Joseph Majzoub, MD
Vice Chair for Research, Department of Pediatrics; Attending Physician, Division of Endocrinology
Thomas Morgan Rotch Professor of Pediatrics, Professor of Medicine, Harvard Medical School
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Joseph Majzoub, MD
Vice Chair for Research, Department of Pediatrics; Attending Physician, Division of Endocrinology
Thomas Morgan Rotch Professor of Pediatrics, Professor of Medicine, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
University of Michigan
Ann Arbor
MI
Medical School
Stanford University School of Medicine
1974
Stanford
CA
Internship
Internal Medicine
Brigham and Women's Hospital
1975
Boston
MA
Residency
Internal Medicine
Brigham and Women's Hospital
1976
Boston
MA
Fellowship
Adult Endocrinology
Massachusetts General Hospital
Boston
MA
Certifications
American Board of Internal Medicine (General)
American Board of Internal Medicine (Endocrinology, Diabetes and Metabolism)
Publications
Harmonizing TUNEL with multiplexed iterative immunofluorescence enriches spatial contextualization of cell death. View Abstract
Absent, but not glucocorticoid-modulated, corticotropin-releasing hormone (Crh) regulates anxiety-like behaviors in mice. View Abstract
Severe Hypernatremia in an Adolescent With Anorexia Nervosa. View Abstract
Ultrasonographic Tissue Perfusion in Peri-implant Health and Disease. View Abstract
A Resident-Led Virtual Journal Club to Educate Pediatric Residents About Coronavirus Disease 2019. View Abstract
The Changing Face of Adrenoleukodystrophy. View Abstract
Correction: The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system. View Abstract
The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system. View Abstract
A novel missense mutation in TFAP2B associated with Char syndrome and central diabetes insipidus. View Abstract
Glycogen storage disease presenting as Cushing syndrome. View Abstract
Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice. View Abstract
Abnormal Glycerol Metabolism in a Child with Global Developmental Delay, Adrenal Insufficiency, and Intellectual Disability. View Abstract
Behavioural dysfunctions of 10-year-old children born extremely preterm associated with corticotropin-releasing hormone expression in the placenta. View Abstract
A New Model for Adrenarche: Inhibition of 3ß-Hydroxysteroid Dehydrogenase Type 2 by Intra-Adrenal Cortisol. View Abstract
Racial differences in neonatal hypoglycemia among very early preterm births. View Abstract
Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice. View Abstract
Maternal first trimester serum levels of free-beta human chorionic gonadotrophin and male genital anomalies. View Abstract
Brain disorders associated with corticotropin-releasing hormone expression in the placenta among children born before the 28th week of gestation. View Abstract
Endocrinology research-reflecting on the past decade and looking to the next. View Abstract
Regulation of human 3ß-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche. View Abstract
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. View Abstract
Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. View Abstract
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. View Abstract
Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice. View Abstract
Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery. View Abstract
Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2. View Abstract
Nocturnal Dexamethasone versus Hydrocortisone for the Treatment of Children with Congenital Adrenal Hyperplasia. View Abstract
Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue. View Abstract
Monitoring of therapy in congenital adrenal hyperplasia. View Abstract
Glucocorticoid treatment--effect on adrenal medullary catecholamine production. View Abstract
Permanent Neonatal Diabetes in a Patient with a KCNJ11/Q52R Mutation Accompanied by Intermittent Hypoglycemia and Liver Failure. View Abstract
Mass spectrometry in the clinical laboratory: how have we done, and where do we need to be? View Abstract
Maternal levels of corticotropin-releasing hormone during pregnancy in relation to adiponectin and leptin in early childhood. View Abstract
Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice. View Abstract
Genetic diagnosis of primary immune deficiencies. View Abstract
Elevated midpregnancy corticotropin-releasing hormone is associated with prenatal, but not postpartum, maternal depression. View Abstract
Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin. View Abstract
Diabetes insipidus: clinical and basic aspects. View Abstract
Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity. View Abstract
