EDUCATION

Undergraduate Degree

  • Aquinas College , 1978 , Milton , MA

Medical School

  • Michigan State University College of Osteopathic Medicine , 1981 , East Lansing , MI

Internship

  • Grand Rapids Osteopathic Hospital , 1982 , Grand Rapids , MI

Internship

Pediatrics
  • Columbus Children's Hospital , 1983 , Columbus , OH

Residency

Pediatrics
  • Columbus Children's Hospital , 1985 , Columbus , OH

Fellowship

Pediatric Pulmonary
  • University of Florida College of Medicine , 1989 , Gainesville , FL

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Pulmonology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. miR-21 antagonism reprograms macrophage metabolism and abrogates chronic allograft vasculopathy. Am J Transplant. 2021 Mar 25. View abstract
  2. Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial. Am J Transplant. 2021 Mar 22. View abstract
  3. N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction. J Heart Lung Transplant. 2021 Mar 02. View abstract
  4. The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients. J Heart Lung Transplant. 2021 Mar; 40(3):210-219. View abstract
  5. Pediatric lung transplant: Correlation of pretransplant condition with post-transplant outcomes. Pediatr Transplant. 2021 Mar; 25(2):e13889. View abstract
  6. FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. Mol Med. 2020 07 31; 26(1):75. View abstract
  7. When to consider a posterolateral descending aortopexy in addition to a posterior tracheopexy for the surgical treatment of symptomatic tracheobronchomalacia. J Pediatr Surg. 2020 Dec; 55(12):2682-2689. View abstract
  8. Current evaluation and management of plastic bronchitis in the pediatric population. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130:109799. View abstract
  9. Mitochondrial transplantation enhances murine lung viability and recovery after ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L78-L88. View abstract
  10. Medical Deferred Action - Living on Borrowed Time. N Engl J Med. 2019 Oct 24; 381(17):1601-1603. View abstract
  11. Absence of evidence that respiratory viral infections influence pediatric lung transplantation outcomes: Results of the CTOTC-03 study. Am J Transplant. 2019 12; 19(12):3284-3298. View abstract
  12. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Circulation. 2019 09 09; 140(10):846-863. View abstract
  13. Treatment of severe persistent asthma with IL-6 receptor blockade. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1639-1642.e4. View abstract
  14. Mitochondrial transplantation prolongs cold ischemia time in murine heart transplantation. J Heart Lung Transplant. 2019 01; 38(1):92-99. View abstract
  15. Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 08 01; 128(8):3583-3594. View abstract
  16. P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes. J Clin Invest. 2018 08 01; 128(8):3490-3503. View abstract
  17. RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of ß-thalassemia intermedia. Am J Hematol. 2018 Jun; 93(6):745-750. View abstract
  18. Descending Aortopexy and Posterior Tracheopexy for Severe Tracheomalacia and Left Mainstem Bronchomalacia. Semin Thorac Cardiovasc Surg. 2019; 31(3):479-485. View abstract
  19. Posterior Tracheopexy for Severe Tracheomalacia Associated with Esophageal Atresia (EA): Primary Treatment at the Time of Initial EA Repair versus Secondary Treatment. Front Surg. 2017; 4:80. View abstract
  20. Anellovirus loads are associated with outcomes in pediatric lung transplantation. Pediatr Transplant. 2018 02; 22(1). View abstract
  21. Risk and outcomes of pulmonary fungal infection after pediatric lung transplantation. Clin Transplant. 2017 Nov; 31(11). View abstract
  22. Lymphatic Vessels: The Next Frontier in Lung Transplant. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3):S226-S232. View abstract
  23. Epstein-Barr viral loads do not predict post-transplant lymphoproliferative disorder in pediatric lung transplant recipients: A multicenter prospective cohort study. Pediatr Transplant. 2017 Sep; 21(6). View abstract
  24. Transplant center volume and outcomes in lung transplantation for cystic fibrosis. Transpl Int. 2017 Apr; 30(4):371-377. View abstract
  25. Impact of gastroesophageal reflux and delayed gastric emptying on pediatric lung transplant outcomes. J Heart Lung Transplant. 2017 Aug; 36(8):854-861. View abstract
  26. Outcomes of mechanical support in a pediatric lung transplant center. Pediatr Pulmonol. 2017 03; 52(3):360-366. View abstract
  27. Paracorporeal lung assist device in infants and toddlers: Coming of age? Pediatr Transplant. 2016 Mar; 20(2):191-3. View abstract
  28. Broader Geographic Sharing of Pediatric Donor Lungs Improves Pediatric Access to Transplant. Am J Transplant. 2016 Mar; 16(3):930-7. View abstract
