Helen Christou, MD
Physician in Medicine, Division of Newborn Medicine
Associate Professor of Pediatrics, Harvard Medical School
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Helen Christou, MD
Physician in Medicine, Division of Newborn Medicine
Associate Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Greek
Education
Medical School
Aristotelian University of Thessaloniki
1988
Thessaloniki
Greece
Residency
Pediatrics
Hospital for Infectious Diseases
1989
Thessaloniki
Greece
Internship
Beth Israel Deaconess Medical Center
1990
Boston
MA
Residency
Pediatrics
Beth Israel Medical Center
1992
New York
MA
Fellowship
Joint Program in Neonatology
Harvard Medical School
1996
Boston
MA
Certifications
American Board of Pediatrics (Neonatal-Perinatal Medicine)
Approach to Care
In the Boston Children’s Hospital (BCH) Neonatal Intensive Care Unit (NICU) our philosophy is to ensure that every patient receives the best care for the best possible outcomes. We consider our “patient” to be the baby and the family; we are constantly striving to serve the needs of both. This requires a team based approach with all members being essential.
Publications
A narrative review of the clinical applications of renal NIRS and integration with cerebral NIRS in the NICU. View Abstract
Impact of persistent pulmonary hypertension on cerebral oxygenation in infants with neonatal encephalopathy. View Abstract
Stress Granule Assembly in Pulmonary Arterial Hypertension. View Abstract
Adult and neonatal models of chemogenetic heart failure caused by oxidative stress. View Abstract
Maternal Obesity Modulates Cord Blood Concentrations of Proprotein Convertase Subtilisin/Kexin-type 9 Levels. View Abstract
Pericytes contribute to pulmonary vascular remodeling via HIF2a signaling. View Abstract
Single center experience with first-intention high-frequency jet vs. volume-targeted ventilation in extremely preterm neonates. View Abstract
Proceedings of the 15th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal. View Abstract
Proceedings of the 15th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc. View Abstract
Pneumoprotein CC16 in the Umbilical Cord Blood of Preterm Neonates. View Abstract
Predictors of successful extubation from volume-targeted ventilation in extremely preterm neonates. View Abstract
Pulmonary Hypertension in Infants and Children with Vein of Galen Malformation and Association with Clinical Outcomes. View Abstract
Proceedings of the 14th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc. View Abstract
Maternal diabetes and the role of neonatal reticulocyte hemoglobin content as a biomarker of iron status in the perinatal period. View Abstract
Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension. View Abstract
Changes, Challenges, and Variations in Neonatal-Perinatal Medicine Fellowship: A View from the Program Directors. View Abstract
Pleiotropic Effects of Pyruvate Kinase M2 in Right Ventricular Failure and Pulmonary Arterial Hypertension. View Abstract
Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies. View Abstract
ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells. View Abstract
Metabolomic and transcriptomic signatures of chemogenetic heart failure. View Abstract
Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring. View Abstract
Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension. View Abstract
Off-label use of PAH-targeted medications approved for adults and their financial coverage by health insurances are vital for children with pulmonary hypertension. View Abstract
Carbonic anhydrase inhibition improves pulmonary artery reactivity and nitric oxide-mediated relaxation in sugen-hypoxia model of pulmonary hypertension. View Abstract
Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension. View Abstract
Lower oxygen saturation targets in preterm infants are not associated with increased rates of pulmonary hypertension. View Abstract
Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension. View Abstract
Association of circulating FGF-21 levels in the first week of life and postnatal growth in hospitalized preterm infants. View Abstract
Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. View Abstract
GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA. View Abstract
Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension. View Abstract
Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical cord blood and associations with birth weight and length. View Abstract
Early caloric deprivation in preterm infants affects Bayley-III scales performance at 18-24 months of corrected age. View Abstract
Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches. View Abstract
Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. View Abstract
Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn. View Abstract
Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome. View Abstract
Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model. View Abstract
Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates. View Abstract
Establishing Effective Mentoring Networks: Rationale and Strategies. View Abstract
Vitamin D and bronchopulmonary dysplasia in preterm infants. View Abstract
Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies. View Abstract
Cord blood irisin levels are positively correlated with birth weight in newborn infants. View Abstract
Hemopexin in severe inflammation and infection: mouse models and human diseases. View Abstract
Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages. View Abstract
Cord blood levels of osteopontin as a phenotype marker of gestational age and neonatal morbidities. View Abstract
Vitamin D status among preterm and full-term infants at birth. View Abstract
Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. View Abstract
An update on pharmacologic approaches to bronchopulmonary dysplasia. View Abstract
Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. View Abstract
Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. View Abstract
Heme oxygenase-1 does not mediate the effects of extracellular acidosis on vascular smooth muscle cell proliferation, migration, and susceptibility to apoptosis. View Abstract
Sex hormones and vascular protection in pulmonary arterial hypertension. View Abstract
Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats. View Abstract
Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. View Abstract
Intrauterine closure of the ductus arteriosus: implications for the neonatologist. View Abstract
The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells. View Abstract
Gender differences in research grant applications and funding outcomes for medical school faculty. View Abstract
Pharmacological strategies in the prevention and management of bronchopulmonary dysplasia. View Abstract
Cerebral endothelial nitric oxide synthase expression is reduced after very-low-flow bypass. View Abstract
Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin. View Abstract
Lung injury and bronchopulmonary dysplasia in newborn infants. View Abstract
Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells. View Abstract
Current concepts in intrauterine growth restriction. View Abstract
Primary ciliary dyskinesia as a cause of neonatal respiratory distress: implications for the neonatologist. View Abstract
Leptin in relation to growth and developmental processes in the fetus. View Abstract
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. View Abstract
Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth. View Abstract
Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn. View Abstract
Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. View Abstract
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. View Abstract
Inhaled nitric oxide does not affect adenosine 5'-diphosphate-dependent platelet activation in infants with persistent pulmonary hypertension of the newborn. View Abstract
Hypoxic responses of vascular cells. View Abstract
Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. View Abstract
Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. View Abstract
Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5'-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. View Abstract
Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. View Abstract
Locations