EDUCATION

Medical School

  • University of Tokyo, Faculty of Medicine , 1999 , Tokyo , Japan

Internship

Surgery
  • Hawaii University Surgical Program , 2001 , Honolulu , HI

Residency

Anesthesia
  • Ichihara Hospital, Teikyo University , 1999 , Chiba , Japan

Graduate Degree

Anesthesia
  • Massachusetts General Hospital , 2002 , Boston , MA

Fellowship

Pediatric Anesthesia
  • Boston Children's Hospital , 2005 , Boston , MA

Fellowship

Pediatric Cardiac Anesthesia
  • Boston Children's Hospital , 2006 , Boston , MA

CERTIFICATIONS

  • American Board of Anesthesiology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Koutsogiannaki S, Bu W, Hou L, Shibamura-Fujiogi M, Ishida H, Ohto U, Eckenhoff RG, Yuki K. The effect of anesthetics on toll like receptor 9. FASEB J. 2020 Sep 09. View abstract
  2. Brustowicz RM, Yuki K. A Simple Screening Test of Filtration Efficiency for Protecting the Gas Sampling Line from CoronavirusUsing Fluorescent Microspheres. Paediatr Anaesth. 2020 Aug 04. View abstract
  3. Mitsui Y, Hou L, Huang X, Odegard KC, Pereira LM, Yuki K. Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation. Anesth Analg. 2020 08; 131(2):631-639. View abstract
  4. Hou L, Yuki K. SerpinB1 expression in Th17 cells depends on hypoxia-inducible factor 1-alpha. Int Immunopharmacol. 2020 Oct; 87:106826. View abstract
  5. Yuki K, Hou L. Role of ß2 Integrins in Neutrophils and Sepsis. Infect Immun. 2020 May 20; 88(6). View abstract
  6. Shaw R, Tighe N, Odegard KC, Alexander P, Emani S, Yuki K. Intubation precautions in a pediatric patient with severe COVID-19. J Pediatr Surg Case Rep. 2020 Jul; 58:101495. View abstract
  7. Mitsui Y, Koutsogiannaki S, Fujiogi M, Yuki K. In Vitro Model of Stretch-Induced Lung Injury to Study Different Lung Ventilation Regimens and the Role of Sedatives. Transl Perioper Pain Med. 2020; 7(3):258-264. View abstract
  8. Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol. 2020 06; 215:108427. View abstract
  9. Yuki K. Anesthetic Management for Heart Transplantation in Adults with Congenital Heart Disease. Transl Perioper Pain Med. 2020; 7(3):248-252. View abstract
  10. Yuki K, Bu W, Eckenhoff RG, Yokomizo T, Okuno T. The role of propofol hydroxyl group in 5-lipoxygenase recognition. Biochem Biophys Res Commun. 2020 May 14; 525(4):909-914. View abstract
  11. Yuki K, Scholl R. Should we Routinely Reverse Neuromuscular Blockade with Sugammadex in Patients with a History of Heart Transplantation? Transl Perioper Pain Med. 2020; 7(2):185-189. View abstract
  12. Lee Y, Banooni A, Yuki K, Staffa SJ, DiNardo JA, Brown ML. Incidence and predictors of postoperative nausea and vomiting in children undergoing electrophysiology ablation procedures. Paediatr Anaesth. 2020 02; 30(2):147-152. View abstract
  13. Okuno T, Koutsogiannaki S, Hou L, Bu W, Ohto U, Eckenhoff RG, Yokomizo T, Yuki K. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. FASEB J. 2019 12; 33(12):14528-14541. View abstract
  14. Hou L, Rao DA, Yuki K, Cooley J, Henderson LA, Jonsson AH, Kaiserman D, Gorman MP, Nigrovic PA, Bird PI, Becher B, Remold-O'Donnell E. SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20635-20643. View abstract
  15. Koutsogiannaki S, Hou L, Babazada H, Okuno T, Blazon-Brown N, Soriano SG, Yokomizo T, Yuki K. The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J. 2019 11; 33(11):12668-12679. View abstract
  16. Kwon R, Koutsogiannaki S, Staffa SJ, Yuki K. The Outcomes of Pediatric Hematopoietic Stem Cell Transplantation Recipients Requiring Intensive Care Unit Admission- A Single Center Experience. Transl Perioper Pain Med. 2019; 6(3):75-80. View abstract
