Joseph Madsen, MD
Neurosurgeon, Department of Neurosurgery
Professor, Harvard Medical School
Image
Joseph Madsen, MD
Neurosurgeon, Department of Neurosurgery
Professor, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
University of Utah
1976
Salt Lake City
UT
Medical School
Harvard-MIT Program in Health, Science, and Technology
1981
Boston
MA
Internship
Surgery
Beth Israel Deaconess Medical Center
1982
Boston
MA
Residency
Massachusetts General Hospital
1989
Boston
MA
Fellowship
Beth Israel Deaconess Medical Center/Massachusetts General Hospital
1983
Boston
MA
Media
Caregiver Profile
Meet Dr. Joseph Madsen
Ask an Expert
Epilepsy Q&A: Understanding the anatomy of the brain
Ask an Expert
Epilepsy Q&A: What is vagal nerve stimulation?
Ask an Expert
Epilepsy Q&A: What is single stage resection?
Ask an Expert
Epilepsy Q&A: How surgical techniques map the brain
Ask an Expert
Epilepsy Q&A: What is a laser ablation?
Ask an Expert
Epilepsy Q&A: What is a hemispherectomy?
Ask an Expert
Epilepsy Q&A: What are the different types of epilepsy surgery?
Ask an Expert
Epilepsy Q&A: What is a deep brain stimulator?
Ask an Expert
Epilepsy Q&A: What is a corpus callosotomy?
Certifications
American Board of Neurological Surgery
Professional History
I am a pediatric neurosurgeon with a strong interest in innovative approaches to the dynamic brain maladies of children, especially epilepsy and hydrocephalus. My clinical efforts are closely tied to my research program, the Neurodynamics Laboratory.
I received my medical degree in 1981 from a joint program poised uniquely at the intersection between engineering and medicine, the Harvard-MIT Program in Health, Science and Technology. I hold the Webster Family Chair in Neurosurgery and Neuroengineering at Boston Children's Hospital, direct the hospital's Epilepsy Surgery Program and am an associate professor at Harvard Medical School. My work is multidisciplinary and focused on applying engineering and mathematical approaches to my practice.
I have brought several innovations to clinical practice. These include a new technique to monitor shunt flow in patients with hydrocephalus, including the use of cardiac-gated MRI scans, thermal detection of shunt flow, and a valve massager technology. I have also developed a new technique to predict seizure focus using intracranial data gathered from implanted electrodes, which will one day allow surgeons like myself to better plan epilepsy surgeries. My practice has grown in part because of successful patient approaches developed during planning of such research programs.
I also have a strong interest in improving pediatric neurosurgery and epilepsy surgery abroad, specifically in China. In that context, I have been an adjunct professor in functional neurosurgery at Xuanwu Hospital, affiliated with Capitol Medical University, Bejing Institute of Functional Neurosurgery. I have been specifically working on a mechanism to review surgical cases in real time with colleagues at Beijing's Children's Hospital.
Approach to Care
The wide-open vistas of my youth and the pioneer spirit of the western settlers have had profound influences on my approach to care and research. I believe in taking my time to talk to patients and charting an individual direction in medicine.
Publications
Specialized Large Language Model Outperforms Neurologists at Complex Diagnosis in Blinded Case-Based Evaluation. View Abstract
Epilepsy surgery in Sturge-Weber syndrome with unilateral or bilateral asymmetric brain involvement: Boston Children's Hospital experience. View Abstract
Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants. View Abstract
Neural correlates of minimal recognizable configurations in the human brain. View Abstract
Measurement of Atmospheric Neutrino Oscillation Parameters Using Convolutional Neural Networks with 9.3 Years of Data in IceCube DeepCore. View Abstract
Machine learning on interictal intracranial EEG predicts surgical outcome in drug resistant epilepsy. View Abstract
Spikes on ripples are better interictal biomarkers of epilepsy than spikes or ripples. View Abstract
Search for an eV-Scale Sterile Neutrino Using Improved High-Energy ?_{µ} Event Reconstruction in IceCube. View Abstract
Expert opinion on use of vagus nerve stimulation therapy in the management of pediatric epilepsy: A Delphi consensus study. View Abstract
Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy. View Abstract
Safety of Pregnancy and Delivery With Shunted Hydrocephalus. View Abstract
Intralesional epileptiform activity in a fourth ventricular hamartoma associated with epileptic hemifacial spasm in a toddler: illustrative case. View Abstract
Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants. View Abstract
Differential cortical layer engagement during seizure initiation and spread in humans. View Abstract
Characterizing the safety profile of vagus nerve stimulation devices for epilepsy from 21,448 manufacturer and user reports. View Abstract
Letter to the Editor. Rise of large language models in neurosurgery. View Abstract
Observation of Seven Astrophysical Tau Neutrino Candidates with IceCube. View Abstract
Interictal EEG source connectivity to localize the epileptogenic zone in patients with drug-resistant epilepsy: A machine learning approach. View Abstract
Aberrant fast spiking interneuronal activity precedes seizure transitions in humans. View Abstract
Somatic Mosaicism in PIK3CA Variant Correlates With Stereoelectroencephalography-Derived Electrophysiology. View Abstract