Measuring corticotropin-releasing hormone in pregnant women - comparing blood collection protocols for epidemiological studies. View Abstract
Recombinant human growth hormone treatment for dilated cardiomyopathy in children. View Abstract
Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. View Abstract
Perioperative management of diabetes insipidus in children. View Abstract
Catecholamine synthesizing enzymes and their modulation by immobilization stress in knockout mice. View Abstract
Urocortin III, a brain neuropeptide of the corticotropin-releasing hormone family: modulation by stress and attenuation of some anxiety-like behaviours. View Abstract
Maternal activating mutation of the calcium-sensing receptor: implications for calcium metabolism in the neonate. View Abstract
Impaired leptin expression and abnormal response to fasting in corticotropin-releasing hormone-deficient mice. View Abstract
Perioperative management of diabetes insipidus in children [corrected]. View Abstract
Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice. View Abstract
Lessons from CRH knockout mice. View Abstract
Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomography. View Abstract
Maternal experiences of racism and violence as predictors of preterm birth: rationale and study design. View Abstract
The physiology of corticotropin-releasing hormone deficiency in mice. View Abstract
Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. View Abstract
Exogenous growth hormone: a new therapy for dilated cardiomyopathy. View Abstract
Pituitary-adrenal axis regulation in CRH-deficient mice. View Abstract
Asthma, steroids, and growth. View Abstract
Endocrinologic and psychological effects of short-term dexamethasone in anorexia nervosa. View Abstract
Effects of various mutations in the neurophysin/glycopeptide portion of the vasopressin gene on vasopressin expression in vitro. View Abstract
Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. View Abstract
Corticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency. View Abstract
Impaired basal and restraint-induced epinephrine secretion in corticotropin-releasing hormone-deficient mice. View Abstract
Neuroanatomy of human appetitive function: A positron emission tomography investigation. View Abstract
Impaired Basal and Restraint-Induced Epinephrine Secretion in Corticotropin-Releasing Hormone- Deficient Mice. View Abstract
CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors. View Abstract
Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency. View Abstract
Urocortin Expression in the Edinger-Westphal Nucleus Is Up-Regulated by Stress and Corticotropin-Releasing Hormone Deficiency1. View Abstract
Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin. View Abstract
Virilising 21-hydroxylase deficiency: timing of newborn screening and confirmatory tests can be crucial. View Abstract
CRH-deficient mice have a normal anorectic response to chronic stress. View Abstract
Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH. View Abstract
Pediatric reference intervals for serum thyroxine, triiodothyronine, thyrotropin, and free thyroxine. View Abstract
Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine. View Abstract
Inducible binding of cyclic adenosine 3',5'-monophosphate (cAMP)-responsive element binding protein (CREB) to a cAMP-responsive promoter in vivo. View Abstract
Animal models of CRH deficiency. View Abstract
Normal suppression of the reproductive axis following stress in corticotropin-releasing hormone-deficient mice. View Abstract
High glycemic index foods, overeating, and obesity. View Abstract
Regulation of hepatic glycogen in the insulin-like growth factor II-deficient mouse. View Abstract
Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice. View Abstract
A central theory of preterm and term labor: putative role for corticotropin-releasing hormone. View Abstract
Placental corticotropin-releasing hormone: function and regulation. View Abstract
Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant. View Abstract
Glucocorticoid deficiency delays stratum corneum maturation in the fetal mouse. View Abstract
Vasopressin messenger ribonucleic acid regulation via the protein kinase A pathway. View Abstract
Four cases of mucosal neuroma syndrome: multiple endocrine neoplasm 2B or not 2B? View Abstract
Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. View Abstract
Positive and negative regulation of the rat vasopressin gene promoter. View Abstract
Sodium balance modulates thirst in normal man. View Abstract
Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice. View Abstract
Protein malnutrition increases plasma adrenocorticotropin and anterior pituitary proopiomelanocortin messenger ribonucleic acid in the rat. View Abstract
