American Board of Pathology (Anatomic Clinical Pathology)
Professional History
Dr. Jeffery Goldsmith began his career at Beth Israel Deaconess Medical Center as a junior gastrointestinal pathologist, starting in 2003, and began work at Boston Children's Hospital as a pediatric gastrointestinal pathologist. As his career evolved, he began specializing in pediatric GI diseases. Dr. Goldsmith began working at BCH full time in 2016.
Dr. Goldsmith practices pediatric gastrointestinal pathology at Boston Children's Hospital and also serves as the director of the gastrointestinal pathology service. His research interests include the clinicopathologic aspects of pediatric gastrointestinal diseases such as celiac disease, inflammatory bowel disease, eosinophilic gastrointestinal diseases, congenital diarrheal illness, and polyposes.
Publications
Intratumoral Heterogeneity of Mismatch Repair Status and Outcome of Treatment With Dostarlimab in a Patient With Locally Advanced Rectal Adenocarcinoma. View Abstract
Using simulations to explore the conditions under which "true" dose-response relationships are detectable for environmental exposures: polychlorinated biphenyls (PCBs) and birthweight: a case study. View Abstract
Uranium exposure and kidney tubule biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA). View Abstract
Regression and alignment for functional data and network topology. View Abstract
Cataloguing the postnatal small intestinal transcriptome during the first postnatal month. View Abstract
Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis. View Abstract
Current status and future directions in food protein-induced enterocolitis syndrome: An NIAID workshop report of the June 22, 2022, virtual meeting. View Abstract
Mitochondrial DNA copy number and neurocognitive outcomes in children. View Abstract
Cytomegalovirus Colitis in a Patient With Ulcerative Colitis With Loss of Corticosteroid Response Upon Upadacitinib Initiation. View Abstract
Characterizing daily physical activity patterns with unsupervised learning via functional mixture models. View Abstract
Associations of Infant Sleep Characteristics with Childhood Cognitive Outcomes. View Abstract
Clinical characteristics and outcomes of pediatric patients with autoimmune gastritis. View Abstract
Principles of Analytic Validation of Immunohistochemical Assays: Guideline Update. View Abstract
Influence of folic acid and vitamin B12 supplementation on arsenic methylation: A double-blinded, placebo-controlled trial in Bangladeshi children. View Abstract
WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. View Abstract
Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity. View Abstract
Regression and Alignment for Functional Data and Network Topology. View Abstract
A tip-predominant distribution of villous intraepithelial lymphocytes is not specific to celiac disease in children with Marsh I lesions. View Abstract
Longitudinal Associations of Food Security with Health and Dietary Factors among Food FARMacy Participants during COVID-19 in New York City. View Abstract
An environmental justice analysis of air pollution emissions in the United States from 1970 to 2010. View Abstract
Method validation for (ultra)-trace element concentrations in urine for small sample volumes in large epidemiological studies: application to the population-based epidemiological multi-ethnic study of atherosclerosis (MESA). View Abstract
Metabolomic Effects of Folic Acid Supplementation in Adults: Evidence from the FACT Trial. View Abstract
Clinical presentation and outcomes of Helicobacter heilmannii gastritis in children in the New England region of the United States. View Abstract
Clinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease: A 13 Center Correlative Study. View Abstract
Gastric Foveolar Hyperplastic Polyps in 2 Children With Short Bowel Syndrome on Long-Term Teduglutide. View Abstract
Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease. View Abstract
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation. View Abstract
Standardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study. View Abstract
Fine particulate matter composition in American Indian vs. Non-American Indian communities. View Abstract
Helicobacter pylori Antimicrobial Resistance Using Next-Generation Sequencing in Stool Samples in a Pediatric Population. View Abstract
Sclerosing epithelioid fibrosarcoma of bone with hybrid features: clinicopathologic, radiologic, and molecular analysis of three cases. View Abstract
A 72-Year-Old Woman with Fatigue and Shortness of Breath. View Abstract
Gastric Intestinal Metaplasia in Children: Natural History and Clinicopathological Correlation. View Abstract