Complications of Intracranial Multimodal Monitoring for Neurocritical Care: A Systematic Review and Meta-Analysis. View Abstract
Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience. View Abstract
Machine learning models for predicting seizure outcome after MR-guided laser interstitial thermal therapy in children. View Abstract
Sleep Spindle Generation Before and After Epilepsy Surgery: A Source Imaging Study in Children with Drug-Resistant Epilepsy. View Abstract
Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy. View Abstract
Electromagnetic source imaging predicts surgical outcome in children with focal cortical dysplasia. View Abstract
Observation of high-energy neutrinos from the Galactic plane. View Abstract
Focal drug-resistant temporal lobe epilepsy associated with an ipsilateral anterior choroidal artery aneurysm: illustrative case. View Abstract
The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex. View Abstract
Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy. View Abstract
Non-invasive mapping of epileptogenic networks predicts surgical outcome. View Abstract
Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures. View Abstract
Reply to: "How to disconnect the splenium and fornix in posterior quadrant disconnection, hemispherotomy, and subtotal hemispherotomy". View Abstract
Cross-task specificity and within-task invariance of cognitive control processes. View Abstract
Stereoelectroencephalography followed by combined electrode removal and MRI-guided laser interstitial thermal therapy or open resection: a single-center series in pediatric patients with medically refractory epilepsy. View Abstract
Seizure outcome of pediatric magnetic resonance-guided laser interstitial thermal therapy versus open surgery: A matched noninferiority cohort study. View Abstract
Evidence for neutrino emission from the nearby active galaxy NGC 1068. View Abstract
Search for Unstable Sterile Neutrinos with the IceCube Neutrino Observatory. View Abstract
Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome. View Abstract
Discrepant expressive language lateralization in children and adolescents with epilepsy. View Abstract
Strong Constraints on Neutrino Nonstandard Interactions from TeV-Scale ?_{µ} Disappearance at IceCube. View Abstract
Limited utility of structural MRI to identify the epileptogenic zone in young children with tuberous sclerosis. View Abstract
Reply to "Added value of high-resolution electrical source imaging of ictal activity in children with structural focal epilepsy". View Abstract
Posterior quadrant disconnection for refractory epilepsy: how I do it. View Abstract
Complete Corpus Callosotomy for Refractory Epilepsy in Children. View Abstract
Virtual implantation using conventional scalp EEG delineates seizure onset and predicts surgical outcome in children with epilepsy. View Abstract
Single-stage resection of bottom-of-a-sulcus dysplasia involving eloquent cortex using navigated transcranial magnetic stimulation and intraoperative modalities. View Abstract
Novel User-Friendly Application for MRI Segmentation of Brain Resection following Epilepsy Surgery. View Abstract
Search for Relativistic Magnetic Monopoles with Eight Years of IceCube Data. View Abstract
Mapping Propagation of Interictal Spikes, Ripples, and Fast Ripples in Intracranial EEG of Children with Refractory Epilepsy. View Abstract
Mapping Functional Connectivity of Epileptogenic Networks through Virtual Implantation. View Abstract
Electric Source Imaging on Intracranial EEG Localizes Spatiotemporal Propagation of Interictal Spikes in Children with Epilepsy. View Abstract
A Standardized Electrode Nomenclature for Stereoelectroencephalography Applications. View Abstract
Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs. View Abstract
Mesoscopic physiological interactions in the human brain reveal small-world properties. View Abstract
Changes in the Functional Brain Network of Children Undergoing Repeated Epilepsy Surgery: An EEG Source Connectivity Study. View Abstract
Microscale Physiological Events on the Human Cortical Surface. View Abstract
Source imaging of seizure onset predicts surgical outcome in pediatric epilepsy. View Abstract
Presurgical accuracy of dipole clustering in MRI-negative pediatric patients with epilepsy: Validation against intracranial EEG and resection. View Abstract
Noninvasive Mapping of Ripple Onset Predicts Outcome in Epilepsy Surgery. View Abstract
Travelling spindles create necessary conditions for spike-timing-dependent plasticity in humans. View Abstract
Anesthetic management and outcomes for MRI-guided laser interstitial thermal therapy (LITT) for seizure focus in pediatrics: A single-centre experience with 10 consecutive patients. View Abstract
Magnetic resonance imaging-guided laser-induced thermal therapy for functional hemispherotomy in a child with refractory epilepsy and multiple medical comorbidities. View Abstract
Diagnostic Accuracy of Non-Invasive Thermal Evaluation of Ventriculoperitoneal Shunt Flow in Shunt Malfunction: A Prospective, Multi-Site, Operator-Blinded Study. View Abstract
eV-Scale Sterile Neutrino Search Using Eight Years of Atmospheric Muon Neutrino Data from the IceCube Neutrino Observatory. View Abstract
Characteristics of the Diffuse Astrophysical Electron and Tau Neutrino Flux with Six Years of IceCube High Energy Cascade Data. View Abstract
