Sanda Alexandrescu, MD
Director of Neuropathology; Director of Autopsy; Attending Physician, Dana-Farber/Boston Children’s Blood Disorders Cent
Associate Professor of Pathology, Harvard Medical School
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Sanda Alexandrescu, MD
Director of Neuropathology; Director of Autopsy; Attending Physician, Dana-Farber/Boston Children’s Blood Disorders Cent
Associate Professor of Pathology, Harvard Medical School
Medical Services
Languages
English
French
Romanian
Spanish
Education
Medical School
The Victor Babes University of Medicine
2004
Timisoara
Romania
Residency
Anatomic and Clinical Pathology
University of Texas
2012
Houston
TX
Fellowship
Pediatric Pathology
Boston Children's Hospital
2013
Boston
MA
Fellowship
Neuropathology
University of California, San Francisco
2015
San Francisco
CA
Certifications
American Board of Pathology (Pediatric Clinical Anatomic)
American Board of Pathology (Anatomic Clinical Pathology)
American Board of Pathology (Neuropathology)
Publications
Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions. View Abstract
Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure. View Abstract
A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients. View Abstract
Primary Central Nervous System Mesenchymal Neoplasms in the Pediatric Population-An Update. View Abstract
Pediatric Neuropathology-Keeping Pace with Progress. View Abstract
Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations. View Abstract
GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant. View Abstract
Author Correction: Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. View Abstract
Antisense Oligonucleotide Therapy for Calmodulinopathy. View Abstract
Pediatric Chordoma: A Tale of Two Genomes. View Abstract
Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. View Abstract
Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations. View Abstract
Clinical utility of DNA methylation profiling for choroid plexus tumors. View Abstract
MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome. View Abstract
CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness. View Abstract
Systematic characterization of antibody-drug conjugate targets in central nervous system tumors. View Abstract
Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome. View Abstract
Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology. View Abstract
H3K27-altered diffuse midline gliomas with MAPK pathway alterations: Prognostic and therapeutic implications. View Abstract
Double-stranded RNA immunohistochemistry as a screening tool for viral encephalitis. View Abstract
ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients. View Abstract
ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma. View Abstract
Molecular profiling identifies at least 3 distinct types of posttransplant lymphoproliferative disorder involving the CNS. View Abstract
Eastern Equine Encephalitis Virus Diversity in Massachusetts Patients, 1938-2020. View Abstract
Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. View Abstract
Clear cell tumor with melanocytic differentiation and MITF::CREM translocation. View Abstract
Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions. View Abstract
Multi-institutional study of the frequency, genomic landscape, and outcome of IDH-mutant glioma in pediatrics. View Abstract
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. View Abstract
Mimics of Pediatric Small Vessel Primary Angiitis of the Central Nervous System. View Abstract
Copy Number Variation and Structural Genomic Findings in 116 Cases of Sudden Unexplained Death between 1 and 28 Months of Age. View Abstract
Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma. View Abstract
Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1. View Abstract
PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors. View Abstract
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma. View Abstract
Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas. View Abstract
DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis. View Abstract
Embryonal and non-meningothelial mesenchymal tumors of the central nervous system - Advances in diagnosis and prognostication. View Abstract
ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. View Abstract
Genetic Determinants of Sudden Unexpected Death in Pediatrics. View Abstract
Medullary Serotonergic Binding Deficits and Hippocampal Abnormalities in Sudden Infant Death Syndrome: One or Two Entities? View Abstract
Intracranial mesenchymal tumors with FET-CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas. View Abstract
Immunohistochemical surrogates for molecular alterations for the classification and grading of gliomas. View Abstract
Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels. View Abstract
Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death. View Abstract
Assessment of BCOR Internal Tandem Duplications in Pediatric Cancers by Targeted RNA Sequencing. View Abstract
IDH-mutant gliomas with additional class-defining molecular events. View Abstract
Outcomes after first relapse of childhood intracranial ependymoma. View Abstract
Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion. View Abstract
Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms. View Abstract
Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant. View Abstract
Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile. View Abstract
Making the most of small samples: Optimization of tissue allocation of pediatric solid tumors for clinical and research use. View Abstract
Molecular and clinicopathologic features of gliomas harboring NTRK fusions. View Abstract
Molecular and clinicopathologic features of gliomas harboring NTRK fusions View Abstract
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. View Abstract
A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood. View Abstract
A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood View Abstract
Immune checkpoint inhibition for pediatric patients with recurrent/refractory CNS tumors: a single institution experience. View Abstract
An Update on Pediatric Gliomas. View Abstract
Mechanisms and therapeutic implications of hypermutation in gliomas. View Abstract
Embryonal Tumors of the Central Nervous System: An Update. View Abstract
Somatic mutations in intracranial arteriovenous malformations. View Abstract
The molecular landscape of ETMR at diagnosis and relapse. View Abstract
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. View Abstract
Increasing value of autopsies in patients with brain tumors in the molecular era. View Abstract
Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors. View Abstract
Characterization of molecular signatures of supratentorial ependymomas. View Abstract
Pediatric CNS-isolated hemophagocytic lymphohistiocytosis. View Abstract
An update on the central nervous system manifestations of DICER1 syndrome. View Abstract
Recurrent EP300-BCOR Fusions in Pediatric Gliomas With Distinct Clinicopathologic Features. View Abstract
Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. View Abstract
Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. View Abstract
Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System. View Abstract
Expanding the spectrum of pediatric NTRK-rearranged fibroblastic tumors to the central nervous system: A case report with RBPMS-NTRK3 fusion. View Abstract
PHOX2B is a reliable immunomarker in distinguishing peripheral neuroblastic tumours from CNS embryonal tumours. View Abstract
Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. View Abstract
Pediatric low-grade gliomas: next biologically driven steps. View Abstract
Mycoplasma hominis Empyema in an 18-Year-old Stem Cell and Lung Transplant Recipient: Case Report and Review of the Literature. View Abstract
A novel GIT2-BRAF fusion in pilocytic astrocytoma. View Abstract
Neurenteric cyst at the dorsal craniocervical junction in a child: Case report. View Abstract
Focal cerebral ß-amyloid angiopathy: A distinct clinicopathologic presentation. View Abstract
Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. View Abstract
Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. View Abstract
Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity? View Abstract
Focal cerebral beta-amyloid angiopathy. A distinct clinicopathologic presentation View Abstract
Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation. View Abstract
Diagnostic Histopathology View Abstract
Diagnostic Histopathology View Abstract
Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. View Abstract
Clinical, pathologic, and genetic features of Wilms tumors with WTX gene mutation. View Abstract
Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas--Same Entity or First Cousins? View Abstract
CNS intravascular large cell lymphoma in a patient with autoimmune hemolytic anemia. View Abstract
Sirolimus therapy in infants with severe hyperinsulinemic hypoglycemia. View Abstract
Role of calretinin immunohistochemical stain in evaluation of Hirschsprung disease: an institutional experience. View Abstract
Morphoproteomics provides support for TGF-ß pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis. View Abstract
Intrahepatic cholangiocarcinoma--a rare indication for liver transplantation. Case report and review of the literature. View Abstract
Neuron precursor features of spindle cell oncocytoma of adenohypophysis. View Abstract
Acute promyelocytic leukemia as a cause of intracoronary drug-eluting-stent thrombosis. View Abstract
Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications. View Abstract
Renin-angiotensin system blockade is renoprotective in immune complex-mediated glomerulonephritis. View Abstract
Locations