MEDIA

Caregiver Profile

Caregiver Profile

Meet Dr. Wayne Tworetzky

MEDICAL SERVICES

EDUCATION

Medical School

  • University of Stellen Bosch , 1985 , Stellenbosch , South Africa

Internship

  • Groote Schuur Hospital , 1989 , Cape Town , South Africa

Residency

  • Groote Schuur Hospital , 1993 , Cape Town , South Africa

Residency

  • University of California , 1995 , Los Angeles , CA

Fellowship

  • University of California , 1999 , San Francisco , CA

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Cardiology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Late gestation predictors of a postnatal biventricular circulation after fetal aortic valvuloplasty. Prenat Diagn. 2021 Mar; 41(4):479-485. View abstract
  2. Extracardiac Doppler indices predict perinatal mortality in fetuses with Ebstein anomaly and tricuspid valve dysplasia. Prenat Diagn. 2021 Feb; 41(3):332-340. View abstract
  3. Effect of In Utero Non-Steroidal Anti-Inflammatory Drug Therapy for Severe Ebstein Anomaly or Tricuspid Valve Dysplasia (NSAID Therapy for Fetal Ebstein anomaly). Am J Cardiol. 2021 02 15; 141:106-112. View abstract
  4. Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease. Ann Neurol. 2021 01; 89(1):143-157. View abstract
  5. Risk Factors for Mortality and Circulatory Outcome Among Neonates Prenatally Diagnosed With Ebstein Anomaly or Tricuspid Valve Dysplasia: A Multicenter Study. J Am Heart Assoc. 2020 11 03; 9(21):e016684. View abstract
  6. Association of Isolated Congenital Heart Disease with Fetal Brain Maturation. AJNR Am J Neuroradiol. 2020 08; 41(8):1525-1531. View abstract
  7. 1.5-Ventricle Repair Using Left Ventricle as the Subpulmonary Ventricle. Ann Thorac Surg. 2020 12; 110(6):e529-e530. View abstract
  8. Low prenatal detection rate of valvar pulmonary stenosis: What are we missing? Prenat Diagn. 2020 07; 40(8):966-971. View abstract
  9. Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome: A Decision Analysis. Circ Cardiovasc Qual Outcomes. 2020 04; 13(4):e006127. View abstract
  10. Low mortality in fetal supraventricular tachycardia: Outcomes in a 30-year single-institution experience. J Cardiovasc Electrophysiol. 2020 05; 31(5):1105-1113. View abstract
  11. Fetal cardiac interventions: Where do we stand? Arch Cardiovasc Dis. 2020 Feb; 113(2):121-128. View abstract
  12. Predictors of index admission mortality and morbidity in contemporary esophageal atresia patients. J Pediatr Surg. 2020 Nov; 55(11):2322-2328. View abstract
  13. Cerebrovascular blood flow in patients with tetralogy of fallot: prediction for early surgical intervention. Prenat Diagn. 2019 12; 39(13):1184-1190. View abstract
  14. Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease. Cereb Cortex. 2019 07 22; 29(8):3605-3616. View abstract
  15. Echocardiographic predictors of neonatal illness severity in fetuses with critical left heart obstruction with intact or restrictive atrial septum. Prenat Diagn. 2018 09; 38(10):788-794. View abstract
  16. Improved technical success, postnatal outcome and refined predictors of outcome for fetal aortic valvuloplasty. Ultrasound Obstet Gynecol. 2018 08; 52(2):212-220. View abstract
  17. Clinical and Hemodynamic Results After Conversion from Single to Biventricular Circulation After Fetal Aortic Stenosis Intervention. Am J Cardiol. 2018 08 01; 122(3):511-516. View abstract
  18. Early hemodynamic changes after fetal aortic stenosis valvuloplasty predict biventricular circulation at birth. Prenat Diagn. 2018 03; 38(4):286-292. View abstract
  19. Myocardial injury in fetal aortic stenosis: Insights from amniotic fluid analysis. Prenat Diagn. 2018 02; 38(3):190-195. View abstract
  20. Fetal interventions for structural heart disease. Echocardiography. 2017 12; 34(12):1834-1841. View abstract
  21. Cardiac output and blood flow redistribution in fetuses with D-loop transposition of the great arteries and intact ventricular septum: insights into pathophysiology. Ultrasound Obstet Gynecol. 2017 Nov; 50(5):612-617. View abstract