Drug-Responsive Inhomogeneous Cortical Modulation by Direct Current Stimulation. View Abstract
Corpus Callosotomy for Refractory Epilepsy in Aicardi Syndrome: Case Report and Focused Review of the Literature. View Abstract
A Noninvasive Retrograde Flushing System for Shunted Hydrocephalus: Initial Case Series of 25 Patients. View Abstract
In situ clearance of a proximal shunt malfunction in a child with hydrocephalus post cerebral arteriovenous malformation rupture noted intraoperatively. View Abstract
Pilot Study of Neurodevelopmental Impact of Early Epilepsy Surgery in Tuberous Sclerosis Complex. View Abstract
Posterior-onset Rasmussen's encephalitis with ipsilateral cerebellar atrophy and uveitis resistant to rituximab. View Abstract
Scalp ripples as prognostic biomarkers of epileptogenicity in pediatric surgery. View Abstract
Time-Integrated Neutrino Source Searches with 10 Years of IceCube Data. View Abstract
Ictal and interictal source imaging on intracranial EEG predicts epilepsy surgery outcome in children with focal cortical dysplasia. View Abstract
Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. View Abstract
Neural Interactions Underlying Visuomotor Associations in the Human Brain. View Abstract
Noninvasive Thermal Evaluation of Ventriculoperitoneal Shunt Patency and Cerebrospinal Fluid Flow Using a Flow Enhancing Device. View Abstract
Intracortical neural activity distal to seizure-onset-areas predicts human focal seizures. View Abstract
Noninvasive Localization of High-Frequency Oscillations in Children with Epilepsy: Validation against Intracranial Gold-Standard. View Abstract
White matter mean diffusivity correlates with myelination in tuberous sclerosis complex. View Abstract
Early Detection of Human Epileptic Seizures Based on Intracortical Microelectrode Array Signals. View Abstract
Constraints on Minute-Scale Transient Astrophysical Neutrino Sources. View Abstract
Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy. View Abstract
Delay differential analysis for dynamical sleep spindle detection. View Abstract
Search for neutrinos from decaying dark matter with IceCube: IceCube Collaboration. View Abstract
Simulating human sleep spindle MEG and EEG from ion channel and circuit level dynamics. View Abstract
Surgical resection of ripple onset predicts outcome in pediatric epilepsy. View Abstract
Magnetoencephalographic Mapping of Epileptic Spike Population Using Distributed Source Analysis: Comparison With Intracranial Electroencephalographic Spikes. View Abstract
Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. View Abstract
Magnetoencephalographic Spike Analysis in Patients With Focal Cortical Dysplasia: What Defines a "Dipole Cluster"? View Abstract
Measurement of Atmospheric Neutrino Oscillations at 6-56 GeV with IceCube DeepCore. View Abstract
Heterogeneous Origins of Human Sleep Spindles in Different Cortical Layers. View Abstract
Superficial Slow Rhythms Integrate Cortical Processing in Humans. View Abstract
VEGF Signaling in Neurological Disorders. View Abstract
Granger Causality Analysis of Interictal iEEG Predicts Seizure Focus and Ultimate Resection. View Abstract
Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias. View Abstract
Measurement of the ?µ energy spectrum with IceCube-79: IceCube Collaboration. View Abstract
What is changing when: Decoding visual information in movies from human intracranial recordings. View Abstract
Human seizures couple across spatial scales through travelling wave dynamics. View Abstract
Current and Emerging Potential of Magnetoencephalography in the Detection and Localization of High-Frequency Oscillations in Epilepsy. View Abstract
Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. View Abstract
Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy. View Abstract
Neuroimaging of Children With Surgically Treated Hydrocephalus: A Practical Approach. View Abstract
Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. View Abstract
Active delineation of Meyer's loop using oriented priors through MAGNEtic tractography (MAGNET). View Abstract
Direct current stimulation induces mGluR5-dependent neocortical plasticity. View Abstract
Rasmussen encephalitis tissue transfer program. View Abstract
Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. View Abstract
Cascade of neural processing orchestrates cognitive control in human frontal cortex. View Abstract
The role of simulation in neurosurgery. View Abstract
Demonstration that a new flow sensor can operate in the clinical range for cerebrospinal fluid flow. View Abstract
Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI. View Abstract
Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures. View Abstract
Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy. View Abstract
Central 5-HT neurotransmission modulates weight loss following gastric bypass surgery in obese individuals. View Abstract
Laminar profile of spontaneous and evoked theta: Rhythmic modulation of cortical processing during word integration. View Abstract
Decrease in gamma-band activity tracks sequence learning. View Abstract
Lexical retrieval pre- and posttemporal lobe epilepsy surgery in a pediatric sample. View Abstract
Sensitivity to timing and order in human visual cortex. View Abstract
Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER. View Abstract
VEGF: a potential target for hydrocephalus. View Abstract
183 Intracranial arachnoid cysts and hemorrhage. View Abstract
