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Daniel Kohane, MD, PhD
Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine
Professor of Anaesthesia, Harvard Medical School
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Daniel Kohane, MD, PhD
Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine
Professor of Anaesthesia, Harvard Medical School
Medical Services
Languages
English
Education
Graduate School
PhD, Physiology
Boston University School of Medicine
1990
Boston
MA
Medical School
Boston University School of Medicine
1990
Boston
MA
Internship
Pediatrics
Boston Children's Hospital
1991
Boston
MA
Residency
Pediatrics/Anesthesia
Boston Combined Residency Program (BCRP)
1995
Boston
MA
Fellowship
Pediatric Critical Care
Boston Children's Hospital
1997
Boston
MA
Certifications
American Board of Pediatrics (Critical Care Medicine)
Publications
Size-dependent Nanoparticle Accumulation In Venous Malformations. View Abstract
Hybrid Nanoparticle-Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications. View Abstract
Reciprocal Interaction with Neutrophils Facilitates Cutaneous Accumulation of Liposomes. View Abstract
Polymeric Prodrugs using Dynamic Covalent Chemistry for Prolonged Local Anesthesia. View Abstract
Injectable hydrogel based on liposome self-assembly for controlled release of small hydrophilic molecules. View Abstract
Correction to "A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose". View Abstract
Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system. View Abstract
Corrigendum to "Selective binding of C-6OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165" [Biomaterials 77(2016) 130-138]. View Abstract
A hybrid nanoparticle-protein hydrogel system for prolonged local anesthesia. View Abstract
Correction to "Enhanced Photothermal Effect of Plasmonic Nanoparticles Coated with Reduced Graphene Oxide". View Abstract
On-Demand Opioid Effect Reversal with an Injectable Light-Triggered Polymer-Naloxone Conjugate. View Abstract
Aromatized liposomes for sustained drug delivery. View Abstract
Methyl-Branched Liposomes as a Depot for Sustained Drug Delivery. View Abstract
Ablation of Venous Malformations by Photothermal Therapy with Intravenous Gold Nanoshells. View Abstract
Enhancement of polymer thermoresponsiveness and drug delivery across biological barriers by addition of small molecules. View Abstract
Squaraine Dye-Sensitized Upconversion with Enhanced Stability and Minimized Aggregation-Caused Quenching. View Abstract
An aptamer-based depot system for sustained release of small molecule therapeutics. View Abstract
Materials for Controlled Release of Local Anesthetics. View Abstract
Benzonatate as a local anesthetic. View Abstract
Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release. View Abstract
Enhancement of Trans-Tympanic Drug Delivery by Pharmacological Induction of Inflammation. View Abstract
Topical Sustained Delivery of Miltefosine Via Drug-Eluting Contact Lenses to Treat Acanthamoeba Keratitis. View Abstract
Enhancement of single upconversion nanoparticle imaging by topologically segregated core-shell structure with inward energy migration. View Abstract
Prolonged Retrobulbar Local Anesthesia of the Cornea Does Not Cause Keratopathy in Mice. View Abstract
A novel, sensitive, and widely accessible besifloxacin quantification method by HPLC-fluorescence: Application to an ocular pharmacokinetic study. View Abstract
Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols. View Abstract
Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel. View Abstract
Dexamethasone-Eluting Contact Lens for the Prevention of Postphotorefractive Keratectomy Scar in a New Zealand White Rabbit Model. View Abstract
Targeting Nanoparticles to Bioengineered Human Vascular Networks. View Abstract
Synergy in Nanomedicine: What It Is Not, and What It Might Be. View Abstract
Permeation of polyethylene glycols across the tympanic membrane. View Abstract
Enhancement of the Mechanical and Drug-Releasing Properties of Poloxamer 407 Hydrogels with Casein. View Abstract
Initial Method for Characterization of Tympanic Membrane Drug Permeability in Human Temporal Bones In Situ. View Abstract
Keeping Nanomedicine on Target. View Abstract
Drug Delivery across Barriers to the Middle and Inner Ear. View Abstract
Local anesthesia enhanced with increasing high-frequency ultrasound intensity. View Abstract
Steroid-eluting contact lenses for corneal and intraocular inflammation. View Abstract
Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy. View Abstract
Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. View Abstract
Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives. View Abstract
Synthesis of Poly(acyclic orthoester)s: Acid-Sensitive Biomaterials for Enhancing Immune Responses of Protein Vaccine. View Abstract
The Duration of Nerve Block from Local Anesthetic Formulations in Male and Female Rats. View Abstract
Transcytosis of Nanomedicine for Tumor Penetration. View Abstract
Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314. View Abstract
Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. View Abstract
Nanoscale systems for local drug delivery. View Abstract
A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose. View Abstract
Topical sustained drug delivery to the retina with a drug-eluting contact lens. View Abstract
Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity. View Abstract
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. View Abstract
Quantile Regression and Its Applications: A Primer for Anesthesiologists. View Abstract
Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. View Abstract
Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media. View Abstract
Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. View Abstract
Nanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia. View Abstract
PLGA-encapsulation of the Pseudomonas aeruginosa PopB vaccine antigen improves Th17 responses and confers protection against experimental acute pneumonia. View Abstract
Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics. View Abstract
Externally triggered patient-controlled local anesthesia. View Abstract
Long-acting liposomal corneal anesthetics. View Abstract
