Arin K. Greene, MD, MMSc
Vascular Anomalies and Pediatric Plastic Surgery Chair; Director Lymphedema Program; Laboratory Director
Professor, Harvard Medical School
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Arin K. Greene, MD, MMSc
Vascular Anomalies and Pediatric Plastic Surgery Chair; Director Lymphedema Program; Laboratory Director
Professor, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
University of Chicago
1993
Chicago
IL
Graduate School
Translational Research, MMsC
Harvard Medical School
2003
Boston
MA
Medical School
University of Illinois College of Medicine
1997
Chicago
IL
Residency
General Surgery
Beth Israel Deaconess Medical Center
2000
Boston
MA
Residency
Plastic Surgery
Beth Israel Deaconess Medical Center
2005
Boston
MA
Residency
Chief Resident; Plastic Surgery
Beth Israel Deaconess Medical Center
2006
Boston
MA
Fellowship
Angiogenesis Research
Boston Children's Hospital/Harvard Medical School
2003
Boston
MA
Fellowship
Craniofacial/Pediatric Plastic Surgery
Boston Children's Hospital
2007
Boston
MA
Certifications
American Board of Plastic Surgery (General)
Professional History
Arin K. Greene, MD, MMSc is a plastic surgeon at Boston Children’s Hospital. Dr. Greene is the Vascular Anomalies and Pediatric Plastic Surgery Endowed Chair and Professor of Surgery at Harvard Medical School. He is a member of the Vascular Anomalies Center, Director of the Lymphedema Program, and Director of the Department of Plastic and Oral Surgery Research Laboratory. During his residency, he completed a Howard Hughes Research Fellowship studying vascular biology in the laboratory of Judah Folkman at Boston Children’s Hospital. During this time, he earned a Masters in Medical Sciences Degree in translational research focused on vascular anomalies. Dr. Greene is past president of the American Association of Pediatric Plastic Surgeons and edited a textbook on pediatric plastic surgery (Pediatric Plastic and Reconstructive Surgery, Thieme Publishing, 2018). His practice is focused on vascular anomalies, lymphedema, ear malformations, breast disorders, pigmented nevi, and general pediatric plastic surgery. Dr. Greene also operates on adults with conditions in his areas of expertise at the Beth Israel Deaconess Medical Center. Dr. Greene’s laboratory is funded by the National Institutes of Health and his major research goal is to develop drugs to treat vascular malformations.
Publications
MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations. View Abstract
An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q. View Abstract
Congenital Lower Extremity. View Abstract
Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema. View Abstract
The Lymphedematous Limb as a Donor Site for Breast Fat Grafting. View Abstract
Understanding Hematoma Risk: Study of Patient and Perioperative Factors in a Large Cohort of Young Women Undergoing Reduction Mammaplasty. View Abstract
MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome. View Abstract
PPAR? agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRa+ mesenchymal cells. View Abstract
Papillary Hemangioma Harbors Somatic GNA11 and GNAQ Mutations. View Abstract
Game Changers: Plastic and Reconstructive Surgery Innovations of the Last 100 Years. View Abstract
Arteriovenous malformation Map2k1 mutation affects vasculogenesis. View Abstract
Power-assisted Liposuction for Lymphedema: A Cost-utility Analysis. View Abstract
Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice. View Abstract
How we approach lymphedema in the pediatric population. View Abstract
Lymphedema and Obesity. View Abstract
How we approach lymphedema in the pediatric population. View Abstract
Parkes Weber syndrome with lymphedema caused by a somatic KRAS variant. View Abstract
Bockenheimer disease is associated with a TEK variant. View Abstract
Realizing topologically ordered states on a quantum processor. View Abstract
Verrucous Venous Malformation-Subcutaneous Variant. View Abstract
Lymphedema and Sports: A Case Series of Athletic Patients. View Abstract
Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels. View Abstract
EPHB4 mutation causes adult and adolescent-onset primary lymphedema. View Abstract
Discussion: Surgical Treatment of Peripheral Vascular Malformations: A Systematic Review and Meta-Analysis. View Abstract
Vascular Malformations: Current Progress Toward Drug Therapy. View Abstract
A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification. View Abstract
Surgical Treatment of Lymphedema: A Systematic Review and Meta-Analysis of Controlled Trials. Results of a Consensus Conference. View Abstract
Lower Extremity Reconstruction in the Pediatric Population. View Abstract
Primary Lymphedema: Update on Genetic Basis and Management. View Abstract
Current Overview of Obesity-Induced Lymphedema. View Abstract
Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1. View Abstract
Lower Extremity Lymphatic Function in Nonambulatory Patients with Neuromuscular Disease. View Abstract
Lipoblastoma phenotype contains a somatic PIK3CA mutation. View Abstract
Lymphedema (Seminars in pediatric surgery). View Abstract
Lower extremity lymphatic function predicted by body mass index: a lymphoscintigraphic study of obesity and lipedema. View Abstract
Arteriovenous malformation phenotype resembling congenital hemangioma contains KRAS mutations. View Abstract
Body Mass Index and Lymphedema Morbidity: Comparison of Obese versus Normal-Weight Patients. View Abstract
Congenital Disseminated Pyogenic Granuloma: Characterization of an Aggressive Multisystemic Disorder. View Abstract
Endothelial MAP2K1 mutations in arteriovenous malformation activate the RAS/MAPK pathway. View Abstract
Elevation of Costal Cartilage Ear Construct for Microtia Using a V-Y Scalp Flap. View Abstract
Study of 700 Referrals to a Lymphedema Program. View Abstract
Body Mass Index and Lymphedema Morbidity: Comparison of Obese Versus Normal-Weighted Patients. View Abstract
Arteriovenous Malformation MAP2K1 Mutation Causes Local Cartilage Overgrowth by a Cell-Non Autonomous Mechanism. View Abstract
Surgical Management of Fibroadipose Vascular Anomaly of the Lower Extremities. View Abstract
Diffuse capillary malformation with overgrowth contains somatic PIK3CA variants. View Abstract
Somatic mutations in intracranial arteriovenous malformations. View Abstract
Arteriovenous malformation associated with a HRAS mutation. View Abstract
Intramuscular fast-flow vascular anomaly contains somatic MAP2K1 and KRAS mutations. View Abstract
Fibroadipose Vascular Anomaly in the Upper Extremity: A Distinct Entity With Characteristic Clinical, Radiological, and Histopathological Findings. View Abstract
Sensitivity and Specificity of the Stemmer Sign for Lymphedema: A Clinical Lymphoscintigraphic Study. View Abstract
Lymphoscintigraphic Evaluation of Systemic Tracer Uptake in Patients With Primary Lymphedema. View Abstract
Adult-Onset Primary Lymphedema: A Clinical-Lymphoscintigraphic Study of 26 Patients. View Abstract
Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. View Abstract
Clinical Practice Guideline for the Management of Infantile Hemangiomas. View Abstract
Primary Lymphedema of the Upper Extremities: Clinical and Lymphoscintigraphic Features in 23 Patients. View Abstract
Vascular Malformation Enlargement During Menopause. View Abstract
Vascular Anomalies: From a Clinicohistologic to a Genetic Framework. View Abstract
Diagnosis and Staging of Lymphedema. View Abstract
Analysis of Follicle-Stimulating Hormone Receptor in Infantile Hemangioma. View Abstract
Congenital Vascular Tumors. View Abstract
Association between extremity kaposiform hemangioendothelioma and lymphedema. View Abstract
Liposuction for Swelling in Patients with Lymphedema. View Abstract
Pediatric Orbital Floor Fractures: Clinical and Radiological Predictors of Tissue Entrapment and the Effect of Operative Timing on Ocular Outcomes. View Abstract
Propranolol Treatment of Vascular Anomalies Other Than Infantile Hemangioma. View Abstract
Role of imaging in the diagnosis of parotid infantile hemangiomas. View Abstract
