Patricia Ellen Grant, MD
Director of the Fetal Neonatal Neuroimaging and Developmental Science Center (FNNDSC); Director of Faculty Affairs, Department of Radiology; Director of Research, Fetal Care and Surgery Center; Neuroradiologist, Department of Radiology
Käthe Beutler, MD Harvard Professor of Pediatrics; Professor of Radiology, Harvard Medical School
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Patricia Ellen Grant, MD
Director of the Fetal Neonatal Neuroimaging and Developmental Science Center (FNNDSC); Director of Faculty Affairs, Department of Radiology; Director of Research, Fetal Care and Surgery Center; Neuroradiologist, Department of Radiology
Käthe Beutler, MD Harvard Professor of Pediatrics; Professor of Radiology, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
BSc, Physics
University of Toronto
1984
Toronto, Ontario
Canada
Graduate School
MSc, Theoretical Physics
University of Toronto
1988
Toronto, Ontario
Canada
Medical School
University of Toronto
1989
Toronto, Ontario
Canada
Internship
St. Paul's Hospital
1990
Vancouver, British Columbia
Canada
Residency
Radiology
Vancouver General Hospital
1994
Vancouver, British Columbia
Canada
Fellowship
Neuroradiology; Pediatric Neuroradiology
University of California, San Francisco
1996
San Francisco
CA
Certifications
American Board of Radiology (Diagnostic Radiology)
American Board of Radiology (Neuroradiology)
Professional History
Dr. Grant is the Käthe Beutler, MD Harvard Professor of Pediatrics and Professor of Radiology at Harvard Medical School. She is the founding Director of the Fetal Neonatal Neuroimaging and Developmental Science Center (FNNDSC) in the Departments of Medicine and Radiology, the Director of Faculty Affairs in the Department of Radiology, the Direct of Research for the Division of Maternal-Fetal Medicine and Surgery and a clinical neuroradiologist at Boston Children’s Hospital.
Dr. Grant founded the FNNDSC in 2009 to develop and optimize tools and analysis streams to better detect and understand both normal and abnormal brain physiology and development. The primary goal is to provide phenotypic and mechanistic information that enables optimization of cognitive, behavioral, and neurological outcomes in children with a focus on fetuses, neonates, infants, and toddlers. Three modalities are being developed in the FNNDSC: Magnetic Resonance Imaging (MRI), Magnetoencephalography (MEG) and quantitative Near Infrared Spectroscopy (qNIRS). She leads a team of MR physicists and engineers doing pulse sequence development and novel MRI analysis at the forefront of fetal and placental MRI. Her team build a novel pediatric specific MEG system that is now FDA approved and provides clinical services for presurgical evaluation of infants and toddlers with epilepsy.
She is a pioneer of frequency domain NIRS (FDNIRS) and diffuse correlation spectroscopy (DCS) which provides quantitative bedside measures of cerebral blood flow and oxygen consumption. To support the computational needs of complex data analysis, her team has developed a sophisticated computational infrastructure in collaboration with RedHat to support deep-learning approaches on large datasets and real time data analysis.
The FNNDSC currently has over 60 members with 17 faculty and 6 postdoctoral students. Dr. Grant is a Senior Fellow of the International Society of Magnetic Resonance in Medicine (ISMRM) and sits on the Board of Scientific Counselors for National Institute of Child Health and Human Development. In 2021 she received the Outstanding Contributions in Research Award from the American Society of Neuroradiology and in 2022 she received the Gold Medal Award from the American Society of Pediatric Neuroradiology. She is currently PI/MPI of 6 NIH grants and her center has over $40M of active funding.
Approach to Care
As a clinical neuroradiologist, I work behind the scenes. I rarely meet the children and their families in person but I am always thinking about the individual child and the family behind the images. What knowledge can our images provide to best guide care for that individual child?
I started out as a physicist studying very theoretical concepts but switched into medicine to have a more direct human impact. I chose imaging as a specialty because I enjoy leveraging technology to provide the most relevant information possible. My research also focuses on developing and optimizing technological innovations to improve our ability to diagnose and manage pediatric disorders.