Predicting the tissue depth for remote triggering of drug delivery systems. View Abstract
Antibody-modified conduits for highly selective cytokine elimination from blood. View Abstract
Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane. View Abstract
Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine. View Abstract
BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging. View Abstract
High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade. View Abstract
Ultrasound-triggered liposomes for on-demand local anesthesia. View Abstract
Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin. View Abstract
Light-Emitting Photon-Upconversion Nanoparticles in the Generation of Transdermal Reactive-Oxygen Species. View Abstract
Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength. View Abstract
Ultrasound-triggered local anaesthesia. View Abstract
Getting Drugs Across Biological Barriers. View Abstract
Tetrodotoxin, Epinephrine, and Chemical Permeation Enhancer Combinations in Peripheral Nerve Blockade. View Abstract
Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. View Abstract
Strong tissue glue with tunable elasticity. View Abstract
Multiply repeatable and adjustable on-demand phototriggered local anesthesia. View Abstract
Ultrasensitive Phototriggered Local Anesthesia. View Abstract
Drug delivery systems for prolonged duration local anesthesia. View Abstract
1074: SEVERITY OF HEMODYNAMIC INSTABILITY AROUND HIGH-DOSE VASOACTIVE SYRINGE CHANGES IN THE PICU. View Abstract
Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles. View Abstract
Phototriggered Drug Delivery Using Inorganic Nanomaterials. View Abstract
Core-Shell Nanostars for Multimodal Therapy and Imaging. View Abstract
Treatment of otitis media by transtympanic delivery of antibiotics. View Abstract
Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. View Abstract
Drug delivery, biomaterials and nanomedicine: an interview with Daniel S Kohane. View Abstract
Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance. View Abstract
RNA therapeutics - The potential treatment for myocardial infarction. View Abstract
A Supramolecular Shear-Thinning Anti-Inflammatory Steroid Hydrogel. View Abstract
Extended Release of Native Drug Conjugated in Polyketal Microparticles. View Abstract
Titanium Coating of the Boston Keratoprosthesis. View Abstract
Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. View Abstract
Phototriggered Local Anesthesia. View Abstract
Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes. View Abstract
Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF(165). View Abstract
New Strategies in Cancer Nanomedicine. View Abstract
Ultraviolet light-mediated drug delivery: Principles, applications, and challenges. View Abstract
Photoresponsive nanoparticles for drug delivery. View Abstract
Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting. View Abstract
Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. View Abstract
Nonlinear Optics: NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation (Adv. Healthcare Mater. 8/2015). View Abstract
NIR-triggered drug delivery by collagen-mediated second harmonic generation. View Abstract
Preparation and characterization of SDF-1a-chitosan-dextran sulfate nanoparticles. View Abstract
Aptamer photoregulation in vivo. View Abstract
Clinicians' perspectives on the use of drug-eluting contact lenses for the treatment of glaucoma. View Abstract
A two-component pre-seeded dermal-epidermal scaffold. View Abstract
Prospects for near-infrared technology in remotely triggered drug delivery. View Abstract
Photothermally targeted thermosensitive polymer-masked nanoparticles. View Abstract
Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. View Abstract
Interview with Daniel Kohane. View Abstract
Multivesicular liposomal bupivacaine at the sciatic nerve. View Abstract
Near-infrared-actuated devices for remotely controlled drug delivery. View Abstract
Prevention of peritoneal adhesions using polymeric rheological blends. View Abstract
Photoswitchable nanoparticles for in vivo cancer chemotherapy. View Abstract
Photoactive electrospun fibers for inducing cell death. View Abstract
SDF-1a in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. View Abstract
In vivo performance of a drug-eluting contact lens to treat glaucoma for a month. View Abstract
A photo-triggered layered surface coating producing reactive oxygen species. View Abstract
Biodegradable mesostructured polymer membranes. View Abstract
Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide. View Abstract
Long-lasting antifouling coating from multi-armed polymer. View Abstract
Topical drug formulations for prolonged corneal anesthesia. View Abstract
Microdevices for nanomedicine. View Abstract
A Stiff Injectable Biodegradable Elastomer. View Abstract
Local toxicity from local anesthetic polymeric microparticles. View Abstract
Controlled-release systems in neuropathic pain. View Abstract
Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. View Abstract
Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA). View Abstract
Modular 'click-in-emulsion' bone-targeted nanogels. View Abstract
Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility. View Abstract
Formulations for trans-tympanic antibiotic delivery. View Abstract
Materials to clinical devices: technologies for remotely triggered drug delivery. View Abstract
Prolonged nerve blockade delays the onset of neuropathic pain. View Abstract
Nanocomposite gold-silk nanofibers. View Abstract
Duration and local toxicity of sciatic nerve blockade with coinjected site 1 sodium-channel blockers and quaternary lidocaine derivatives. View Abstract
Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. View Abstract
Shedding light on nanomedicine. View Abstract
The smartest materials: the future of nanoelectronics in medicine. View Abstract
Thermoresponsive nanogels for prolonged duration local anesthesia. View Abstract
Electrospun drug-eluting sutures for local anesthesia. View Abstract
Delivering bioactive molecules as instructive cues to engineered tissues. View Abstract
Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. View Abstract
Novel resonating nanowire arrays function as highly sensitive biosensors. View Abstract
