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Nutan Sharma, MD, PhD
Affiliate Neurologist, Department of Neurology
Associate Professor of Neurology, Harvard Medical School
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NPI
1700867975
Locations
Nutan Sharma, MD, PhD
Affiliate Neurologist, Department of Neurology
Associate Professor of Neurology, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Stanford University
1986
Stanford
CA
Graduate School
SUNY at Stony Brook
1995
Stony Brook
NY
Medical School
SUNY at Stony Brook
1995
Stony Brook
NY
Internship
Internal Medicine
Northwestern University
1996
Evanston
IL
Residency
Neurology
Yale University
1999
New Haven
CT
Fellowship
Movement Disorders
Boston Children's Hospital
2001
Boston
MA
Certifications
American Board of Psychiatry and Neurology (Neurology)
Professional History
Dr. Sharma is a clinician scientist specializing in movement disorders, with a special expertise in dystonia. Dr. Sharma provides diagnostic evaluation and treatment for children with movement disorders.
Approach to Care
I am focused on understanding the causes of brain-driven movement disorders, across the lifespan. I work in close collaboration with my basic science colleagues to understand the genetics underlying movement disorders and the way in which the brain controls movement.
Publications
Globally Reduced Brain Volume in Rett Syndrome. View Abstract
KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation. View Abstract
Non-invasive detection of allele-specific CRISPR-SaCas9-KKH disruption of TOR1A DYT1 allele in a xenograft mouse model. View Abstract
Sex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders. View Abstract
Efficacy and Safety of Sodium Oxybate in Isolated Focal Laryngeal Dystonia: A Phase IIb Double-Blind Placebo-Controlled Cross-Over Randomized Clinical Trial. View Abstract
Dysphagia is a risk factor of malnutrition in X-linked Dystonia-Parkinsonism. View Abstract
Genetic Risk Factors in Isolated Dystonia Escape Genome-Wide Association Studies. View Abstract
Neurological disorders caused by novel non-coding repeat expansions: clinical features and differential diagnosis. View Abstract
Motor assessment of X-linked dystonia parkinsonism via machine-learning-based analysis of wearable sensor data. View Abstract
The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome. View Abstract
Sex Differences in People with Tourette Syndrome and Persistent Motor or Vocal Tic Disorder in the Tourette Association of America International Consortium for Genetics Database. View Abstract
Oral diadochokinetic markers of X-linked dystonia-parkinsonism. View Abstract
In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments. View Abstract
Editorial: Current opinions in neurology editorial. View Abstract
Establishing a natural history of X-linked dystonia parkinsonism. View Abstract
Dystonias: Clinical Recognition and the Role of Additional Diagnostic Testing. View Abstract
Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia. View Abstract
Functional validation of novel variants in B4GALNT1 associated with early-onset complex hereditary spastic paraplegia with impaired ganglioside synthesis. View Abstract
DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction. View Abstract
Correction to: Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat. View Abstract
Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat. View Abstract
Dystonia-specific mutations in THAP1 alter transcription of genes associated with neurodevelopment and myelin. View Abstract
Speech and swallowing deficits in X-Linked Dystonia-Parkinsonism. View Abstract
A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy. View Abstract
Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism. View Abstract
Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities. View Abstract
The dystonia gene THAP1 controls DNA double-strand break repair choice. View Abstract
Hyperkinetic Movements in Children: Differential Diagnosis, Evaluation, and Treatment. View Abstract
Functional dystonia: A case-control study and risk prediction algorithm. View Abstract
Functional Dystonia: Differentiation From Primary Dystonia and Multidisciplinary Treatments. View Abstract
SVA insertion in X-linked Dystonia Parkinsonism alters histone H3 acetylation associated with TAF1 gene. View Abstract
Progressive Decline in Voice and Voice-Related Quality of Life in X-Linked Dystonia Parkinsonism. View Abstract
KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation. View Abstract
Cautionary notes on diagnosing functional neurologic disorder as a neurologist-in-training. View Abstract
Isolated Cervical Dystonia: Management and Barriers to Care. View Abstract
Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2a signaling leading to a compromised stress response. View Abstract
TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-linked Dystonia-Parkinsonism. View Abstract
Editorial: Advances in rare movement disorders. View Abstract
Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex. View Abstract
Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-country Cohort. View Abstract
Advances in rare movement disorders. View Abstract
Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function. View Abstract
Phasic Knee Bending Dystonic and Parkinsonian Gait: A Characteristic Finding in X-Linked Dystonia Parkinsonism. View Abstract