  29. Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection. J Clin Invest. 2015 Nov 02; 125(11):4255-68. View abstract
  30. Official American Thoracic Society technical standards: flexible airway endoscopy in children. Am J Respir Crit Care Med. 2015 May 01; 191(9):1066-80. View abstract
  31. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015 Jan; 21(1):47-54. View abstract
  32. Inhibition of the purinergic pathway prolongs mouse lung allograft survival. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):300-10. View abstract
  33. The purinergic system in allotransplantation. Am J Transplant. 2014 Mar; 14(3):507-14. View abstract
  34. Identification of dedifferentiation and redevelopment phases during postpneumonectomy lung growth. . 2013 Oct 15; 305(8):L542-54. View abstract
  35. Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. Am J Respir Crit Care Med. 2013 Aug 15; 188(4):482-91. View abstract
  36. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. Circulation. 2013 Jan 29; 127(4):463-75. View abstract
  37. Lung transplantation in children following bone marrow transplantation: a multi-center experience. Pediatr Transplant. 2013 May; 17(3):231-6. View abstract
  38. Inhibitory effects of pirfenidone on dendritic cells and lung allograft rejection. Transplantation. 2012 Jul 27; 94(2):114-22. View abstract
  39. Indoleamine 2,3-dioxygenase and metabolites protect murine lung allografts and impair the calcium mobilization of T cells. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):405-16. View abstract
  40. Induction therapy with antithymocyte globulin before reperfusion. Ann Thorac Surg. 2010 Oct; 90(4):1110-4; discussion 1114-5. View abstract
  41. Neonatal respiratory failure due to a novel mutation in the surfactant protein C gene. J Perinatol. 2010 Feb; 30(2):151-3. View abstract
  42. Minimal acute rejection in pediatric lung transplantation--does it matter? Pediatr Transplant. 2010 Jun; 14(4):534-9. View abstract
  43. Cytomegalovirus immunoglobulin decreases the risk of cytomegalovirus infection but not disease after pediatric lung transplantation. J Heart Lung Transplant. 2009 Oct; 28(10):1050-6. View abstract
  44. Pirfenidone inhibits T-cell activation, proliferation, cytokine and chemokine production, and host alloresponses. Transplantation. 2009 Aug 15; 88(3):330-8. View abstract
  45. Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression. J Immunol. 2009 Jul 15; 183(2):1022-31. View abstract
  46. The risk, prevention, and outcome of cytomegalovirus after pediatric lung transplantation. Transplantation. 2009 May 27; 87(10):1541-8. View abstract
  47. Respiratory viral infections within one year after pediatric lung transplant. Transpl Infect Dis. 2009 Aug; 11(4):304-12. View abstract
  48. Increased mortality after pulmonary fungal infection within the first year after pediatric lung transplantation. J Heart Lung Transplant. 2008 Jun; 27(6):655-61. View abstract
  49. Lung transplantation in cystic fibrosis--primum non nocere? N Engl J Med. 2007 Nov 22; 357(21):2186-8. View abstract
  50. Nonviral gene delivery with indoleamine 2,3-dioxygenase targeting pulmonary endothelium protects against ischemia-reperfusion injury. Am J Transplant. 2007 Oct; 7(10):2291-300. View abstract
  51. Applications of Sleeping Beauty transposons for nonviral gene therapy. IUBMB Life. 2007 Jun; 59(6):374-9. View abstract
  52. Posttransplant monitoring of pediatric lung transplant recipients. Curr Opin Pediatr. 2007 Jun; 19(3):321-6. View abstract
  53. American Society of Transplantation executive summary on pediatric lung transplantation. Am J Transplant. 2007 Feb; 7(2):285-92. View abstract
  54. Sleeping Beauty-mediated eNOS gene therapy attenuates monocrotaline-induced pulmonary hypertension in rats. FASEB J. 2006 Dec; 20(14):2594-6. View abstract
  55. Sleeping Beauty-based gene therapy with indoleamine 2,3-dioxygenase inhibits lung allograft fibrosis. FASEB J. 2006 Nov; 20(13):2384-6. View abstract
  56. Bone marrow stem cells as a vehicle for delivery of heme oxygenase-1 gene. Stem Cells Dev. 2006 Feb; 15(1):79-86. View abstract
  57. Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension. Lab Invest. 2006 Jan; 86(1):62-71. View abstract
  58. Novel action of indoleamine 2,3-dioxygenase attenuating acute lung allograft injury. Am J Respir Crit Care Med. 2006 Mar 01; 173(5):566-72. View abstract
  59. Pirfenidone inhibits obliterative airway disease in mouse tracheal allografts. J Heart Lung Transplant. 2005 Oct; 24(10):1577-85. View abstract
  60. Pirfenidone inhibits inflammatory responses and ameliorates allograft injury in a rat lung transplant model. J Thorac Cardiovasc Surg. 2005 Sep; 130(3):852-8. View abstract
  61. Bone marrow-derived stem-cell repopulation contributes minimally to the Type II pneumocyte pool in transplanted human lungs. Transplantation. 2005 Jul 27; 80(2):206-12. View abstract
