EDUCATION

Undergraduate Degree

  • Aquinas College , 1978 , Milton , MA

Medical School

  • Michigan State University College of Osteopathic Medicine , 1981 , East Lansing , MI

Internship

  • Grand Rapids Osteopathic Hospital , 1982 , Grand Rapids , MI

Internship

Pediatrics
  • Columbus Children's Hospital , 1983 , Columbus , OH

Residency

Pediatrics
  • Columbus Children's Hospital , 1985 , Columbus , OH

Fellowship

Pediatric Pulmonary
  • University of Florida College of Medicine , 1989 , Gainesville , FL

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Pulmonology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Precision Cut Lung Slices as an Efficient Tool for Ex vivo Pulmonary Vessel Structure and Contractility Studies. J Vis Exp. 2021 05 24; (171). View abstract
  2. Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients. J Heart Lung Transplant. 2021 Jul; 40(7):539-556. View abstract
  3. Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial. Am J Transplant. 2021 Sep; 21(9):3112-3122. View abstract
  4. miR-21 antagonism reprograms macrophage metabolism and abrogates chronic allograft vasculopathy. Am J Transplant. 2021 Mar 25. View abstract
  5. N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction. J Heart Lung Transplant. 2021 Jun; 40(6):447-457. View abstract
  6. The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients. J Heart Lung Transplant. 2021 03; 40(3):210-219. View abstract
  7. Pediatric lung transplant: Correlation of pretransplant condition with post-transplant outcomes. Pediatr Transplant. 2021 03; 25(2):e13889. View abstract
  8. FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. Mol Med. 2020 07 31; 26(1):75. View abstract
  9. When to consider a posterolateral descending aortopexy in addition to a posterior tracheopexy for the surgical treatment of symptomatic tracheobronchomalacia. J Pediatr Surg. 2020 Dec; 55(12):2682-2689. View abstract
  10. Current evaluation and management of plastic bronchitis in the pediatric population. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130:109799. View abstract
  11. Mitochondrial transplantation enhances murine lung viability and recovery after ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L78-L88. View abstract
  12. Medical Deferred Action - Living on Borrowed Time. N Engl J Med. 2019 Oct 24; 381(17):1601-1603. View abstract
  13. Absence of evidence that respiratory viral infections influence pediatric lung transplantation outcomes: Results of the CTOTC-03 study. Am J Transplant. 2019 12; 19(12):3284-3298. View abstract
  14. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Circulation. 2019 09 09; 140(10):846-863. View abstract
  15. Treatment of severe persistent asthma with IL-6 receptor blockade. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1639-1642.e4. View abstract
  16. Mitochondrial transplantation prolongs cold ischemia time in murine heart transplantation. J Heart Lung Transplant. 2019 01; 38(1):92-99. View abstract
  17. Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 08 01; 128(8):3583-3594. View abstract
  18. P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes. J Clin Invest. 2018 08 01; 128(8):3490-3503. View abstract
  19. RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of ß-thalassemia intermedia. Am J Hematol. 2018 Jun; 93(6):745-750. View abstract
  20. Descending Aortopexy and Posterior Tracheopexy for Severe Tracheomalacia and Left Mainstem Bronchomalacia. Semin Thorac Cardiovasc Surg. 2019; 31(3):479-485. View abstract
  21. Posterior Tracheopexy for Severe Tracheomalacia Associated with Esophageal Atresia (EA): Primary Treatment at the Time of Initial EA Repair versus Secondary Treatment. Front Surg. 2017; 4:80. View abstract
  22. Anellovirus loads are associated with outcomes in pediatric lung transplantation. Pediatr Transplant. 2018 02; 22(1). View abstract
  23. Risk and outcomes of pulmonary fungal infection after pediatric lung transplantation. Clin Transplant. 2017 Nov; 31(11). View abstract
  24. Lymphatic Vessels: The Next Frontier in Lung Transplant. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3):S226-S232. View abstract
  25. Epstein-Barr viral loads do not predict post-transplant lymphoproliferative disorder in pediatric lung transplant recipients: A multicenter prospective cohort study. Pediatr Transplant. 2017 Sep; 21(6). View abstract
  26. Transplant center volume and outcomes in lung transplantation for cystic fibrosis. Transpl Int. 2017 Apr; 30(4):371-377. View abstract
  27. Impact of gastroesophageal reflux and delayed gastric emptying on pediatric lung transplant outcomes. J Heart Lung Transplant. 2017 Aug; 36(8):854-861. View abstract
  28. Outcomes of mechanical support in a pediatric lung transplant center. Pediatr Pulmonol. 2017 03; 52(3):360-366. View abstract
  29. Paracorporeal lung assist device in infants and toddlers: Coming of age? Pediatr Transplant. 2016 Mar; 20(2):191-3. View abstract