  17. Zha H, Matsunami E, Blazon-Brown N, Koutsogiannaki S, Hou L, Bu W, Babazada H, Odegard KC, Liu R, Eckenhoff RG, Yuki K. Volatile anesthetics affect macrophage phagocytosis. PLoS One. 2019; 14(5):e0216163. View abstract
  18. Koutsogiannaki S, Shimaoka M, Yuki K. The Use of Volatile Anesthetics as Sedatives for Acute Respiratory Distress Syndrome. Transl Perioper Pain Med. 2019; 6(2):27-38. View abstract
  19. Koutsogiannaki S, Bernier R, Tazawa K, Yuki K. Volatile Anesthetic Attenuates Phagocyte Function and Worsens Bacterial Loads in Wounds. J Surg Res. 2019 01; 233:323-330. View abstract
  20. Lee S, Reddington E, Koutsogiannaki S, Hernandez MR, Odegard KC, DiNardo JA, Yuki K. Incidence and Risk Factors for Perioperative Cardiovascular and Respiratory Adverse Events in Pediatric Patients With Congenital Heart Disease Undergoing Noncardiac Procedures. Anesth Analg. 2018 09; 127(3):724-729. View abstract
  21. Yuki K, Lee S, Staffa SJ, DiNardo JA. Induction techniques for pediatric patients with congenital heart disease undergoing noncardiac procedures are influenced by cardiac functional status and residual lesion burden. J Clin Anesth. 2018 Nov; 50:14-17. View abstract
  22. Koutsogiannaki S, Zha H, Yuki K. Volatile Anesthetic Isoflurane Attenuates Liver Injury in Experimental Polymicrobial Sepsis Model. Transl Perioper Pain Med. 2018; 5(3):63-74. View abstract
  23. Yuki K, Koutsogiannaki S, Lee S, DiNardo JA. Unanticipated hospital admission in pediatric patients with congenital heart disease undergoing ambulatory noncardiac surgical procedures. Paediatr Anaesth. 2018 07; 28(7):607-611. View abstract
  24. Aubrey J, Zha H, Yuki K. Incidence and Risk Factors of Perioperative Mortality in Pediatric ICU Patients. Transl Perioper Pain Med. 2018; 5(2):49-54. View abstract
  25. Sen M, Koksal AC, Yuki K, Wang J, Springer TA. Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1. J Biol Chem. 2018 04 27; 293(17):6565-6577. View abstract
  26. Fang ZA, Ghelani SJ, Koutsogiannaki S, DiNardo JA, Yuki K. Validation of a Mathematical Model of Bidirectional Glenn Circulation With Aortopulmonary Collaterals and the Implications for QP/QS Calculation. J Cardiothorac Vasc Anesth. 2018 02; 32(1):395-401. View abstract
  27. Koutsogiannaki S, Schaefers MM, Okuno T, Ohba M, Yokomizo T, Priebe GP, DiNardo JA, Sulpicio SG, Yuki K. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci. 2017 04 01; 156(2):402-411. View abstract
  28. Ferradal SL, Yuki K, Vyas R, Ha CG, Yi F, Stopp C, Wypij D, Cheng HH, Newburger JW, Kaza AK, Franceschini MA, Kussman BD, Grant PE. Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. Sci Rep. 2017 03 09; 7:44117. View abstract
  29. Chamberlain M, Koutsogiannaki S, Schaefers M, Babazada H, Liu R, Yuki K. The Differential Effects of Anesthetics on Bacterial Behaviors. PLoS One. 2017; 12(1):e0170089. View abstract
  30. Okuno T, Koutsogiannaki S, Ohba M, Chamberlain M, Bu W, Lin FY, Eckenhoff RG, Yokomizo T, Yuki K. Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. FASEB J. 2017 04; 31(4):1584-1594. View abstract
  31. Yuki K, Matsunami E, Tazawa K, Wang W, DiNardo JA, Koutsogiannaki S. Pediatric Perioperative Stress Responses and Anesthesia. Transl Perioper Pain Med. 2017; 2(1):1-12. View abstract
  32. Tazawa K, Koutsogiannaki S, Chamberlain M, Yuki K. The effect of different anesthetics on tumor cytotoxicity by natural killer cells. Toxicol Lett. 2017 Jan 15; 266:23-31. View abstract