Somatic PIK3CA mutations are present in multiple tissues of facial infiltrating lipomatosis. View Abstract
Diagnostic Accuracy of Lymphoscintigraphy for Lymphedema and Analysis of False-Negative Tests. View Abstract
Correlation Between Lymphedema Disease Severity and Lymphoscintigraphic Findings: A Clinical-Radiologic Study. View Abstract
Sonographic screening for Wilms tumor in children with CLOVES syndrome. View Abstract
A Nonsurgical Approach to Adolescent Breast Asymmetry Using External Prostheses. View Abstract
Resolution of Primary Lymphedema: A Case Report. View Abstract
Somatic MAP2K1 Mutations Are Associated with Extracranial Arteriovenous Malformation. View Abstract
A somatic GNA11 mutation is associated with extremity capillary malformation and overgrowth. View Abstract
Massive Localized Lymphedema: A Case-Control Study. View Abstract
Beckwith-Wiedemann Syndrome and Primary Lymphedema of the Lower Extremity. View Abstract
Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. View Abstract
Operative Treatment of Lymphedema Using Suction-Assisted Lipectomy. View Abstract
Diagnosis and Management of Obesity-Induced Lymphedema. View Abstract
Bevacizumab and interferon reduce venous recanalization following sclerotherapy. View Abstract
Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. View Abstract
Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. View Abstract
Imaging features of kaposiform lymphangiomatosis. View Abstract
Discussion: Surgical Treatment of Facial Infantile Hemangiomas: An Analysis Based on Tumor Characteristics and Outcomes. View Abstract
An Experimental Study of Particulate Bone Graft for Secondary Inlay Cranioplasty Over Scarred Dura. View Abstract
Reply: Obesity-Induced Lymphedema: Clinical and Lymphoscintigraphic Features. View Abstract
Combined Lymphedema and Capillary Malformation of the Lower Extremity. View Abstract
Endothelial Cells from Capillary Malformations Are Enriched for Somatic GNAQ Mutations. View Abstract
Management of Vascular Anomalies and Related Conditions Using Suction-Assisted Tissue Removal. View Abstract
Facial Infiltrating Lipomatosis Contains Somatic PIK3CA Mutations in Multiple Tissues. View Abstract
Management of Vascular Anomalies and Related Conditions Using Liposuction. View Abstract
Diagnosis and Management of Infantile Hemangioma: Executive Summary. View Abstract
Diagnosis and Management of Infantile Hemangioma. View Abstract
Congenital Melanocytic Nevus of the Nose Removed Using Dermabrasion, Hydroquinone, and Serial Excision. View Abstract
Weight Changes After Reduction Mammaplasty in Adolescents. View Abstract
Nodular Foot Myxedema Masquerading as Lymphedema. View Abstract
Management of Primary and Secondary Lymphedema: Analysis of 225 Referrals to a Center. View Abstract
Obesity-induced Lymphedema Nonreversible following Massive Weight Loss. View Abstract
Reply: Psychological Impact of Breast Asymmetry on Adolescents: A Prospective Cohort. View Abstract
Circular Excision and Purse-String Closure for Pediatric Facial Skin Lesions. View Abstract
Subcostal Skin Graft Donor Site for Autologous Ear Construction. View Abstract
Obesity-induced lymphedema: clinical and lymphoscintigraphic features. View Abstract
A somatic MAP3K3 mutation is associated with verrucous venous malformation. View Abstract
Surgical Site Infection After Skin Excisions in Children: Is Field Sterility Sufficient? View Abstract
Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA. View Abstract
Stewart-Treves Phenomenon: Lymphangiosarcoma Arising in Lymphedematous Tissue Is not a Syndrome. View Abstract
Facial wound closure in children using a 7-0 absorbable suture dressing. View Abstract
Management of challenging congenital melanocytic nevi: outcomes study of serial excision. View Abstract
Psychological impact of breast asymmetry on adolescents: a prospective cohort study. View Abstract
AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. View Abstract
Progressive Postnatal Pansynostosis. View Abstract
