Scellig S. D. Stone, MD, PhD, FRCSC
Co-Director, Epilepsy Center; Director, Stereotactic and Functional Neurosurgery; Neurosurgical Director, Movement Disorders and Deep Brain Stimulation Program
Associate Professor of Neurosurgery, Harvard Medical School
Image
Scellig S. D. Stone, MD, PhD, FRCSC
Co-Director, Epilepsy Center; Director, Stereotactic and Functional Neurosurgery; Neurosurgical Director, Movement Disorders and Deep Brain Stimulation Program
Associate Professor of Neurosurgery, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Queen’s University
1999
Kingston
Canada
Medical School
University of Toronto
2003
Toronto
Canada
Residency
Neurosurgery
University of Toronto
2013
Toronto
Canada
Fellowship
Pediatric Neurosurgery
Boston Children’s Hospital
2014
Boston
MA
Media
Caregiver Profile
Meet Dr. Scellig Stone
Ask an Expert
Epilepsy Q&A: Understanding the anatomy of the brain
Ask an Expert
Epilepsy Q&A: What is vagal nerve stimulation?
Ask an Expert
Epilepsy Q&A: What is single stage resection?
Ask an Expert
Epilepsy Q&A: How surgical techniques map the brain
Ask an Expert
Epilepsy Q&A: What is a laser ablation?
Ask an Expert
Epilepsy Q&A: What is a hemispherectomy?
Ask an Expert
Epilepsy Q&A: What are the different types of epilepsy surgery?
Ask an Expert
Epilepsy Q&A: What is a deep brain stimulator?
Ask an Expert
Epilepsy Q&A: What is a corpus callosotomy?
Professional History
My practice is focused mainly on functional disorders in children, including treatments for movement disorders, spasticity, and epilepsy, with a focus on advance minimally invasive techniques such as MRI-guided laser ablation, deep brain stimulation, stereoelectroencephalography, selective dorsal rhizotomy, and neuroendoscopy.
I hold both a medical degree and a PhD in neuroscience from the Institute of Medical Science at the University of Toronto, training that gives me a unique perspective on the treatment of neurosurgical patients. I completed the prestigious Shillito neurosurgical fellowship at Boston Children's Hospital in 2014, and am the founding surgical director of our department's movement disorders and deep brain stimulation program.
As an example, one of my clinical work focuses is on advanced neurosurgical treatments for dystonia, a movement disorder in which faulty brain signals cause involuntary muscle contractions in children. I specialize in deep brain stimulation, a surgical procedure in which I implant electrodes on different targets in the brain to deliver electrical stimulation to those areas via a simultaneously-implanted pacemaker-like device called a neurostimulator. Deep brain stimulation is currently indicated for primary dystonia, and holds enormous future potential for other conditions.
I also run a general neurosurgical practice, encompassing areas such as brain tumors, neuroendoscopy and epilepsy surgeries. I am a passionate advocate for dystonia awareness and the potential application of deep brain stimulation for patients, and have been an invited speaker locally and internationally on the topic.
As a surgeon-scientist, I am interested in encouraging functional regeneration and repair of the brain using targeting therapies such as deep brain stimulation. Through understanding mechanisms of adult neurogenesis and neurostimulation, I am hopeful that we will be able to harness intrinsic brain mechanisms to repair and restore damaged and diseased brain.
Approach to Care
My approach to care reflects the satisfaction I get from helping a child suffering from neurologic illness. I find working with kids inspiring. They are usually much braver patients than adults and their potential for recovery is often great. Giving a child the ability to reach his or her full potential is something that motivates my work every day.