I started out as a physicist studying very theoretical concepts but switched into medicine to have a more direct human impact. I chose imaging as a specialty because I enjoy leveraging technology to provide the most relevant information possible. My research also focuses on developing and optimizing technological innovations to improve our ability to diagnose and manage pediatric disorders.
Publications
Zero-DeepSub: Zero-shot deep subspace reconstruction for rapid multiparametric quantitative MRI using 3D-QALAS. View Abstract
Shape-aware Segmentation of the Placenta in BOLD Fetal MRI Time Series. View Abstract
Time-efficient, high-resolution 3T whole-brain relaxometry using 3D-QALAS with wave-CAIPI readouts. View Abstract
SSL-QALAS: Self-Supervised Learning for rapid multiparameter estimation in quantitative MRI using 3D-QALAS. View Abstract
Aluminum Thin Film Nanostructure Traces in Pediatric EEG Net for MRI and CT Artifact Reduction. View Abstract
Effect of neonatal seizure burden and etiology on the long-term outcome: data from a randomized, controlled trial. View Abstract
Proceedings of the 13th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical. View Abstract
Numerical simulation of the radiofrequency safety of 128-channel hd-EEG nets on a 29-month-old whole-body model in a 3 Tesla MRI. View Abstract
Development, validation, and pilot MRI safety study of a high-resolution, open source, whole body pediatric numerical simulation model. View Abstract
Voxelwise and Regional Brain Apparent Diffusion Coefficient Changes on MRI from Birth to 6 Years of Age. View Abstract
Infant FreeSurfer: An automated segmentation and surface extraction pipeline for T1-weighted neuroimaging data of infants 0-2 years. View Abstract
Abnormalities in cerebral hemodynamics and changes with surgical intervention in neonates with congenital heart disease. View Abstract
Markerless high-frequency prospective motion correction for neuroanatomical MRI. View Abstract
Publisher Correction: Shedding light on the neonatal brain: probing cerebral hemodynamics by diffuse optical spectroscopic methods. View Abstract
MNE Scan: Software for real-time processing of electrophysiological data. View Abstract
Shedding light on the neonatal brain: probing cerebral hemodynamics by diffuse optical spectroscopic methods. View Abstract
Using clinically acquired MRI to construct age-specific ADC atlases: Quantifying spatiotemporal ADC changes from birth to 6-year old. View Abstract
Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. View Abstract
High-angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults. View Abstract
Reduced cerebral blood flow and oxygen metabolism in extremely preterm neonates with low-grade germinal matrix- intraventricular hemorrhage. View Abstract
Brain extraction in pediatric ADC maps, toward characterizing neuro-development in multi-platform and multi-institution clinical images. View Abstract
Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study. View Abstract
Multi-shell diffusion signal recovery from sparse measurements. View Abstract
Wave-CAIPI for highly accelerated 3D imaging. View Abstract
Diffuse correlation spectroscopy for measurement of cerebral blood flow: future prospects. View Abstract
Time efficiency and diagnostic agreement of 2-D versus 3-D ultrasound acquisition of the neonatal brain. View Abstract
Genetic influences and neuropathological sequelae of repetitive brain injury. Reply. View Abstract
Localization of the epileptogenic foci in tuberous sclerosis complex: a pediatric case report. View Abstract
Sex and the migraine brain. View Abstract
Development of cerebellar connectivity in human fetal brains revealed by high angular resolution diffusion tractography. View Abstract
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. View Abstract
Maximum entropy estimation of glutamate and glutamine in MR spectroscopic imaging. View Abstract
Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia. View Abstract
Altered white matter connectivity and network organization in polymicrogyria revealed by individual gyral topology-based analysis. View Abstract
Clinical correlates in an experimental model of repetitive mild brain injury. View Abstract
Radial and tangential neuronal migration pathways in the human fetal brain: anatomically distinct patterns of diffusion MRI coherence. View Abstract
Whole genome sequencing identifies SCN2A mutation in monozygotic twins with Ohtahara syndrome and unique neuropathologic findings. View Abstract
Effects of sutures and fontanels on MEG and EEG source analysis in a realistic infant head model. View Abstract
Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. View Abstract
Non-invasive optical measurement of cerebral metabolism and hemodynamics in infants. View Abstract
