Martha Sola-Visner, MD
Physician in Medicine, Division of Newborn Medicine; Director, Newborn Medicine Clinical Research Program
Associate Professor in Pediatrics, Harvard Medical School
Image
Martha Sola-Visner, MD
Physician in Medicine, Division of Newborn Medicine; Director, Newborn Medicine Clinical Research Program
Associate Professor in Pediatrics, Harvard Medical School
Medical Services
Languages
English
Spanish
Education
Medical School
School of Medicine, Santiago de Guayaquil Catholic University
1992
Guayaquil
Ecuador
Internship
University of Florida, Schands Teaching Hospital
1995
Gainesville
FL
Residency
Pediatrics
University of Florida, Schands Teaching Hospital
1997
Gainesville
FL
Fellowship
Neonatal-Perinatal Medicine
University of Florida, Shands Teaching Hospital
2000
Gainesville
FL
Certifications
American Board of Pediatrics (Neonatal-Perinatal Medicine)
Approach to Care
In the Boston Children’s Hospital (BCH) Neonatal Intensive Care Unit (NICU) our philosophy is to ensure that every patient receives the best care for the best possible outcomes. We consider our “patient” to be the baby and the family; we are constantly striving to serve the needs of both. This requires a team based approach with all members being essential.
Publications
Recent advances in NICU platelet transfusions. View Abstract
CDK8/19 inhibition triggers a switch from mitosis to endomitosis in cord blood megakaryocytes. View Abstract
The number of blood transfusions received and the incidence and severity of chronic lung disease among NICU patients born >31 weeks gestation. View Abstract
Promoting Child Health by Protecting the Patient-Clinician Relationship From Politics. View Abstract
Implementing evidence-based restrictive neonatal intensive care unit platelet transfusion guidelines. View Abstract
Sex differences in the association of pretransfusion haemoglobin and cognition in preterm infants. View Abstract
Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates. View Abstract
Efficacy and safety of antithrombin supplementation in neonates and infants on a continuous heparin infusion. View Abstract
Alport syndrome: A puzzling case of thrombocytopenia and giant unusual platelets in blood smear. View Abstract
Platelet Transfusion and Death or Neurodevelopmental Impairment in Children Born Extremely Preterm. View Abstract
Quantitative label-free mass spectrometry reveals content and signaling differences between neonatal and adult platelets. View Abstract
Can Red Blood Cell and Platelet Transfusions Have a Pathogenic Role in Bronchopulmonary Dysplasia? View Abstract
Phosphoproteomics reveals content and signaling differences between neonatal and adult platelets. View Abstract
Hemostatic and Immunologic Effects of Platelet Transfusions in Neonates. View Abstract
Neonatal Thrombocytopenia: Factors Associated With the Platelet Count Increment Following Platelet Transfusion. View Abstract
Prophylactic Platelet Transfusion: Is There Evidence of Benefit, Harm, or No Effect? View Abstract
Associations of donor, component, and recipient factors on hemoglobin increments following red blood cell transfusion in very low birth weight infants. View Abstract
Platelet Transfusions in Neonates: Beyond Hemostasis. View Abstract
EBNEO commentary: Platelet transfusions in neonates and brain development: The new frontier. View Abstract
Pitfalls and Limitations of Platelet Counts and Coagulation Tests in the Neonatal Intensive Care Unit. View Abstract
Immunologic effects of red blood cell and platelet transfusions in neonates. View Abstract
Postnatal treatment for children with fetal and neonatal alloimmune thrombocytopenia: a multicentre, retrospective, cohort study. View Abstract
Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice. View Abstract
Fetal vs adult megakaryopoiesis. View Abstract
Platelets in the neonate: Not just a small adult. View Abstract
Platelet transfusions in a murine model of neonatal polymicrobial sepsis: Divergent effects on inflammation and mortality. View Abstract
Neonatal platelet transfusions: New evidence and the challenges of translating evidence-based recommendations into clinical practice. View Abstract
Iron status influences the response of cord blood megakaryocyte progenitors to eltrombopag in vitro. View Abstract
Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia. View Abstract
Sex Differences in the Association of Pretransfusion Hemoglobin Levels with Brain Structure and Function in the Preterm Infant. View Abstract
Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database. View Abstract
Association of Blood Donor Sex and Age With Outcomes in Very Low-Birth-Weight Infants Receiving Blood Transfusion. View Abstract
Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). View Abstract
Neonatal platelet physiology and implications for transfusion. View Abstract
Haematological issues in neonates with neonatal encephalopathy treated with hypothermia. View Abstract
Development of gates to measure the immature platelet fraction in C57BL/6J mice using the Sysmex XN-V series multispecies hematology analyzer. View Abstract
Embryonic MK activation: a delicate balance. View Abstract
Transfusion practices in a large cohort of hospitalized children. View Abstract
Sex-specific cytokine responses and neurocognitive outcome after blood transfusions in preterm infants. View Abstract
Variation in Neonatal Transfusion Practice. View Abstract
Implementation of a neonatal platelet transfusion guideline to reduce non-indicated transfusions using a quality improvement framework. View Abstract
Hemostatic Challenges in Neonates. View Abstract
Platelet-derived extracellular vesicles infiltrate and modify the bone marrow during inflammation. View Abstract
Pooling, room temperature, and extended storage time increase the release of adult-specific biologic response modifiers in platelet concentrates: a hidden transfusion risk for neonates? View Abstract
Association of Bleeding Scores and Platelet Transfusions With Platelet Counts and Closure Times in Response to Adenosine Diphosphate (CT-ADPs) Among Preterm Neonates With Thrombocytopenia. View Abstract
Changes in megakaryopoiesis over ontogeny and their implications in health and disease. View Abstract
Screening With Reticulocyte Hemoglobin Increased Iron Sufficiency Among NICU Patients. View Abstract
Developmental Differences in Platelet Inhibition Response to Prostaglandin E1. View Abstract
Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. View Abstract
