Da Zhang, PhD, DABR

Program Director, Diagnostic Medical Physics
Assistant Professor of Radiology, Harvard Medical School
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Da Zhang, PhD, DABR

Da Zhang, PhD, DABR

Program Director, Diagnostic Medical Physics
Assistant Professor of Radiology, Harvard Medical School

Medical Services

Languages
Chinese
English
Education
Graduate School
University of Oklahoma
2009
Norman
OK
Professional History

Dr. Da Zhang earned his PhD in Electrical and Computer Engineering from the University of Oklahoma. He received clinical training in diagnostic medical physics at Massachusetts General Hospital for five years and became a board-certified medical physicist there. Dr. Zhang spent the next six years of his career at the Beth Israel Deaconess Medical Center and was promoted to Assistant Professor of Radiology at Harvard Medical School. Dr Zhang joined Boston Children’s Hospital Radiology in 2020, his duty includes overseeing the operations of the diagnostic medical physics team in the Radiology department, as well as directing the joint diagnostic and nuclear medicine medical physics residency program. His clinical duties include medical imaging physics coverage for the radiology clinics, as well as training and consultation for physicians and clinical staff. His team is responsible for optimizing equipment performance, organizing quality control, control of radiation hazards, as well as the research and development in imaging physics and radiology informatics.