  62. Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway. Am J Transplant. 2005 Jun; 5(6):1256-63. View abstract
  63. The use of multiple transbronchial biopsies as the standard approach to evaluate lung allograft rejection. Pediatr Transplant. 2004 Aug; 8(4):322-8. View abstract
  64. Role of transbronchial biopsies in pediatric lung diseases. Chest. 2004 Jul; 126(1):273-80. View abstract
  65. Heme oxygenase-1 expression in human lungs with cystic fibrosis and cytoprotective effects against Pseudomonas aeruginosa in vitro. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):633-40. View abstract
  66. Heme-oxygenase-1 expression correlates with severity of acute cellular rejection in lung transplantation. J Am Coll Surg. 2004 Jun; 198(6):945-52. View abstract
  67. Graft protective effects of heme oxygenase 1 in mouse tracheal transplant-related obliterative bronchiolitis. Transplantation. 2003 Aug 27; 76(4):650-6. View abstract
  68. A cis-acting region regulates oxidized lipid-mediated induction of the human heme oxygenase-1 gene in endothelial cells. Arterioscler Thromb Vasc Biol. 2003 Aug 01; 23(8):1416-22. View abstract
  69. Toxic serum trough concentrations after administration of nebulized tobramycin. Pharmacotherapy. 2003 Apr; 23(4):543-5. View abstract
  70. Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin. Circulation. 2003 Feb 18; 107(6):911-6. View abstract
  71. Resistance to hyperoxia with heme oxygenase-1 disruption: role of iron. Free Radic Biol Med. 2003 Jan 01; 34(1):124-33. View abstract
  72. Increased expression of heme oxygenase-1 in human lung transplantation. J Heart Lung Transplant. 2002 Oct; 21(10):1120-6. View abstract
  73. Analysis of early deaths after isolated lung transplantation. Chest. 2001 Jul; 120(1):225-32. View abstract
  74. Geneticin induces endogenous heme oxygenase-1 expression: implication in transfection studies. Anal Biochem. 2001 Feb 15; 289(2):303-5. View abstract
  75. Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells. J Biol Chem. 2000 Dec 29; 275(52):40904-9. View abstract
  76. Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am J Physiol Renal Physiol. 2000 May; 278(5):F726-36. View abstract
  77. Transcriptional regulation and structural organization of the human cytosolic phospholipase A(2) gene. . 2000 Apr; 278(4):L649-57. View abstract
  78. Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells. Am J Respir Cell Mol Biol. 1999 Apr; 20(4):797-804. View abstract
  79. Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells. J Am Soc Nephrol. 1998 Nov; 9(11):1990-7. View abstract
  80. Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells. Chest. 1998 Jul; 114(1 Suppl):63S-64S. View abstract
  81. Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells. Am J Physiol. 1998 05; 274(5):L854-63. View abstract
  82. Identification of urokinase as a hyperoxia-inducible gene. Mol Genet Metab. 1998 Apr; 63(4):295-301. View abstract
  83. Hyperoxia-responsive proteins in rat pulmonary microvascular endothelial cells. Am J Physiol. 1996 Apr; 270(4 Pt 1):L517-25. View abstract
  84. Effects of vasoactive and inflammatory mediators on endothelin-1 expression in pulmonary endothelial cells. Am J Respir Cell Mol Biol. 1995 May; 12(5):503-12. View abstract
  85. Endothelin-1 expression in myenteric neurons cultured from rat small intestine. Regul Pept. 1995 Jan 26; 55(2):167-77. View abstract
  86. Isolation and maintenance of human pulmonary artery endothelial cells in culture isolated from transplant donors. Am J Physiol. 1994 Oct; 267(4 Pt 1):L406-13. View abstract
  87. Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-gamma, TGF-beta, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages. Biochem Biophys Res Commun. 1994 Apr 15; 200(1):126-34. View abstract
  88. Regulation of endothelin-1 expression in normal and transfected endothelial cells. J Cardiovasc Pharmacol. 1993; 22 Suppl 8:S38-41. View abstract
  89. Regulation of manganese superoxide dismutase: IL-1 and TNF induction in pulmonary artery and microvascular endothelial cells. Biochem Biophys Res Commun. 1992 Oct 15; 188(1):453-62. View abstract
  90. Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison. Biochem Biophys Res Commun. 1992 Jul 31; 186(2):936-43. View abstract
  91. Multiple mRNA species generated by alternate polyadenylation from the rat manganese superoxide dismutase gene. Nucleic Acids Res. 1992 Jun 25; 20(12):2985-90. View abstract
  92. Regulation of manganese superoxide dismutase in porcine pulmonary artery endothelial cells. Am J Physiol. 1991 Jun; 260(6 Pt 1):L444-9. View abstract
  93. Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response. J Biol Chem. 1990 Feb 15; 265(5):2856-64. View abstract