  33. Williams MR, Atkinson DB, Bezzerides VJ, Yuki K, Franklin K, Casta A, Alexander ME. Pausing With the Gauze: Inhibition of Temporary Pacemakers by Radiofrequency Scan During Cardiac Surgery. Anesth Analg. 2016 11; 123(5):1143-1148. View abstract
  34. Liu JR, Yuki K, Baek C, Han XH, Soriano SG. Dexmedetomidine-Induced Neuroapoptosis Is Dependent on Its Cumulative Dose. Anesth Analg. 2016 10; 123(4):1008-17. View abstract
  35. Yuki K, Eckenhoff RG. Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review. Anesth Analg. 2016 08; 123(2):326-35. View abstract
  36. Lee J, Faraoni D, Lee S, Brown M, Odegard K, Randolph A, DiNardo JA, Yuki K. Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. Paediatr Anaesth. 2016 Jun; 26(6):644-8. View abstract
  37. Faraoni D, Zurakowski D, Vo D, Goobie SM, Yuki K, Brown ML, DiNardo JA. Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2016 Feb 23; 67(7):793-801. View abstract
  38. Greenwald E, Yuki K. A translational consideration of intercellular adhesion molecule-1 biology in the perioperative setting. Transl Perioper Pain Med. 2016; 1(2):17-23. View abstract
  39. Liu JR, Han X, Soriano SG, Yuki K. Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. World J Clin Cases. 2015 Sep 16; 3(9):793-806. View abstract
  40. Whiting D, Yuki K, DiNardo JA. Cardiopulmonary bypass in the pediatric population. Best Pract Res Clin Anaesthesiol. 2015 Jun; 29(2):241-56. View abstract
  41. Jung S, Yuki K. Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen. J Immunotoxicol. 2016; 13(2):148-56. View abstract
  42. Yuki K, Murakami N. Sepsis pathophysiology and anesthetic consideration. Cardiovasc Hematol Disord Drug Targets. 2015; 15(1):57-69. View abstract
  43. Liu JR, Han X, Soriano SG, Yuki K. The role of macrophage 1 antigen in polymicrobial sepsis. Shock. 2014 Dec; 42(6):532-9. View abstract
  44. Yuki K, DiNardo JA. Comparison of actual oxygen delivery kinetics to those predicted by mathematical modeling following stage 1 palliation just prior to superior cavopulmonary anastomosis. Paediatr Anaesth. 2015 Feb; 25(2):174-9. View abstract
  45. Bu W, Pereira LM, Eckenhoff RG, Yuki K. Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. PLoS One. 2014; 9(5):e96649. View abstract
  46. Kollmann CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer TA, Shimaoka M, Evindar G. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. Bioorg Med Chem. 2014 Apr 01; 22(7):2353-65. View abstract
  47. Sen M, Yuki K, Springer TA. An internal ligand-bound, metastable state of a leukocyte integrin, aXß2. J Cell Biol. 2013 Nov 25; 203(4):629-42. View abstract
  48. Yuki K, Bu W, Xi J, Shimaoka M, Eckenhoff R. Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. Anesth Analg. 2013 Oct; 117(4):803-11. View abstract
  49. Yuki K, Bu W, Shimaoka M, Eckenhoff R. Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin aIIbß3. PLoS One. 2013; 8(4):e60415. View abstract
  50. Bertolizio G, Yuki K, Odegard K, Collard V, Dinardo J. Cardiac arrest and neuromuscular blockade reversal agents in the transplanted heart. J Cardiothorac Vasc Anesth. 2013 Dec; 27(6):1374-8. View abstract
  51. Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M. Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth. 2013 Apr; 27(2):261-8. View abstract
  52. Yuki K, Bu W, Xi J, Sen M, Shimaoka M, Eckenhoff RG. Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J. 2012 Nov; 26(11):4408-17. View abstract
  53. Yuki K, Emani S, DiNardo JA. A mathematical model of transitional circulation toward biventricular repair in hypoplastic left heart syndrome. Anesth Analg. 2012 Sep; 115(3):618-26. View abstract