  30. Broader Geographic Sharing of Pediatric Donor Lungs Improves Pediatric Access to Transplant. Am J Transplant. 2016 Mar; 16(3):930-7. View abstract
  31. Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection. J Clin Invest. 2015 Nov 02; 125(11):4255-68. View abstract
  32. Official American Thoracic Society technical standards: flexible airway endoscopy in children. Am J Respir Crit Care Med. 2015 May 01; 191(9):1066-80. View abstract
  33. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015 Jan; 21(1):47-54. View abstract
  34. Inhibition of the purinergic pathway prolongs mouse lung allograft survival. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):300-10. View abstract
  35. The purinergic system in allotransplantation. Am J Transplant. 2014 Mar; 14(3):507-14. View abstract
  36. Identification of dedifferentiation and redevelopment phases during postpneumonectomy lung growth. . 2013 Oct 15; 305(8):L542-54. View abstract
  37. Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. Am J Respir Crit Care Med. 2013 Aug 15; 188(4):482-91. View abstract
  38. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. Circulation. 2013 Jan 29; 127(4):463-75. View abstract
  39. Lung transplantation in children following bone marrow transplantation: a multi-center experience. Pediatr Transplant. 2013 May; 17(3):231-6. View abstract
  40. Inhibitory effects of pirfenidone on dendritic cells and lung allograft rejection. Transplantation. 2012 Jul 27; 94(2):114-22. View abstract
  41. Indoleamine 2,3-dioxygenase and metabolites protect murine lung allografts and impair the calcium mobilization of T cells. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):405-16. View abstract
  42. Induction therapy with antithymocyte globulin before reperfusion. Ann Thorac Surg. 2010 Oct; 90(4):1110-4; discussion 1114-5. View abstract
  43. Neonatal respiratory failure due to a novel mutation in the surfactant protein C gene. J Perinatol. 2010 Feb; 30(2):151-3. View abstract
  44. Minimal acute rejection in pediatric lung transplantation--does it matter? Pediatr Transplant. 2010 Jun; 14(4):534-9. View abstract
  45. Cytomegalovirus immunoglobulin decreases the risk of cytomegalovirus infection but not disease after pediatric lung transplantation. J Heart Lung Transplant. 2009 Oct; 28(10):1050-6. View abstract
  46. Pirfenidone inhibits T-cell activation, proliferation, cytokine and chemokine production, and host alloresponses. Transplantation. 2009 Aug 15; 88(3):330-8. View abstract
  47. Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression. J Immunol. 2009 Jul 15; 183(2):1022-31. View abstract
  48. The risk, prevention, and outcome of cytomegalovirus after pediatric lung transplantation. Transplantation. 2009 May 27; 87(10):1541-8. View abstract
  49. Respiratory viral infections within one year after pediatric lung transplant. Transpl Infect Dis. 2009 Aug; 11(4):304-12. View abstract
  50. Increased mortality after pulmonary fungal infection within the first year after pediatric lung transplantation. J Heart Lung Transplant. 2008 Jun; 27(6):655-61. View abstract
  51. Lung transplantation in cystic fibrosis--primum non nocere? N Engl J Med. 2007 Nov 22; 357(21):2186-8. View abstract
  52. Nonviral gene delivery with indoleamine 2,3-dioxygenase targeting pulmonary endothelium protects against ischemia-reperfusion injury. Am J Transplant. 2007 Oct; 7(10):2291-300. View abstract
  53. Applications of Sleeping Beauty transposons for nonviral gene therapy. IUBMB Life. 2007 Jun; 59(6):374-9. View abstract
  54. Posttransplant monitoring of pediatric lung transplant recipients. Curr Opin Pediatr. 2007 Jun; 19(3):321-6. View abstract
  55. American Society of Transplantation executive summary on pediatric lung transplantation. Am J Transplant. 2007 Feb; 7(2):285-92. View abstract
  56. Sleeping Beauty-mediated eNOS gene therapy attenuates monocrotaline-induced pulmonary hypertension in rats. FASEB J. 2006 Dec; 20(14):2594-6. View abstract
  57. Sleeping Beauty-based gene therapy with indoleamine 2,3-dioxygenase inhibits lung allograft fibrosis. FASEB J. 2006 Nov; 20(13):2384-6. View abstract
  58. Bone marrow stem cells as a vehicle for delivery of heme oxygenase-1 gene. Stem Cells Dev. 2006 Feb; 15(1):79-86. View abstract
  59. Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension. Lab Invest. 2006 Jan; 86(1):62-71. View abstract
  60. Novel action of indoleamine 2,3-dioxygenase attenuating acute lung allograft injury. Am J Respir Crit Care Med. 2006 Mar 01; 173(5):566-72. View abstract
  61. Pirfenidone inhibits obliterative airway disease in mouse tracheal allografts. J Heart Lung Transplant. 2005 Oct; 24(10):1577-85. View abstract
  62. Pirfenidone inhibits inflammatory responses and ameliorates allograft injury in a rat lung transplant model. J Thorac Cardiovasc Surg. 2005 Sep; 130(3):852-8. View abstract
