Koichi Yuki, MD
Senior Associate in Cardiac Anesthesia, Department of Anesthesiology, Critical Care and Pain Medicine
Professor of Anaesthesia, Harvard Medical School
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Koichi Yuki, MD
Senior Associate in Cardiac Anesthesia, Department of Anesthesiology, Critical Care and Pain Medicine
Professor of Anaesthesia, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
University of Tokyo, Faculty of Medicine
1999
Tokyo
Japan
Internship
Surgery
Hawaii University Surgical Program
2001
Honolulu
HI
Residency
Anesthesia
Ichihara Hospital, Teikyo University
1999
Chiba
Japan
Graduate School
Anesthesia
Massachusetts General Hospital
2002
Boston
MA
Fellowship
Pediatric Anesthesia
Boston Children's Hospital
2005
Boston
MA
Fellowship
Pediatric Cardiac Anesthesia
Boston Children's Hospital
2006
Boston
MA
Certifications
American Board of Anesthesiology (General)
Publications
The Role of Extracellular-Vesicle-Derived miRNAs in Postoperative Organ Dysfunction in Neonates and Infants Undergoing Congenital Cardiac Surgery: An Exploratory Study. View Abstract
Multifaceted, unique role of CD11c in leukocyte biology. View Abstract
Obesity as a Risk Factor in Pediatric Sepsis: A Retrospective Comparative Study Under the Phoenix Definition. View Abstract
Physiology of Cardiac Arrest with del Nido Cardioplegia. View Abstract
The Perioperative Use of Codeine and Tramadol in Pediatric Population. View Abstract
IQGAP1 Influences Neutrophil Maturation and Its Effector Functions. View Abstract
2024 US-China Round Table Consensus Discussion on Perioperative Opioid Management. View Abstract
Postoperative mechanical ventilation after corrective Tetralogy of Fallot surgery in infants: Assessment of perioperative factors and radiographic severity scores. View Abstract
Perioperative Outcomes in Congenital Heart Disease: A Review of Clinical Factors Associated With Prolonged Ventilation and Length of Stay in Four Common CHD Operations. View Abstract
Neutrophil extracellular traps formation is associated with postoperative complications in congenital cardiac surgery. View Abstract
Postoperative Organ Dysfunction Risk Stratification Using Extracellular Vesicle-Derived circRNAs in Pediatric Congenital Heart Surgery. View Abstract
Dexmedetomidine directly binds to and inhibits Toll-like receptor 4. View Abstract
The Fontan Circulation in Pregnancy: Hemodynamic Challenges and Anesthetic Considerations. View Abstract
Toll-like receptors and integrins crosstalk. View Abstract
Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3ß interaction. View Abstract
Mechanism of isoflurane-mediated breast cancer growth in vivo. View Abstract
The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution. View Abstract
Integrin CD11c regulates B cell homeostasis. View Abstract
Cystic Fibrosis Mice Are Highly Susceptible to Repeated Acute Pseudomonas aeruginosa Pneumonia after Intranasal Inoculation. View Abstract
The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution. View Abstract
Perioperative Factors and Radiographic Severity Scores for Predicting the Duration of Mechanical Ventilation After Arterial Switch Surgery. View Abstract
Neutrophil extracellular traps formation is associated with postoperative complications in neonates and infants undergoing congenital cardiac surgery. View Abstract
Volatile anesthetic isoflurane exposure facilitates Enterococcus biofilm infection. View Abstract
Perioperative prophylactic corticosteroids for cardiac surgery in children: A systematic review and meta-analysis. View Abstract
CD11a regulates hematopoietic stem and progenitor cells. View Abstract
Age-dependent transcriptomic profiles of leukocytes in pediatric population. View Abstract
Trailblazing through the Opioid Epidemic. Will Science Prevail? View Abstract
Predictability of Pediatric Sepsis Outcome Using SEPSIS-3 Definition in a Single Tertiary Pediatric Institution. View Abstract
Differential effects of dexmedetomidine on Gram-positive and Gram-negative bacterial killing and phagocytosis. View Abstract
CD11c regulates neutrophil maturation. View Abstract
Narrative review of systemic inflammatory response mechanisms in cardiac surgery and immunomodulatory role of anesthetic agents. View Abstract
Surgical site infection in pediatric spinal fusion surgery revisited: outcome and risk factors after preventive bundle implementation. View Abstract
GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus. View Abstract
aDß2 as a novel target of experimental polymicrobial sepsis. View Abstract
CD11c regulates late-stage T cell development in the thymus. View Abstract
Exploring Noncardiac Surgical Needs From Infancy to Adulthood in Patients With Congenital Heart Disease. View Abstract
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis. View Abstract
Propofol directly binds to and inhibits TLR7. View Abstract
