Pratiti (Mimi) Bandopadhayay, MBBS, PhD
Attending Pediatric Neuro-Oncologist, Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Assistant Professor of Pediatrics, Harvard Medical School
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Pratiti (Mimi) Bandopadhayay, MBBS, PhD
Attending Pediatric Neuro-Oncologist, Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Assistant Professor of Pediatrics, Harvard Medical School
Medical Services
Education
Medical School
Monash University Medical School
Melbourne
Australia
Residency
Pediatrics
Royal Children's Hospital
2005
Melbourne
Australia
Fellowship
Pediatric Hematology-Oncology
Royal Children's Hospital
2009
Melbourne
Australia
Fellowship
Pediatric Neuro-Oncology
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2013
Boston
MA
Publications
Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification. View Abstract
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib. View Abstract
N-terminal modification of Histone H3 inhibits H3K27M-mediated loss of H3K27 trimethylation. View Abstract
A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer. View Abstract
FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma. View Abstract
Multimodal deep learning improves recurrence risk prediction in pediatric low-grade gliomas. View Abstract
Pediatric neuro-oncology: Highlights of the last quarter-century. View Abstract
A foundation model for generalized brain MRI analysis. View Abstract
Author Correction: Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. View Abstract
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma. View Abstract
Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition: A modified Delphi approach to build international consensus-based definitions-International Pediatric Low-Grade Glioma Coalition. View Abstract
Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. View Abstract
Longitudinal risk prediction for pediatric glioma with temporal deep learning. View Abstract
Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis. View Abstract
Noninvasive Molecular Subtyping of Pediatric Low-Grade Glioma with Self-Supervised Transfer Learning. View Abstract
Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors. View Abstract
Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma: Guidelines established by the International Pediatric Low-Grade Glioma Coalition Clinical Trial Working Group. View Abstract
Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial. View Abstract
Pediatric low-grade glioma: State-of-the-art and ongoing challenges. View Abstract
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma. View Abstract
A Pilot Study Omitting Radiation in the Treatment of Children with Newly Diagnosed Wnt-Activated Medulloblastoma. View Abstract
A road map for the treatment of pediatric diffuse midline glioma. View Abstract
Noninvasive molecular subtyping of pediatric low-grade glioma with self-supervised transfer learning. View Abstract
"LOGGIC" of RNA-sequencing in enhancing diagnoses of pediatric low-grade gliomas. View Abstract
ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma. View Abstract
Genome-wide pooled CRISPR screening in neurospheres. View Abstract
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma. View Abstract
BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma. View Abstract
Accurate diagnosis of pediatric brain cancers. View Abstract
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. View Abstract
Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era. View Abstract
Integrated response analysis of pediatric low-grade gliomas during and after targeted therapy treatment. View Abstract
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas. View Abstract
Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration. View Abstract
Molecular genetics of paediatric brain tumours and opportunities for precision medicine - a focus on infant tumours. View Abstract
FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits. View Abstract
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma. View Abstract
Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine. View Abstract
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma. View Abstract
Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry. View Abstract
Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data. View Abstract
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation. View Abstract
Characteristics of patients =10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry. View Abstract
The challenges in treating embryonal tumors with multilayered rosettes (ETMR) and other infant brain tumors. View Abstract
Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death. View Abstract
A first-generation pediatric cancer dependency map. View Abstract
Bromodomain and extra-terminal inhibitors-A consensus prioritisation after the Paediatric Strategy Forum for medicinal product development of epigenetic modifiers in children-ACCELERATE. View Abstract
Outcomes after first relapse of childhood intracranial ependymoma. View Abstract
Advances in the classification and treatment of pediatric brain tumors. View Abstract
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. View Abstract
CloneSifter: enrichment of rare clones from heterogeneous cell populations. View Abstract
Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma. View Abstract
Mechanisms and therapeutic implications of hypermutation in gliomas. View Abstract
The "Risk" in Pediatric Low-Grade Glioma. View Abstract
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. View Abstract
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. View Abstract
The Power of Human Cancer Genetics as Revealed by Low-Grade Gliomas. View Abstract
Longitudinal molecular trajectories of diffuse glioma in adults. View Abstract
Increasing value of autopsies in patients with brain tumors in the molecular era. View Abstract
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells. View Abstract
Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations. View Abstract
Towards Immunotherapy for Pediatric Brain Tumors. View Abstract
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. View Abstract
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. View Abstract
Old meet new-the path to combination treatments in pediatric low-grade gliomas. View Abstract
Management of pediatric low-grade glioma. View Abstract
Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling. View Abstract
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. View Abstract
Genetic and transcriptional evolution alters cancer cell line drug response. View Abstract
Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. View Abstract
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. View Abstract
Landscapes of childhood tumours. View Abstract
SvABA: genome-wide detection of structural variants and indels by local assembly. View Abstract
Landscapes of childhood tumours. View Abstract
Pediatric low-grade gliomas: next biologically driven steps. View Abstract
Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response. View Abstract
Open data: Spot data glitches before publication. View Abstract
Brainstem angiocentric gliomas with MYB-QKI rearrangements. View Abstract
Case-based review: pediatric medulloblastoma. View Abstract
Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival. View Abstract
Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. View Abstract
Pediatric low-grade gliomas: implications of the biologic era. View Abstract
Population Control: Cortical Interneurons Modulate Oligodendrogenesis. View Abstract
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. View Abstract
Central Versus Extraventricular Neurocytoma in Children: A Clinicopathologic Comparison and Review of the Literature. View Abstract
Tyrosine receptor kinase B is a drug target in astrocytomas. View Abstract
Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation. View Abstract
Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study. View Abstract
Building a new process: Nursing verification of pediatric oral chemotherapy. View Abstract
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. View Abstract
Myxopapillary ependymomas in children: imaging, treatment and outcomes. View Abstract
Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. View Abstract
An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. View Abstract
Epigenetic targeting of hedgehog pathway transcriptional output. View Abstract
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. View Abstract
Pediatric low-grade gliomas: how modern biology reshapes the clinical field. View Abstract
Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: an analysis of the Surveillance Epidemiology and End Results (SEER) database. View Abstract
The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. View Abstract
BET bromodomain inhibition of MYC-amplified medulloblastoma. View Abstract
Morning glory disc anomaly in association with ipsilateral optic nerve glioma. View Abstract
ANZCCSG BabyBrain99; intensified systemic chemotherapy, second look surgery and involved field radiation in young children with central nervous system malignancy. View Abstract
The evolution of the histology in pleomorphic xanthoastrocytomas in children: a study of 15 cases. View Abstract
Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour. View Abstract
Arousal responses and risk factors for sudden infant death syndrome. View Abstract
Effects of age and sleeping position on arousal from sleep in preterm infants. View Abstract
Temperament ratings do not predict arousability in normal infants and infants at increased risk of sudden infant death syndrome. View Abstract