  54. Yuki K, Sharma R, DiNardo J. Ventricular-assist device therapy in children. Best Pract Res Clin Anaesthesiol. 2012 Jun; 26(2):247-64. View abstract
  55. Ishigaki D, Okuyama H, Yuki K, Sato Y, Ogawa N, Hirono O, Kubota I. Serial evaluation of left ventricular contraction and relaxation in Takotsubo cardiomyopathy by 2D speckle tracking echocardiography. J Med Ultrason (2001). 2012 Oct; 39(4):265-9. View abstract
  56. Collard V, Segura LG, Daaboul DG, Yuki K. Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. J Anesth. 2012 Apr; 26(2):273-4. View abstract
  57. Yuki K, Chilson K, DiNardo JA. Improvement of PaO2 during one-lung ventilation with partial left-heart bypass in pediatric patients is caused by increased blood flow to the dependent lung. J Cardiothorac Vasc Anesth. 2013 Jun; 27(3):542-5. View abstract
  58. Yuki K. Cell-free ligand-binding assays for integrin LFA-1. Methods Mol Biol. 2012; 757:73-8. View abstract
  59. Koeberle A, Shindou H, Harayama T, Yuki K, Shimizu T. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 2012 Jan; 26(1):169-80. View abstract
  60. Wesley MC, Yuki K, Daaboul DG, Dinardo JA. Blood utilization in neonates and infants undergoing cardiac surgery requiring cardiopulmonary bypass. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):382-92. View abstract
  61. Daaboul DG, Yuki K, Wesley MC, Dinardo JA. Anesthetic and cardiopulmonary bypass considerations for cardiac surgery in unique pediatric patient populations: sickle cell disease and cold agglutinin disease. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):364-70. View abstract
  62. Yuki K, Daaboul DG. Postoperative maladaptive behavioral changes in children. Middle East J Anaesthesiol. 2011 Jun; 21(2):183-9. View abstract
  63. Yuki K, Soriano SG, Shimaoka M. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011 Apr; 112(4):830-8. View abstract
  64. Yuki K, Casta A, Uezono S. Anesthetic management of noncardiac surgery for patients with single ventricle physiology. J Anesth. 2011 Apr; 25(2):247-56. View abstract
  65. Yuki K, Astrof NS, Bracken C, Soriano SG, Shimaoka M. Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 2010 Sep; 113(3):600-9. View abstract
  66. Okuyama H, Hirono O, Ishigaki D, Yuki K, Kubota I. Percutaneous transvenous stent implantation to external iliac vein stenosis in a patient with retroperitoneal fibrosis. Intern Med. 2010; 49(10):913-8. View abstract
  67. Yuki K, Sakuramoto C, Matsumoto C, Hoshino M, Niimi Y. The effect of left heart bypass on pulmonary blood flow and arterial oxygenation during one-lung ventilation in patients undergoing descending thoracic aortic surgery. J Clin Anesth. 2009 Dec; 21(8):562-6. View abstract
  68. Yuki K, Casta A. Management of difficult airway in pediatric patients with right ventricular outflow tract obstruction. J Anesth. 2009; 23(2):281-3. View abstract
  69. Yuki K, Shindou H, Hishikawa D, Shimizu T. Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. J Lipid Res. 2009 May; 50(5):860-9. View abstract
  70. Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T. Recent progress on acyl CoA: lysophospholipid acyltransferase research. J Lipid Res. 2009 Apr; 50 Suppl:S46-51. View abstract
  71. Yuki K, Astrof NS, Bracken C, Yoo R, Silkworth W, Soriano SG, Shimaoka M. The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008 Dec; 22(12):4109-16. View abstract
  72. Yuki K, Chilson K, Odegard KC, DiNardo JA. Trendelenburg position, simulated Valsalva maneuver, and liver compression do not alter the size of the right internal jugular vein in patients with a bidirectional Glenn shunt. Anesth Analg. 2007 Aug; 105(2):365-8. View abstract
