Medical School

  • University of Tokyo, Faculty of Medicine , 1999 , Tokyo , Japan


  • Hawaii University Surgical Program , 2001 , Honolulu , HI


  • Ichihara Hospital, Teikyo University , 1999 , Chiba , Japan

Graduate Degree

  • Massachusetts General Hospital , 2002 , Boston , MA


Pediatric Anesthesia
  • Boston Children's Hospital , 2005 , Boston , MA


Pediatric Cardiac Anesthesia
  • Boston Children's Hospital , 2006 , Boston , MA


  • American Board of Anesthesiology


Publications powered by Harvard Catalyst Profiles

  1. Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis. Int Immunopharmacol. 2021 Feb 01; 93:107425. View abstract
  2. Left Ventricular Outflow Tract Gradient Is Associated With Coronary Artery Obstruction in Children With Williams-Beuren Syndrome. J Cardiothorac Vasc Anesth. 2021 Jan 04. View abstract
  3. CD11c regulates hematopoietic stem and progenitor cells under stress. Blood Adv. 2020 Dec 22; 4(24):6086-6097. View abstract
  4. The Microbial Flora in an Experimental Polymicrobial Abdominal Sepsis Model Probed by 16S rRNA Sequencing. Transl Perioper Pain Med. 2021; 8(1):305-311. View abstract
  5. Long QT Syndrome and Perioperative Torsades de Pointes: What the Anesthesiologist Should Know. J Cardiothorac Vasc Anesth. 2020 Dec 13. View abstract
  6. A simple screening test of filtration efficiency for protecting the gas sampling line from coronavirus using fluorescent microspheres. Paediatr Anaesth. 2020 11; 30(11):1269-1274. View abstract
  7. The Role of Anesthetic Management in Surgical Site Infections After Pediatric Intestinal Surgery. J Surg Res. 2021 Mar; 259:546-554. View abstract
  8. Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes. Clin Immunol. 2021 Jan; 222:108635. View abstract
  9. The effect of anesthetics on toll like receptor 9. FASEB J. 2020 Nov; 34(11):14645-14654. View abstract
  10. Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation. Anesth Analg. 2020 08; 131(2):631-639. View abstract
  11. SerpinB1 expression in Th17 cells depends on hypoxia-inducible factor 1-alpha. Int Immunopharmacol. 2020 Oct; 87:106826. View abstract
  12. Role of ß2 Integrins in Neutrophils and Sepsis. Infect Immun. 2020 05 20; 88(6). View abstract
  13. Intubation precautions in a pediatric patient with severe COVID-19. J Pediatr Surg Case Rep. 2020 Jul; 58:101495. View abstract
  14. In Vitro Model of Stretch-Induced Lung Injury to Study Different Lung Ventilation Regimens and the Role of Sedatives. Transl Perioper Pain Med. 2020; 7(3):258-264. View abstract
  15. COVID-19 pathophysiology: A review. Clin Immunol. 2020 06; 215:108427. View abstract
  16. Anesthetic Management for Heart Transplantation in Adults with Congenital Heart Disease. Transl Perioper Pain Med. 2020; 7(3):248-252. View abstract
  17. The role of propofol hydroxyl group in 5-lipoxygenase recognition. Biochem Biophys Res Commun. 2020 05 14; 525(4):909-914. View abstract
  18. Should we Routinely Reverse Neuromuscular Blockade with Sugammadex in Patients with a History of Heart Transplantation? Transl Perioper Pain Med. 2020; 7(2):185-189. View abstract
  19. Incidence and predictors of postoperative nausea and vomiting in children undergoing electrophysiology ablation procedures. Paediatr Anaesth. 2020 02; 30(2):147-152. View abstract
  20. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. FASEB J. 2019 12; 33(12):14528-14541. View abstract
  21. SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20635-20643. View abstract
  22. The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J. 2019 11; 33(11):12668-12679. View abstract
  23. The Outcomes of Pediatric Hematopoietic Stem Cell Transplantation Recipients Requiring Intensive Care Unit Admission- A Single Center Experience. Transl Perioper Pain Med. 2019; 6(3):75-80. View abstract
  24. Volatile anesthetics affect macrophage phagocytosis. PLoS One. 2019; 14(5):e0216163. View abstract
  25. The Use of Volatile Anesthetics as Sedatives for Acute Respiratory Distress Syndrome. Transl Perioper Pain Med. 2019; 6(2):27-38. View abstract
  26. Volatile Anesthetic Attenuates Phagocyte Function and Worsens Bacterial Loads in Wounds. J Surg Res. 2019 01; 233:323-330. View abstract
  27. Incidence and Risk Factors for Perioperative Cardiovascular and Respiratory Adverse Events in Pediatric Patients With Congenital Heart Disease Undergoing Noncardiac Procedures. Anesth Analg. 2018 09; 127(3):724-729. View abstract
  28. Induction techniques for pediatric patients with congenital heart disease undergoing noncardiac procedures are influenced by cardiac functional status and residual lesion burden. J Clin Anesth. 2018 Nov; 50:14-17. View abstract
