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David Breault, MD, PhD
Associate Chief, Division of Endocrinology; Attending Physician, Division of Endocrinology
Associate Professor of Pediatrics, Harvard Medical School
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David Breault, MD, PhD
Associate Chief, Division of Endocrinology; Attending Physician, Division of Endocrinology
Associate Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Trinity College
1990
Hartford
CT
Graduate School
University of Connecticut School of Medicine
1997
Farmington
CT
Medical School
University of Connecticut School of Medicine
1997
Farmington
CT
Internship
Pediatrics
Yale-New Haven Hospital
New Haven
CT
Residency
Pediatrics
Yale-New Haven Hospital
2000
New Haven
CT
Fellowship
Pediatric Endocrinology
Boston Children's Hospital
2003
Boston
MA
Certifications
American Board of Pediatrics (Endocrinology)
Publications
Human mesofluidic intestinal model for studying transport of drug carriers and bacteria through a live mucosal barrier. View Abstract
Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex. View Abstract
The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion. View Abstract
Clonal memory of colitis accumulates and promotes tumor growth. View Abstract
Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma. View Abstract
Clonal memory of colitis accumulates and promotes tumor growth. View Abstract
RELMß sets the threshold for microbiome-dependent oral tolerance. View Abstract
Cataloguing the postnatal small intestinal transcriptome during the first postnatal month. View Abstract
Human Mesofluidic Intestinal Model for Studying Transport of Drug Carriers and Bacteria Through a Live Mucosal Barrier. View Abstract
Response to Letter to the Editor From Hoekstra: "Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis". View Abstract
Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production. View Abstract
Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma. View Abstract
Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. View Abstract
Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes. View Abstract
Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. View Abstract
Faecalibacterium prausnitzii A2-165 metabolizes host- and media-derived chemicals and induces transcriptional changes in colonic epithelium in GuMI human gut microphysiological system. View Abstract
WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. View Abstract
An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii. View Abstract
Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice. View Abstract
Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis. View Abstract
Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens. View Abstract
Direct therapeutic effect of sulfadoxine-pyrimethamine on nutritional deficiency-induced enteric dysfunction in a human Intestine Chip. View Abstract
RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells. View Abstract
Generation of glucocorticoid-producing cells derived from human pluripotent stem cells. View Abstract
Inflammation-induced adrenal dysfunction. View Abstract
An immune-competent human gut microphysiological system enables inflammation-modulation of Faecalibacterium prausnitzii. View Abstract
Calcineurin regulates aldosterone production via dephosphorylation of NFATC4. View Abstract
ß-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer. View Abstract
Stomach-derived human insulin-secreting organoids restore glucose homeostasis. View Abstract
WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. View Abstract
Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells. View Abstract
Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. View Abstract
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. View Abstract
Intrinsic Adrenal TWIK-Related Acid-Sensitive TASK Channel Dysfunction Produces Spontaneous Calcium Oscillations Sufficient to Drive AngII (Angiotensin II)-Unresponsive Hyperaldosteronism. View Abstract
Mislocalization of protein kinase A drives pathology in Cushing's syndrome. View Abstract
Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. View Abstract
Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain. View Abstract
Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease. View Abstract
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips. View Abstract
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. View Abstract
Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. View Abstract
Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. View Abstract
Robust differentiation of human enteroendocrine cells from intestinal stem cells. View Abstract
Triple-Decker Sandwich Cultures of Intestinal Organoids for Long-Term Live Imaging, Uniform Perturbation, and Statistical Sampling. View Abstract
Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure. View Abstract
Coculture of primary human colon monolayer with human gut bacteria. View Abstract
Rosette morphology in zona glomerulosa formation and function. View Abstract
Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells. View Abstract
Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers. View Abstract
False-positive very long-chain fatty acids in a case of autoimmune adrenal insufficiency. View Abstract
Organoid culture system for patient-derived lung metastatic osteosarcoma. View Abstract
Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture. View Abstract
Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-a Induced Injury. View Abstract
Wnt/ß-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. View Abstract
Rapid Prototyping of Multilayer Microphysiological Systems. View Abstract
Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids. View Abstract
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. View Abstract
Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. View Abstract
ß-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. View Abstract
Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium. View Abstract
Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation. View Abstract
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology. View Abstract
Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice. View Abstract
Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. View Abstract
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. View Abstract
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. View Abstract
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. View Abstract
Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. View Abstract
A ZNRF3-dependent Wnt/ß-catenin signaling gradient is required for adrenal homeostasis. View Abstract
The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms. View Abstract
Telomerase Reverse Transcriptase Expression in Mouse Endometrium During Reepithelialization and Regeneration in a Menses-Like Model. View Abstract
Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. View Abstract
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. View Abstract
Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. View Abstract
Adrenocortical development: Lessons from mouse models. View Abstract
The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. View Abstract
Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. View Abstract
Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip. View Abstract
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. View Abstract
PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. View Abstract
JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. View Abstract
Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models. View Abstract
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. View Abstract
A case report of methadone-associated hypoglycemia in an 11-month-old male. View Abstract
The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration. View Abstract
CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. View Abstract
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. View Abstract
Regulation of zonation and homeostasis in the adrenal cortex. View Abstract
An enduring role for quiescent stem cells. View Abstract
Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex. View Abstract
Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. View Abstract
Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues. View Abstract
The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. View Abstract
Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. View Abstract
Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. View Abstract
Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy. View Abstract
Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. View Abstract
Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. View Abstract
Optimised protocols for the identification of the murine cardiac side population. View Abstract
Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. View Abstract
Telomerase expression in the mammalian heart. View Abstract
International workshop: radiation effects on mutation in somatic and germline stem cells. View Abstract
Tales from the crypt: the expanding role of slow cycling intestinal stem cells. View Abstract
Characterization and fate of telomerase-expressing epithelia during kidney repair. View Abstract
Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy. View Abstract
Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative. View Abstract
Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. View Abstract
Regulation of gene expression in the intestinal epithelium. View Abstract
Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. View Abstract
Small intestinal stem cell markers. View Abstract
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. View Abstract
Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. View Abstract
COL1A1 transgene expression in stably transfected osteoblastic cells. Relative contributions of first intron, 3'-flanking sequences, and sequences derived from the body of the human COL1A1 minigene. View Abstract
Role of the first intron in the regulation of the COL 1A1 gene. View Abstract
Novel use for BAL 31 nuclease-generated nested deletions: sequencing from the inside out. View Abstract
Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: structure-activity relations and signal transduction mechanisms. View Abstract
Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells. View Abstract
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