Pediatric Colonic Xanthomas, a Previously Unreported Colonoscopic Finding. View Abstract
Distinguishing Distinct Neural Systems for Proximal vs Distal Upper Extremity Motor Control After Acute Stroke. View Abstract
WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. View Abstract
The Folic Acid and Creatine Trial: Treatment Effects of Supplementation on Arsenic Methylation Indices and Metabolite Concentrations in Blood in a Bangladeshi Population. View Abstract
Association of a primary care-based mobile food pantry with child body mass index: A propensity score matched cohort study. View Abstract
Validation of Linear Range HER2/Estrogen Receptor/Progesterone Receptor IHControls for Daily Quality Assurance. View Abstract
How many days are needed? Measurement reliability of wearable device data to assess physical activity. View Abstract
Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis. View Abstract
Mitochondrial DNA copy number dynamics and associations with the prenatal environment from birth through adolescence in a population of Dominican and African American children. View Abstract
Applying principal component pursuit to investigate the association between source-specific fine particulate matter and myocardial infarction hospitalizations in New York City. View Abstract
Unintended impacts of the Open Streets program on noise complaints in New York City. View Abstract
Metabolomic changes associated with chronic arsenic exposure in a Bangladeshi population. View Abstract
Factors Associated With Chronic Intestinal Inflammation Resembling Inflammatory Bowel Disease in Pediatric Intestinal Failure: A Matched Case-Control Study. View Abstract
Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids. View Abstract
Longitudinal trends in parent-reported child sleep, physical activity, and screen use during the COVID-19 pandemic in New York City. View Abstract
Principal Component Pursuit for Pattern Identification in Environmental Mixtures. View Abstract
Arguments for the biological and predictive relevance of the proportional recovery rule. View Abstract
Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14?years. View Abstract
Long-term Traffic-related Air Pollutant Exposure and Amyotrophic Lateral Sclerosis Diagnosis in Denmark: A Bayesian Hierarchical Analysis. View Abstract
Cytotoxic T Lymphocyte Antigen 4 Haploinsufficiency Presenting As Refractory Celiac-Like Disease: Case Report. View Abstract
Racial/Ethnic Disparities in Nationwide PM2.5 Concentrations: Perils of Assuming a Linear Relationship. View Abstract
Serrated Polyposis Syndrome in a Young Adolescent Patient. View Abstract
Giant Filiform Polyposis of the Colon in a 6-Year Old Male With Ulcerative Colitis. View Abstract
Registration of 24-hour accelerometric rest-activity profiles and its application to human chronotypes. View Abstract
Air Pollution in American Indian Versus Non-American Indian Communities, 2000-2018. View Abstract
PM2.5 composition and disease aggravation in amyotrophic lateral sclerosis: An analysis of long-term exposure to components of fine particulate matter in New York State. View Abstract
Pediatric Gastrointestinal Histopathology in Patients With Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A Rare Condition Leading to Multiple Intestinal Atresias, Severe Combined Immunodeficiency, and Congenital Enteropathy. View Abstract
Impact of Intraoperative Data on Risk Prediction for Mortality After Intra-Abdominal Surgery. View Abstract
Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. View Abstract
Blood DNA Methylation and Incident Coronary Heart Disease: Evidence From the Strong Heart Study. View Abstract
Pediatric Collagenous Gastritis: Clinical and Histologic Outcomes in a Large Pediatric Cohort. View Abstract
Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor ??B kinase alpha (IKKa). View Abstract
Cytomegalovirus Colitis in An Immunocompetent Patient. View Abstract
Liver Pathology, Including MOC31 Immunohistochemistry, in Congenital Tufting Enteropathy. View Abstract
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants. View Abstract
Cognitive correlates of autism spectrum disorder symptoms. View Abstract
Prenatal exposure to air pollution is associated with childhood inhibitory control and adolescent academic achievement. View Abstract
Parkinson's disease aggravation in association with fine particle components in New York State. View Abstract
Reflection on modern methods: good practices for applied statistical learning in epidemiology. View Abstract
The association between ambient temperature variability and myocardial infarction in a New York-State-based case-crossover study: An examination of different variability metrics. View Abstract
