Alfred specializes in the endovascular and microsurgical care of patients with diseases of the blood vessels in the brain and spinal cord. To provide a comprehensive approach to these problems, he has focused his training with an emphasis on a broad range of tools and techniques as well as novel applications of combined surgeries to treat these diseases. Endovascular techniques use catheters from within the blood vessels to treat problems of the blood vessels but also to deliver medications in a very precisely targeted fashion. Microsurgical techniques allow meticulous separation of diseased blood vessels from the brain and allow reconstruction of diseased vessels as well as creation of new blood supply to the brain.

Having developed this expertise, he continues to engage in research to better understand normal and abnormal blood vessels. His background in engineering leads to his emphasis on quantitative analysis of blood flow and the application of new technologies such as computational analysis and robotics.