Defining research priorities in dystonia. View Abstract
X-Linked Dystonia-Parkinsonism: recent advances. View Abstract
White Matter Changes in Cervical Dystonia Relate to Clinical Effectiveness of Botulinum Toxin Treatment. View Abstract
Voice and swallowing dysfunction in X-linked dystonia parkinsonism. View Abstract
Neuropathology of Dystonia. View Abstract
Functional neurological disorders in Parkinson disease. View Abstract
Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. View Abstract
Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1. View Abstract
Low CSF 5-HIAA in Myoclonus Dystonia. View Abstract
A Case of Functional Dystonia with Associated Functional Neurological Symptoms: Diagnostic and Therapeutic Challenges. View Abstract
Neuropsychological and psychiatric outcome of GPi-deep brain stimulation in dystonia. View Abstract
Defining Hand Stereotypies in Rett Syndrome: A Movement Disorders Perspective. View Abstract
Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia. View Abstract
X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B. View Abstract
Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2a Signaling as a Generalizable Mechanism for Dystonia. View Abstract
Dystonia-Causing Mutations as a Contribution to the Etiology of Spasmodic Dysphonia. View Abstract
Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias. View Abstract
Treatment of ADCY5-Associated Dystonia, Chorea, and Hyperkinetic Disorders With Deep Brain Stimulation: A Multicenter Case Series. View Abstract
Beyond Dystonia-Parkinsonism: Chorea and Ataxia with ATP1A3 Mutations. View Abstract
Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. View Abstract
Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. View Abstract
Dopamine receptor and Ga(olf) expression in DYT1 dystonia mouse models during postnatal development. View Abstract
Update on treatments for dystonia. View Abstract
Clinical neurogenetics: dystonia from phenotype to genotype. View Abstract
Pallidal deep brain stimulation for dystonia: a case series. View Abstract
Dopa-responsive dystonia: functional analysis of single nucleotide substitutions within the 5' untranslated GCH1 region. View Abstract
Lysosomal enzyme defects and Parkinson disease. View Abstract
EDITORIAL: Advances in Dystonia. View Abstract
Mutations in GNAL cause primary torsion dystonia. View Abstract
Neurogenesis and neuronal migration in the forebrain of the TorsinA knockout mouse embryo. View Abstract
Evidence for altered basal ganglia-brainstem connections in cervical dystonia. View Abstract
Deep brain stimulation for medically refractory life-threatening status dystonicus in children. View Abstract
Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain. View Abstract
Mutation in 5' upstream region of GCHI gene causes familial dopa-responsive dystonia. View Abstract
Consideration of genetic contributions to the risk for spasmodic dysphonia. View Abstract
Extrapyramidal epilepsy. View Abstract
Molecular pathways in dystonia. View Abstract
Genetic evidence for an association of the TOR1A locus with segmental/focal dystonia. View Abstract
Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo. View Abstract
Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. View Abstract
Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia. View Abstract
Gene Repression or Imprinting: Rett Syndrome View Abstract
Effectiveness of Botulinum Toxin in the Treatment of Movement Disorders View Abstract
Parkinson's disease View Abstract
Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration. View Abstract
Structural abnormalities in the cerebellum and sensorimotor circuit in writer's cramp View Abstract
Dopamine release is impaired in a mouse model of DYT1 dystonia. View Abstract
Patient Preference in Botulinum Toxin for Writer’s Cramp View Abstract
Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia. View Abstract
White matter abnormalities in dystonia normalize after botulinum toxin treatment. View Abstract
Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation. View Abstract
Rodent models for dystonia research: characteristics, evaluation, and utility. View Abstract
DYT1 Transgenic Mouse View Abstract
Parkinson's disease and the Family View Abstract
Botulinum Toxin A Reduces Drooling in Neurodegenerative Diseases View Abstract
Dopa-Responsive Dystonia Manifesting as Markedly Different Phenotypes in Monozygotic Twins View Abstract
Progressive Supranuclear Palsy View Abstract
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. View Abstract
Inherited movement disorders. View Abstract
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. View Abstract
Neuroprotective Strategies in Parkinson's Disease View Abstract
Parkinson's View Abstract
Blackwell's Underground Clinical Vignettes, Neurology View Abstract
Movement Disorders in Pregnancy View Abstract
Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies. View Abstract
A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. View Abstract
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. View Abstract
Neurology Classic Clinical Cases for USMLE Step 2 and Clerkship Review View Abstract
Neurology View Abstract
Nerve growth factor regulates the abundance and distribution of K+ channels in PC12 cells. View Abstract
Characterization of Kv2.1 in PC12 cells View Abstract
Locations