Colin Sieff, MB, BCh
Attending Physician, Cancer and Blood Disorders Center
Associate Professor of Pediatrics, Harvard Medical School
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Colin Sieff, MB, BCh
Attending Physician, Cancer and Blood Disorders Center
Associate Professor of Pediatrics, Harvard Medical School
Medical Services
Education
Graduate School
University of Witwatersrand
1968
Johannesburg
South Africa
Publications
A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies. View Abstract
L-leucine improves anemia and growth in patients with transfusion-dependent Diamond-Blackfan anemia: Results from a multicenter pilot phase I/II study from the Diamond-Blackfan Anemia Registry. View Abstract
TGFß signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome. View Abstract
Aberrant splicing contributes to severe a-spectrin-linked congenital hemolytic anemia. View Abstract
A Successful Collaborative Approach to the Perioperative Management After Hip Arthroscopy of a Patient with Heterozygous Prothrombin G20210A Mutation: A Case Report. View Abstract
The Genetic Landscape of Diamond-Blackfan Anemia. View Abstract
The Genetic Landscape of Diamond-Blackfan Anemia. View Abstract
Acquired and Inherited Bone Marrow Failure Syndromes. View Abstract
Introduction to Acquired and Inherited Bone Marrow Failure. View Abstract
The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2. View Abstract
Critical Issues in Diamond-Blackfan Anemia and Prospects for Novel Treatment. View Abstract
Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. View Abstract
Characteristic peripheral blood smear findings in disorders of cobalamin metabolism. View Abstract
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. View Abstract
Altered translation of GATA1 in Diamond-Blackfan anemia. View Abstract
Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). View Abstract
Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. View Abstract
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. View Abstract
Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. View Abstract
Genetic variants in the noncoding region of RPS19 gene in Diamond-Blackfan anemia: potential implications for phenotypic heterogeneity. View Abstract
Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. View Abstract
Pathogenesis of the erythroid failure in Diamond Blackfan anaemia. View Abstract
Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. View Abstract
Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. View Abstract
Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. View Abstract
Recent insights into the pathogenesis of Diamond-Blackfan anaemia. View Abstract
Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia. View Abstract
Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia. View Abstract
An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray. View Abstract
Accumulation of an intron-retained mRNA for granulocyte macrophage-colony stimulating factor receptor common beta chain in neutrophils of myelodysplastic syndromes. View Abstract
RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations. View Abstract
Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. View Abstract
Congenital bone marrow failure syndromes. View Abstract
Diamond-Blackfan anemia. View Abstract
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. View Abstract
Maturation and lineage-specific expression of the coxsackie and adenovirus receptor in hematopoietic cells. View Abstract
Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level. View Abstract
Pure red-cell aplasia. View Abstract
One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus. View Abstract
Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes. View Abstract
Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer. View Abstract
Identification of distinct elements of the stromal microenvironment that control human hematopoietic stem/progenitor cell growth and differentiation. View Abstract
Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. View Abstract
Diamond-Blackfan anemia. View Abstract
The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. View Abstract
Preapheresis peripheral blood CD34+ mononuclear cell counts as predictors of progenitor cell yield. View Abstract
Selective transgene expression for detection and elimination of contaminating carcinoma cells in hematopoietic stem cell sources. View Abstract
The beta c component of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3)/IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression. View Abstract
A constitutively activated chimeric cytokine receptor confers factor-independent growth in hematopoietic cell lines. View Abstract
Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. View Abstract
Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor. View Abstract
The collection and evaluation of peripheral blood progenitor cells sufficient for repetitive cycles of high-dose chemotherapy support. View Abstract
Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor. View Abstract
Clonality in juvenile chronic myelogenous leukemia. View Abstract
Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit. View Abstract
