans. View Abstract
O-009 Lymphotoxin Links Microbiota and Group 3 Innate Lymphoid Cells to Protect Against Intestinal Inflammation. View Abstract
O-018 New Evidence for Structural Brain Differences in Pediatric Crohn's Disease: Impact of Underlying Disease Factors. View Abstract
Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease. View Abstract
Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: a case report. View Abstract
N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome. View Abstract
Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease. View Abstract
MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR?? regulatory T cells. View Abstract
Very-Early-Onset Inflammatory Bowel Disease. View Abstract
Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies. View Abstract
Very early-onset inflammatory bowel disease: gaining insight through focused discovery. View Abstract
Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. View Abstract
The diagnostic approach to monogenic very early onset inflammatory bowel disease. View Abstract
CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis. View Abstract
N-wasp is required for structural integrity of the blood-testis barrier. View Abstract
Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease. View Abstract
Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease. View Abstract
The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment. View Abstract
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. View Abstract
Protective mucosal immunity mediated by epithelial CD1d and IL-10. View Abstract
Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation. View Abstract
Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease. View Abstract
Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. View Abstract
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. View Abstract
N-wasp is essential for the negative regulation of B cell receptor signaling. View Abstract
Colitis and colon cancer in WASP-deficient mice require helicobacter species. View Abstract
Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. View Abstract
Characterization of adherent bacteroidales from intestinal biopsies of children and young adults with inflammatory bowel disease. View Abstract
N-wasp is required for stabilization of podocyte foot processes. View Abstract
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. View Abstract
Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. View Abstract
Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. View Abstract
The actin regulator N-WASp is required for muscle-cell fusion in mice. View Abstract
The age of gene discovery in very early onset inflammatory bowel disease. View Abstract
Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. View Abstract
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. View Abstract
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. View Abstract
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. View Abstract
Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance. View Abstract
Gut-tropic T cells that express integrin a4ß7 and CCR9 are required for induction of oral immune tolerance in mice. View Abstract
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. View Abstract
The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release. View Abstract
MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. View Abstract
Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. View Abstract
N-WASP is required for membrane wrapping and myelination by Schwann cells. View Abstract
Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation. View Abstract
Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. View Abstract
Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. View Abstract
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. View Abstract
Phosphorylation of WASp is a key regulator of activity and stability in vivo. View Abstract
Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. View Abstract
Activating mutations of N-WASP alter Shigella pathogenesis. View Abstract
Targeting Smads to restore transforming growth factor-beta signaling and regulatory T-cell function in inflammatory bowel disease. View Abstract
Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and men. View Abstract
Regulatory T cells in inflammatory bowel disease. View Abstract
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. View Abstract
Challenges in IBD research: Assessing progress and rethinking the research agenda. View Abstract
Genetic tracing reveals a stereotyped sensory map in the olfactory cortex. View Abstract
Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. View Abstract
Teaching tolerance with a probiotic antigen delivery system. View Abstract
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. View Abstract
The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. View Abstract
Retroviral WASP gene transfer into human hematopoietic stem cells reconstitutes the actin cytoskeleton in myeloid progeny cells differentiated in vitro. View Abstract
Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival. View Abstract
A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis. View Abstract
Role of the WASP family proteins for Mycobacterium marinum actin tail formation. View Abstract
WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. View Abstract
WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. View Abstract
The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function. View Abstract
A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. View Abstract
Cortactin regulates cell migration through activation of N-WASP. View Abstract
Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. View Abstract
Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins. View Abstract
Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization. View Abstract
Innate immune response to encephalomyocarditis virus infection mediated by CD1d. View Abstract
Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. View Abstract
A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria. View Abstract
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. View Abstract
A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome. View Abstract
A family of WASPs. View Abstract
Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice. View Abstract
Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. View Abstract
Cdc42 facilitates invasion but not the actin-based motility of Shigella. View Abstract
Genetic tracing reveals a stereotyped sensory map in the olfactory cortex. View Abstract
Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function. View Abstract
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. View Abstract
Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes. View Abstract
Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. View Abstract
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. View Abstract
Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. View Abstract
The cytoskeleton in lymphocyte signaling. View Abstract
Heterogeneity of NK1.1+ T cells in the bone marrow: divergence from the thymus. View Abstract
CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. View Abstract
Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. View Abstract
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. View Abstract
The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization. View Abstract
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. View Abstract
Ulcerative colitis and colon cancer: more controversy than clarity. View Abstract
Identification of expression signals of the mycobacteriophages Bxb1, L1 and TM4 using the Escherichia-Mycobacterium shuttle plasmids pYUB75 and pYUB76 designed to create translational fusions to the lacZ gene. View Abstract
Genetic systems for mycobacteria. View Abstract
Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. View Abstract
Development of BCG as a recombinant vaccine vehicle. View Abstract
Mycobacteriophage vector systems. View Abstract
Vaccine development. On relating immunology to the Third World: some studies on leprosy. View Abstract
Development of genetic systems for the mycobacteria. View Abstract
Lysogeny and transformation in mycobacteria: stable expression of foreign genes. View Abstract
Use of anti-idiotypic antibodies to explore genetic mechanisms of production of anti-DNA antibodies. View Abstract
The distribution of thyrotropin-releasing hormone (TRH) in the rhesus monkey spinal cord. View Abstract
Evidence that spinal cord thyrotropin-releasing hormone is independent of the paraventricular nucleus. View Abstract