Publications
Epstein-Barr virus-associated smooth muscle tumor partially occluding the superior sagittal sinus: illustrative case. View Abstract
Intrathecal baclofen pump versus combined dorsal/ventral rhizotomy for spastic quadriplegia: healthcare cost and complication analysis. View Abstract
Gabapentinoids confer survival benefit in human glioblastoma. View Abstract
Epilepsy surgery in Sturge-Weber syndrome with unilateral or bilateral asymmetric brain involvement: Boston Children's Hospital experience. View Abstract
A pre-operative gastrointestinal optimization protocol to improve outcomes after intrathecal baclofen pump surgery. View Abstract
Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants. View Abstract
Neural correlates of minimal recognizable configurations in the human brain. View Abstract
Machine learning on interictal intracranial EEG predicts surgical outcome in drug resistant epilepsy. View Abstract
Evaluating the effectiveness of medical therapy in infantile epileptic spasms syndrome due to surgically-remediable lesions. View Abstract
Spikes on ripples are better interictal biomarkers of epilepsy than spikes or ripples. View Abstract
Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy. View Abstract
Transient Ipsilateral Hemineglect Following Brain Laser Ablation in Patient with Focal Cortical Dysplasia. View Abstract
Intralesional epileptiform activity in a fourth ventricular hamartoma associated with epileptic hemifacial spasm in a toddler: illustrative case. View Abstract
In Search of a Common Language: The Standardized Electrode Nomenclature for Stereoelectroencephalography Applications. View Abstract
The Case for Neurosurgical Intervention in Cancer Neuroscience. View Abstract
Spinal catheter revision in pediatric intrathecal baclofen pumps: risk factors and postoperative outcomes. View Abstract
Predictive factors for seizure freedom after epilepsy surgery for pediatric low-grade tumors and focal cortical dysplasia. View Abstract
Recommendations for the Management of Initial and Refractory Pediatric Status Dystonicus. View Abstract
The role of occipital condyle and atlas anomalies on occipital cervical fusion outcomes in Chiari malformation type I with syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium. View Abstract
Interictal EEG source connectivity to localize the epileptogenic zone in patients with drug-resistant epilepsy: A machine learning approach. View Abstract
Somatic Mosaicism in PIK3CA Variant Correlates With Stereoelectroencephalography-Derived Electrophysiology. View Abstract
Deep Learning-Based Visual Complexity Analysis of Electroencephalography Time-Frequency Images: Can It Localize the Epileptogenic Zone in the Brain? View Abstract
Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox-Gastaut syndrome: A multicenter, multinational study. View Abstract
Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience. View Abstract
Machine learning models for predicting seizure outcome after MR-guided laser interstitial thermal therapy in children. View Abstract
Sleep Spindle Generation Before and After Epilepsy Surgery: A Source Imaging Study in Children with Drug-Resistant Epilepsy. View Abstract
Using robotics to move a neurosurgeon's hands to the tip of their endoscope. View Abstract
Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy. View Abstract
Focal drug-resistant temporal lobe epilepsy associated with an ipsilateral anterior choroidal artery aneurysm: illustrative case. View Abstract
Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy. View Abstract
Comparison of fMRI language laterality with and without sedation in pediatric epilepsy. View Abstract
Endoscopic third ventriculostomy with choroid plexus cauterization: predictors of long-term success and comparison with shunt placement for primary treatment of infant hydrocephalus. View Abstract
Non-invasive mapping of epileptogenic networks predicts surgical outcome. View Abstract
Deep brain stimulation for medically refractory status dystonicus in UBA5-related disorder. View Abstract
Recurrent abdominal dislodgement of intrathecal pump and utility of infraclavicular site for patients with elevated body mass index: illustrative case. View Abstract
Cross-task specificity and within-task invariance of cognitive control processes. View Abstract
Stereoelectroencephalography followed by combined electrode removal and MRI-guided laser interstitial thermal therapy or open resection: a single-center series in pediatric patients with medically refractory epilepsy. View Abstract
Seizure outcome of pediatric magnetic resonance-guided laser interstitial thermal therapy versus open surgery: A matched noninferiority cohort study. View Abstract
Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome. View Abstract
Discrepant expressive language lateralization in children and adolescents with epilepsy. View Abstract
Limited utility of structural MRI to identify the epileptogenic zone in young children with tuberous sclerosis. View Abstract
Nusinersen for Patients With Spinal Muscular Atrophy: 1415 Doses via an Interdisciplinary Institutional Approach. View Abstract
Complications and outcomes of posterior fossa decompression with duraplasty versus without duraplasty for pediatric patients with Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium. View Abstract
