American Board of Internal Medicine (Adult Rheumatology)
Professional History
Dr. Nigrovic graduated from Amherst College in philosophy and obtained his medical doctorate at Harvard Medical School. He trained in pediatrics and internal medicine at the Harvard Combined Med/Peds Program before completing fellowship in pediatric and adult rheumatology at Boston Children’s Hospital and the Brigham and Women’s Hospital, joining the staff of both hospitals in 2004. In 2021 he became Chief of the Division of Immunology at Boston Children’s Hospital. He also directs the Brigham’s Center for Adults with Pediatric Rheumatic Illness (CAPRI), specializing in the long-term care of individuals with childhood-onset rheumatic disease. In his academic work, he directs the Nigrovic laboratory, a basic and translational research group focused on mechanisms of inflammation in arthritis and systemic lupus erythematosus. He is Professor of Pediatrics and holds the Prince Turki Bin Abdul Aziz Al-Saud Chair in Pediatrics at Harvard Medical School, and is an elected member of the American Society for Clinical Investigation.
Publications
Sex Differences in B Cells From the Joints of Children With Oligoarticular Juvenile Idiopathic Arthritis. View Abstract
Utility of Cytokine Biomarkers for the Diagnosis of Pediatric Pyogenic Musculoskeletal Infections. View Abstract
The joint accumulation model of arthritis. View Abstract
Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networks. View Abstract
A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis. View Abstract
The 'Treg paradox' in inflammatory arthritis. View Abstract
Features of hyperinflammation link the biology of Epstein-Barr virus infection and cytokine storm syndromes. View Abstract
Sex-specific NLRP3 activation in neutrophils promotes neutrophil recruitment and NETosis in the murine model of diffuse alveolar hemorrhage. View Abstract
EULAR/PReS recommendations for the diagnosis and management of Still's disease, comprising systemic juvenile idiopathic arthritis and adult-onset Still's disease. View Abstract
Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis. View Abstract
Regional specialization within the mammalian respiratory immune system. View Abstract
Classification Criteria for Axial Disease in Youth With Juvenile Spondyloarthritis. View Abstract
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus. View Abstract
Real-world application of the pediatric Glucocorticoid Toxicity Index in childhood-onset lupus. View Abstract
Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework. View Abstract
Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis. View Abstract
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus. View Abstract
Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis. View Abstract
"Rounding Third Base and Heading Home": Arthritis & Rheumatology in 2024. View Abstract
Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development. View Abstract
Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant. View Abstract
Recent advances and evolving concepts in Still's disease. View Abstract
The 4th NextGen Therapies for SJIA and MAS: part 1 the elephant in the room: diagnostic/classification criteria for systemic juvenile idiopathic arthritis and adult-onset still's disease. View Abstract
Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework. View Abstract
Human and mouse neutrophils share core transcriptional programs in both homeostatic and inflamed contexts. View Abstract
Elevation of IL-17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders. View Abstract
Type I interferon signature and cycling lymphocytes in macrophage activation syndrome. View Abstract
Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant. View Abstract
Development of a Screening Algorithm for Lung Disease in Systemic Juvenile Idiopathic Arthritis. View Abstract
NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient. View Abstract
Therapeutic Development in Polyarticular Course Juvenile Idiopathic Arthritis: Extrapolation, Dose Selection, and Clinical Trial Design. View Abstract
Incidence and Risk Factors for Eosinophilia and Lung Disease in Biologic-Exposed Children With Systemic Juvenile Idiopathic Arthritis. View Abstract
Comparison of disease phenotypes and mechanistic insight on causal variants in patients with DADA2. View Abstract
Biologics and JAK inhibitors for the treatment of monogenic systemic autoinflammatory diseases in children. View Abstract
Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis. View Abstract
First-line options for systemic juvenile idiopathic arthritis treatment: an observational study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans. View Abstract
mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome. View Abstract
Joint-Specific Memory and Sustained Risk for New Joint Accumulation in Autoimmune Arthritis. View Abstract
VEXAS Syndrome and Disease Taxonomy in Rheumatology. View Abstract
TET2-mutant clonal hematopoiesis and risk of gout. View Abstract
Correction: Stoll et al. Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients. Children 2022, 9, 569. View Abstract
An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. View Abstract
The Conundrum of Lung Disease and Drug Hypersensitivity-like Reactions in Systemic Juvenile Idiopathic Arthritis. View Abstract
Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients. View Abstract
Neutrophil transit time and localization within the megakaryocyte define morphologically distinct forms of emperipolesis. View Abstract
Implications of Evolving Disease Classification for Drug Approval in Juvenile Idiopathic Arthritis. View Abstract
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging. View Abstract
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis. View Abstract
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging. View Abstract
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis. View Abstract