Use of clindamycin as an alternative antibiotic prophylaxis. View Abstract
The Role of Pulmonary Function Test in Perioperative Management of Patients with Cystic Fibrosis. View Abstract
Predictive Factors for Postoperative Intensive Care Unit Admission and Mechanical Ventilation After Cardiac Catheterization for Pediatric Pulmonary Vein Stenosis. View Abstract
Isoflurane attenuates sepsis-associated lung injury. View Abstract
CCR6 and CXCR6 Identify the Th17 Cells With Cytotoxicity in Experimental Autoimmune Encephalomyelitis. View Abstract
How Should We Care for Patients with Congenital Heart Diseases Undergoing Surgical Procedures in Ambulatory Settings? View Abstract
Translational Role of Rodent Models to Study Ventilator-Induced Lung Injury. View Abstract
The Role of General Anesthetic Drug Selection in Cancer Outcome. View Abstract
Neutrophil and T Cell Functions in Patients with Congenital Heart Diseases: A Review. View Abstract
Pattern recognition receptors as therapeutic targets for bacterial, viral and fungal sepsis. View Abstract
Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA. View Abstract
The Role of Anesthetic Selection in Perioperative Bleeding. View Abstract
The immunomodulatory mechanism of dexmedetomidine. View Abstract
The Characterization of Postoperative Mechanical Respiratory Requirement in Neonates and Infants Undergoing Cardiac Surgery on Cardiopulmonary Bypass in a Single Tertiary Institution. View Abstract
Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung. View Abstract
Risk factors for pediatric surgical site infection following neurosurgical procedures for hydrocephalus: a retrospective single-center cohort study. View Abstract
Surgical Site Infections and Perioperative Optimization of Host Immunity by Selection of Anesthetics. View Abstract
The Use of Regional Catheters in Children Undergoing Repair of Aortic Coarctation. View Abstract
Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis. View Abstract
Left Ventricular Outflow Tract Gradient Is Associated With Coronary Artery Obstruction in Children With Williams-Beuren Syndrome. View Abstract
CD11c regulates hematopoietic stem and progenitor cells under stress. View Abstract
The Microbial Flora in an Experimental Polymicrobial Abdominal Sepsis Model Probed by 16S rRNA Sequencing. View Abstract
Long QT Syndrome and Perioperative Torsades de Pointes: What the Anesthesiologist Should Know. View Abstract
A simple screening test of filtration efficiency for protecting the gas sampling line from coronavirus using fluorescent microspheres. View Abstract
The Role of Anesthetic Management in Surgical Site Infections After Pediatric Intestinal Surgery. View Abstract
Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes. View Abstract
The effect of anesthetics on toll like receptor 9. View Abstract
Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation. View Abstract
SerpinB1 expression in Th17 cells depends on hypoxia-inducible factor 1-alpha. View Abstract
Role of ß2 Integrins in Neutrophils and Sepsis. View Abstract
Intubation precautions in a pediatric patient with severe COVID-19. View Abstract
In Vitro Model of Stretch-Induced Lung Injury to Study Different Lung Ventilation Regimens and the Role of Sedatives. View Abstract
COVID-19 pathophysiology: A review. View Abstract
Anesthetic Management for Heart Transplantation in Adults with Congenital Heart Disease. View Abstract
The role of propofol hydroxyl group in 5-lipoxygenase recognition. View Abstract
Should we Routinely Reverse Neuromuscular Blockade with Sugammadex in Patients with a History of Heart Transplantation? View Abstract
Incidence and predictors of postoperative nausea and vomiting in children undergoing electrophysiology ablation procedures. View Abstract
Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. View Abstract
SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. View Abstract
The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. View Abstract
The Outcomes of Pediatric Hematopoietic Stem Cell Transplantation Recipients Requiring Intensive Care Unit Admission- A Single Center Experience. View Abstract
Volatile anesthetics affect macrophage phagocytosis. View Abstract
The Use of Volatile Anesthetics as Sedatives for Acute Respiratory Distress Syndrome. View Abstract
Volatile Anesthetic Attenuates Phagocyte Function and Worsens Bacterial Loads in Wounds. View Abstract
Incidence and Risk Factors for Perioperative Cardiovascular and Respiratory Adverse Events in Pediatric Patients With Congenital Heart Disease Undergoing Noncardiac Procedures. View Abstract
Induction techniques for pediatric patients with congenital heart disease undergoing noncardiac procedures are influenced by cardiac functional status and residual lesion burden. View Abstract
Volatile Anesthetic Isoflurane Attenuates Liver Injury in Experimental Polymicrobial Sepsis Model. View Abstract