  29. Volatile Anesthetic Isoflurane Attenuates Liver Injury in Experimental Polymicrobial Sepsis Model. Transl Perioper Pain Med. 2018; 5(3):63-74. View abstract
  30. Unanticipated hospital admission in pediatric patients with congenital heart disease undergoing ambulatory noncardiac surgical procedures. Paediatr Anaesth. 2018 07; 28(7):607-611. View abstract
  31. Incidence and Risk Factors of Perioperative Mortality in Pediatric ICU Patients. Transl Perioper Pain Med. 2018; 5(2):49-54. View abstract
  32. Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1. J Biol Chem. 2018 04 27; 293(17):6565-6577. View abstract
  33. Validation of a Mathematical Model of Bidirectional Glenn Circulation With Aortopulmonary Collaterals and the Implications for QP/QS Calculation. J Cardiothorac Vasc Anesth. 2018 02; 32(1):395-401. View abstract
  34. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci. 2017 04 01; 156(2):402-411. View abstract
  35. Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. Sci Rep. 2017 03 09; 7:44117. View abstract
  36. The Differential Effects of Anesthetics on Bacterial Behaviors. PLoS One. 2017; 12(1):e0170089. View abstract
  37. Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. FASEB J. 2017 04; 31(4):1584-1594. View abstract
  38. Pediatric Perioperative Stress Responses and Anesthesia. Transl Perioper Pain Med. 2017; 2(1):1-12. View abstract
  39. The effect of different anesthetics on tumor cytotoxicity by natural killer cells. Toxicol Lett. 2017 Jan 15; 266:23-31. View abstract
  40. Pausing With the Gauze: Inhibition of Temporary Pacemakers by Radiofrequency Scan During Cardiac Surgery. Anesth Analg. 2016 11; 123(5):1143-1148. View abstract
  41. Dexmedetomidine-Induced Neuroapoptosis Is Dependent on Its Cumulative Dose. Anesth Analg. 2016 10; 123(4):1008-17. View abstract
  42. Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review. Anesth Analg. 2016 08; 123(2):326-35. View abstract
  43. Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. Paediatr Anaesth. 2016 Jun; 26(6):644-8. View abstract
  44. Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2016 Feb 23; 67(7):793-801. View abstract
  45. A translational consideration of intercellular adhesion molecule-1 biology in the perioperative setting. Transl Perioper Pain Med. 2016; 1(2):17-23. View abstract
  46. Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. World J Clin Cases. 2015 Sep 16; 3(9):793-806. View abstract
  47. Cardiopulmonary bypass in the pediatric population. Best Pract Res Clin Anaesthesiol. 2015 Jun; 29(2):241-56. View abstract
  48. Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen. J Immunotoxicol. 2016; 13(2):148-56. View abstract
  49. Sepsis pathophysiology and anesthetic consideration. Cardiovasc Hematol Disord Drug Targets. 2015; 15(1):57-69. View abstract
  50. The role of macrophage 1 antigen in polymicrobial sepsis. Shock. 2014 Dec; 42(6):532-9. View abstract
  51. Comparison of actual oxygen delivery kinetics to those predicted by mathematical modeling following stage 1 palliation just prior to superior cavopulmonary anastomosis. Paediatr Anaesth. 2015 Feb; 25(2):174-9. View abstract
  52. Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. PLoS One. 2014; 9(5):e96649. View abstract
  53. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. Bioorg Med Chem. 2014 Apr 01; 22(7):2353-65. View abstract
  54. An internal ligand-bound, metastable state of a leukocyte integrin, aXß2. J Cell Biol. 2013 Nov 25; 203(4):629-42. View abstract
  55. Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. Anesth Analg. 2013 Oct; 117(4):803-11. View abstract
  56. Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin aIIbß3. PLoS One. 2013; 8(4):e60415. View abstract
  57. Cardiac arrest and neuromuscular blockade reversal agents in the transplanted heart. J Cardiothorac Vasc Anesth. 2013 Dec; 27(6):1374-8. View abstract
  58. Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth. 2013 Apr; 27(2):261-8. View abstract
  59. Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J. 2012 Nov; 26(11):4408-17. View abstract
  60. A mathematical model of transitional circulation toward biventricular repair in hypoplastic left heart syndrome. Anesth Analg. 2012 Sep; 115(3):618-26. View abstract
  61. Ventricular-assist device therapy in children. Best Pract Res Clin Anaesthesiol. 2012 Jun; 26(2):247-64. View abstract
  62. Serial evaluation of left ventricular contraction and relaxation in Takotsubo cardiomyopathy by 2D speckle tracking echocardiography. J Med Ultrason (2001). 2012 Oct; 39(4):265-9. View abstract
  63. Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. J Anesth. 2012 Apr; 26(2):273-4. View abstract