  22. The boundaries of fetal cardiac intervention: Expand or tighten? Semin Fetal Neonatal Med. 2017 12; 22(6):399-403. View abstract
  23. Right Atrial Dysfunction in the Fetus with Severely Regurgitant Tricuspid Valve Disease: A Potential Source of Cardiovascular Compromise. J Am Soc Echocardiogr. 2017 Jun; 30(6):579-588. View abstract
  24. Sonographic Pulmonary Abnormalities in Fetuses With Hypoplastic Left Heart Syndrome and Intact Atrial Septum Undergoing Attempted Atrial Septostomy In Utero. Ultrasound Q. 2017 Mar; 33(1):82-85. View abstract
  25. Neurodevelopmental Outcome in Children after Fetal Cardiac Intervention for Aortic Stenosis with Evolving Hypoplastic Left Heart Syndrome. J Pediatr. 2017 05; 184:130-136.e4. View abstract
  26. Umbilical Venous Catheter Malposition Is Associated with Necrotizing Enterocolitis in Premature Infants. Neonatology. 2017; 111(4):337-343. View abstract
  27. The Fetus with Ectopia Cordis: Experience and Expectations from Two Centers. Pediatr Cardiol. 2017 Mar; 38(3):531-538. View abstract
  28. Assessment of Progressive Pathophysiology After Early Prenatal Diagnosis of the Ebstein Anomaly or Tricuspid Valve Dysplasia. Am J Cardiol. 2017 Jan 01; 119(1):106-111. View abstract
  29. Assessment of the Melody valve in the mitral position in young children by echocardiography. J Thorac Cardiovasc Surg. 2017 01; 153(1):153-160.e1. View abstract
  30. Detection and successful treatment of emergent anti-SSA-mediated fetal atrioventricular block. Am J Obstet Gynecol. 2016 Oct; 215(4):527-8. View abstract
  31. Detection and successful treatment of emergent anti-SSA mediated fetal atrioventricular block. Am J Obstet Gynecol. 2016 Jul 09. View abstract
  32. Cardiac Findings in the Fetus with Cerebral Arteriovenous Malformation Are Associated with Adverse Outcome. Fetal Diagn Ther. 2017; 41(2):108-114. View abstract
  33. Fetal interventions for congenital heart disease. Curr Opin Pediatr. 2016 Apr; 28(2):156-62. View abstract
  34. Brain Injury in Neonates with Complex Congenital Heart Disease: What Is the Predictive Value of MRI in the Fetal Period? AJNR Am J Neuroradiol. 2016 Jul; 37(7):1338-46. View abstract
  35. International Fetal Cardiac Intervention Registry: A Worldwide Collaborative Description and Preliminary Outcomes. J Am Coll Cardiol. 2015 Jul 28; 66(4):388-99. View abstract
  36. Outcomes and Predictors of Perinatal Mortality in Fetuses With Ebstein Anomaly or Tricuspid Valve Dysplasia in the Current Era: A Multicenter Study. Circulation. 2015 Aug 11; 132(6):481-9. View abstract
  37. Left Ventricular Remodeling and Function in Children with Biventricular Circulation After Fetal Aortic Valvuloplasty. Pediatr Cardiol. 2015 Oct; 36(7):1502-9. View abstract
  38. Prenatal diagnosis of transposition of the great arteries over a 20-year period: improved but imperfect. Ultrasound Obstet Gynecol. 2015 Jun; 45(6):678-82. View abstract
  39. Perinatal outcome after prenatal diagnosis of single-ventricle cardiac defects. Ultrasound Obstet Gynecol. 2015 Jun; 45(6):657-63. View abstract
  40. Low rate of prenatal diagnosis among neonates with critical aortic stenosis: insight into the natural history in utero. Ultrasound Obstet Gynecol. 2015 Mar; 45(3):326-32. View abstract
  41. Fetal aortic valvuloplasty for evolving hypoplastic left heart syndrome: postnatal outcomes of the first 100 patients. Circulation. 2014 Aug 19; 130(8):638-45. View abstract
  42. Percutaneous fetal cardiac interventions for structural heart disease. Am J Perinatol. 2014 Aug; 31(7):629-36. View abstract
  43. Perinatal and infant outcomes of prenatal diagnosis of heterotaxy syndrome (asplenia and polysplenia). Am J Cardiol. 2014 Aug 15; 114(4):612-7. View abstract
  44. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. Circulation. 2014 May 27; 129(21):2183-242. View abstract