  63. Bone marrow-derived stem-cell repopulation contributes minimally to the Type II pneumocyte pool in transplanted human lungs. Transplantation. 2005 Jul 27; 80(2):206-12. View abstract
  64. Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway. Am J Transplant. 2005 Jun; 5(6):1256-63. View abstract
  65. The use of multiple transbronchial biopsies as the standard approach to evaluate lung allograft rejection. Pediatr Transplant. 2004 Aug; 8(4):322-8. View abstract
  66. Role of transbronchial biopsies in pediatric lung diseases. Chest. 2004 Jul; 126(1):273-80. View abstract
  67. Heme oxygenase-1 expression in human lungs with cystic fibrosis and cytoprotective effects against Pseudomonas aeruginosa in vitro. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):633-40. View abstract
  68. Heme-oxygenase-1 expression correlates with severity of acute cellular rejection in lung transplantation. J Am Coll Surg. 2004 Jun; 198(6):945-52. View abstract
  69. Graft protective effects of heme oxygenase 1 in mouse tracheal transplant-related obliterative bronchiolitis. Transplantation. 2003 Aug 27; 76(4):650-6. View abstract
  70. A cis-acting region regulates oxidized lipid-mediated induction of the human heme oxygenase-1 gene in endothelial cells. Arterioscler Thromb Vasc Biol. 2003 Aug 01; 23(8):1416-22. View abstract
  71. Toxic serum trough concentrations after administration of nebulized tobramycin. Pharmacotherapy. 2003 Apr; 23(4):543-5. View abstract
  72. Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin. Circulation. 2003 Feb 18; 107(6):911-6. View abstract
  73. Resistance to hyperoxia with heme oxygenase-1 disruption: role of iron. Free Radic Biol Med. 2003 Jan 01; 34(1):124-33. View abstract
  74. Increased expression of heme oxygenase-1 in human lung transplantation. J Heart Lung Transplant. 2002 Oct; 21(10):1120-6. View abstract
  75. Analysis of early deaths after isolated lung transplantation. Chest. 2001 Jul; 120(1):225-32. View abstract
  76. Geneticin induces endogenous heme oxygenase-1 expression: implication in transfection studies. Anal Biochem. 2001 Feb 15; 289(2):303-5. View abstract
  77. Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells. J Biol Chem. 2000 Dec 29; 275(52):40904-9. View abstract
  78. Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am J Physiol Renal Physiol. 2000 May; 278(5):F726-36. View abstract
  79. Transcriptional regulation and structural organization of the human cytosolic phospholipase A(2) gene. . 2000 Apr; 278(4):L649-57. View abstract
  80. Iron regulates hyperoxia-dependent human heme oxygenase 1 gene expression in pulmonary endothelial cells. Am J Respir Cell Mol Biol. 1999 Apr; 20(4):797-804. View abstract
  81. Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells. J Am Soc Nephrol. 1998 Nov; 9(11):1990-7. View abstract
  82. Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells. Chest. 1998 Jul; 114(1 Suppl):63S-64S. View abstract
  83. Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells. Am J Physiol. 1998 05; 274(5):L854-63. View abstract
  84. Identification of urokinase as a hyperoxia-inducible gene. Mol Genet Metab. 1998 Apr; 63(4):295-301. View abstract
  85. Hyperoxia-responsive proteins in rat pulmonary microvascular endothelial cells. Am J Physiol. 1996 Apr; 270(4 Pt 1):L517-25. View abstract
  86. Effects of vasoactive and inflammatory mediators on endothelin-1 expression in pulmonary endothelial cells. Am J Respir Cell Mol Biol. 1995 May; 12(5):503-12. View abstract
  87. Endothelin-1 expression in myenteric neurons cultured from rat small intestine. Regul Pept. 1995 Jan 26; 55(2):167-77. View abstract
  88. Isolation and maintenance of human pulmonary artery endothelial cells in culture isolated from transplant donors. Am J Physiol. 1994 Oct; 267(4 Pt 1):L406-13. View abstract
  89. Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-gamma, TGF-beta, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages. Biochem Biophys Res Commun. 1994 Apr 15; 200(1):126-34. View abstract
  90. Regulation of endothelin-1 expression in normal and transfected endothelial cells. J Cardiovasc Pharmacol. 1993; 22 Suppl 8:S38-41. View abstract
  91. Regulation of manganese superoxide dismutase: IL-1 and TNF induction in pulmonary artery and microvascular endothelial cells. Biochem Biophys Res Commun. 1992 Oct 15; 188(1):453-62. View abstract
  92. Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison. Biochem Biophys Res Commun. 1992 Jul 31; 186(2):936-43. View abstract
  93. Multiple mRNA species generated by alternate polyadenylation from the rat manganese superoxide dismutase gene. Nucleic Acids Res. 1992 Jun 25; 20(12):2985-90. View abstract
  94. Regulation of manganese superoxide dismutase in porcine pulmonary artery endothelial cells. Am J Physiol. 1991 Jun; 260(6 Pt 1):L444-9. View abstract
  95. Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response. J Biol Chem. 1990 Feb 15; 265(5):2856-64. View abstract