Weather Alert
Snow is in the forecast. Consider switching to a virtual visit to receive care from home. Learn more >>
Popular Search Terms
Pui Lee, MD, PhD
Rheumatologist, Rheumatology Program
Assistant Professor of Pediatrics, Harvard Medical School
Image
Pui Lee, MD, PhD
Rheumatologist, Rheumatology Program
Assistant Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
Cantonese
English
Education
Medical School
University of Florida College of Medicine
2010
Gainesville
FL
Internship
Boston Children's Hospital
2011
Boston
MA
Residency
Boston Children's Hospital
2013
Boston
MA
Fellowship
Boston Children's Hospital
2016
Boston
MA
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Rheumatology)
Publications
Sex Differences in B Cells From the Joints of Children With Oligoarticular Juvenile Idiopathic Arthritis. View Abstract
T-ing up the storm: pathogenic cycling lymphocytes in the biology of macrophage activation syndrome. View Abstract
Utility of Cytokine Biomarkers for the Diagnosis of Pediatric Pyogenic Musculoskeletal Infections. View Abstract
Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus. View Abstract
T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice. View Abstract
DOCK8 at the crossroads of immunodeficiency and hyperinflammation. View Abstract
Implications of the choroid plexus in Niemann-Pick disease Type C neuropathogenesis. View Abstract
Features of hyperinflammation link the biology of Epstein-Barr virus infection and cytokine storm syndromes. View Abstract
IL-4Ra signaling promotes barrier-altering oncostatin M and IL-6 production in aspirin-exacerbated respiratory disease. View Abstract
Monocytic Phagocytes in the Immunopathogenesis of Cytokine Storm Syndromes. View Abstract
Elevation of IL-17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders. View Abstract
Type I interferon signature and cycling lymphocytes in macrophage activation syndrome. View Abstract
In cis "benign" SOCS1 variants linked to enhanced interferon signaling and autoimmunity. View Abstract
Development of a Screening Algorithm for Lung Disease in Systemic Juvenile Idiopathic Arthritis. View Abstract
Suppressor of Cytokine Signaling 1 Haploinsufficiency: A New Driver of Autoimmunity and Immunodysregulation. View Abstract
Incidence and Risk Factors for Eosinophilia and Lung Disease in Biologic-Exposed Children With Systemic Juvenile Idiopathic Arthritis. View Abstract
Comparison of disease phenotypes and mechanistic insight on causal variants in patients with DADA2. View Abstract
Evaluation and Management of Deficiency of Adenosine Deaminase 2: An International Consensus Statement. View Abstract
The Multifaceted Immunology of Cytokine Storm Syndrome. View Abstract
A Cohort Study on Deficiency of ADA2 from China. View Abstract
Biologics and JAK inhibitors for the treatment of monogenic systemic autoinflammatory diseases in children. View Abstract
Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis. View Abstract
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children. View Abstract
At the Heart of Treating Kawasaki Disease: The Search for New Approaches to Prevent Coronary Artery Aneurysms. View Abstract
Editorial: DADA2 and other monogenic vasculitides. View Abstract
mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome. View Abstract
SOCS1 Haploinsufficiency Presenting as Severe Enthesitis, Bone Marrow Hypocellularity, and Refractory Thrombocytopenia in a Pediatric Patient with Subsequent Response to JAK Inhibition. View Abstract
Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer. View Abstract
An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. View Abstract
Pediatric EVALI in the Age of COVID-19/MIS-C: Diagnostic Considerations. View Abstract
Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis. View Abstract
Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction and Subclinical Autoinflammation. View Abstract
Low-ratio somatic NLRC4 mutation causes late-onset autoinflammatory disease. View Abstract
Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children. View Abstract
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils. View Abstract
Mechanisms of vascular inflammation in deficiency of adenosine deaminase 2 (DADA2). View Abstract
Clinical characteristics of juvenile gout and treatment response to febuxostat. View Abstract
Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production. View Abstract
TNF inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2). View Abstract
Child Neurology: Recurrent Brainstem Strokes and Aphthous Ulcers in a Child With Mutations in the ADA2 Gene. View Abstract
Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. View Abstract
Coagulation profiles and viscoelastic testing in multisystem inflammatory syndrome in children. View Abstract
IL-1ß-driven osteoclastogenic Tregs accelerate bone erosion in arthritis. View Abstract
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency. View Abstract
Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C). View Abstract
Deficiency of Adenosine Deaminase 2 (DADA2): One Disease, Several Faces. View Abstract
Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach. View Abstract
