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William Pu, MD
Associate Chair, Basic and Translational Cardiovascular Research; Senior Cardiologist, Department of Cardiology
Aldo R. Castaneda Professor of Pediatrics, Harvard Medical School
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William Pu, MD
Associate Chair, Basic and Translational Cardiovascular Research; Senior Cardiologist, Department of Cardiology
Aldo R. Castaneda Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Yale University
1988
New Haven
CT
Medical School
Harvard Medical School
1993
Boston
MA
Internship
Boston Children's Hospital
1994
Boston
MA
Residency
Boston Children's Hospital
1996
Boston
MA
Fellowship
Boston Children's Hospital
1999
Boston
MA
Certifications
American Board of Pediatrics (Cardiology)
Professional History
I grew up in upstate New York. From college at Yale through medical school at Harvard and training in pediatrics and pediatric cardiology at Boston Children’s, my passion has been to bring advances in science to bear on the problems faced by patients.
Approach to Care
I am committed to providing the highest quality care for pediatric patients with heart disease, and to advance their diagnosis and treatment through research and innovation.
Publications
SCIG: Machine learning uncovers cell identity genes in single cells by genetic sequence codes. View Abstract
Response by Bortolin and Pu to Letter Regarding Article, "Antisense Oligonucleotide Therapy for Calmodulinopathy". View Abstract
A murine model of Barth syndrome recapitulates human cardiac and skeletal muscle phenotypes. View Abstract
Translational insights into statin-induced myotoxicity: Differential impact of lipophilic and hydrophilic statins on iPSC-derived skeletal muscle cells from patients with familial hypercholesterolemia. View Abstract
Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy. View Abstract
Somatic Genomic and Transcriptomic Changes in Single Ischemic Human Heart Cardiomyocytes. View Abstract
Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer. View Abstract
CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes. View Abstract
Genetic and Molecular Underpinnings of Atrial Fibrillation. View Abstract
Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing. View Abstract
Virally delivered CMYA5 enhances the assembly of cardiac dyads. View Abstract
Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice. View Abstract
Antisense Oligonucleotide Therapy for Calmodulinopathy. View Abstract
Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth. View Abstract
Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue. View Abstract
In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury. View Abstract
Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy. View Abstract
Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems. View Abstract
Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy. View Abstract
Remote assessment and management of patients with dizziness: development, validation, and feasibility of a gamified vestibular rehabilitation therapy platform. View Abstract
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment. View Abstract
MicroRNA-122-Mediated Liver Detargeting Enhances the Tissue Specificity of Cardiac Genome Editing. View Abstract
Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy. View Abstract
The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation. View Abstract
Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor. View Abstract
From vitality to vulnerability: the impact of oxygen on cardiac function and regeneration. View Abstract
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. View Abstract
Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution. View Abstract
Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice. View Abstract
A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. View Abstract
In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury. View Abstract
Author Correction: Tbx5 maintains atrial identity in postnatal cardiomyocytes by regulating an atrial-specific enhancer network. View Abstract
Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration. View Abstract
Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network. View Abstract
Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy. View Abstract
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation. View Abstract
Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles. View Abstract
Editing the trajectory of hypertrophic cardiomyopathy. View Abstract
Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome. View Abstract
Molecule in mothers' milk nurses pups' heart cells to maturity. View Abstract
Tbx5 maintains atrial identity by regulating an atrial enhancer network. View Abstract
Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. View Abstract
Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. View Abstract
Future Directions and Resource Needs for National Heart, Lung, and Blood Institute (NHLBI) Gene Therapy Research: A Report of an NHLBI Workshop. View Abstract
In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. View Abstract
RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. View Abstract
Addendum: A tissue-engineered scale model of the heart ventricle. View Abstract
GATA4 Regulates Developing Endocardium Through Interaction With ETS1. View Abstract
Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. View Abstract
Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload. View Abstract
Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development. View Abstract
ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes. View Abstract
Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis. View Abstract
A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis. View Abstract
CMYA5 establishes cardiac dyad architecture and positioning. View Abstract
CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart. View Abstract
Cardiac ISL1-Interacting Protein, a Cardioprotective Factor, Inhibits the Transition From Cardiac Hypertrophy to Heart Failure. View Abstract
Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes. View Abstract
Current and future treatment approaches for Barth syndrome. View Abstract
Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. View Abstract
Experimental models of Barth syndrome. View Abstract
Cardiac CIP protein regulates dystrophic cardiomyopathy. View Abstract
Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. View Abstract
Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts. View Abstract
YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. View Abstract
Calcific aortic valve disease: turning therapeutic discovery up a notch. View Abstract
Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome. View Abstract
Two sides of the same coin: new insights into mechanisms of ventricular fibrillation. View Abstract
LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. View Abstract
TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes. View Abstract
Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. View Abstract
