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Brent R. Weil, MD, MPH
Pediatric Surgeon, Department of Surgery; Associate Program Director, Pediatric Surgery Fellowship
Associate Professor of Surgery, Harvard Medical School
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Brent R. Weil, MD, MPH
Pediatric Surgeon, Department of Surgery; Associate Program Director, Pediatric Surgery Fellowship
Associate Professor of Surgery, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
The Ohio State University School of Medicine
2006
Columbus
OH
Internship
General Surgery
Indiana University School of Medicine
2007
Indianapolis
IN
Residency
Surgery
Indiana University School of Medicine
2012
Indianapolis
IN
Fellowship
Pediatric General Surgery
Boston Children's Hospital
2015
Boston
MA
Certifications
American Board of Surgery (General)
American Board of Surgery (Pediatric Surgery)
Professional History
Dr. Weil's clinical interests are pediatric surgical oncology, inflammatory bowel disease, pediatric general surgery, and minimally invasive surgery.
Publications
Prevalence, Characteristics, and Management of Pancreatic Tumors Among Children With Tuberous Sclerosis Complex. View Abstract
Prevalence of carotid ultrasound screening in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. View Abstract
Poverty, race, ethnicity, and survival in pediatric nonmetastatic osteosarcoma: a Children's Oncology Group report. View Abstract
Current surgical approach: Extracranial malignant germ cell tumors. View Abstract
Long-term outcomes among survivors of childhood osteosarcoma: A report from the Childhood Cancer Survivor Study (CCSS). View Abstract
Impact of risk-based therapy on late morbidity and mortality in neuroblastoma survivors: a report from the Childhood Cancer Survivor Study. View Abstract
Biallelic EPCAM deletions induce tissue-specific DNA repair deficiency and cancer predisposition. View Abstract
Critical elements of pediatrics sacrococcygeal germ cell tumor surgery. View Abstract
Critical elements in the operative management of pediatric malignant ovarian germ cell tumors. View Abstract
Characterizing Lymphovascular Invasion in Pediatric and Adolescent Malignant Ovarian Nongerminomatous Germ Cell Tumors: A Report from the Children's Oncology Group. View Abstract
A single-institution pediatric and young adult interventional oncology collaborative: Novel therapeutic options for relapsed/refractory solid tumors. View Abstract
Lymphatic Embolization for the Management of Post-operative Chyle Leaks Following Solid Tumor Resection in Pediatric Patients. View Abstract
Efficacy and Safety of Tacrolimus or Infliximab Therapy in Children and Young Adults With Acute Severe Colitis. View Abstract
Cumulative burden of late, major surgical intervention in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study (CCSS) cohort. View Abstract
Development and Validation of a Prediction Model for Kidney Failure in Long-Term Survivors of Childhood Cancer. View Abstract
Late Health Outcomes Among Survivors of Wilms Tumor Diagnosed Over Three Decades: A Report From the Childhood Cancer Survivor Study. View Abstract
Long-Term Morbidity and Mortality Among Survivors of Neuroblastoma Diagnosed During Infancy: A Report From the Childhood Cancer Survivor Study. View Abstract
What Are Risk Factors for and Outcomes of Late Amputation After Treatment for Lower Extremity Sarcoma: A Childhood Cancer Survivor Study Report. View Abstract
Pattern and predictors of sites of relapse in neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project. View Abstract
Complications associated with totally implantable access ports in children less than 1 year of age. View Abstract
Belzutifan, a Potent HIF2a Inhibitor, in the Pacak-Zhuang Syndrome. View Abstract
Interdisciplinary Management of Malignant Ovarian Tumors in the Pediatric and Adolescent Age Group. View Abstract
Where Did the Blood Go?: A Meckel's Diverticulum Bleed Without Hematochezia or Melena. View Abstract
Late-onset kidney failure in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. View Abstract
Sex-Specific Associations Between Chemotherapy, Chronic Conditions, and Neurocognitive Impairment in Acute Lymphoblastic Leukemia Survivors: A Report From the Childhood Cancer Survivor Study. View Abstract
Safety of Surgical Fertility Preservation Procedures in Children Prior to Hematopoietic Stem Cell Transplant. View Abstract
Neonatal Malignant Disorders: Germ Cell Tumors. View Abstract
Management of Germ Cell Tumors in Pediatric Patients. View Abstract