Neuronal ensemble synchrony during human focal seizures. View Abstract
Spatiotemporal dynamics underlying object completion in human ventral visual cortex. View Abstract
Comparison of rapid cranial MRI to CT for ventricular shunt malfunction. View Abstract
3 Tesla intraoperative MRI for brain tumor surgery. View Abstract
Surgery for intractable epilepsy due to unilateral brain disease: a retrospective study comparing hemispherectomy techniques. View Abstract
Rasmussen's encephalitis presenting as focal cortical dysplasia. View Abstract
Neural dynamics underlying target detection in the human brain. View Abstract
Clinical value of magnetoencephalographic spike propagation represented by spatiotemporal source analysis: correlation with surgical outcome. View Abstract
Outcomes of vagal nerve stimulation in a pediatric population: a single center experience. View Abstract
Resection of supratentorial lobar cavernous malformations in children: clinical article.. View Abstract
Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. View Abstract
Perfusion Imaging of Focal Cortical Dysplasia Using Arterial Spin Labeling: Correlation With Histopathological Vascular Density. View Abstract
Moyamoya disease with mesial temporal sclerosis. View Abstract
First result from the Alpha Magnetic Spectrometer on the International Space Station: precision measurement of the positron fraction in primary cosmic rays of 0.5-350 GeV. View Abstract
VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats. View Abstract
The frequency modulated auditory evoked response (FMAER), a technical advance for study of childhood language disorders: cortical source localization and selected case studies. View Abstract
Detecting epileptic regions based on global brain connectivity patterns. View Abstract
The postnatal human filum terminale is a source of autologous multipotent neurospheres capable of generating motor neurons. View Abstract
Human seizures self-terminate across spatial scales via a critical transition. View Abstract
Postshunting corpus callosum swelling with depiction on tractography. View Abstract
Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. View Abstract
Impaired pulsation absorber mechanism in idiopathic normal pressure hydrocephalus: laboratory investigation. View Abstract
Temporal stability of visually selective responses in intracranial field potentials recorded from human occipital and temporal lobes. View Abstract
Language lateralization represented by spatiotemporal mapping of magnetoencephalography. View Abstract
Thiol-Functionalized Block Copolymer Vesicles. View Abstract
Predictors of ventricular shunt infection among children presenting to a pediatric emergency department. View Abstract
Autonomic changes with seizures correlate with postictal EEG suppression. View Abstract
Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia. View Abstract
Convulsive seizure detection using a wrist-worn electrodermal activity and accelerometry biosensor. View Abstract
Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep. View Abstract
Robotic Neuro-Endoscope with Concentric Tube Augmentation. View Abstract
Individualized localization and cortical surface-based registration of intracranial electrodes. View Abstract
Multimodal imaging of spike propagation: a technical case report. View Abstract
Widespread Brain Areas Engaged during a Classical Auditory Streaming Task Revealed by Intracranial EEG. View Abstract
Nasal glioma: prenatal diagnosis and multidisciplinary surgical approach. View Abstract
Algorithms for Design of Continuum Robots Using the Concentric Tubes Approach: A Neurosurgical Example. View Abstract
Single-neuron dynamics in human focal epilepsy. View Abstract
Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. View Abstract
The pulsating brain: A review of experimental and clinical studies of intracranial pulsatility. View Abstract
Evaluation of the ShuntCheck noninvasive thermal technique for shunt flow detection in hydrocephalic patients. View Abstract
Idiopathic syrinx in the pediatric population: a combined center experience. View Abstract
Modeling of blood flow in arterial trees. View Abstract
Alterations of pulsation absorber characteristics in experimental hydrocephalus. View Abstract
Modeling blood flow circulation in intracranial arterial networks: a comparative 3D/1D simulation study. View Abstract
Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. View Abstract
Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy. View Abstract
Right-lateralized brain oscillations in human spatial navigation. View Abstract
Robust selectivity to two-object images in human visual cortex. View Abstract
A dynamic nonlinear relationship between the static and pulsatile components of intracranial pressure in patients with subarachnoid hemorrhage. View Abstract
Arterial blood pressure vs intracranial pressure in normal pressure hydrocephalus. View Abstract
Continuous monitoring of electrodermal activity during epileptic seizures using a wearable sensor. View Abstract
Propagation of epileptic spikes reconstructed from spatiotemporal magnetoencephalographic and electroencephalographic source analysis. View Abstract
Magnetoencephalographic analysis in patients with vagus nerve stimulator. View Abstract
Task-free presurgical mapping using functional magnetic resonance imaging intrinsic activity. View Abstract
Estimation of Eeg Signal Dispersion During Seizure Propagation. View Abstract