A novel syndrome caused by the E410K amino acid substitution in the neuronal ß-tubulin isotype 3. View Abstract
Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates. View Abstract
Reliable identification of deep sulcal pits: the effects of scan session, scanner, and surface extraction tool. View Abstract
Diffusion propagator estimation from sparse measurements in a tractography framework. View Abstract
Detection of postmortem human cerebellar cortex and white matter pathways using high angular resolution diffusion tractography: a feasibility study. View Abstract
Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights. View Abstract
An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation. View Abstract
Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. View Abstract
A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting cerebral ischemic insults. View Abstract
Diffusion tensor analysis of pediatric multiple sclerosis and clinically isolated syndromes. View Abstract
Regional infant brain development: an MRI-based morphometric analysis in 3 to 13 month olds. View Abstract
Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. View Abstract
Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines. View Abstract
Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant. View Abstract
Regional and hemispheric asymmetries of cerebral hemodynamic and oxygen metabolism in newborns. View Abstract
Altered fetal cerebral and cerebellar development in twin-twin transfusion syndrome. View Abstract
The confounding effect of systemic physiology on the hemodynamic response in newborns. View Abstract
Restricted diffusion in spinal cord infarction demonstrated by magnetic resonance line scan diffusion imaging. View Abstract
Near-infrared spectroscopy assessment of cerebral oxygen metabolism in the developing premature brain. View Abstract
MR imaging of the term and preterm neonate with diffuse brain injury. View Abstract
Multimodal imaging of spike propagation: a technical case report. View Abstract
Emerging cerebral connectivity in the human fetal brain: an MR tractography study. View Abstract
Size-optimized 32-channel brain arrays for 3 T pediatric imaging. View Abstract
Quantitative comparison and analysis of sulcal patterns using sulcal graph matching: a twin study. View Abstract
Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. View Abstract
Diffusion-weighted imaging in neonates. View Abstract
The relationship between the presence of sulcal pits and intelligence in human brains. View Abstract
Acute liver failure and reversible leukoencephalopathy in a pediatric patient with homocystinuria. View Abstract
Fetal MR imaging evidence of prolonged apparent diffusion coefficient decrease in fetal death. View Abstract
In vivo proton beam range verification using spine MRI changes. View Abstract
Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life. View Abstract
MR connectomics: Principles and challenges. View Abstract
Tract-based analysis of callosal, projection, and association pathways in pediatric patients with multiple sclerosis: a preliminary study. View Abstract
Associations between the size of the amygdala in infancy and language abilities during the preschool years in normally developing children. View Abstract
New directions in clinical imaging of cortical dysplasias. View Abstract
Development of cerebral fiber pathways in cats revealed by diffusion spectrum imaging. View Abstract
Changes in white matter microstructure in patients with TLE and hippocampal sclerosis. View Abstract
Probabilistic atlas can improve reconstruction from optical imaging of the neonatal brain. View Abstract
Case records of the Massachusetts General Hospital. Case 23-2009. A 13-year-old boy with headache, nausea, seizures, and hypertension. View Abstract
Increased cerebral blood volume and oxygen consumption in neonatal brain injury. View Abstract
Progressive multifocal cystlike cortical tubers in tuberous sclerosis complex: Clinical and neuropathologic findings. View Abstract
Predicting the location of entorhinal cortex from MRI. View Abstract
Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy. View Abstract
Case records of the Massachusetts General Hospital. Case 7-2009. A pregnant woman with a large mass in the fetal oral cavity. View Abstract
Case records of the Massachusetts General Hospital. Case 1-2009. A 57-year-old man with progressive cognitive decline. View Abstract
Case records of the Massachusetts General Hospital. Case 28-2008. An 8-day-old infant with congenital deafness, lethargy, and hypothermia. View Abstract
Shape analysis with overcomplete spherical wavelets. View Abstract
