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David G. Nathan, MD
President Emeritus, Dana-Farber Cancer Institute
Robert A. Stranahan Distinguished Professor of Pediatrics, Harvard Medical School
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David G. Nathan, MD
President Emeritus, Dana-Farber Cancer Institute
Robert A. Stranahan Distinguished Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
Harvard Medical School
Boston
MA
Internship
Brigham and Women's Hospital
Boston
MA
Residency
Brigham and Women's Hospital
Boston
MA
Fellowship
Brigham and Women's Hospital
Bethesda
MD
Certifications
American Board of Internal Medicine (General)
Publications
Correcting the record on anemia of aging: a statistical reanalysis. View Abstract
COVID-19, nuclear war, and global warming: lessons for our vulnerable world. View Abstract
The Genetic Landscape of Diamond-Blackfan Anemia. View Abstract
The Pathophysiology of Acquired Aplastic Anemia: Current Concepts Revisited. View Abstract
Training. View Abstract
Cholesterol: the debate should be terminated. View Abstract
Eulogy for the clinical research center. View Abstract
Thalassemia: a look to the future. View Abstract
Amino acid uptake in erythropoiesis. View Abstract
A conversation with David Nathan. View Abstract
Hereditary xerocytosis revisited. View Abstract
A tribute to Emil Frei III. View Abstract
Pathophysiology and Clinical Manifestations of the ß-Thalassemias. View Abstract
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. View Abstract
Sickle cell disease (SCD), iNKT cells, and regadenoson infusion. View Abstract
Fetal hemoglobin levels and morbidity in untransfused patients with ß-thalassemia intermedia. View Abstract
Guilt by association. View Abstract
Reversing the hemoglobin switch. View Abstract
Thalassemia: an overview of 50 years of clinical research. View Abstract
A life-long quest to understand and treat genetic blood disorders. View Abstract
Pulmonary hypertension and nitric oxide depletion in sickle cell disease. View Abstract
Musings on genome medicine: Hepatitis C. View Abstract
Sickle cell disease and stroke. View Abstract
Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. View Abstract
Musings on genome medicine: Crohn's disease. View Abstract
Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. View Abstract
Call for a slower approach to health care reform. View Abstract
Musings on genome medicine: the Obama effect redux. View Abstract
Musings on genome medicine: cholesterol and coronary artery disease. View Abstract
Musings on genome medicine: cancer genetics and the promise of effective treatment. View Abstract
Musings on genome medicine: gene therapy. View Abstract
Musings on genome medicine: the Obama effect. View Abstract
Musings on genome medicine: abuse of genetic tests. View Abstract
Musings on genome medicine: genome wide association studies. View Abstract
Judah Folkman, MD, 1933-2008. View Abstract
Targeting the cell death-survival equation. View Abstract
Stanley J. Korsmeyer. View Abstract
Acceptance of the 2006 Kober medal. View Abstract
The cancer treatment revolution. View Abstract
Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. View Abstract
NIH support for basic and clinical research: biomedical researcher angst in 2006. View Abstract
The several Cs of translational clinical research. View Abstract
New developments in iron chelators. View Abstract
Thalassemia: the continued challenge. View Abstract
RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations. View Abstract
Determination can win the battle. View Abstract
Acceptance of the 2003 John Howland Award: a journey in clinical research. View Abstract
Clinical research and the NIH--a report card. View Abstract
First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus. View Abstract
Deferiprone and hepatic fibrosis. View Abstract
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. View Abstract
Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. View Abstract
Clinical research: a tale of two studies. View Abstract
Academic freedom in clinical research. View Abstract
A novel diagnostic screen for defects in the Fanconi anemia pathway. View Abstract
Careers in translational clinical research-historical perspectives, future challenges. View Abstract
Educational-debt relief for clinical investigators--a vote of confidence. View Abstract
Comprehensive cancer centres and the war on cancer. View Abstract
Neurovisual abnormalities preceding the retinopathy in patients with long-term type 1 diabetes mellitus. View Abstract
Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. View Abstract
The National Institutes of Health and clinical research: a progress report. View Abstract
Congenital bone marrow failure syndromes. View Abstract
One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus. View Abstract
Academia and industry: lessons from the unfortunate events in Toronto. View Abstract
Iron chelation with oral deferiprone in patients with thalassemia. View Abstract
Clinical research: perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research. View Abstract
Pioneers and modern ideas. Prospective on thalassemia. View Abstract
The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. View Abstract
