Samuel Lux, MD
Chief Emeritus, Division of Hematology/Oncology; Director, Internship Selection
Robert A. Stranahan Distinguished Professor of Pediatrics, Harvard Medical School
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Samuel Lux, MD
Chief Emeritus, Division of Hematology/Oncology; Director, Internship Selection
Robert A. Stranahan Distinguished Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
Kansas University Medical School
1967
Kansas City
MO
Internship
Boston Children's Hospital
1968
Boton
MA
Residency
Boston Children's Hospital
1969
Boston
MA
Fellowship
Boston Children's Hospital
1973
Boston
MA
Certifications
American Board of Pediatrics (General)
Publications
Application Factors Associated With Clinical Performance During Pediatric Internship. View Abstract
Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia. View Abstract
Anatomy of the red cell membrane skeleton: unanswered questions. View Abstract
Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. View Abstract
Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. View Abstract
The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding. View Abstract
Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. View Abstract
Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells. View Abstract
Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner. View Abstract
A uniform third-year application and offer date for pediatric fellow applicants: pro and con. View Abstract
Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate. View Abstract
Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer. View Abstract
A functional magnetic resonance imaging study of local/global processing with stimulus presentation in the peripheral visual hemifields. View Abstract
Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency. View Abstract
Simultaneous (AC)n microsatellite polymorphism analysis and single-stranded conformation polymorphism screening is an efficient strategy for detecting ankyrin-1 mutations in dominant hereditary spherocytosis. View Abstract
Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. View Abstract
A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. View Abstract
The human ankyrin-1 gene is selectively transcribed in erythroid cell lines despite the presence of a housekeeping-like promoter. View Abstract
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. View Abstract
Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. View Abstract
Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. View Abstract
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. View Abstract
Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. View Abstract
Red blood cell membrane disorders. View Abstract
Notch1 inhibits neurite outgrowth in postmitotic primary neurons. View Abstract
Regulation of band 3 rotational mobility by ankyrin in intact human red cells. View Abstract
A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles. View Abstract
Distribution of epithelial ankyrin (Ank3) spliceoforms in renal proximal and distal tubules. View Abstract
Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing. View Abstract
Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. View Abstract
Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. View Abstract
Isolated beta-globin chains reproduce, in normal red cell membranes, the defective binding of spectrin to alpha-thalassaemic membranes. View Abstract
Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis. View Abstract
Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. View Abstract
A nonsense mutation in the erythrocyte band 3 gene associated with decreased mRNA accumulation in a kindred with dominant hereditary spherocytosis. View Abstract
Differential expression of Na(+)-K(+)-ATPase, ankyrin, fodrin, and E-cadherin along the kidney nephron. View Abstract
Increased cation permeability in mutant mouse red blood cells with defective membrane skeletons. View Abstract
Characterization of the binary interaction between human erythrocyte protein 4.1 and actin. View Abstract
Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain. View Abstract
Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3. View Abstract
Combined spectrin and ankyrin deficiency is common in autosomal dominant hereditary spherocytosis. View Abstract
A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin. View Abstract
Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1. View Abstract
Complex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene. View Abstract
Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. View Abstract
Ankyrins: structure and function in normal cells and hereditary spherocytes. View Abstract
The murine pallid mutation is a platelet storage pool disease associated with the protein 4.2 (pallidin) gene. View Abstract
Expression, purification, and characterization of the functional dimeric cytoplasmic domain of human erythrocyte band 3 in Escherichia coli. View Abstract
Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo. View Abstract
Murine erythrocyte ankyrin cDNA: highly conserved regions of the regulatory domain. View Abstract
Large numbers of alternatively spliced isoforms of the regulatory region of human erythrocyte ankyrin. View Abstract
Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. View Abstract
Isolation and chromosomal localization of a novel nonerythroid ankyrin gene. View Abstract