Unanticipated hospital admission in pediatric patients with congenital heart disease undergoing ambulatory noncardiac surgical procedures. View Abstract
Incidence and Risk Factors of Perioperative Mortality in Pediatric ICU Patients. View Abstract
Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1. View Abstract
Validation of a Mathematical Model of Bidirectional Glenn Circulation With Aortopulmonary Collaterals and the Implications for QP/QS Calculation. View Abstract
From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. View Abstract
Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. View Abstract
The Differential Effects of Anesthetics on Bacterial Behaviors. View Abstract
Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. View Abstract
Pediatric Perioperative Stress Responses and Anesthesia. View Abstract
The effect of different anesthetics on tumor cytotoxicity by natural killer cells. View Abstract
Pausing With the Gauze: Inhibition of Temporary Pacemakers by Radiofrequency Scan During Cardiac Surgery. View Abstract
Dexmedetomidine-Induced Neuroapoptosis Is Dependent on Its Cumulative Dose. View Abstract
Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review. View Abstract
Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. View Abstract
Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. View Abstract
A translational consideration of intercellular adhesion molecule-1 biology in the perioperative setting. View Abstract
Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. View Abstract
Cardiopulmonary bypass in the pediatric population. View Abstract
Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen. View Abstract
Sepsis pathophysiology and anesthetic consideration. View Abstract
The role of macrophage 1 antigen in polymicrobial sepsis. View Abstract
Comparison of actual oxygen delivery kinetics to those predicted by mathematical modeling following stage 1 palliation just prior to superior cavopulmonary anastomosis. View Abstract
Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. View Abstract
Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. View Abstract
An internal ligand-bound, metastable state of a leukocyte integrin, aXß2. View Abstract
Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. View Abstract
Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin aIIbß3. View Abstract
Cardiac arrest and neuromuscular blockade reversal agents in the transplanted heart. View Abstract
Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. View Abstract
Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. View Abstract
A mathematical model of transitional circulation toward biventricular repair in hypoplastic left heart syndrome. View Abstract
Ventricular-assist device therapy in children. View Abstract
Serial evaluation of left ventricular contraction and relaxation in Takotsubo cardiomyopathy by 2D speckle tracking echocardiography. View Abstract
Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. View Abstract
Improvement of PaO2 during one-lung ventilation with partial left-heart bypass in pediatric patients is caused by increased blood flow to the dependent lung. View Abstract
Cell-free ligand-binding assays for integrin LFA-1. View Abstract
Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. View Abstract
Anesthetic and cardiopulmonary bypass considerations for cardiac surgery in unique pediatric patient populations: sickle cell disease and cold agglutinin disease. View Abstract
Blood utilization in neonates and infants undergoing cardiac surgery requiring cardiopulmonary bypass. View Abstract
Postoperative maladaptive behavioral changes in children. View Abstract
Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. View Abstract
Anesthetic management of noncardiac surgery for patients with single ventricle physiology. View Abstract
Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. View Abstract
The effect of left heart bypass on pulmonary blood flow and arterial oxygenation during one-lung ventilation in patients undergoing descending thoracic aortic surgery. View Abstract
Management of difficult airway in pediatric patients with right ventricular outflow tract obstruction. View Abstract
Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. View Abstract
Recent progress on acyl CoA: lysophospholipid acyltransferase research. View Abstract
The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. View Abstract
Trendelenburg position, simulated Valsalva maneuver, and liver compression do not alter the size of the right internal jugular vein in patients with a bidirectional Glenn shunt. View Abstract
The perioperative management of a patient with Fontan physiology for pheochromocytoma resection. View Abstract
Induction of supraventricular tachycardia during transesophageal echocardiography: an unusual complication. View Abstract