Publications

Mapping rare protein-coding variants on multi-organ imaging traits. View Abstract
Author Correction: Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. View Abstract
Sub-mSv CT for pediatric and young adult hip imaging: a low-radiation-dose alternative to pelvic radiography. View Abstract
Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways. View Abstract
Novel methods for temporally varying gene identification in longitudinal studies reveal bleeding and clotting pathway activation caused by blood draws. View Abstract
Celastrol derivatives ameliorate arthritis in AIA rats via modulating calcium signaling. View Abstract
Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks. View Abstract
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. View Abstract
Mapping rare protein-coding variants on multi-organ imaging traits. View Abstract
Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum. View Abstract
Advancing quantitative PCR with color cycle multiplex amplification. View Abstract
Microsatellite Instability Detection in Cancer: A Multiplex qPCR Approach that Obviates the Need for Matching Normal Samples. View Abstract
Two-dimensional molybdenum ditelluride waveguide-integrated near-infrared photodetector. View Abstract
Age-specific Dose Catalog for Diagnostic Fluoroscopy and Fluoroscopically Guided Interventional Procedures from a Pediatric Hospital. View Abstract
A Call for Action on Patient Communication Efforts in Pediatric Radiology. View Abstract
Reconsidering pregnancy screening policies for minors: patient-specific estimate of fetus and effective dose for potentially pregnant minors undergoing optimized dose CT of the pelvis. View Abstract
The added value of skeletal surveys in the initial evaluation of children diagnosed with Langerhans cell histiocytosis in the era of staging 18 F-FDG PET/CT: A retrospective study. View Abstract
Hip Imaging in Children With Cerebral Palsy: Estimation and Intrapatient Comparison of Patient-Specific Radiation Doses of Low-Dose CT and Radiography. View Abstract
Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors. View Abstract
Spider Web-like Flexible Tactile Sensor for Pressure-Strain Simultaneous Detection. View Abstract
Development of a novel framework to evaluate the localization accuracy of tomosynthesis-guided breast biopsy units. View Abstract
Artificial intelligence and computational pathology. View Abstract
Minimizing Radiation Dose Outliers Through Systematic Analysis, Computed Tomography Technologist Education, and Standardized System Solutions. View Abstract
Long-term outcome of endovascular therapy for acute basilar artery occlusion. View Abstract
Single-Energy Retrospective Metal Artifact Reduction Using Adaptive Thresholding for Metal Implants in the Abdomen and Pelvis. View Abstract
Estimating patient water equivalent diameter from CT localizer images - A longitudinal and multi-institutional study of the stability of calibration parameters. View Abstract
Protein expression profiles and clinicopathologic characteristics associate with gastric cancer survival. View Abstract
Machine Learning for Medical Imaging. View Abstract
Comparative Dose of Contrast-Enhanced Spectral Mammography (CESM), Digital Mammography, and Digital Breast Tomosynthesis. View Abstract
A new method for CT dose estimation by determining patient water equivalent diameter from localizer radiographs: Geometric transformation and calibration methods using readily available phantoms. View Abstract
The expression of serum sEGFR, sFlt-1, sEndoglin and PLGF in preeclampsia. View Abstract
Slit2-Robo2 signaling modulates the fibrogenic activity and migration of hepatic stellate cells. View Abstract
Antiproliferative effects of the CDK6 inhibitor PD0332991 and its effect on signaling networks in gastric cancer cells. View Abstract
Serum protein marker panel for predicting preeclampsia. View Abstract
The screening and analysis of protein signatures and signaling associated with chemoresistance based on Protein Pathway Array technology in gastric cancer. View Abstract
Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications. View Abstract
Point Organ Radiation Dose in Abdominal CT: Effect of Patient Off-Centering in an Experimental Human Cadaver Study. View Abstract
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. View Abstract
Metal implants on CT: comparison of iterative reconstruction algorithms for reduction of metal artifacts with single energy and spectral CT scanning in a phantom model. View Abstract
The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy. View Abstract
Protein Profiling of Bladder Urothelial Cell Carcinoma. View Abstract
Breast cancer molecular subtypes: from TNBC to QNBC. View Abstract
Protein profiling of alpha-fetoprotein producing gastric adenocarcinoma. View Abstract
Serum biomarker panels for diagnosis of gastric cancer. View Abstract
Clinical Outcomes in Patients with Recurrent or Metastatic Human Papilloma Virus-positive Head and Neck Cancer. View Abstract
Comparison of Measured and Estimated CT Organ Doses for Modulated and Fixed Tube Current:: A Human Cadaver Study. View Abstract
A new technique to characterize CT scanner bow-tie filter attenuation and applications in human cadaver dosimetry simulations. View Abstract
Induction and contribution of beta platelet-derived growth factor signalling by hepatic stellate cells to liver regeneration after partial hepatectomy in mice. View Abstract
A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection. View Abstract
CT dose equilibration and energy absorption in polyethylene cylinders with diameters from 6 to 55 cm. View Abstract
BRD4 inhibitor inhibits colorectal cancer growth and metastasis. View Abstract
Signaling proteins and pathways affected by flavonoids in leukemia cells. View Abstract
Data-driven CT protocol review and management—experience from a large academic hospital. View Abstract
Protein profiling of preeclampsia placental tissues. View Abstract
Electronic cleansing in fecal-tagging dual-energy CT colonography based on material decomposition and virtual colon tagging. View Abstract
Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer. View Abstract
Longitudinal dose distribution and energy absorption in PMMA and water cylinders undergoing CT scans. View Abstract
IL-1ß induces IL-6 production in retinal Müller cells predominantly through the activation of p38 MAPK/NF-?B signaling pathway. View Abstract
Improved photoelectrical properties of n-ZnO/p-Si heterojunction by inserting an optimized thin Al2O3 buffer layer. View Abstract
A study of the short- to long-phantom dose ratios for CT scanning without table translation. View Abstract
In vitro dose measurements in a human cadaver with abdomen/pelvis CT scans. View Abstract
Novel lead-free drape applied to the X-ray detector protects against scatter radiation in the angiography suite. View Abstract
Biomarkers for bladder cancer management: present and future. View Abstract
Detection of genetic variations in coagulopathy-related genes using ramified rolling circle amplification. View Abstract
Protein profiling of Helicobacter pylori-associated gastric cancer. View Abstract
Anti-tumor activity of the X-linked inhibitor of apoptosis (XIAP) inhibitor embelin in gastric cancer cells. View Abstract
A parameterization method and application in breast tomosynthesis dosimetry. View Abstract
A method to acquire CT organ dose map using OSL dosimeters and ATOM anthropomorphic phantoms. View Abstract
Calculations of two new dose metrics proposed by AAPM Task Group 111 using the measurements with standard CT dosimetry phantoms. View Abstract
Workload and transmission data for the installation of a digital breast tomosynthesis system. View Abstract
Aberrant expression of signaling proteins in essential thrombocythemia. View Abstract
Monte Carlo assessment of CT dose equilibration in PMMA and water cylinders with diameters from 6 to 55 cm. View Abstract
Dual-energy index value of luminal air in fecal-tagging computed tomography colonography: findings and impact on electronic cleansing. View Abstract
Image performance evaluation of a cone beam O-arm imaging system. View Abstract
Protein predictive signatures for lymph node metastasis of gastric cancer. View Abstract
Virtual monochromatic reconstruction of dual-energy unenhanced head CT at 65-75 keV maximizes image quality compared with conventional polychromatic CT. View Abstract
Equations for CT dose calculations on axial lines based on the principle of symmetry. View Abstract
Transmission of broad W/Rh and W/Al (target/filter) x-ray beams operated at 25-49 kVp through common shielding materials. View Abstract
X-ray spectral measurements for tungsten-anode from 20 to 49 kVp on a digital breast tomosynthesis system. View Abstract
Estimation of the weighted CTDI(8) for multislice CT examinations. View Abstract
Cranial CT with adaptive statistical iterative reconstruction: improved image quality with concomitant radiation dose reduction. View Abstract
Protein signatures for classification and prognosis of gastric cancer a signaling pathway-based approach. View Abstract
A practical approach to estimate the weighted CT dose index over an infinite integration length. View Abstract
Automated extraction of radiation dose information from CT dose report images. View Abstract
Objective characterization of GE discovery CT750 HD scanner: gemstone spectral imaging mode. View Abstract
Sensitivity analysis of a geometric calibration method using projection matrices for digital tomosynthesis systems. View Abstract
A generic geometric calibration method for tomographic imaging systems with flat-panel detectors--a detailed implementation guide. View Abstract
A comparison of iterative algorithms and a mixed approach for in-line x-ray phase retrieval. View Abstract
Step by step analysis toward optimal MTF algorithm using an edge test device. View Abstract
A convenient alignment approach for x-ray imaging experiments based on laser positioning devices. View Abstract
Preliminary feasibility study of an in-line phase contrast X-ray imaging prototype. View Abstract
DQE analysis on a dual detector phase x-ray imaging system. View Abstract
Impact of additive noise on system performance of a digital X-ray imaging system. View Abstract
Intratumoral delivery of adenovirus-mediated interleukin-12 gene in mice with metastatic cancer in the liver. View Abstract