Radiolabel-transfer cross-linking demonstrates that protein 4.1 binds to the N-terminal region of beta spectrin and to actin in binary interactions. View Abstract
Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin. View Abstract
Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8. View Abstract
Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin. View Abstract
Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. View Abstract
Demonstration of the deletion of a copy of the ankyrin gene in a patient with hereditary spherocytosis by in situ hybridization. View Abstract
Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1). View Abstract
Hereditary disorders of the red cell membrane skeleton. View Abstract
Mapping the ankyrin-binding site of the human erythrocyte anion exchanger. View Abstract
Differing erythrocyte membrane skeletal protein defects in alpha and beta thalassemia. View Abstract
Hemoglobin Brockton [beta 138 (H16) Ala----Pro]: an unstable variant near the C-terminus of the beta-subunits with normal oxygen-binding properties. View Abstract
Abnormal oxidant sensitivity and beta-chain structure of spectrin in hereditary spherocytosis associated with defective spectrin-protein 4.1 binding. View Abstract
Molecular defect in the membrane skeleton of blood bank-stored red cells. Abnormal spectrin-protein 4.1-actin complex formation. View Abstract
Cation depletion by the sodium pump in red cells with pathologic cation leaks. Sickle cells and xerocytes. View Abstract
The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin. View Abstract
An examination of the soluble oligomeric complexes extracted from the red cell membrane and their relation to the membrane cytoskeleton. View Abstract
Hereditary spherocytosis and related disorders. View Abstract
The effect of oxidation on the structure and function of human erythrocyte spectrin. View Abstract
Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles. View Abstract
Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. View Abstract
The erythrocyte membrane skeleton: pathophysiology. View Abstract
The erythrocyte membrane skeleton: biochemistry. View Abstract
Analysis of the ternary interaction of the red cell membrane skeletal proteins spectrin, actin, and 4.1. View Abstract
An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells. View Abstract
A phenomenological difference between membrane skeletal protein complexes isolated from normal and hereditary spherocytosis erythrocytes. View Abstract
High yield purification of protein 4.1 from human erythrocyte membranes. View Abstract
Red cell membrane skeletal defects in hereditary and acquired hemolytic anemias. View Abstract
Hemolytic anemia in the mouse. Report of a new mutation and clarification of its genetics. View Abstract
A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis. View Abstract
A technique to detect reduced mechanical stability of red cell membranes: relevance to elliptocytic disorders. View Abstract
Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. View Abstract
Elliptical erythrocyte membrane skeletons and heat-sensitive spectrin in hereditary elliptocytosis. View Abstract
Hemolytic anemias due to abnormalities in red cell spectrin: a brief review. View Abstract
Structural characterization of the phosphorylation sites of human erythrocyte spectrin. View Abstract
Comparison of the phosphorylation of human erythrocyte spectrin in the intact red cell and in various cell-free systems. View Abstract
Inherited disorders of the red cell membrane skeleton. View Abstract
Dissecting the red cell membrane skeleton. View Abstract
Spectrin-actin membrane skeleton of normal and abnormal red blood cells. View Abstract
Hemolytic anemias associated with deficient or dysfunctional spectrin. View Abstract
Energy reserve and cation composition of irreversibly sickled cells in vivo. View Abstract
Membrane protein phosphorylation of intact normal and hereditary spherocytic erythrocytes. View Abstract
Diminished spectrin extraction from ATP-depleted human erythrocytes. Evidence relating spectrin to changes in erythrocyte shape and deformability. View Abstract
Isolation and partial characterization of a high molecular weight red cell membrane protein complex normally removed by the spleen. View Abstract
Evidence that spectrin is a determinant of shape and deformability in the human erythrocyte. View Abstract
Irreversible deformation of the spectrin-actin lattice in irreversibly sickled cells. View Abstract
Human plasma high density lipoprotein. Interaction of the cyanogen bromide fragments from apolipoprotein glutamine II (A-II) with phosphatidylcholine. View Abstract
Isolation and characterization of apoLp-Gln-II (apoA-II), a plasma high density apolipoprotein containing two identical polypeptide chains. View Abstract
Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein. View Abstract
Identification of the lipid-binding cyanogen bromide fragment from the cystine-containing high density apolipoprotein, APOLP-GLN-II. View Abstract
Studies on the protein defect in Tangier disease. Isolation and characterization of an abnormal high density lipoprotein. View Abstract
Further characterization of the polymorphic forms of a human high density apolipoprotein, apoLP-Gln-I (apoA-I). View Abstract
Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex. View Abstract
Degradation of membrane phospholipids and thiols in peroxide hemolysis: studies in vitamin E deficiency. View Abstract