Ageing and interferon gamma response drive the phenotype of neutrophils in the inflamed joint. View Abstract
Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis. View Abstract
Weekly Adalimumab, an Effective Alternative for Refractory Uveitis in Children. View Abstract
Arthritis flares mediated by tissue-resident memory T cells in the joint. View Abstract
Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. View Abstract
IL-1ß-driven osteoclastogenic Tregs accelerate bone erosion in arthritis. View Abstract
Serologic Response to Borrelia Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease. View Abstract
Genome editing to define the function of risk loci and variants in rheumatic disease. View Abstract
A multidisciplinary assessment of pain in juvenile idiopathic arthritis. View Abstract
Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism. View Abstract
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. View Abstract
The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments. View Abstract
Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach. View Abstract
Publisher Correction: Biological classification of childhood arthritis: roadmap to a molecular nomenclature. View Abstract
A Picture Is Worth a Thousand Words, But Only If It Is a Good Picture. View Abstract
Biological classification of childhood arthritis: roadmap to a molecular nomenclature. View Abstract
Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity. View Abstract
Estrogen-Driven Changes in Immunoglobulin G Fc Glycosylation. View Abstract
Intraperitoneal corticosteroids for recurrent ascites in patients with Fontan circulation: Initial clinical experience. View Abstract
COVID-19 cytokine storm: what is in a name? View Abstract
NF-E2-Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus. View Abstract
Arthritis & Rheumatology: Evolving to Meet the Challenges of Rheumatology. View Abstract
The Fyn-Stat5 cascade is required for Fc? receptor-mediated mast cell function. View Abstract
Identification of Prevotella Oralis as a possible target antigen in children with Enthesitis related arthritis. View Abstract
On the Alert for Cytokine Storm: Immunopathology in COVID-19. View Abstract
Polyarteritis nodosa and deficiency of adenosine deaminase 2 - Shared genealogy, generations apart. View Abstract
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. View Abstract
Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils. View Abstract
Response to: 'Total adenosine deaminase highly correlated with adenosine deaminase 2 activity in serum' by Gao et al. View Abstract
Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2). View Abstract
Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon. View Abstract
Megakaryocyte emperipolesis: a new frontier in cell-in-cell interaction. View Abstract
Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. View Abstract
IgG Fc glycosylation as an axis of humoral immunity in childhood. View Abstract
PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21. View Abstract
SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. View Abstract
Implications of juvenile idiopathic arthritis genetic risk variants for disease pathogenesis and classification. View Abstract
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians. View Abstract
High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. View Abstract
Increased ILC3s associated with higher levels of IL-1ß aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase. View Abstract
A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. View Abstract
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-?B via phosphoinosotide remodeling of endosomes. View Abstract
Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. View Abstract
2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis. View Abstract
2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis. View Abstract
2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis. View Abstract
2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis. View Abstract
Antibody-dependent and -independent mechanisms of inflammatory arthritis. View Abstract
Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease. View Abstract
Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. View Abstract
Differential attenuation of ß2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. View Abstract
The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses. View Abstract
Juvenile Idiopathic Arthritis: An Idea Whose Time Has Gone? View Abstract
Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. View Abstract
Hip Synovial Fluid Cell Counts in Children From a Lyme Disease Endemic Area. View Abstract
The Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans: Toward Comparative Effectiveness in the Pediatric Rheumatic Diseases. View Abstract
Bayesian comparative effectiveness study of four consensus treatment plans for initial management of systemic juvenile idiopathic arthritis: FiRst-Line Options for Systemic juvenile idiopathic arthritis Treatment (FROST). View Abstract
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. View Abstract
Barriers and Facilitators of Mentoring for Trainees and Early Career Investigators in Rheumatology Research: Current State, Identification of Needs, and Road Map to an Inter-Institutional Adult Rheumatology Mentoring Program. View Abstract
Age and fecal microbial strain-specific differences in patients with spondyloarthritis. View Abstract
Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis. View Abstract
Mycobacterial infection induces higher interleukin-1ß and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase. View Abstract
High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis. View Abstract
Review: Genetics and the Classification of Arthritis in Adults and Children. View Abstract
Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. View Abstract
CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. View Abstract