Hematopoietic cell proliferation and differentiation. View Abstract
Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem cells in liquid culture. View Abstract
[Regulation of hematopoiesis]. View Abstract
Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domains of the alpha and beta subunits. View Abstract
In vitro enhancement of erythropoiesis by steel factor in Diamond-Blackfan anemia and treatment of other congenital cytopenias with recombinant interleukin 3/granulocyte-macrophage colony stimulating factor. View Abstract
A low-affinity human granulocyte-macrophage colony-stimulating factor/murine erythropoietin hybrid receptor functions in murine cell lines. View Abstract
The production of steel factor mRNA in Diamond-Blackfan anaemia long-term cultures and interactions of steel factor with erythropoietin and interleukin-3. View Abstract
Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. View Abstract
Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease. View Abstract
New hats for hematopoietic hormones. View Abstract
A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. View Abstract
Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. View Abstract
A phase I/II trial of recombinant granulocyte-macrophage colony-stimulating factor for children with aplastic anemia. View Abstract
Biology and clinical aspects of the hematopoietic growth factors. View Abstract
Hematopoiesis in vitro coexists with natural killer lymphocytes. View Abstract
Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells. View Abstract
Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. View Abstract
Combinations of recombinant colony-stimulating factors are required for optimal hematopoietic differentiation in serum-deprived culture. View Abstract
Interleukin-1, tumor necrosis factor, and the production of colony-stimulating factors by cultured mesenchymal cells. View Abstract
The biology of the colony stimulating factors. View Abstract
Human colony-stimulating factors and stromal cell function. View Abstract
Combinations of purified recombinant colony-stimulating factors are required for optimal hematopoietic differentiation. View Abstract
The sources and actions of the human colony stimulating factors. View Abstract
Decreased hematopoietic accessory cell function following bone marrow transplantation. View Abstract
Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3. View Abstract
Differential binding of erythroid and myeloid progenitors to fibroblasts and fibronectin. View Abstract
Hematopoietic growth factors. View Abstract
Gamma-interferon alters globin gene expression in neonatal and adult erythroid cells. View Abstract
The production of hematopoietic growth factors by endothelial accessory cells. View Abstract
The role of endothelial cells in hematopoiesis. View Abstract
The biological activities and uses of recombinant granulocyte-macrophage and multi-colony stimulating factors. View Abstract
Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. View Abstract
Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes. View Abstract
Stromal cell-associated erythropoiesis. View Abstract
Isolation of a human stromal cell strain secreting hemopoietic growth factors. View Abstract
Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T cell removal using CAMPATH-I monoclonal antibody and E-rosetting. View Abstract
Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin. View Abstract
Membrane antigen expression during hemopoietic differentiation. View Abstract
Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin. View Abstract
Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity. View Abstract
Selective expression of cell surface antigens on human haemopoietic progenitor cells. View Abstract
Pure red cell aplasia. View Abstract
Monoclonal antiglycophorin as a probe for erythroleukemias. View Abstract
Allogeneic bone-marrow transplantation in infantile malignant osteopetrosis. View Abstract
Antigen expression on normal and leukaemic erythroid precursors. View Abstract
Acute myeloid leukaemia in childhood: treatment in the United Kingdom. View Abstract
Changes in cell surface antigen expression during hemopoietic differentiation. View Abstract
Cellular immune defects to Epstein-Barr virus-determined antigens in young males. View Abstract
Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by clinical, virological, and immunopathological studies. View Abstract
Monosomy 7 in childhood: a myeloproliferative disorder. View Abstract
Comparative antigenic phenotypes of normal and leukemic hemopoietic precursor cells analysed with a "library" of monoclonal antibodies. View Abstract
Acquired pure red-cell aplasia associated with an increase of T cells bearing receptors for the Fc of IgG. View Abstract
Expression of cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation. View Abstract
Mapping cell surface antigen expression of haemopoietic progenitor cells using monoclonal antibodies. View Abstract
Familial myelofibrosis. View Abstract
The response of a child with primary sideroblastic anemia to cyclophosphamide. View Abstract
In vitro tests for distinguishing possible immune-mediated aplastic anemia from transfusion-induced sensitization. View Abstract