John Kheir, MD
Senior Associate Cardiologist, Department of Cardiology
Associate Professor of Pediatrics, Harvard Medical School
Image
John Kheir, MD
Senior Associate Cardiologist, Department of Cardiology
Associate Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
University of Virginia
1998
Charlottesville
VA
Medical School
University of Virginia
2002
Charlottesville
VA
Internship
Cincinnati Children's Hospital Medical Center
2003
Cincinnati
OH
Residency
Chief Resident, Pediatrics
Cincinnati Children's Hospital Medical Center
2006
Cincinnati
OH
Fellowship
Clinical Fellow, Anesthesia
Boston Children's Hospital
2010
Boston
MA
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Critical Care Medicine)
Professional History
Dr. Kheir joined the staff of the Boston Children’s Hospital Heart Center in 2010. He is a staff physician in the cardiac intensive care unit, where he cares for critically ill patients with congenital heart disease. He is also the co-founder of the Translational Research Lab within the Heart Center, a group focused upon the development of new diagnostic and treatment tools related to oxygen deprivation, a common problem in patients with severe heart disease. For example, he and his group are developing tools to deliver oxygen directly to the bloodstream for use in extreme emergencies. Among his other interests are new ways to determine whether patients are receiving sufficient oxygen delivery following their operations, particularly in infants with hypoplastic left heart syndrome.
Approach to Care
Caring for critically ill patients and their families is a tremendous privilege and responsibility. A responsibility because there is nothing more precious to a human being than their child, and a privilege because I consider it an honor to walk along side families during such trying times. The ICU can be an imposing place to be, with many caregivers to get to know and a sick child. My goal is to provide expertise, love and support to patients and their families in real time, and also to look for ways to make the care we provide better in the future.
Publications
Adjunctive Corticosteroids for Hypotension in the Pediatric Cardiac ICU: Single-Center Retrospective Study, 2020-2021. View Abstract
Resonance Raman Spectroscopy Detects Ischemia in Experimental Coarctation of the Aorta in a Rodent Model. View Abstract
Performance of Unmodified Mechanical Ventilators With 2% Hydrogen Gas Mixtures. View Abstract
Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO. View Abstract
Generating Risk Reduction Analytics in Complex Cardiac Care Environments (GR2AC3E): Risk Prediction in Congenital Catheterization. View Abstract
Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation. View Abstract
Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine. View Abstract
Pediatric Sedation Gets a Wake-Up Call. View Abstract
Efficacy and safety of early postoperative ablation in patients with congenital heart disease. View Abstract
Esophageal oxyhemoglobin saturation as a resuscitative metric in hemorrhagic shock. View Abstract
Arch watch: current approaches and opportunities for improvement. View Abstract
Social Drivers of Health and Pediatric Extracorporeal Membrane Oxygenation Outcomes. View Abstract
Administration of Milrinone Following Tetralogy of Fallot Repair Increases Postoperative Volume Administration Without Improving Cardiac Output. View Abstract
Administration of Milrinone Following Tetralogy of Fallot Repair Increases Postoperative Volume Administration Without Improving Cardiac Output. View Abstract
Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit. View Abstract
Predicting favorable response to intravenous morphine in pediatric critically ill cardiac patients. View Abstract
Injectable Oxygen Microparticles Boost Radiation-Mediated In Situ Vaccination and Systemic Antitumor Immune Responses. View Abstract
Insight into the Role of the Child Opportunity Index on Surgical Outcomes in Congenital Heart Disease. View Abstract
Clinical risk prediction score for postoperative accelerated junctional rhythm and junctional ectopic tachycardia in children with congenital heart disease. View Abstract
Low-Fouling Zwitterionic Polymeric Colloids as Resuscitation Fluids for Hemorrhagic Shock. View Abstract
Prediction of impending central-line-associated bloodstream infections in hospitalized cardiac patients: development and testing of a machine-learning model. View Abstract
A microfluidic device for real-time on-demand intravenous oxygen delivery. View Abstract
Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults. View Abstract
Modeling severe functional impairment or death following ECPR in pediatric cardiac patients: Planning for an interventional trial. View Abstract
Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among 5 Centers. View Abstract
Commentary: Hydrogen: Lightweight molecule takes on a heavyweight problem. View Abstract
Avoidable Serum Potassium Testing in the Cardiac ICU: Development and Testing of a Machine-Learning Model. View Abstract
Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome. View Abstract