The Emergence and Future of Public Health Data Science. View Abstract
Is Asking Questions on Rounds a Teachable Skill?[Response to Letter]. View Abstract
Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. View Abstract
Is Asking Questions on Rounds a Teachable Skill? A Randomized Controlled Trial to Increase Attendings' Asking Questions. View Abstract
Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial. View Abstract
Response to Letter to the Editor on "Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up". View Abstract
Unveiling outcomes in coexisting severe aortic stenosis and transthyretin cardiac amyloidosis. View Abstract
United network for organ sharing outcomes after heart transplantation for al compared to ATTR cardiac amyloidosis. View Abstract
Daily Dilemmas in Pediatric Gastrointestinal Pathology. View Abstract
Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease. View Abstract
Barrett Esophagus and Intestinal Metaplasia of the Gastroesophageal Junction in Children: A Clinicopathologic Study. View Abstract
Estimated Prevalence of Nonverbal Learning Disability Among North American Children and Adolescents. View Abstract
Pediatric Collagenous Gastroenterocolitis Successfully Treated with Methotrexate. View Abstract
Short- and intermediate-term exposure to NO2 and mortality: A multi-county analysis in China. View Abstract
Nonnegative decomposition of functional count data. View Abstract
Markers of nutritional status and inflammation in transthyretin cardiac amyloidosis: association with outcomes and the clinical phenotype. View Abstract
Oral viscous mometasone is an effective treatment for eosinophilic esophagitis. View Abstract
An overview of methods to address distinct research questions on environmental mixtures: an application to persistent organic pollutants and leukocyte telomere length. View Abstract
Advances in Evaluation of Chronic Diarrhea in Infants. View Abstract
Multispectral light scattering endoscopic imaging of esophageal precancer. View Abstract
In vivo tissue regeneration with robotic implants. View Abstract
An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. View Abstract
A Collision Tumor Involving a Primary Leiomyosarcoma of the Lower Extremity and a Metastatic Medullary Thyroid Carcinoma: A Case Report. View Abstract
Modeling motor learning using heteroskedastic functional principal components analysis. View Abstract
Can a Left Ventricular Assist Device in Individuals with Advanced Systolic Heart Failure Improve or Reverse Frailty? View Abstract
Prolonged, Uninterrupted Sedentary Behavior and Glycemic Biomarkers Among US Hispanic/Latino Adults: The HCHS/SOL (Hispanic Community Health Study/Study of Latinos). View Abstract
The Importance of Epitope Density in Selecting a Sensitive Positive IHC Control. View Abstract
Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. View Abstract
Apoptotic Enteropathy in a Neonate With Allergic Enterocolitis. View Abstract
Analytic Validation of Immunohistochemistry Assays: New Benchmark Data From a Survey of 1085 Laboratories. View Abstract
Analytic Validation of Immunohistochemical Assays: A Comparison of Laboratory Practices Before and After Introduction of an Evidence-Based Guideline. View Abstract
Heterogeneity of proliferative markers in pancreatic ß-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass. View Abstract
An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. View Abstract
The Use of Ancillary Stains in the Diagnosis of Barrett Esophagus and Barrett Esophagus-associated Dysplasia: Recommendations From the Rodger C. Haggitt Gastrointestinal Pathology Society. View Abstract
Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy. View Abstract
MRI guided needle localization in a patient with recurrence pleomorphic sarcoma and post-operative scarring. View Abstract
Wrist-based cut-points for moderate- and vigorous-intensity physical activity for the Actical accelerometer in adults. View Abstract
Variable selection in the functional linear concurrent model. View Abstract
Achieving High Reliability in Histology: ?An Improvement Series to Reduce Errors. View Abstract
Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. View Abstract
New Insights into Activity Patterns in Children, Found Using Functional Data Analyses. View Abstract
Depression and genetic causal attribution of epilepsy in multiplex epilepsy families. View Abstract
Serum I-FABP Detects Gluten Responsiveness in Adult Celiac Disease Patients on a Short-Term Gluten Challenge. View Abstract
Validation of the Fitbit One® for physical activity measurement at an upper torso attachment site. View Abstract