Urological outcome following multiple repeat spinal cord untethering operations. Clinical article. View Abstract
Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding. View Abstract
Simulation of the human intracranial arterial tree. View Abstract
The human K-complex represents an isolated cortical down-state. View Abstract
Timing, timing, timing: fast decoding of object information from intracranial field potentials in human visual cortex. View Abstract
Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy. View Abstract
Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use. View Abstract
Task-free presurgical mapping using fMRI intrinsic activity View Abstract
Large-scale simulation of the human arterial tree. View Abstract
Intracranial pressure waves: characterization of a pulsation absorber with notch filter properties using systems analysis: laboratory investigation. View Abstract
Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. View Abstract
Nonresective Surgical Management of Refractory Epilepsy: Callosotomy and Vagal Stimulation View Abstract
Gamma oscillations distinguish true from false memories. View Abstract
Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshop. View Abstract
Minimal heating of titanium skull plates during 1Hz repetitive transcranial magnetic stimulation. View Abstract
Apparatus and method for measuring a human head View Abstract
Outcome following multiple repeated spinal cord untethering operations. View Abstract
Treatment of subdural hematomas in infants. View Abstract
The emerging field of third circulation research. View Abstract
Limits on the high-energy gamma and neutrino fluxes from the SGR 1806-20 giant flare of 27 December 2004 with the AMANDA-II detector. View Abstract
MRI and Physiologically Guided Brain Tumor Removal (Live Webcast, ORLive) View Abstract
Hippocampal and neocortical gamma oscillations predict memory formation in humans. View Abstract
Electroencephalography in epilepsy surgery planning. View Abstract
Human neocortical oscillations exhibit theta phase differences between encoding and retrieval. View Abstract
The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. View Abstract
What we don't (but should) know about hydrocephalus. View Abstract
Cerebrospinal fluid pulsatility and hydrocephalus: the fourth circulation. View Abstract
Treatment of refractory epilepsy: General approach and nonresective strategies View Abstract
Theta oscillations in human cortex during a working-memory task: evidence for local generators. View Abstract
GMFM 1 year after continuous intrathecal baclofen infusion. View Abstract
Invasive group A, B, C and G streptococcal infections in Denmark 1999-2002: epidemiological and clinical aspects. View Abstract
Ictal asystole with convulsive syncope mimicking secondary generalisation: a depth electrode study. View Abstract
Increased Phase Synchronization between Intracranial Pressure and Arterial Blood Pressure during Elevated Intracranial Pressure in Dogs. View Abstract
Direction-oriented and spatially controlled bipolar for in-situ cauterization of adherent cranial tissue occluding a ventricular catheter previously implanted in-vivo View Abstract
Gamma EEG dynamics in neocortex and hippocampus during human wakefulness and sleep. View Abstract
Cerebral pathophysiology and critical care neurology: basic hemodynamic principles, cerebral perfusion, and intracranial pressure. View Abstract
Neurosurgical aspects of critical care neurology. View Abstract
Antenatal neurosurgical counseling: approach to the unborn patient. View Abstract
Hip status in cerebral palsy after one year of continuous intrathecal baclofen infusion. View Abstract
Search for extraterrestrial point sources of neutrinos with AMANDA-II. View Abstract
Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis. View Abstract
Laminar analysis of human neocortical interictal spike generation and propagation: current source density and multiunit analysis in vivo. View Abstract
Treatment of epilepsy by vagal nerve stimulation View Abstract
Antenatal Neurosurgical counseling: Approach to the unborn patient View Abstract
Gamma oscillations correlate with working memory load in humans. View Abstract
Theta and gamma oscillations during encoding predict subsequent recall. View Abstract
Sleep-dependent theta oscillations in the human hippocampus and neocortex. View Abstract
Limits on diffuse fluxes of high energy extraterrestrial neutrinos with the AMANDA-B10 detector. View Abstract
Reset of human neocortical oscillations during a working memory task. View Abstract
Human theta oscillations related to sensorimotor integration and spatial learning. View Abstract
Pharyngeal dysesthesia in refractory complex partial epilepsy: new seizure or adverse effect of vagal nerve stimulation? View Abstract
Non-invasive in vivo pressure measurement View Abstract
Neonatal hydrocephalus View Abstract
Syringomyelia View Abstract
Neurosurgery of the Newborn View Abstract
Carotid and vertebral artery dissections in children and adults View Abstract
Surgical treatment of pain in the child View Abstract
Neonatal hydrocephalus View Abstract
Syringomyelia View Abstract
Shunt technology: Contemporary concepts and prospects View Abstract
Gamma oscillations increase with working memory load in humans View Abstract
Shunt technology: contemporary concepts and prospects. View Abstract
Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy. View Abstract