Shock Index, Coronary Perfusion Pressure, and Rate Pressure Product As Predictors of Adverse Outcome After Pediatric Cardiac Surgery. View Abstract
Vein of Galen Malformation. View Abstract
Sensitivity of a Next-Generation NIRS Device to Detect Low Mixed Venous Oxyhemoglobin Saturations in the Single Ventricle Population. View Abstract
Hyperbaric polymer microcapsules for tunable oxygen delivery. View Abstract
Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery. View Abstract
WITHDRAWN: Complete Heart Block, Severe Ventricular Dysfunction and Myocardial Inflammation in a Child with COVID-19 Infection. View Abstract
Complete Heart Block, Severe Ventricular Dysfunction, and Myocardial Inflammation in a Child With COVID-19 Infection. View Abstract
Red Blood Cell Transfusion After Stage I Palliation Is Associated With Worse Clinical Outcomes. View Abstract
Development of a Respiratory Support Score as a Visualization Tool in Intensive Care. View Abstract
Impact of the superior cavopulmonary anastomosis on cerebral oxygenation. View Abstract
Value of Troponin Testing for Detection of Heart Disease in Previously Healthy Children. View Abstract
Fontan with lateral tunnel is associated with improved survival compared with extracardiac conduit. View Abstract
Safety of inhaled hydrogen gas in healthy mice. View Abstract
Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. View Abstract
Reply to Li, J "The Fick principle remains accurate to calculate cardiac output under hyperoxia". View Abstract
Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study. View Abstract
Tunable Nonlinear Acoustic Reporters Using Micro- and Nanosized Air Bubbles with Porous Polymeric Hard Shells. View Abstract
Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science. View Abstract
Physiologic effects of delayed sternal closure following stage 1 palliation. View Abstract
Changes in tissue oxygen tension, venous saturation, and Fick-based assessments of cardiac output during hyperoxia. View Abstract
Tunable Polymer Microcapsules for Controlled Release of Therapeutic Gases. View Abstract
A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range. View Abstract
Impact of a Composite Valved RV-PA Graft After Stage 1 Palliation. View Abstract
An anticoagulation protocol for use after congenital cardiac surgery. View Abstract
Partial thromboplastin time is more predictive of bleeding than anti-Xa levels in heparinized pediatric patients after cardiac surgery. View Abstract
Use of Oxyhemoglobin Saturation or Oxygen Tension-an Unsolved Question-Reply. View Abstract
Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid. View Abstract
Measurement of Dead Space Fraction Upon ICU Admission Predicts Length of Stay and Clinical Outcomes Following Bidirectional Cavopulmonary Anastomosis. View Abstract
Use of Oxyhemoglobin Saturation, Rather Than Oxygen Tension, as a Marker of Oxygenation in Cyanotic Patients. View Abstract
Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. View Abstract
Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents. View Abstract
Cerebral near-infrared spectroscopy insensitively detects low cerebral venous oxygen saturations after stage 1 palliation. View Abstract
Accuracy of Oxygen Consumption and Carbon Dioxide Elimination Measurements in 2 Breath-by-Breath Devices. View Abstract
Reply to Span et al.: Rational design of oxygen microparticles for radiation therapy. View Abstract
191: QUANTIFYING ICU SUPPORT IN THE CONTEXT OF DISEASE-MATCHED PATIENTS OVER TIME USING PERCENTILE CURVES. View Abstract
450: SUBOPTIMAL PROTEIN INTAKE MAY PROLONG CICU LENGTH OF STAY AND WORSEN NUTRITIONAL STATUS IN CHILDREN. View Abstract
462: BEDSIDE VCO2 AS A GUIDE TO INDIVIDUALIZED ENERGY PRESCRIPTION IN VENTILATED CHILDREN IN THE CICU. View Abstract
Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. View Abstract
Oxygen delivery using engineered microparticles. View Abstract
Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption. View Abstract
Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions. View Abstract
Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. View Abstract
The effects of lung recruitment maneuvers on exhaled breath condensate pH. View Abstract
Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration. View Abstract
Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. View Abstract
Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. View Abstract
Comparison of 2 lung recruitment strategies in children with acute lung injury. View Abstract
Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. View Abstract
Oxygen gas-filled microparticles provide intravenous oxygen delivery. View Abstract
Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. View Abstract
Phospholipid-stabilized microbubble foam for injectable oxygen delivery. View Abstract
Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. View Abstract
Implementation of a medical emergency team in a large pediatric teaching hospital prevents respiratory and cardiopulmonary arrests outside the intensive care unit. View Abstract
Locations