Association Between In Vitro Bleeding Time and Bleeding in Preterm Infants With Thrombocytopenia. View Abstract
Anemia induces gut inflammation and injury in an animal model of preterm infants. View Abstract
Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. View Abstract
Platelet Transfusions in Neonates - Less Is More. View Abstract
Platelet transfusions and mortality in necrotizing enterocolitis. View Abstract
Thrombocytopenia is associated with severe retinopathy of prematurity. View Abstract
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence. View Abstract
Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. View Abstract
Down Regulation of the Munc18b-syntaxin-11 Complex and ß1-tubulin Impairs Secretion and Spreading in Neonatal Platelets. View Abstract
Eltrombopag: a powerful chelator of cellular or extracellular iron(III) alone or combined with a second chelator. View Abstract
Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis. View Abstract
Developmental differences between newborn and adult mice in response to romiplostim. View Abstract
The immature platelet fraction: creating neonatal reference intervals and using these to categorize neonatal thrombocytopenias. View Abstract
Assessing Initial Response to High-Frequency Jet Ventilation in Premature Infants With Hypercapnic Respiratory Failure. View Abstract
2016 proceedings of the National Heart, Lung, and Blood Institute's scientific priorities in pediatric transfusion medicine. View Abstract
Eltrombopag, a thrombopoietin mimetic, crosses the blood-brain barrier and impairs iron-dependent hippocampal neuron dendrite development. View Abstract
Platelet Transfusion Practices Among Very-Low-Birth-Weight Infants. View Abstract
Neonatal Platelet Transfusions and Future Areas of Research. View Abstract
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. View Abstract
Innate immunity against molecular mimicry: Examining galectin-mediated antimicrobial activity. View Abstract
Thrombocytopenia in Small-for-Gestational-Age Infants. View Abstract
Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies. View Abstract
Platelet Transfusions in the Neonatal Intensive Care Unit. View Abstract
BCL-2 is dispensable for thrombopoiesis and platelet survival. View Abstract
Phlebotomy-induced anemia alters hippocampal neurochemistry in neonatal mice. View Abstract
Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein. View Abstract
Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates. View Abstract
Proteasome function is required for platelet production. View Abstract
Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. View Abstract
The silent crisis: children hurt by current immigration enforcement policies. View Abstract
MiR-9 contributes to the developmental differences in CXCR-4 expression in human megakaryocytes. View Abstract
MiR-9 contributes to the developmental differences in CXCR-4 expression in human megakaryocytes. View Abstract
Primary hemostasis in neonates with thrombocytopenia. View Abstract
Distinct differences in platelet production and function between neonates and adults: implications for platelet transfusion practice. View Abstract
Prognostic significance of low-grade intraventricular hemorrhage in the current era of neonatology. View Abstract
A de novo T73I mutation in PTPN11 in a neonate with severe and prolonged congenital thrombocytopenia and Noonan syndrome. View Abstract
Developmental differences in megakaryocyte size in infants and children. View Abstract
The hibernating 13-lined ground squirrel as a model organism for potential cold storage of platelets. View Abstract
Clinical and research issues in neonatal anemia and thrombocytopenia. View Abstract
Platelets in the neonatal period: developmental differences in platelet production, function, and hemostasis and the potential impact of therapies. View Abstract
Neonatal and adult megakaryopoiesis. View Abstract
Cardiovascular disease and weight ... at birth. View Abstract
Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland. View Abstract
Effects of in vitro adult platelet transfusions on neonatal hemostasis. View Abstract
Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. View Abstract
Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants? View Abstract
Neonatal thrombocytopenia and megakaryocytopoiesis. View Abstract
Increasing platelets without transfusion: is it time to introduce novel thrombopoietic agents in neonatal care? View Abstract
Differences between newborn and adult mice in their response to immune thrombocytopenia. View Abstract
Neonatal respiratory failure due to a novel mutation in the surfactant protein C gene. View Abstract
Correction for effect of cold storage on immature platelet fraction. View Abstract
Closure times measured by the platelet function analyzer PFA-100 are longer in neonatal blood compared to cord blood samples. View Abstract
Testing platelet mass versus platelet count to guide platelet transfusions in the neonatal intensive care unit. View Abstract
Hematologic Issues. Introduction. View Abstract
Current approaches to the evaluation and management of the fetus and neonate with immune thrombocytopenia. View Abstract
New insights into the mechanisms of nonimmune thrombocytopenia in neonates. View Abstract
Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. View Abstract
Effects of sepsis on neonatal thrombopoiesis. View Abstract
Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. View Abstract
Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles. View Abstract
Improving platelet transfusion practices in the neonatal intensive care unit. View Abstract
Type 2B von Willebrand disease associated with the release of platelet agglutinates from megakaryocytes in the bone marrow. View Abstract
Neonatal thrombocytopenia: what we do and don't know. View Abstract
Do platelet transfusions in the NICU adversely affect survival? Analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system. View Abstract
Sites and kinetics of donor thrombopoiesis following transplantation of whole bone marrow and progenitor subsets. View Abstract
Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. View Abstract
Megakaryocyte size and concentration in the bone marrow of thrombocytopenic and nonthrombocytopenic neonates. View Abstract
Umbilical cord blood produces small megakaryocytes after transplantation. View Abstract
Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes. View Abstract
Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system. View Abstract