Adriamycin injection into the medial cord of the brachial plexus: computed tomography-guided targeted pain therapy. View Abstract
Intrafamilial phenotypic variability in tuberous sclerosis complex. View Abstract
Magnetic resonance imaging evaluation of possible neonatal sinovenous thrombosis. View Abstract
Magnetoencephalographic mapping of interictal spike propagation: a technical and clinical report. View Abstract
Assessment of infant brain development with frequency-domain near-infrared spectroscopy. View Abstract
Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation. View Abstract
Cortical surface shape analysis based on spherical wavelets. View Abstract
Significance of tissue anisotropy in optical tomography of the infant brain. View Abstract
Changes in cerebral cortex of children treated for medulloblastoma. View Abstract
Case records of the Massachusetts General Hospital. Case 35-2006. A newborn boy with hypotonia. View Abstract
Proton magnetic resonance spectroscopy and diffusion-weighted imaging in isolated sulfite oxidase deficiency. View Abstract
Case records of the Massachusetts General Hospital. Case 26-2006. A 19-year-old woman with difficulty walking. View Abstract
Our unborn children at risk? View Abstract
Detailed semiautomated MRI based morphometry of the neonatal brain: preliminary results. View Abstract
Acute injury to the immature brain with hypoxia with or without hypoperfusion. View Abstract
The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. View Abstract
Diffusion-weighted MR imaging: pediatric clinical applications. View Abstract
Acute injury to the immature brain with hypoxia with or without hypoperfusion. View Abstract
Case records of the Massachusetts General Hospital. Case 36-2005. A 61-year-old woman with seizure, disturbed gait, and altered mental status. View Abstract
3T phased array MRI improves the presurgical evaluation in focal epilepsies: a prospective study. View Abstract
Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature. View Abstract
Pediatric stroke: the child is not merely a small adult. View Abstract
Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. View Abstract
Can noninvasive imaging of biomarkers improve clinical grading of pediatric brain tumors? View Abstract
Dynamic statistical parametric mapping for analyzing the magnetoencephalographic epileptiform activity in patients with epilepsy. View Abstract
Imaging the developing epileptic brain. View Abstract
Parenchymal abnormalities associated with cerebral venous sinus thrombosis: assessment with diffusion-weighted MR imaging. View Abstract
Bilateral generalized polymicrogyria (BGP): a distinct syndrome of cortical malformation. View Abstract
Multimodal longitudinal imaging of focal status epilepticus. View Abstract
Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2. View Abstract
Structural MR imaging. View Abstract
Aids to telemetry in the presurgical evaluation of epilepsy patients: MRI, MEG and other non-invasive imaging techniques. View Abstract
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. View Abstract
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 25-2003. A newborn boy with petechiae and thrombocytopenia. View Abstract
Application of new MR techniques in pediatric patients. View Abstract
Diffusion-weighted imaging abnormalities in the splenium after seizures. View Abstract
A novel form of pontocerebellar hypoplasia maps to chromosome 7q11-21. View Abstract
Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16. View Abstract
Abnormal cortical development shown by 3D MRI in Prader-Willi syndrome. View Abstract
Diffusion magnetic resonance imaging of acute ischemic stroke. View Abstract
Perfusion magnetic resonance imaging of acute ischemic stroke. View Abstract
Practice parameter: neuroimaging of the neonate: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. View Abstract
Arterial ischemic stroke in childhood: the role of plasma-phase risk factors. View Abstract
Diffusion-weighted images in neonatal cerebral hypoxic-ischemic injury. View Abstract
An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21. View Abstract
Pediatric functional magnetic resonance imaging: progress and challenges. View Abstract
Diffusion MR imaging of acute ischemic stroke. View Abstract
Frequency and clinical context of decreased apparent diffusion coefficient reversal in the human brain. View Abstract
Diffusion-weighted MR imaging of the brain. View Abstract
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. View Abstract
MEG versus BOLD MR imaging: functional imaging, the next generation? View Abstract
Genetic and neuroradiological heterogeneity of double cortex syndrome. View Abstract
Diffusion MR imaging. Theory and applications. View Abstract
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