Epidural Analgesia Versus Lumbar Plexus Blockade After Hip Reconstruction Surgery in Children With Cerebral Palsy and Intrathecal Baclofen Pumps: A Comparison of Safety and Efficacy. View Abstract
Mendelian etiologies identified with whole exome sequencing in cerebral palsy. View Abstract
Socioeconomic and demographic factors in the diagnosis and treatment of Chiari malformation type I and syringomyelia. View Abstract
The low utility of routine cranial imaging after pediatric shunt revision. View Abstract
A Standardized Electrode Nomenclature for Stereoelectroencephalography Applications. View Abstract
Intrathecal catheter and port placement for nusinersen infusion in children with spinal muscular atrophy and spinal fusion. View Abstract
Extradural decompression versus duraplasty in Chiari malformation type I with syrinx: outcomes on scoliosis from the Park-Reeves Syringomyelia Research Consortium. View Abstract
Epidural analgesia for reduction of postoperative systemic opioid use following selective dorsal rhizotomy in children. View Abstract
Dural augmentation approaches and complication rates after posterior fossa decompression for Chiari I malformation and syringomyelia: a Park-Reeves Syringomyelia Research Consortium study. View Abstract
Occipital-Cervical Fusion and Ventral Decompression in the Surgical Management of Chiari-1 Malformation and Syringomyelia: Analysis of Data From the Park-Reeves Syringomyelia Research Consortium. View Abstract
Anesthetic management and outcomes for MRI-guided laser interstitial thermal therapy (LITT) for seizure focus in pediatrics: A single-centre experience with 10 consecutive patients. View Abstract
Epidural catheter placement in children with baclofen pumps. View Abstract
Magnetic resonance imaging-guided laser-induced thermal therapy for functional hemispherotomy in a child with refractory epilepsy and multiple medical comorbidities. View Abstract
Endoscope-assisted microsurgical resection of intrinsic brainstem epidermoid: technical note and review of the literature. View Abstract
Drug-Responsive Inhomogeneous Cortical Modulation by Direct Current Stimulation. View Abstract
Complex Management of Hydrocephalus Secondary To Choroid Plexus Hyperplasia. View Abstract
Pilot Study of Neurodevelopmental Impact of Early Epilepsy Surgery in Tuberous Sclerosis Complex. View Abstract
Factors associated with syrinx size in pediatric patients treated for Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium. View Abstract
Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. View Abstract
The Palliative Use of Intrathecal Baclofen in Niemann-Pick Disease Type C. View Abstract
Long-term outcomes of lumbar microdiscectomy in the pediatric population: a large single-institution case series. View Abstract
Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium. View Abstract
Noninvasive Thermal Evaluation of Ventriculoperitoneal Shunt Patency and Cerebrospinal Fluid Flow Using a Flow Enhancing Device. View Abstract
VAC14 Gene-Related Parkinsonism-Dystonia With Response to Deep Brain Stimulation. View Abstract
Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. View Abstract
Deep brain stimulation for monogenic dystonia. View Abstract
Localization of stereo-electroencephalography signals using a finite difference complete electrode model. View Abstract
Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer's Disease. View Abstract
Comparative effectiveness of flexible versus rigid neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization: a propensity score-matched cohort and survival analysis. View Abstract
High frequency stimulation of the infralimbic cortex induces morphological changes in rat hippocampal neurons. View Abstract
Episodic ventriculomegaly due to hypernatremia mimicking shunt malfunction: case report. View Abstract
Reopening of an obstructed third ventriculostomy: long-term success and factors affecting outcome in 215 infants. View Abstract
The neurosurgical treatment of Alzheimer's disease: a review. View Abstract
Combined endoscopic third ventriculostomy and choroid plexus cauterization as primary treatment for infant hydrocephalus: a prospective North American series. View Abstract
Occipital pial synangiosis. View Abstract
Cranial sutures: a multidisciplinary review. View Abstract
Phosphorylation prevents polyglucosan transport in Lafora disease. View Abstract
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. View Abstract
Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone. View Abstract
Impact of early adverse experience on complexity of adult-generated neurons. View Abstract
The subcallosal cingulate gyrus in the context of major depression. View Abstract
Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory. View Abstract
Anterior thalamus deep brain stimulation at high current impairs memory in rats. View Abstract
Utility of neuronavigation and neuromonitoring in epilepsy surgery. View Abstract
Prospective error recording in surgery: an analysis of 1108 elective neurosurgical cases. View Abstract
The pedunculopontine nucleus and movement disorders: anatomy and the role for deep brain stimulation. View Abstract
Locations