The metabolic regulator mTORC1 controls terminal myeloid differentiation. View Abstract
Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans. View Abstract
Megakaryocytes compensate for Kit insufficiency in murine arthritis. View Abstract
Building an ARC to Grant Success: The Aims Review Committee. View Abstract
Estrogens regulate glycosylation of IgG in women and men. View Abstract
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. View Abstract
Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases. View Abstract
Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. View Abstract
Frequency and Morbidity of Temporomandibular Joint Involvement in Adult Patients With a History of Juvenile Idiopathic Arthritis. View Abstract
Quantifying Temporomandibular Joint Synovitis in Children With Juvenile Idiopathic Arthritis. View Abstract
Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses. View Abstract
The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. View Abstract
Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. View Abstract
Efficacy of an Interinstitutional Mentoring Program Within Pediatric Rheumatology. View Abstract
Antibodies to native and citrullinated RA33 (hnRNP A2/B1) challenge citrullination as the inciting principle underlying loss of tolerance in rheumatoid arthritis. View Abstract
Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis. View Abstract
Increased pretreatment serum IFN-ß/a ratio predicts non-response to tumour necrosis factor a inhibition in rheumatoid arthritis. View Abstract
MICL controls inflammation in rheumatoid arthritis. View Abstract
Redox Regulation of Pro-IL-1ß Processing May Contribute to the Increased Severity of Serum-Induced Arthritis in NOX2-Deficient Mice. View Abstract
Inhibition of inflammatory arthritis using fullerene nanomaterials. View Abstract
Enthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity. View Abstract
Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. View Abstract
Evaluation of synovial mast cell functions in autoimmune arthritis. View Abstract
Adding canakinumab to the Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for systemic juvenile idiopathic arthritis: Comment on the article by DeWitt et al. View Abstract
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. View Abstract
Highly parallel characterization of IgG Fc binding interactions. View Abstract
IL-33/ST2 axis promotes mast cell survival via BCLXL. View Abstract
Review: is there a window of opportunity for treatment of systemic juvenile idiopathic arthritis? View Abstract
Choosing Wisely: the American College of Rheumatology's Top 5 for pediatric rheumatology. View Abstract
A119: deep sequencing analysis of the T regulatory and T effector repertoire in juvenile idiopathic arthritis. View Abstract
A161: Novel 3-Dimensional Explant Method Facilitates the Study of Lymphocyte Populations in the Synovium and Reveals a Large Population of Resident Memory T cells in Rheumatoid Arthritis. View Abstract
A177: Program Evaluation of the ACR/CARRA Inter-Institutional Mentoring Program (AMIGO) in Pediatric Rheumatology. View Abstract
AMIGO: a novel approach to the mentorship gap in pediatric rheumatology. View Abstract
Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. View Abstract
Synovial fluid findings in children with knee monoarthritis in lyme disease endemic areas. View Abstract
Transition and transfer of adolescents and young adults with pediatric onset chronic disease: the patient and parent perspective. View Abstract
Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. View Abstract
Sweets are good for you: fine tuning antibodies via glycosylation. View Abstract
2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. View Abstract
2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. View Abstract
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. View Abstract
Race, ethnicity, and disease outcomes in juvenile idiopathic arthritis: a cross-sectional analysis of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. View Abstract
Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. View Abstract
Ly6 family proteins in neutrophil biology. View Abstract
PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. View Abstract
Shrinking lung syndrome as a manifestation of pleuritis: a new model based on pulmonary physiological studies. View Abstract
Ly6G: a work in progress--author's reply to Yipp. View Abstract
The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes. View Abstract
Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis. View Abstract
Interleukin-33 primes mast cells for activation by IgG immune complexes. View Abstract
Ly6G ligation blocks recruitment of neutrophils via a ß2-integrin-dependent mechanism. View Abstract
Platelets can enhance vascular permeability. View Abstract
Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. View Abstract
Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis. View Abstract
Clinical comparison of early-onset psoriatic and non-psoriatic oligoarticular juvenile idiopathic arthritis. View Abstract
Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. View Abstract
C5a receptor enables participation of mast cells in immune complex arthritis independently of Fc? receptor modulation. View Abstract
Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1). View Abstract
Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1. View Abstract
Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. View Abstract
Juvenile psoriatic arthritis: bathwater or baby? View Abstract
Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes. View Abstract
Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy. View Abstract
Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis. View Abstract
Comparison of Vancouver and International League of Associations for rheumatology classification criteria for juvenile psoriatic arthritis. View Abstract