  64. Improvement of PaO2 during one-lung ventilation with partial left-heart bypass in pediatric patients is caused by increased blood flow to the dependent lung. J Cardiothorac Vasc Anesth. 2013 Jun; 27(3):542-5. View abstract
  65. Cell-free ligand-binding assays for integrin LFA-1. Methods Mol Biol. 2012; 757:73-8. View abstract
  66. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 2012 Jan; 26(1):169-80. View abstract
  67. Blood utilization in neonates and infants undergoing cardiac surgery requiring cardiopulmonary bypass. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):382-92. View abstract
  68. Anesthetic and cardiopulmonary bypass considerations for cardiac surgery in unique pediatric patient populations: sickle cell disease and cold agglutinin disease. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):364-70. View abstract
  69. Postoperative maladaptive behavioral changes in children. Middle East J Anaesthesiol. 2011 Jun; 21(2):183-9. View abstract
  70. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011 Apr; 112(4):830-8. View abstract
  71. Anesthetic management of noncardiac surgery for patients with single ventricle physiology. J Anesth. 2011 Apr; 25(2):247-56. View abstract
  72. Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 2010 Sep; 113(3):600-9. View abstract
  73. Percutaneous transvenous stent implantation to external iliac vein stenosis in a patient with retroperitoneal fibrosis. Intern Med. 2010; 49(10):913-8. View abstract
  74. The effect of left heart bypass on pulmonary blood flow and arterial oxygenation during one-lung ventilation in patients undergoing descending thoracic aortic surgery. J Clin Anesth. 2009 Dec; 21(8):562-6. View abstract
  75. Management of difficult airway in pediatric patients with right ventricular outflow tract obstruction. J Anesth. 2009; 23(2):281-3. View abstract
  76. Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. J Lipid Res. 2009 May; 50(5):860-9. View abstract
  77. Recent progress on acyl CoA: lysophospholipid acyltransferase research. J Lipid Res. 2009 Apr; 50 Suppl:S46-51. View abstract
  78. The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008 Dec; 22(12):4109-16. View abstract
  79. Trendelenburg position, simulated Valsalva maneuver, and liver compression do not alter the size of the right internal jugular vein in patients with a bidirectional Glenn shunt. Anesth Analg. 2007 Aug; 105(2):365-8. View abstract
  80. The perioperative management of a patient with Fontan physiology for pheochromocytoma resection. J Cardiothorac Vasc Anesth. 2008 Oct; 22(5):748-50. View abstract
  81. Induction of supraventricular tachycardia during transesophageal echocardiography: an unusual complication. J Cardiothorac Vasc Anesth. 2008 Aug; 22(4):592-3. View abstract
  82. Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1 alpha. Clin Sci (Lond). 2002 Aug; 103 Suppl 48:210S-214S. View abstract
  83. Endothelin-1 stimulates cardiomyocyte injury during mitochondrial dysfunction in culture. Eur J Pharmacol. 2001 Nov 16; 431(2):163-70. View abstract
  84. Reverse redistribution of 99m Tc-sestamibi after direct percutaneous transluminal coronary angioplasty in acute myocardial infarction: relationship with wall motion and functional response to dobutamine stimulation. Nucl Med Commun. 2001 Nov; 22(11):1223-30. View abstract
  85. Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation. . 2001 Jul; 281(1):R25-30. View abstract
  86. Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism. Circulation. 2001 May 15; 103(19):2387-94. View abstract
  87. Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S205-8. View abstract
  88. Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S201-4. View abstract
  89. Impairment of cardiac energy metabolism in vivo causes hemodynamic abnormality and increases cardiac expression of preproendothelin-1 mRNA. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S128-31. View abstract
  90. Intense exercise causes decrease in expression of both endothelial NO synthase and tissue NOx level in hearts. . 2000 Sep; 279(3):R951-9. View abstract
  91. Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in inner Mongolia. Free Radic Biol Med. 2000 Apr 01; 28(7):1137-42. View abstract
  92. Ultrasonic assessment of vascular complications in coronary angiography and angioplasty after transradial approach. Am J Cardiol. 1999 Jan 15; 83(2):180-6. View abstract
  93. Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo. Life Sci. 1999; 65(16):1671-83. View abstract
  94. [A case of unruptured aneurysm of the sinus of Valsalva producing a right ventricular outflow obstruction]. Kokyu To Junkan. 1985 Apr; 33(4):581-5. View abstract