Injectable scaffolds achieve sustained siRNA release for tissue repair. View Abstract
External electric fields trigger drug release from new hydrogel formulation. View Abstract
Toxicogenomic analysis of a sustained release local anesthetic delivery system. View Abstract
An in situ cross-linking hybrid hydrogel for controlled release of proteins. View Abstract
Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels. View Abstract
Nanowired three-dimensional cardiac patches. View Abstract
Hydroxyapatite for keratoprosthesis biointegration. View Abstract
Nanoparticles targeting the infarcted heart. View Abstract
Liposomes for HIV prophylaxis. View Abstract
A prototype antifungal contact lens. View Abstract
Microgels for efficient protein purification. View Abstract
Surface modification and drug delivery for biointegration. View Abstract
Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. View Abstract
Nanotechnology for surgeons. View Abstract
Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release. View Abstract
Drug delivery and translation. View Abstract
Nanotechnological strategies for engineering complex tissues. View Abstract
Remotely triggerable drug delivery systems. View Abstract
Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. View Abstract
A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. View Abstract
Prolonged sensory-selective nerve blockade. View Abstract
Rheological blends for drug delivery. I. Characterization in vitro. View Abstract
Rheological blends for drug delivery. II. Prolongation of nerve blockade, biocompatibility, and in vitro-in vivo correlations. View Abstract
Photo-targeted nanoparticles. View Abstract
Injectable in situ cross-linking hydrogels for local antifungal therapy. View Abstract
Three-dimensional conductive constructs for nerve regeneration. View Abstract
A magnetically triggered composite membrane for on-demand drug delivery. View Abstract
Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. View Abstract
Contact lenses for drug delivery. View Abstract
Prolonged duration local anesthesia with minimal toxicity. View Abstract
A drug-eluting contact lens. View Abstract
Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. View Abstract
Effect of chemical permeation enhancers on nerve blockade. View Abstract
Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum. View Abstract
The biocompatibility of mesoporous silicates. View Abstract
Microparticles for inhalational delivery of antipseudomonal antibiotics. View Abstract
Polymeric biomaterials in tissue engineering. View Abstract
Local myotoxicity from sustained release of bupivacaine from microparticles. View Abstract
Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. View Abstract
Antifungal hydrogels. View Abstract
Polymers in the prevention of peritoneal adhesions. View Abstract
Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model. View Abstract
Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide. View Abstract
Photocrosslinkable hydrogel for myocyte cell culture and injection. View Abstract
In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions. View Abstract
Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions. View Abstract
Microparticles and nanoparticles for drug delivery. View Abstract
Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone. View Abstract
Tetrodotoxin for prolonged local anesthesia with minimal myotoxicity. View Abstract
Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. View Abstract
The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives. View Abstract
Peritoneal application of chitosan and UV-cross-linkable chitosan. View Abstract
Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures. View Abstract
In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model. View Abstract
A photolithographic method to create cellular micropatterns. View Abstract
Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. View Abstract
Tissue injury from tricyclic antidepressants used as local anesthetics. View Abstract
Prolonged duration local anesthesia with lipid-protein-sugar particles containing bupivacaine and dexamethasone. View Abstract
Complex coacervates for thermally sensitive controlled release of flavor compounds. View Abstract
Engineering vascularized skeletal muscle tissue. View Abstract
Case records of the Massachusetts General Hospital. Case 16-2005. A nine-year-old girl with headaches and hypertension. View Abstract
In vivo evaluation of tetrahedral amorphous carbon. View Abstract
Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization. View Abstract
Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects. View Abstract
pH-triggered microparticles for peptide vaccination. View Abstract
Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid. View Abstract
Site 1 sodium channel blockers prolong the duration of sciatic nerve blockade from tricyclic antidepressants. View Abstract
Microparticulate formulations for the controlled release of interleukin-2. View Abstract
Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. View Abstract
pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. View Abstract
Local anesthetics inhibit uterine activity in vitro. Possible application on preterm labor prevention and treatment. View Abstract
Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. View Abstract
Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. View Abstract
Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. View Abstract
Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. View Abstract
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. View Abstract
High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. View Abstract
Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. View Abstract
Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine. View Abstract
The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. View Abstract
Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. View Abstract
Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. View Abstract
A re-examination of tetrodotoxin for prolonged duration local anesthesia. View Abstract
Stress-induced proteins in aortic smooth muscle cells and aorta of hypertensive rats. View Abstract
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