The beta c component of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3)/IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression. View Abstract
Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. View Abstract
Diamond-Blackfan anemia. Natural history and sequelae of treatment. View Abstract
Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings: A Thirty Year Follow Up. View Abstract
An orally active iron chelator. View Abstract
Survival in medically treated patients with homozygous beta-thalassemia. View Abstract
Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. View Abstract
Academic careers: choice and activity of graduates of a pediatric residency program 1974-1986. View Abstract
Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate. View Abstract
A service chief model for general pediatric inpatient care and residency training. View Abstract
Careers chosen by graduates of a major pediatrics residency program, 1974-1986. View Abstract
Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. View Abstract
Intrinsic potential for high fetal hemoglobin production in a Druz family with beta-thalassemia is due to an unlinked genetic determinant. View Abstract
The effect of desferrithiocin, an oral iron chelator, on T-cell function. View Abstract
The treatment of Cooley's anemia. View Abstract
Treatment of Cooley's anemia. View Abstract
Positive and negative elements regulate human interleukin 3 expression. View Abstract
Regulation of hematopoiesis. View Abstract
Oral iron chelators. View Abstract
Pharmacologic manipulation of fetal hemoglobin in the hemoglobinopathies. View Abstract
The Jeremiah Metzger lecture. Regulation of hematopoiesis. View Abstract
The beneficence of neonatal hematopoiesis. View Abstract
Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells. View Abstract
Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene. View Abstract
Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. View Abstract
Combinations of recombinant colony-stimulating factors are required for optimal hematopoietic differentiation in serum-deprived culture. View Abstract
Saudi Arabian sickle cell anemia. A molecular approach. View Abstract
Regulation of the human interleukin-3 gene. View Abstract
Combinations of purified recombinant colony-stimulating factors are required for optimal hematopoietic differentiation. View Abstract
Decreased hematopoietic accessory cell function following bone marrow transplantation. View Abstract
Leukemia and the regulation of hematopoiesis. View Abstract
Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3. View Abstract
Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia. View Abstract
Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. View Abstract
Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. View Abstract
Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia. View Abstract
Regulation of fetal hemoglobin synthesis in sickle cell anemia. View Abstract
Investigations of the simian ontogenic switch from fetal to adult hemoglobin at the progenitor cell level. View Abstract
High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. View Abstract
Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin. View Abstract
Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. View Abstract
Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity. View Abstract
Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis. View Abstract
Determination of the hemoglobin F program in human progenitor-derived erythroid cells. View Abstract
Identification of three accessory cell populations in human bone marrow with erythroid burst-promoting properties. View Abstract
Current therapy and new approaches to the treatment of thalassemia major. View Abstract
Regulation of fetal hemoglobin synthesis by cell cycle specific drugs. View Abstract
Regulation of fetal hemoglobin synthesis in the hemoglobinopathies. View Abstract
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. View Abstract
Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. View Abstract
Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. View Abstract
Nutrition classics: the Journal of Clinical Investigation, volume 43, 1964. Iron deficiency anemia associated with an error of iron metabolism in two siblings. View Abstract
Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man. View Abstract
Synthesis of hemoglobin F in adult simian erythroid progenitor-derived colonies. View Abstract
Clinical removal of iron. View Abstract
Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. View Abstract
Heterogeneity of DNA deletion in gamma delta beta-thalassemia. View Abstract
Control of the simian fetal hemoglobin switch at the progenitor cell level. View Abstract
The molecular genetics of thalassemia. View Abstract
Treatment of acute myelogenous leukemia in children and adults. View Abstract
Aplastic and hypoplastic anemia. View Abstract
New approaches to the transfusion management of thalassemia. View Abstract
F-cell regulation. View Abstract
Monocytes do not inhibit peripheral blood erythroid burst forming unit colony formation. View Abstract
Prenatal diagnosis of hemoglobinopathies: the New England approach. View Abstract
Prenatal diagnosis of hemoglobinopathies. View Abstract
Progress in thalassemia research. View Abstract
The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. View Abstract
Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. View Abstract
Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. View Abstract
Antenatal diagnosis of thalassaemia major. View Abstract
Erythroid precursors in congenital hypoplastic (Diamond-Blackfan) anemia. View Abstract
Treatment of iron overload in adults with continuous parenteral desferrioxamine. View Abstract
Continuous subcutaneous administration of deferoxamine in patients with iron overload. View Abstract
Evaluation of continuous desferrioxamine administration in adults with transfusional hemosiderosis. View Abstract
Prenatal diagnosis of hemoglobinopathies: detection of alpha-thalassemia trait and of sickle cell disease in utero. View Abstract
Fetal research: an investigator's view. View Abstract
Prenatal diagnosis of hemoglobinopathies. A review of 15 cases. View Abstract
The thalassemias. View Abstract
Reassessment of the use of desferrioxamine B in iron overload. View Abstract
Prenatal diagnosis of sickle-cell anemia and alpha G Philadelphia. Study of a Fetus also at risk for H b S/beta+-thalassemia. View Abstract
The acute and transient nature of idiopathic immune hemolytic anemia in childhood. View Abstract
Molecular pathology of the thalassemias. View Abstract
The molecular genetics of thalassemia. View Abstract
Expression of the beta-thalassemia gene in the first trimester fetus. View Abstract
Antenatal diagnosis of hemoglobinopathies: social and technical considerations. View Abstract
Hemoglobin Syracuse (alpha2beta2-143(H21)His leads to Pro), a new high-affinity variant detected by special electrophoretic methods. Observations on the auto-oxidation of normal and variant hemoglobins. View Abstract
Thalassemia. View Abstract
Progress in the methodology for antenatal diagnosis of the beta chain hemoglobinopathies. View Abstract
Ethical problems in fetal research. View Abstract
Globin translation in thalassemic bone marrow. View Abstract
In utero diagnosis of hemoglobinopathies. Hemoglobin synthesis in fetal red cells. View Abstract
Relation of beta to gamma synthesis during the first trimester: an approach to prenatal diagnosis of thalassemia. View Abstract
Intrauterine diagnosis of thalassemia. View Abstract
Translational control of hemoglobin synthesis in thalassemic bone marrow. View Abstract
Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation. View Abstract
The mortality of acquired aplastic anemia in children. View Abstract
Equal synthesis of - and -globin chains in erythroid precursors in heterozygous -thalassemia. View Abstract
Energy metabolism in human erythrocytes. II. Effects of glucose depletion. View Abstract
Thalassemia. View Abstract
Changes in fatty acid metabolism after erythrocyte peroxidation: stimulation of a membrane repair process. View Abstract
Gamma-beta thalassemia: a cause of hemolytic disease of the newborn. View Abstract
Oxidant injury of caucasian glucose-6-phosphate dehydrogenase-deficient red blood cells by phagocytosing leukocytes during infection. View Abstract
Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing. View Abstract
Energy metabolism in human erythrocytes. I. Effects of sodium fluoride. View Abstract
Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency. View Abstract
Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants. View Abstract
Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia. View Abstract
Correction of metabolic deficiencies in the leukocytes of patients with chronic granulomatous disease. View Abstract
Mild thalassemia: the result of interactions of alpha and beta thalassemia genes. View Abstract
Mild thalassemia--a guide to therapy. View Abstract
Unbalanced globin chain synthesis in alpha-thalassemia heterozygotes. View Abstract
Globin chain synthesis in the alpha thalassemia syndromes. View Abstract
Failure of nitro blue tetrazolium reduction in the phagocytic vacuoles of leukocytes in chronic granulomatous disease. View Abstract
Influence of hemoglobin precipitation on erythrocyte metabolism in alpha and beta thalassemia. View Abstract
Stages in the incorporation of fatty acids into red blood cells. View Abstract
Erythrocyte production and metabolism in anephric and uremic men. View Abstract
Hemoglobin F and beta thalassemia. View Abstract
THE METABOLISM OF THE INDIVIDUAL C14 LABELED HEMOGLOBINS IN PATIENTS WITH H-THALASSEMIA, WITH OBSERVATIONS ON RADIOCHROMATE BINDING TO THE HEMOGLOBINS DURING RED CELL SURVIVAL. View Abstract
ERYTHROPOIESIS IN ANEPHRIC MAN. View Abstract
THALASSEMIA TRAIT. GENETIC COMBINATIONS OF INCREASED FETAL AND A2 HEMOGLOBINS. View Abstract
IRON DEFICIENCY ANEMIA ASSOCIATED WITH AN ERROR OF IRON METABOLISM IN TWO SIBLINGS. View Abstract
THE TURNOVER OF HEMOGLOBINS A, F, AND A(2) IN THE PERIPHERAL BLOOD OF THREE PATIENTS WITH THALASSEMIA. View Abstract
THE EFFECT OF ANDROGENS ON SOME ASPECTS OF BODY COMPOSITION AND ERYTHROPOISIS IN OCTOGENARIAN MALES. View Abstract
Erythroid cell maturation and hemoglobin synthesis in megaloblastic anemia. View Abstract
The synthesis of heme and globin in the maturing human erythroid cell. View Abstract
Hypochromic anemia and hemochromatosis--response to combined testosterone, pyridoxine, and liver extract therapy. View Abstract
The passage of ammonia across the blood-brain-barrier and its relation to blood pH. View Abstract