Epidemiology of abdominal wall and groin hernia repairs in children. View Abstract
Opioid Prescription Patterns for Children Following Laparoscopic Appendectomy. View Abstract
The use of interval-compressed chemotherapy with the addition of vincristine, irinotecan, and temozolomide for pediatric patients with newly diagnosed desmoplastic small round cell tumor. View Abstract
Incidence of and risk factors for late cholecystectomy in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. View Abstract
Comparison of Military Health System Data Repository and American College of Surgeons National Surgical Quality Improvement Program-Pediatric. View Abstract
Late-onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. View Abstract
Therapeutic Impact and Complications Associated with Surgical Lung Biopsy after Allogeneic Hematopoietic Stem Cell Transplantation in Children. View Abstract
Multicenter pre-operative assessment of pediatric ovarian malignancy. View Abstract
Fertility and hormone preservation and restoration for female children and adolescents receiving gonadotoxic cancer treatments: A systematic review. View Abstract
Update on Wilms tumor. View Abstract
Update on neuroblastoma. View Abstract
Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. View Abstract
Incidence and risk factors for sepsis after childhood splenectomy. View Abstract
New Agents, Emerging Late Effects, and the Development of Precision Survivorship. View Abstract
Late Infection-Related Mortality in Asplenic Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. View Abstract
Testicular atrophy following inguinal hernia repair in children. View Abstract
Hernia recurrence following inguinal hernia repair in children. View Abstract
Primary laparoscopic gastrojejunostomy tubes as a feeding modality in the pediatric population. View Abstract
The role of thymectomy in the treatment of juvenile myasthenia gravis: a systematic review. View Abstract
Autoamputation of the Appendix Presenting as a Calcified Abdominal Mass Following Necrotizing Enterocolitis. View Abstract
Safety and cost-effectiveness of port removal outside of the operating room among pediatric patients. View Abstract
Autoamputation of the appendix presenting as a calcified abdominal mass following necrotizing enterocolitis. View Abstract
Commentary on "Simultaneous Resection of High-risk Liver Tumors and Pulmonary Metastases in Children". View Abstract
Prospective determination of percutaneous endoscopic gastrostomy complication rates in children: still a safe procedure. View Abstract
The jury is still out: changes in gastroschisis management over the last decade are associated with both benefits and shortcomings. View Abstract
TGF-a equalizes age disparities in stem cell-mediated cardioprotection. View Abstract
Pretreating mesenchymal stem cells with interleukin-1ß and transforming growth factor-ß synergistically increases vascular endothelial growth factor production and improves mesenchymal stem cell-mediated myocardial protection after acute ischemia. View Abstract
Predictive value of response to steroid therapy on response to splenectomy in children with immune thrombocytopenic purpura. View Abstract
Transforming growth factor-a enhances stem cell-mediated postischemic myocardial protection. View Abstract
Intravenous infusion of mesenchymal stem cells is associated with improved myocardial function during endotoxemia. View Abstract
Pretreatment with intracoronary mimosine improves postischemic myocardial functional recovery. View Abstract
Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1a and VEGF production and improves functional recovery after acute ischemia/reperfusion. View Abstract
Transforming growth factor-alpha does not protect myocardium during acute ischemia/reperfusion. View Abstract
Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway. View Abstract
Intracoronary mesenchymal stem cells promote postischemic myocardial functional recovery, decrease inflammation, and reduce apoptosis via a signal transducer and activator of transcription 3 mechanism. View Abstract
IL-6 and TGF-a costimulate mesenchymal stem cell vascular endothelial growth factor production by ERK-, JNK-, and PI3K-mediated mechanisms. View Abstract
Female stem cells are superior to males in preserving myocardial function following endotoxemia. View Abstract
TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection. View Abstract
Surgical treatment of atrial fibrillation: the time is now. View Abstract
Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury. View Abstract