Interactive graphics for functional data analyses. View Abstract
Histology Grade Is Independently Associated With Relapse Risk in Patients With Ulcerative Colitis in Clinical Remission: A Prospective Study. View Abstract
Variable Selection in Function-on-Scalar Regression. View Abstract
Parents' interest in genetic testing of their offspring in multiplex epilepsy families. View Abstract
Principles of Analytic Validation of Clinical Immunohistochemistry Assays. View Abstract
Genetic causal attribution of epilepsy and its implications for felt stigma. View Abstract
Assessing systematic effects of stroke on motorcontrol by using hierarchical function-on-scalar regression. View Abstract
Robotic therapy for chronic stroke: general recovery of impairment or improved task-specific skill? View Abstract
Low and moderate prenatal ethanol exposures of mice during gastrulation or neurulation delays neurobehavioral development. View Abstract
Weight-related behaviors when children are in school versus on summer breaks: does income matter? View Abstract
Case report of a traumatic rectal neuroma. View Abstract
Pediatric non-Helicobacter pylori atrophic gastritis: a case series. View Abstract
Giant Cystic Arteriovenous Malformation of the Mesentery and the Role of Cross-Sectional Imaging in Occult Gastrointestinal Bleeding. View Abstract
Fitbit®: An accurate and reliable device for wireless physical activity tracking. View Abstract
Corrigendum to "Statistical normalization techniques for magnetic resonance imaging" [NeuroImage: Clinical 6 (2014) 9-19]. View Abstract
A novel mutation in ICOS presenting as hypogammaglobulinemia with susceptibility to opportunistic pathogens. View Abstract
Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. View Abstract
Generalized multilevel function-on-scalar regression and principal component analysis. View Abstract
Pleomorphic liposarcoma of the inferior vena cava. View Abstract
Standardization of positive controls in diagnostic immunohistochemistry: recommendations from the International Ad Hoc Expert Committee. View Abstract
Pathological rib fracture and soft tissue mass simulating malignancy--Cryptococcus, an unsuspected culprit. View Abstract
Genetic testing preferences in families containing multiple individuals with epilepsy. View Abstract
Collagenous gastritis: a morphologic and immunohistochemical study of 40 patients. View Abstract
Statistical normalization techniques for magnetic resonance imaging. View Abstract
Prevalence and prognostic significance of low QRS voltage among the three main types of cardiac amyloidosis. View Abstract
Good agreement between endoscopic findings and biopsy reports supports limited tissue sampling during pediatric colonoscopy. View Abstract
Estimating energy expenditure from heart rate in older adults: a case for calibration. View Abstract
Principles of analytic validation of immunohistochemical assays: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center. View Abstract
Non-reflux esophagitis: a review of inflammatory diseases of the esophagus exclusive of reflux esophagitis. View Abstract
Bursal synovial chondromatosis formation following osteochondroma resection. View Abstract
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. View Abstract
Reply to the letter to the editor: in response to "Lipomatosis of the sciatic nerve secondary to compression by a desmoid tumor". View Abstract
Diarrheal Illness in the Pediatric Population: A Review of Neonatal Enteropathies and Childhood Idiopathic Inflammatory Bowel Disease. View Abstract
Image guided core needle biopsy of musculoskeletal lesions: are nondiagnostic results clinically useful? View Abstract
Lipomatosis of the sciatic nerve secondary to compression by a desmoid tumor. View Abstract
Bayesian scalar-on-image regression with application to association between intracranial DTI and cognitive outcomes. View Abstract
Probiotic yeast inhibits VEGFR signaling and angiogenesis in intestinal inflammation. View Abstract
Histologic markers of inflammation in patients with ulcerative colitis in clinical remission. View Abstract
Predictors of endoscopic inflammation in patients with ulcerative colitis in clinical remission. View Abstract
MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. View Abstract
Orthopaedic case of the month: pulsatile soft tissue mass. View Abstract
A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study. View Abstract
Immunohistochemistry cocktails are here to stay: Center of Medicare and Medicaid Services should revise its new reimbursement policy. View Abstract
Immunohistochemistry cocktails are here to stay: Center for Medicare and Medicaid Services should revise its new reimbursement policy. View Abstract