Variable anti-siphon valve apparatus and method View Abstract
Congenital malformations of the cerebellum and posterior fossa View Abstract
Neurotrauma View Abstract
Theta returns. View Abstract
Vagus nerve stimulation in pediatric epilepsy: a review. View Abstract
Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: retrospective study. View Abstract
Non-invasive in vivo pressure measurement View Abstract
Gentle dorsal root retraction and dissection can cause areflexia: implications for intraoperative monitoring during "selective" partial dorsal rhizotomy. View Abstract
Temporal lobectomy in early childhood: the need for long-term follow-up. View Abstract
Distinct patterns of brain oscillations underlie two basic parameters of human maze learning. View Abstract
Gating of human theta oscillations by a working memory task. View Abstract
Observation of high-energy neutrinos using Cerenkov detectors embedded deep in Antarctic ice. View Abstract
Prenatal diagnosis and counseling for the neurosurgeon View Abstract
Vagus nerve stimulation in pediatric epilepsy: A review View Abstract
Shunt Malfunction View Abstract
Corpus callosotomy View Abstract
Long-term vagus nerve stimulation beneficial in refractory epilepsy View Abstract
834 Event Related Potentials (ERPs) for Memory: Toward Localization of Cognitive Functions in Children. View Abstract
Subdural electrode arrays for monitoring cortical electrical activity View Abstract
Non-invasive in vivo pressure measurement View Abstract
[Chronic inflammatory bowel disease--pathogenic concepts and therapeutic perspectives]. View Abstract
Intrathecal baclofen for management of spastic cerebral palsy: multicenter trial. View Abstract
Pathophysiology, prevention, and potential treatment of neural tube defects. View Abstract
The effect of propofol on intraoperative electrocorticography and cortical stimulation during awake craniotomies in children. View Abstract
The living shunt: a tissue engineering approach in the treatment of hydrocephalus. View Abstract
Procedures for intrathecal pharmacological therapy View Abstract
Neurotrauma View Abstract
Human Theta Oscillations are Gated by a Working Memory Task View Abstract
Treatment of intractable epilepsy by electrical stimulation of the vagus nerve View Abstract
Human Theta Oscillations During Virtual Maze Navigation View Abstract
Pathology, Prevention, and Potential Treatment of Neural Tube Defects View Abstract
Theta Oscillations, memory and epilepsy View Abstract
Case Records of the Massachusetts General Hospital. Case 34-2000: a 71-year-old woman with an enlarging pituitary mass View Abstract
Task dependence of human theta: the case for multiple cognitive functions View Abstract
Central nervous system abnormalities assessed with prenatal magnetic resonance imaging. View Abstract
Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. View Abstract
Using intracranial recordings to study thetaResponse to J. O'Keefe and N. Burgess (1999). View Abstract
MRI signal changes in the white matter after corpus callosotomy. View Abstract
Seizure outcome after surgery in very young children View Abstract
Human theta oscillations exhibit task dependence during virtual maze navigation. View Abstract
Fetal CNS anomalies revealed on ultrafast MR imaging. View Abstract
A 2-month-old female infant with progressive macrocephaly and irritability -clinical conference-. View Abstract
Using intracranial recordings to study theta: Response to J. O’Keefe and N. Burgess View Abstract
Vagal Nerve Stimulation for Treatment of Epilepsy in Pediatric Patients View Abstract
Vagal nerve stimulation in children with intractable epilepsy—results in five centers - Poster Presentation View Abstract
The Role of Theta Oscillations in Human Spatial Cognition: Evidence from Intracranial Recordings View Abstract
Neurosurgery of the Newborn View Abstract
Corpus callosotomy in children View Abstract
Vagal Nerve Stimulation for Treatment of Epilepsy in Pediatric Patients View Abstract
Intracranial Pressure during Seizures in Children - Poster Presentation View Abstract
Task-related Theta Activity from Intracranial Recordings During Virtual Maze Navigation - Oral Presentation View Abstract
Craniotomy of Unusual Interest: Issues for Medicine, Law, Journalism, and Society in a Highly Publicized Case of Nonaccidental Trauma View Abstract
The Sternberg Task Evokes Theta Oscillations in Human Intracranial Recordings View Abstract
Vagal Nerve Stimulation In Children With Medically Intractable Epilepsy Following Epilepsy Surgery View Abstract
Task-related Theta Activity from Intracranial Recordings During Virtual Maze Navigation View Abstract
Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats. View Abstract
Functional transplantation of the rat pituitary gland. View Abstract
Focal cortical dysplasia with glioproliferative changes causing seizures: report of 3 cases. View Abstract
Intraventricular pressure dynamics in patients with ventriculopleural shunts: a telemetric study. View Abstract
Surgical management of cutis aplasia with high-flow sinus pericranii. View Abstract
Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. View Abstract
Prenatal neurosurgical diagnosis and counseling. View Abstract
Surgical management of neonatal hydrocephalus. View Abstract
Syringomyelia View Abstract
Tacrolimus (FK-506) increases neuronal expression of GAP-43 and improves neurological outcome after spinal cord injury in rats View Abstract