Repair of tegmen defect using cranial particulate bone graft. View Abstract
An Experimental Study of Particulate Bone Graft for Secondary Inlay Cranioplasty over Scarred Dura. View Abstract
Management of lymphedema with suction-assisted lipectomy. View Abstract
Obesity-induced lymphedema: presentation, diagnosis, and management. View Abstract
Infantile hemangioma: treatment rate during the proliferating phase. View Abstract
Lymphedema. View Abstract
Management of problematic infantile hemangioma using intralesional triamcinolone: efficacy and safety in 100 infants. View Abstract
Male genital lymphedema: clinical features and management in 25 pediatric patients. View Abstract
Lymphedema and obesity: is there a link? View Abstract
Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. View Abstract
Safety and efficacy of bleomycin sclerotherapy for microcystic lymphatic malformation. View Abstract
Abstract 63: expression of follicle-stimulating hormone receptor in vascular anomalies. View Abstract
Expression of follicle-stimulating hormone receptor in vascular anomalies. View Abstract
Abstract 55: management of problematic infantile hemangioma using intralesional triamcinolone: efficacy and safety in 87 consecutive infants. View Abstract
Abstract 71: obesity-induced lymphedema: presentation, diagnosis, and management. View Abstract
Abstract 75: expression of follicle-stimulating hormone receptor in vascular anomalies. View Abstract
Abstract 78: An Experimental Study of Particulate Bone Graft for Secondary Inlay Cranioplasty over Scarred Dura. View Abstract
Fibro-adipose vascular anomaly: clinical-radiologic-pathologic features of a newly delineated disorder of the extremity. View Abstract
PIK3CA activating mutations in facial infiltrating lipomatosis. View Abstract
Obesity-induced Upper Extremity Lymphedema. View Abstract
Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential. View Abstract
Psychosocial impact of adolescent gynecomastia: a prospective case-control study. View Abstract
Extremity fasciotomy wound closure: comparison of skin grafting to staged linear closure. View Abstract
Effect of calvarial burring on resorption of onlay cranial bone graft. View Abstract
Reharvested cranial particulate bone graft ossifies inlay calvarial defects. View Abstract
Infantile hemangioma: clinical assessment of the involuting phase and implications for management. View Abstract
Experimental Comparison of Cranial Particulate Bone Graft, rhBMP-2, and Split Cranial Bone Graft for Inlay Cranioplasty. View Abstract
Expression analysis of macrodactyly identifies pleiotrophin upregulation. View Abstract
The impact of macromastia on adolescents: a cross-sectional study. View Abstract
Infantile hemangioma in four siblings. View Abstract
Current surgical management of bilateral cleft lip in North America. View Abstract
Expression of androgen, estrogen, progesterone, and growth hormone receptors in vascular malformations. View Abstract
Lower-extremity lymphedema and elevated body-mass index. View Abstract
Cranial particulate bone graft ossifies calvarial defects by osteogenesis. View Abstract
Reply: oral prednisolone for infantile hemangioma: efficacy and safety using a standardized treatment protocol. View Abstract
Extradural myelomeningocele reconstruction using local turnover fascial flaps and midline linear skin closure. View Abstract
The effect of obesity on early outcomes in adolescents undergoing reduction mammaplasty. View Abstract
Venous malformation: risk of progression during childhood and adolescence. View Abstract
Primary lymphedema: definition of onset based on developmental age. View Abstract
Lymphatic malformation: risk of progression during childhood and adolescence. View Abstract
Current concepts of vascular anomalies. View Abstract
Autogenous bone graft: basic science and clinical implications. View Abstract
Critical-size defect ossification: effect of leporid age in a cranioplasty model. View Abstract
Facial infiltrating lipomatosis: expression of angiogenic and vasculogenic factors. View Abstract