The phosphoinositide-3 kinase survival signaling mechanism in sepsis. View Abstract
Ablation of TNF-alpha receptors influences mesenchymal stem cell-mediated cardiac protection against ischemia. View Abstract
Exogenous high-mobility group box 1 improves myocardial recovery after acute global ischemia/reperfusion injury. View Abstract
The immunomodulatory properties of mesenchymal stem cells: implications for surgical disease. View Abstract
Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury. View Abstract
Mesenchymal stem cells attenuate myocardial functional depression and reduce systemic and myocardial inflammation during endotoxemia. View Abstract
Pericardial effusion and cardiac tamponade associated with central venous catheters in children: an uncommon but serious and treatable condition. View Abstract
Optimizing stem cell function for the treatment of ischemic heart disease. View Abstract
TNF receptor 2, not TNF receptor 1, enhances mesenchymal stem cell-mediated cardiac protection following acute ischemia. View Abstract
Postinfarct intramyocardial injection of mesenchymal stem cells pretreated with TGF-alpha improves acute myocardial function. View Abstract
Bleeding risk for surgical dialysis procedures in children with hemolytic uremic syndrome. View Abstract
Gender dimorphisms in progenitor and stem cell function in cardiovascular disease. View Abstract
Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury. View Abstract
Preconditioning mesenchymal stem cells with transforming growth factor-alpha improves mesenchymal stem cell-mediated cardioprotection. View Abstract
Cell-based therapy for ischemic heart disease: a clinical update. View Abstract
What's new in Shock, October 2009? View Abstract
Proinflammatory cytokine effects on mesenchymal stem cell therapy for the ischemic heart. View Abstract
MEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells. View Abstract
Proinflammatory stem cell signaling in cardiac ischemia. View Abstract
Acute postischemic treatment with estrogen receptor-alpha agonist or estrogen receptor-beta agonist improves myocardial recovery. View Abstract
Mesenchymal stem cells enhance the viability and proliferation of human fetal intestinal epithelial cells following hypoxic injury via paracrine mechanisms. View Abstract
Animal models of myocardial and vascular injury. View Abstract
Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1alpha mediates estrogen receptor-alpha-induced mesenchymal stem cell vascular endothelial growth factor production. View Abstract
Stem cells in sepsis. View Abstract
MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells. View Abstract
Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion. View Abstract
High glucose concentration in cell culture medium does not acutely affect human mesenchymal stem cell growth factor production or proliferation. View Abstract
Role of tumor necrosis factor receptor 1 in sex differences of stem cell mediated cardioprotection. View Abstract
Estrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia. View Abstract
Exogenous estrogen rapidly attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction. View Abstract
Nitric oxide suppresses the secretion of vascular endothelial growth factor and hepatocyte growth factor from human mesenchymal stem cells. View Abstract
Proestrus female rats are more resistant to right ventricular pressure overload. View Abstract
Spontaneous duodenal hematoma: a rare cause of upper gastrointestinal tract obstruction. View Abstract
The effects of estrogen on pulmonary artery vasoreactivity and hypoxic pulmonary vasoconstriction: potential new clinical implications for an old hormone. View Abstract
Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production. View Abstract
[Results of 25 years of kidney transplantation]. View Abstract
Comparison between allogeneic and xenogeneic lymphocyte reactivity. View Abstract
Low prevalence of antibodies to hepatitis C virus among adult patients with idiopathic membranoproliferative type I glomerulonephritis in France. View Abstract
[Etiologies of chronic polyarthritis in Lomé (Togo)]. View Abstract
Split tolerance in chimeric GVH mice. View Abstract
Proteinuria selectivity index--prognostic value in lipoid nephrosis and related diseases. View Abstract
[Cholelithiasis: therapeutic strategy. Report from an European concensus conference]. View Abstract
IgA antigliadin antibodies as a possible marker for IgA mesangial glomerulonephritis in adults with primary glomerulonephritis. View Abstract
Locations