Cervical spinal cord injury in children View Abstract
Antenatal diagnosis and counseling in neurosurgical anomalies View Abstract
The use of clinical practice guidelines (CPGs) to evaluate practice and control costs in ventriculoperitoneal shunt management. View Abstract
Cerebral edema, cell volume regulation, and the role of ion channels in organic osmolyte transport. View Abstract
Identification of the volume-sensitive organic osmolyte/anion channel in human glial cells. View Abstract
Molecular biology of axonal outgrowth. 2. Pathfinding and molecular guidance cues. View Abstract
Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus. View Abstract
Fetal central nervous system anomalies: MR imaging augments sonographic diagnosis. View Abstract
Connections of the hippocampal formation in humans: I. The mossy fiber pathway. View Abstract
Connections of the hippocampal formation in humans: II. The endfolial fiber pathway. View Abstract
Molecular biology of axonal outgrowth. 1. Growth cones and GAP-43. View Abstract
Optic chiasm astrocytomas of childhood. 1. Long-term follow-up. View Abstract
Presentation and management of Chiari I malformation in children. View Abstract
Solitary fibrous tumor presenting as a symptomatic intraspinal mass: case report. View Abstract
Clinical characteristics of complex partial seizures: a temporal versus a frontal lobe onset. View Abstract
Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus: Fibrinolytic state does not preclude need for CSF shunt View Abstract
A tissue engineering approach for dural and cranial grafts - Oral Presentation View Abstract
Miscellaneous benign tumors View Abstract
Neck Pain [book review] View Abstract
Tacrolimus (FK506) increases neuronal expression of GAP-43 as it improves neurological recovery after spinal cord injury in rats - Oral Presentation View Abstract
The future of epilepsy surgery for children View Abstract
Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus View Abstract
Neonatal hydrocephalus: hemodynamic response to fontanelle compression-- correlation with intracranial pressure and need for shunt placement. View Abstract
Lamotrigine high-dose tolerability and safety in patients with epilepsy: a double-blind, placebo-controlled, eleven-week study. View Abstract
The critical importance of stimulus intensity in intraoperative monitoring for partial dorsal rhizotomy. View Abstract
Intraventricular urokinase for the treatment of posthemorrhagic hydrocephalus - abstract View Abstract
Hemodynamic Response to Fontanelle Compression in Neonatal Hydrocephalus: Correlation with intracranial pressure and need for shunt placement - Radiology View Abstract
FK-506 improvement in recovery after spinal cord injury: possible role of GAP-43 expression in calcineurin effect View Abstract
Congenital Malformations of the Cerebrum View Abstract
FK-506 Improvement in Recovery after Spinal Cord Injury: Possible Role of GAP-43 Expression and Calcineurin Effect View Abstract
After neurotrauma: brain and spinal cord repair View Abstract
FK-506 improves recovery after spinal cord injury: immunophilins as a new therapeutic target View Abstract
FK-506 Improves Neurological Outcome and Increases Neuronal Expression of GAP-43 after Spinal Cord Injury in Rats View Abstract
Posterior fossa arachnoid cyst: an in utero mimicker of Dandy-Walker malformation. View Abstract
Corpus callosotomy in children. View Abstract
The future of pediatric epilepsy surgery. Signposts and science. View Abstract
EEG prior to hemispherectomy: correlation with outcome and pathology. View Abstract
A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge. View Abstract
Nitrous oxide depresses the H-reflex in children with cerebral palsy. View Abstract
Use of subdural grids and strip electrodes to identify a seizure focus in children. View Abstract
The latency test: criterion for valid reflexes in dorsal rhizotomy surgery View Abstract
The critical importance of stimulus intensity in intraoperative monitoring for selective dorsal rhizotomy (DR) View Abstract
The role of surgery in the management of optic chiasm astrocytomas in childhood View Abstract
Technetium-99m HmPAO brain SPECT and outcome of hemispherectomy for intractable seizures. View Abstract
H reflex studies in cerebral palsy patients undergoing partial dorsal rhizotomy. View Abstract
Identification of volume-sensitive organic osmolyte channels in human glial cells View Abstract
Nitrous oxide depresses the H-reflex in children with cerebral palsy View Abstract
Conditioned media from a transformed glial-like cell line enhances neurite outgrowth and GAP-43 expression View Abstract
Effect of surgical repair on the neurologic function in infants with lipomeningocele. View Abstract
Chiari malformations, syringomyelia, and intramedullary spinal cord tumors. View Abstract
Thallium-201 versus technetium-99m-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison. View Abstract
Process variables as predictors of risk factor changes in a family health behavior change program. View Abstract
EEG patterns in patients undergoing hemispherectomy evaluation View Abstract
SPECT scan findings in the evaluation of hemispherectomy for intractable seizures: A predictor of favorable outcome View Abstract
Epilepsy surgery, ed by HO Luders [book review] View Abstract
Treatment of medulloblastoma with pre-irradiation chemotherapy: experience at Boston Children’s Hospital from 1984 to 1991 - Pediatric Session View Abstract