  73. Yuki K, Shamberger RC, McGowan FX, Seefelder C. The perioperative management of a patient with Fontan physiology for pheochromocytoma resection. J Cardiothorac Vasc Anesth. 2008 Oct; 22(5):748-50. View abstract
  74. Casta A, Brown DW, Yuki K. Induction of supraventricular tachycardia during transesophageal echocardiography: an unusual complication. J Cardiothorac Vasc Anesth. 2008 Aug; 22(4):592-3. View abstract
  75. Kakinuma Y, Miyauchi T, Suzuki T, Yuki K, Murakoshi N, Goto K, Yamaguchi I. Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1 alpha. Clin Sci (Lond). 2002 Aug; 103 Suppl 48:210S-214S. View abstract
  76. Yuki K, Suzuki T, Katoh S, Kakinuma Y, Miyauchi T, Mitsui Y. Endothelin-1 stimulates cardiomyocyte injury during mitochondrial dysfunction in culture. Eur J Pharmacol. 2001 Nov 16; 431(2):163-70. View abstract
  77. Fujiwara S, Takeishi Y, Hirono O, Fukui A, Okuyama M, Yamaguchi S, Ito M, Kaneko K, Shishido T, Miyamoto T, Yuki K, Miyashita T, Takahashi K, Minamihaba O, Tomoike H, Yamauchi S, Fatema K. Reverse redistribution of 99m Tc-sestamibi after direct percutaneous transluminal coronary angioplasty in acute myocardial infarction: relationship with wall motion and functional response to dobutamine stimulation. Nucl Med Commun. 2001 Nov; 22(11):1223-30. View abstract
  78. Kumagai Y, Hayashi T, Miyauchi T, Endo A, Iguchi A, Kiriya-Sakai M, Sakai S, Yuki K, Kikushima M, Shimojo N. Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation. Am J Physiol Regul Integr Comp Physiol. 2001 Jul; 281(1):R25-30. View abstract
  79. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I. Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism. Circulation. 2001 May 15; 103(19):2387-94. View abstract
  80. Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Suzuki T, Hayashi J, Goto K, Yamaguchi I. Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S205-8. View abstract
  81. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I. Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S201-4. View abstract
  82. Murakoshi N, Miyauchi T, Kakinuma Y, Yuki K, Goto K, Yamaguchi I. Impairment of cardiac energy metabolism in vivo causes hemodynamic abnormality and increases cardiac expression of preproendothelin-1 mRNA. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S128-31. View abstract
  83. Iemitsu M, Miyauchi T, Maeda S, Yuki K, Kobayashi T, Kumagai Y, Shimojo N, Yamaguchi I, Matsuda M. Intense exercise causes decrease in expression of both endothelial NO synthase and tissue NOx level in hearts. Am J Physiol Regul Integr Comp Physiol. 2000 Sep; 279(3):R951-9. View abstract
  84. Pi J, Kumagai Y, Sun G, Yamauchi H, Yoshida T, Iso H, Endo A, Yu L, Yuki K, Miyauchi T, Shimojo N. Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in inner Mongolia. Free Radic Biol Med. 2000 Apr 01; 28(7):1137-42. View abstract
  85. Nagai S, Abe S, Sato T, Hozawa K, Yuki K, Hanashima K, Tomoike H. Ultrasonic assessment of vascular complications in coronary angiography and angioplasty after transradial approach. Am J Cardiol. 1999 Jan 15; 83(2):180-6. View abstract
  86. Kakinuma Y, Miyauchi T, Kobayashi T, Yuki K, Maeda S, Sakai S, Goto K, Yamaguchi I. Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo. Life Sci. 1999; 65(16):1671-83. View abstract
  87. Naito H, Miyoshi A, Nakatsuka M, Yuki K, Yamada H, Kobayashi Y, Tanimoto Y. [A case of unruptured aneurysm of the sinus of Valsalva producing a right ventricular outflow obstruction]. Kokyu To Junkan. 1985 Apr; 33(4):581-5. View abstract