Spectral Imaging with Scattered Light: From Early Cancer Detection to Cell Biology. View Abstract
Clinical implications of mucinous nonneoplastic cysts of the pancreas. View Abstract
Revitalizing pathology laboratories in a gastrointestinal pathophysiology course using multimedia and team-based learning techniques. View Abstract
Predicting breakdown of the blood-brain barrier in multiple sclerosis without contrast agents. View Abstract
Histologic examinations of arthroplasty specimens are not cost-effective: a retrospective cohort study. View Abstract
Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcoma. View Abstract
Penalized functional regression analysis of white-matter tract profiles in multiple sclerosis. View Abstract
The incidence and clinical spectrum of refractory celiac disease in a north american referral center. View Abstract
Fixation time does not affect expression of HER2/neu. View Abstract
Orthopaedic case of the month: ankle pain and swelling in a 23-year-old man. View Abstract
Juvenile polyps: recurrence in patients with multiple and solitary polyps. View Abstract
Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus. View Abstract
Analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance. View Abstract
Heterotopic pancreas: typical and atypical imaging findings. View Abstract
An unusual variant of anomalous pancreaticobiliary junction in a patient with pancreas divisum diagnosed with secretin-magnetic resonance cholangiopancreatography. View Abstract
Best practices in diagnostic immunohistochemistry: spindle cell neoplasms of the gastrointestinal tract. View Abstract
Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. View Abstract
Pregnant patients suspected of having acute appendicitis: effect of MR imaging on negative laparotomy rate and appendiceal perforation rate. View Abstract
Reporting guidelines for clinical laboratory reports in surgical pathology. View Abstract
A mouse model of Clostridium difficile-associated disease. View Abstract
Clinical significance of colonic intraepithelial lymphocytosis in a pediatric population. View Abstract
Bone and soft-tissue lesions: what factors affect diagnostic yield of image-guided core-needle biopsy? View Abstract
Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis. View Abstract
Quantifying gastric Helicobacter pylori infection: a comparison of quantitative culture, urease breath testing, and histology. View Abstract
Abnormal intrahepatic portal vasculature in native and allograft liver biopsies: a comparative analysis. View Abstract
Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. View Abstract
Topical antisense oligonucleotide therapy against LIX, an enterocyte-expressed CXC chemokine, reduces murine colitis. View Abstract
Magnetic resonance imaging findings in solitary fibrous tumor of the kidney. View Abstract
Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation. View Abstract
Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. View Abstract
Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. View Abstract
Orbital hemangiopericytoma and solitary fibrous tumor: a morphologic continuum. View Abstract
Oral ganciclovir in children: pharmacokinetics, safety, tolerance, and antiviral effects. The Pediatric AIDS Clinical Trials Group. View Abstract
Amyloid goiter: report of two cases and review of the literature. View Abstract
Cancer incidence and risks in selected agricultural settlements in the Negev of Israel. View Abstract
Reducing costs and improving processes for the interventional cardiology patient. View Abstract
Reducing costs and improving processes for the interventional cardiology patient. View Abstract
In vivo release of neuroactive amino acids from the inferior colliculus of the guinea pig using brain microdialysis. View Abstract
Eleven-year experience with tibiotibial bypass: an unusual but effective solution to distal tibial artery occlusive disease and limited autologous vein. View Abstract
Management of arterial injuries produced by percutaneous femoral procedures. View Abstract
Management of infected lower extremity autologous vein grafts by selective graft preservation. View Abstract
Limb salvage surgery in end stage renal disease: is it worthwhile? View Abstract
Immunohistochemistry of Pneumocystis carinii infection. View Abstract
Resting gated pool ejection fraction: a poor predictor of perioperative myocardial infarction in patients undergoing vascular surgery for infrainguinal bypass grafting. View Abstract
A technique for donor lung procurement and preservation for transplantation after completion of cardiac donation. View Abstract