Detailed Assessment of Left Ventricular Function in Multisystem Inflammatory Syndrome in Children, Using Strain Analysis. View Abstract
Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome. View Abstract
Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India. View Abstract
Reply. View Abstract
Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children. View Abstract
Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach. View Abstract
Atrioventricular Block in Children With Multisystem Inflammatory Syndrome. View Abstract
Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. View Abstract
NF-E2-Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus. View Abstract
Interstitial Lung Disease and Psoriasis in a Child With Aicardi-Goutières Syndrome. View Abstract
On the Alert for Cytokine Storm: Immunopathology in COVID-19. View Abstract
Polyarteritis nodosa and deficiency of adenosine deaminase 2 - Shared genealogy, generations apart. View Abstract
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. View Abstract
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. View Abstract
Serine/threonine phosphatase PP2A is essential for optimal B cell function. View Abstract
Response to: 'Total adenosine deaminase highly correlated with adenosine deaminase 2 activity in serum' by Gao et al. View Abstract
Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2). View Abstract
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1. View Abstract
Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon. View Abstract
Giant Cell Tumor of Tendon Sheath and Tendinopathy as Early Features of Early Onset Sarcoidosis. View Abstract
Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. View Abstract
High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. View Abstract
NETing the mechanism of inflammation in DADA2. View Abstract
Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. View Abstract
Tofacitinib Treatment of Refractory Systemic Juvenile Idiopathic Arthritis. View Abstract
Differential attenuation of ß2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. View Abstract
Vasculopathy, Immunodeficiency, and Bone Marrow Failure: The Intriguing Syndrome Caused by Deficiency of Adenosine Deaminase 2. View Abstract
Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. View Abstract
A quality improvement initiative to increase access to food challenges. View Abstract
Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. View Abstract
The metabolic regulator mTORC1 controls terminal myeloid differentiation. View Abstract
Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus. View Abstract
A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM. View Abstract
The presentation and management of granulomatosis with polyangiitis (Wegener's Granulomatosis) in the pediatric airway. View Abstract
Maintenance of autoantibody production in pristane-induced murine lupus. View Abstract
Effects of Long-Term Type I Interferon on the Arterial Wall and Smooth Muscle Progenitor Cells Differentiation. View Abstract
Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder. View Abstract
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome associated with neonatal epidermolysis bullosa acquisita. View Abstract
Hypercalcemia and miliary sarcoidosis in a 15-year-old boy. View Abstract
Ly6 family proteins in neutrophil biology. View Abstract
Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells. View Abstract
Toll-like receptor 3 ligand, polyIC, induces proteinuria and glomerular CD80, and increases urinary CD80 in mice. View Abstract
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus. View Abstract
Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. View Abstract
B cells enhance early innate immune responses during bacterial sepsis. View Abstract
IL-1a modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil. View Abstract
Monocyte and macrophage abnormalities in systemic lupus erythematosus. View Abstract
Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus. View Abstract
Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus. View Abstract
Type I interferon modulates monocyte recruitment and maturation in chronic inflammation. View Abstract
Induction of autoimmunity by pristane and other naturally occurring hydrocarbons. View Abstract
Idiopathic nephrotic syndrome and atopy: is there a common link? View Abstract
B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus. View Abstract
Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus. View Abstract
TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. View Abstract
Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen. View Abstract
A novel type I IFN-producing cell subset in murine lupus. View Abstract
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. View Abstract
Deficiency of the type I interferon receptor protects mice from experimental lupus. View Abstract
Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane). View Abstract
Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers. View Abstract
Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus. View Abstract
The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. View Abstract
Locations