Intraoperative cooling of iliac bone graft: an experimental evaluation of cell viability. View Abstract
Increased endothelial progenitor cells and vasculogenic factors in higher-staged arteriovenous malformations. View Abstract
Vascular anomalies in 5,621 patients: guidelines for referral. View Abstract
Oral prednisolone for infantile hemangioma: efficacy and safety using a standardized treatment protocol. View Abstract
Agminated atypical Spitz tumor: large nasal lesion in a child with Down syndrome. View Abstract
Primary lymphedema: clinical features and management in 138 pediatric patients. View Abstract
Exchange cranioplasty using autologous calvarial particulate bone graft effectively repairs large cranial defects. View Abstract
Differential diagnosis of lower extremity enlargement in pediatric patients referred with a diagnosis of lymphedema. View Abstract
Safety and clinical efficacy of Onyx for embolization of extracranial head and neck vascular anomalies. View Abstract
Pilomatrixoma imitating infantile hemangioma. View Abstract
Evaluation of terminology for vascular anomalies in current literature. View Abstract
Autologous cranial particulate bone graft: an experimental study of onlay cranioplasty. View Abstract
Preface vascular anomalies. View Abstract
Vascular anomalies: current overview of the field. View Abstract
Management of hemangiomas and other vascular tumors. View Abstract
Management of lymphatic malformations. View Abstract
Management of venous malformations. View Abstract
Management of arteriovenous malformations. View Abstract
Expression of angiogenic and vasculogenic factors in human lymphedematous tissue. View Abstract
Inlay cranioplasty: an experimental comparison of particulate graft versus bone dust. View Abstract
Metastatic neuroblastoma mimicking infantile hemangioma. View Abstract
Subcutaneous epinephrine for vasoconstriction: an evidence-based evaluation. View Abstract
Adolescent gynecomastia: not only an obesity issue. View Abstract
Systemic corticosteroid is effective and safe treatment for problematic infantile hemangioma. View Abstract
Extracranial arteriovenous malformations: natural progression and recurrence after treatment. View Abstract
Infantile myofibroma or lymphatic malformation: differential diagnosis of neonatal cystic cervicofacial lesions. View Abstract
Perioperative corticosteroid reduces hospital stay after fronto-orbital advancement. View Abstract
Autologous cranial particulate bone grafting reduces the frequency of osseous defects after cranial expansion. View Abstract
Nipple adenoma in infancy. View Abstract
Diffuse lipofibromatosis of the lower extremity masquerading as a vascular anomaly. View Abstract
Adult-onset kaposiform hemangioendothelioma in a posttraumatic site. View Abstract
Zygomaticotemporal suture synostosis causes progressive facial deformity and asymmetry. View Abstract
Increased prevalence of left-handedness in hemifacial microsomia. View Abstract
Sturge-Weber syndrome: soft-tissue and skeletal overgrowth. View Abstract
Phenotypically unusual combined craniosynostoses: presentation and management. View Abstract
Pediatric cranioplasty using particulate calvarial bone graft. View Abstract
Soft tissue sarcomas of the hand: functional reconstruction and outcome analysis. View Abstract
Corticosteroid treatment for problematic infantile hemangioma: evidence does not support an increased risk for cerebral palsy. View Abstract
Onlay frontal cranioplasty using wire reinforced methyl methacrylate. View Abstract
Applying to plastic surgery residency: factors associated with medical student career choice. View Abstract
A critical role for matrix metalloproteinases in liver regeneration. View Abstract
Risk of vascular anomalies with Down syndrome. View Abstract
Inhibition of intra-abdominal adhesion formation with the angiogenesis inhibitor sunitinib. View Abstract
Primary grafting with autologous cranial particulate bone prevents osseous defects following fronto-orbital advancement. View Abstract