Neurite outgrowth and GAP-43 expression: effects of glial substrate and of monoclonal antibodies recognizing glial cell surface proteins View Abstract
HMPAO SPECT versus outcomes of hemispherectomy for intractable seizures View Abstract
EEG Patterns in patients undergoing hemispherectomy correlation with outcome and pathology View Abstract
Discharge morphology and propagation patterns in temporal lobe epilepsy in children and adolescents: effects of age View Abstract
Astrocytomas of the cerebellum View Abstract
The latency test: distinguishing valid reflexes in dorsal rhizotomy surgery - Pediatric SEssion View Abstract
201Tl versus 99mTc-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison View Abstract
Neurosurgical procedures for the relief of pain in children and adolescents View Abstract
Immunological approach to putative glial surface molecules affecting neurite outgrowth: changes with normal development and after lesions - Poster Session View Abstract
Cavernous angioma of the posterior fossa dura mimicking a meningioma: case report and review of literature. View Abstract
Comparison of surface and intracranial electrode studies in children with temporal lobe seizures View Abstract
Case records of the Massachusetts General Hospital, case 16-1992: a 27-year-old woman with pain in the neck and shoulder View Abstract
Glial surface molecules in lesions and regeneration: generation of a panel of monoclonal antibodies View Abstract
Glial surface molecules affecting neurite outgrowth: immunological dissection using monoclonal antibodies - Poster Session View Abstract
Chronic increased intracranial pressure View Abstract
The pediatric neurosurgical patient: a cooperative approach, ed. by LP Ivan. [book review] View Abstract
Glial surface molecules affecting neurite outgrowth: immunological dissection using monoclonal antibodies - Open Scientific Session View Abstract
Spinal tumors in children and adolescents, ed by I Pascual-Castroviejo. [book review] View Abstract
Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. View Abstract
Immunoreactivity for two promotors of neurite outgrowth in pituitary cell subsets - Poster Session, View Abstract
Giant peripheral aneurysms of the posterior inferior cerebellar artery presenting as cerebellar masses View Abstract
Psychosis and aggressive behavior after corpus callosotomy - Poster Presentation View Abstract
Giant peripheral aneurysms of the posterior inferior cerebellar artery presenting as cerebellar masses View Abstract
An interview with Dr. HT Ballantine - video presentation View Abstract
X Hapten immunoreactivity in oligodendrogliomas View Abstract
Immunoreactivity in pituitary gonadotropes and hypothalamic vasopressinergic neurons for the monoclonal antibody INO. View Abstract
Giant peripheral aneurysm of the posterior inferior cerebellar artery treated with excision and end-to-end anastomosis. View Abstract
Expression of X hapten immunoreactivity by human and rat adenohypophyseal cells. View Abstract
Spinal arteriovenous malformations and neurogenic claudication. Report of two cases. View Abstract
Untitled Publication View Abstract
Spinal arteriovenous malformations and spinal claudication: a diagnostic dilemma View Abstract
Neurosurgery of the Neonate View Abstract
Commentary on the transvenous treatment of antero-inferior dural venous fistulae View Abstract
Immunologically defined astrocyte subsets: implications for axonal regeneration after central nervous system injury View Abstract
Hemodynamic method to predict whether Hunterian ligation of the basilar artery will lead to thrombosis of basilar bifurcation aneurysms: Comment View Abstract
Immunohistochemistry of pituitary adenomas View Abstract
Neuromethods, volumes 1 and 2 [book review] View Abstract
Expression of X-hapten immunoreactivity by human and rat adenohypophyseal cells: alterations in tumors and estrogen-induced hyperplasia View Abstract
Transplantation of neonatal rat pituicytes into the third ventricle of hypophysectomized recipients leads to restitution of plasma adenohypophyseal hormone levels View Abstract
Functional transplantation of the pituitary gland - Open Scientific Session View Abstract
Neuropeptide investigations with an ovine surgical model. View Abstract
Re-expression of an antigen present in developing CNS by injured and sprouting adult neurons - Open Scientific Session View Abstract
Cerebrospinal fluid anion transport: studies of pertechnetate in unanesthetized sheep. View Abstract
Pertechnetate as a probe of the anion clearance mechanisms of the brain - Poster Session View Abstract
Circadian changes in the destruction and effects of haloperidol in the rat. View Abstract
Chronopsychopharmacology View Abstract
Effects of prenatal treatment of rats with haloperidol due to altered drug distribution in neonatal brain. View Abstract
Special report. The nature of aggression during epileptic seizures. View Abstract
Intoxication associated with lithium and ECT. View Abstract
[Electro-clinical changes following traumatic cerebral contusion in children. Risk of epileptic sequela]. View Abstract
Diurnal changes in effects of haloperidol in rats View Abstract
Occlusive arterial disease of the child and young adult. Clinical electroencephalographical analysis of 26 cases. View Abstract
Unsaturated carbenes from primary vinyl triflates: competitive addition of isopropylidene to olefins View Abstract
Lupus erythematosus and pregnancy. View Abstract
Locations