AAV Gene Transfer to the Heart. View Abstract
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. View Abstract
Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. View Abstract
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. View Abstract
Enhancer dependence of cell-type-specific gene expression increases with developmental age. View Abstract
LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. View Abstract
L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. View Abstract
Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein. View Abstract
Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. View Abstract
Gene therapy for inherited arrhythmias. View Abstract
The architecture and function of cardiac dyads. View Abstract
Genetic and Epigenetic Control of Heart Development. View Abstract
Cardiomyocyte Maturation: New Phase in Development. View Abstract
AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome. View Abstract
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. View Abstract
Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. View Abstract
aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. View Abstract
Investigation of Streptococcus agalactiae using pcsB-based LAMP in milk, tilapia and vaginal swabs in Haikou, China. View Abstract
A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. View Abstract
Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification. View Abstract
Molecular mechanisms of arrhythmogenic cardiomyopathy. View Abstract
Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. View Abstract
Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II. View Abstract
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. View Abstract
Three species of Aeromonas (A. dhakensis, A. hydrophila and A. jandaei) isolated from freshwater crocodiles (Crocodylus siamensis) with pneumonia and septicemia. View Abstract
A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. View Abstract
Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. View Abstract
Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. View Abstract
Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor. View Abstract
Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review. View Abstract
A tissue-engineered scale model of the heart ventricle. View Abstract
Exercising engineered heart muscle to maturity. View Abstract
Genetic Mosaics for Greater Precision in Cardiovascular Research. View Abstract
Enhancing the precision of genetic lineage tracing using dual recombinases. View Abstract
Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. View Abstract
CASAAV: A CRISPR-Based Platform for Rapid Dissection of Gene Function In Vivo. View Abstract
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. View Abstract
Identification of a hybrid myocardial zone in the mammalian heart after birth. View Abstract
Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. View Abstract
The complex genetics of hypoplastic left heart syndrome. View Abstract
Divergent Requirements for EZH1 in Heart Development Versus Regeneration. View Abstract
Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. View Abstract
Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis. View Abstract
[Long-term outcomes after cataract surgery in infants with congenital cataract]. View Abstract
EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. View Abstract
Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. View Abstract
Cardiac Regeneration: Lessons From Development. View Abstract
Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq. View Abstract
Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts. View Abstract
Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. View Abstract
Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. View Abstract
Single-Cell Resolution of Temporal Gene Expression during Heart Development. View Abstract
Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. View Abstract
Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. View Abstract
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. View Abstract
Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types. View Abstract
Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. View Abstract
GATA4 regulates Fgf16 to promote heart repair after injury. View Abstract
Recounting Cardiac Cellular Composition. View Abstract
Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. View Abstract
Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia. View Abstract
Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. View Abstract
SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. View Abstract
Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. View Abstract
Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. View Abstract
Trbp regulates heart function through microRNA-mediated Sox6 repression. View Abstract
Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. View Abstract
Cellular origin and developmental program of coronary angiogenesis. View Abstract
Releasing YAP from an a-catenin trap increases cardiomyocyte proliferation. View Abstract
Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. View Abstract
Introduction to the special issue on heart regeneration and rejuvenation. View Abstract
Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. View Abstract
Epicardium-to-fat transition in injured heart. View Abstract
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. View Abstract
Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. View Abstract
Optimization of genome engineering approaches with the CRISPR/Cas9 system. View Abstract
Ultrasound-guided transthoracic intramyocardial injection in mice. View Abstract
Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. View Abstract
Strategies for cardiac regeneration and repair. View Abstract
GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27. View Abstract
Notching up vascular regeneration. View Abstract
Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. View Abstract
Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. View Abstract
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. View Abstract
Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. View Abstract
Hippo activation in arrhythmogenic cardiomyopathy. View Abstract
Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. View Abstract
WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. View Abstract
Developing insights into cardiac regeneration. View Abstract
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. View Abstract
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. View Abstract
HCN4 charges up the first heart field. View Abstract
The mysterious origins of coronary vessels. View Abstract
Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. View Abstract
A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. View Abstract
A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. View Abstract
GATA factors promote ER integrity and ß-cell survival and contribute to type 1 diabetes risk. View Abstract
Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles. View Abstract
Myocardial regeneration: expanding the repertoire of thymosin ß4 in the ischemic heart. View Abstract
Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. View Abstract
Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2. View Abstract
Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. View Abstract
Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. View Abstract
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. View Abstract
Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. View Abstract
Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. View Abstract
CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. View Abstract
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. View Abstract
Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. View Abstract
PRC2 directly methylates GATA4 and represses its transcriptional activity. View Abstract
Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells. View Abstract
Regulation of GATA4 transcriptional activity in cardiovascular development and disease. View Abstract
Polycomb repressive complex 2 regulates normal development of the mouse heart. View Abstract
Adult cardiac-resident MSC-like stem cells with a proepicardial origin. View Abstract
Epicardial epithelial-to-mesenchymal transition in injured heart. View Abstract
Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. View Abstract
miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. View Abstract
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. View Abstract
De novo cardiomyocytes from within the activated adult heart after injury. View Abstract
WT1 regulates epicardial epithelial to mesenchymal transition through ß-catenin and retinoic acid signaling pathways. View Abstract
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. View Abstract
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. View Abstract
Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. View Abstract
Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation. View Abstract
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] View Abstract
Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. View Abstract
Reprogramming fibroblasts into cardiomyocytes. View Abstract
CompleteMOTIFs: DNA motif discovery platform for transcription factor binding experiments. View Abstract
Genome-wide location analysis by pull down of in vivo biotinylated transcription factors. View Abstract
Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. View Abstract
Expression and function of microRNAs in heart disease. View Abstract
Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine. View Abstract
Dissecting spatio-temporal protein networks driving human heart development and related disorders. View Abstract
Heart failure-associated changes in RNA splicing of sarcomere genes. View Abstract
Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. View Abstract
Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. View Abstract
Identification of a cardiac disease modifier gene using forward genetics in the mouse. View Abstract
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. View Abstract
MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. View Abstract
Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. View Abstract
More than a cover: epicardium as a novel source of cardiac progenitor cells. View Abstract
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. View Abstract
Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. View Abstract
GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. View Abstract
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. View Abstract
Altered microRNA expression in human heart disease. View Abstract
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. View Abstract
Spectrum of heart disease associated with murine and human GATA4 mutation. View Abstract
Therapeutic neovascularization for peripheral arterial diseases: advances and perspectives. View Abstract
Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes. View Abstract
Mesenchymal stem/stromal cells (MSC) transfected with stromal derived factor 1 (SDF-1) for therapeutic neovascularization: enhancement of cell recruitment and entrapment. View Abstract
Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. View Abstract
Chaperoning of estrogen receptor and induction of mammary gland proliferation by neuronal protein synuclein gamma. View Abstract
Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. View Abstract
Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. View Abstract
Development of heart valves requires Gata4 expression in endothelial-derived cells. View Abstract
Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure
View Abstract
A multivariate approach for integrating genome-wide expression data and biological knowledge. View Abstract
Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. View Abstract
Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. View Abstract
Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. View Abstract
Morphogenesis of the right ventricle requires myocardial expression of Gata4. View Abstract
GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. View Abstract
Molecular Basis of Heart Failure View Abstract
Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos. View Abstract
NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro. View Abstract
Structural characterization of the mouse Girk genes. View Abstract
Transcription factors and heart failure: does the stressed heart need a hand? View Abstract
Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. View Abstract
[Diagnostic and differential diagnostic potential of mitochondrial DNA assessment in patients with Leber's hereditary optic neuropathy]. View Abstract
Diagnostic potential of mitochondrial DNA assessment in patients with optic neuropathy. View Abstract
ICln is essential for cellular and early embryonic viability. View Abstract
pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. View Abstract
pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. View Abstract
[An experimental study on effects of biomembrane on prevention of filtering bleb adhesion in trabeculectomy]. View Abstract
Diagnosis and management of agenesis of the right lung and left pulmonary artery sling. View Abstract
Dimerization of leucine zippers analyzed by random selection. View Abstract
Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity. View Abstract
Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. View Abstract
Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. View Abstract
The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding. View Abstract
Biosynthesis of glucose oxidase by producing strain Z-I-C in batch and chemostat culture. View Abstract
UvrABC incision of N-methylmitomycin A-DNA monoadducts and cross-links. View Abstract
Effects of pH and sulfhydryl specific reagents on 4-fumarylacetoacetate fumarylhydrolase. View Abstract
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