Homocystinuria: an unrecognized cause of microvascular failure. View Abstract
Endothelial progenitor cells contribute to accelerated liver regeneration. View Abstract
Calvarial defects associated with neurofibromatosis type 1. Report of two cases. View Abstract
Intraosseous "hemangiomas" are malformations and not tumors. View Abstract
Flap ischemia after pedicled tissue transfer to a lateral thigh wound: an example of complication assessment using the end result system of E. A. Codman. View Abstract
Ernest Amory Codman, M.D. (1869 to 1940): the influence of the End Result Idea on plastic and reconstructive surgery. View Abstract
Schimmelpenning syndrome: an association with vascular anomalies. View Abstract
Zygomaticotemporal synostosis: a rare cause of progressive facial asymmetry. View Abstract
Treatment of lower extremity lymphedema with suction-assisted lipectomy. View Abstract
Prevention of temporal depression that follows fronto-orbital advancement for craniosynostosis. View Abstract
Images in clinical medicine. Skin redundancy after massive weight loss. View Abstract
Microdeformational wound therapy: effects on angiogenesis and matrix metalloproteinases in chronic wounds of 3 debilitated patients. View Abstract
Determining the need for simulated training of invasive procedures. View Abstract
Blood pressure monitoring and venipuncture in the lymphedematous extremity. View Abstract
The route of lipid administration affects parenteral nutrition-induced hepatic steatosis in a mouse model. View Abstract
Management of parotid hemangioma. View Abstract
Prevention of intra-abdominal adhesions using the antiangiogenic COX-2 inhibitor celecoxib. View Abstract
Frontonasal osteotomy to facilitate removal of an intracranial nasal dermoid. View Abstract
Pneumonectomy in the mouse: technique and perioperative management. View Abstract
Management of epinephrine injection injury to the digit. View Abstract
Schwannoma of the median nerve: Iatrogenic injury after axillary lymph node biopsy. View Abstract
Periorbital lymphatic malformation: clinical course and management in 42 patients. View Abstract
Urinary matrix metalloproteinases and their endogenous inhibitors predict hepatic regeneration after murine partial hepatectomy. View Abstract
Wilms tumor screening is unnecessary in Klippel-Trenaunay syndrome. View Abstract
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. View Abstract
Management of parotid hemangioma in 100 children. View Abstract
Endothelial-directed hepatic regeneration after partial hepatectomy. View Abstract
Partial hepatectomy in the mouse: technique and perioperative management. View Abstract
Professor Edmund Rose: his position in surgery. View Abstract
Hepatic exstrophy complicating Poland's anomaly. View Abstract
A resident's guide to personal finance. View Abstract
Phosphatidylinositol 4,5-bisphosphate modifies tubulin participation in phospholipase Cbeta1 signaling. View Abstract
Laparoscopic splenectomy for massive splenomegaly using a Lahey bag. View Abstract
Ignacio Barraquer (1884-1965) and the Barraquer family of ophthalmologists. View Abstract
Lluis Barraquer-Roviralta (1855-1928): Spanish neurologist described progressive lipodystrophy. View Abstract
Laparoscopically assisted ileocolectomy for Crohn's disease through a pfannenstiel incision. View Abstract
Is sestamibi-guided parathyroidectomy really cost-effective? View Abstract
Conditional differentiation of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen. View Abstract
Sequential Tc 99m mercaptoacetyl-triglycine (MAG3) renography as an evaluator of early renal transplant function. View Abstract
School-based health care: an inner-city experience. View Abstract
Comparison of topical tetracaine, adrenaline, and cocaine anesthesia with lidocaine infiltration for repair of lacerations in children. View Abstract
Measurement of cardiopulmonary function in ventilated neonates with respiratory distress syndrome using rebreathing methodology. View Abstract
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