CRH and the immune system. View Abstract
Chronic central nervous system exposure to interleukin-1 beta causes catabolism in the rat. View Abstract
Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. View Abstract
Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation. View Abstract
Knockout mice. View Abstract
Production of corticotropin-releasing hormone-deficient mice by targeted mutation in embryonic stem cells. View Abstract
Molecular and transgenic studies of the corticotropin-releasing hormone gene. View Abstract
Regulation of placental corticotropin-releasing hormone by steroids. Possible implications in labor initiation. View Abstract
Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. View Abstract
Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells. View Abstract
Regulation of the ectopically expressed human glycoprotein alpha-subunit gene in the human hepatoma cell line NPLC. View Abstract
Corticotrophin releasing hormone levels in human plasma and amniotic fluid during gestation. View Abstract
Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma. View Abstract
Contribution of vasopressin to blood pressure regulation during hypovolemic hypotension in humans. View Abstract
Transgenic mouse models of vasopressin expression. View Abstract
Tissue-specific expression and osmotic regulation of a rat vasopressin gene in transgenic mice. View Abstract
Expression of the rat arginine vasopressin gene in transgenic mice. View Abstract
Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitors. View Abstract
Second messenger regulation of mRNA for corticotropin-releasing factor. View Abstract
Regulated expression of vasopressin gene by cAMP and phorbol ester in primary rat fetal hypothalamic cultures. View Abstract
Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells. View Abstract
Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells. View Abstract
The effect of insulin-induced hypoglycemia on gene expression in the hypothalamic-pituitary-adrenal axis of the rat. View Abstract
Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea. View Abstract
Both cyclooxygenase-dependent and cyclooxygenase-independent pathways mediate the neuroendocrine response in humans. View Abstract
Second messengers involved in the regulation of corticotropin-releasing hormone mRNA and peptide in cultured rat fetal hypothalamic primary cultures. View Abstract
Regulated expression of the human corticotropin releasing hormone gene by cyclic AMP. View Abstract
Differential regulation of corticotropin-releasing hormone mRNA in rat brain. View Abstract
The testicular effects of tumor necrosis factor. View Abstract
Developmental expression of corticotropin releasing hormone messenger RNA and peptide in rat hypothalamus. View Abstract
Vasopressin-mediated forearm vasodilation in normal humans. Evidence for a vascular vasopressin V2 receptor. View Abstract
Increases in plasma digitalis-like factor activity during insulin-induced hypoglycemia. View Abstract
Species-specific placental corticotropin releasing hormone messenger RNA and peptide expression. View Abstract
Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing. View Abstract
Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length. View Abstract
Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta. View Abstract
Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. View Abstract
The vasopressin mRNA poly(A) tract is unusually long and increases during stimulation of vasopressin gene expression in vivo. View Abstract
A chemically synthesized radiolabeled signal peptide: design, preparation, and biological evaluation of an iodinated analog of preproparathyroid hormone. View Abstract
Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line. View Abstract
Human corticotropin releasing hormone gene is located on the long arm of chromosome 8. View Abstract
Relationship of cardiac chamber volume to baroreflex activity in normal humans. View Abstract
Influence of infused hypertonic saline on the response to insulin-induced hypoglycemia in man. View Abstract
Defective regulation of vasopressin gene expression in Brattleboro rats. View Abstract
Vasopressin gene is expressed at low levels in the hypothalamus of the Brattleboro rat. View Abstract
Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides. View Abstract
Cellular and cell-free processing of parathyroid secretory proteins. View Abstract
Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones. View Abstract
Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone. View Abstract
Identification and cell-free translation of mRNA coding for a precursor of parathyroid secretory protein. View Abstract
Letter: "Smudge" ECG. View Abstract