  45. Left ventricular diastolic function and characteristics in fetal aortic stenosis. Am J Cardiol. 2014 Jul 01; 114(1):122-7. View abstract
  46. Technical challenges of atrial septal stent placement in fetuses with hypoplastic left heart syndrome and intact atrial septum. Catheter Cardiovasc Interv. 2014 Jul 01; 84(1):77-85. View abstract
  47. Perinatal outcome in fetuses with heterotaxy syndrome and atrioventricular block or bradycardia. Pediatr Cardiol. 2014 Aug; 35(6):906-13. View abstract
  48. Ventricular strain in fetuses with aortic stenosis and evolving hypoplastic left heart syndrome before and after prenatal aortic valvuloplasty. Fetal Diagn Ther. 2014; 35(1):18-26. View abstract
  49. Biventricular conversion after single ventricle palliation in patients with small left heart structures: short-term outcomes. Ann Thorac Surg. 2013 Oct; 96(4):1406-1412. View abstract
  50. Midgestation fetal pulmonary annulus size is predictive of outcome in tetralogy of fallot. Congenit Heart Dis. 2014 May-Jun; 9(3):187-93. View abstract
  51. Staged left ventricular recruitment after single-ventricle palliation in patients with borderline left heart hypoplasia. J Am Coll Cardiol. 2012 Nov 06; 60(19):1966-74. View abstract
  52. Delayed cortical development in fetuses with complex congenital heart disease. Cereb Cortex. 2013 Dec; 23(12):2932-43. View abstract
  53. Left ventricular function and geometry in fetuses with severe tricuspid regurgitation. Ultrasound Obstet Gynecol. 2012 Jul; 40(1):55-61. View abstract
  54. Hypoplastic left heart syndrome: current considerations and expectations. J Am Coll Cardiol. 2012 Jan 03; 59(1 Suppl):S1-42. View abstract
  55. Ebstein's malformation of the tricuspid valve: short-term outcomes of the "cone procedure" versus conventional surgery. Congenit Heart Dis. 2012 Jan-Feb; 7(1):50-8. View abstract
  56. Circumferential and longitudinal ventricular strain in the normal human fetus. J Am Soc Echocardiogr. 2012 Jan; 25(1):105-11. View abstract
  57. Postnatal left ventricular diastolic function after fetal aortic valvuloplasty. Am J Cardiol. 2011 Aug 15; 108(4):556-60. View abstract
  58. Early reintervention on the pulmonary arteries and right ventricular outflow tract after neonatal or early infant repair of truncus arteriosus using homograft conduits. Am J Cardiol. 2011 Jul 01; 108(1):106-13. View abstract
  59. 2010 Report from the ISPD Special Interest Group fetal therapy: fetal cardiac interventions. Prenat Diagn. 2011 Mar; 31(3):249-51. View abstract
  60. Aortic stenosis and severe mitral regurgitation in the fetus resulting in giant left atrium and hydrops: pathophysiology, outcomes, and preliminary experience with pre-natal cardiac intervention. J Am Coll Cardiol. 2011 Jan 18; 57(3):348-55. View abstract
  61. The Fetus as a Cardiac Patient: Assessment and Therapy of Cardiovascular Pathology before Birth. Int J Pediatr. 2010; 2010:974520. View abstract
  62. Assessment of left ventricular endocardial fibroelastosis in fetuses with aortic stenosis and evolving hypoplastic left heart syndrome. Am J Cardiol. 2010 Dec 15; 106(12):1792-7. View abstract
  63. Validation of 3D echocardiographic assessment of left ventricular volumes, mass, and ejection fraction in neonates and infants with congenital heart disease: a comparison study with cardiac MRI. Circ Cardiovasc Imaging. 2010 Nov; 3(6):735-42. View abstract
  64. Current status of fetal cardiac intervention. Circulation. 2010 Mar 16; 121(10):1256-63. View abstract
  65. Fetal diagnosis of interrupted aortic arch. Am J Cardiol. 2010 Mar 01; 105(5):727-34. View abstract
  66. Significance and outcome of left heart hypoplasia in fetal congenital diaphragmatic hernia. Ultrasound Obstet Gynecol. 2010 Mar; 35(3):310-7. View abstract
  67. Cerebral blood flow characteristics and biometry in fetuses undergoing prenatal intervention for aortic stenosis with evolving hypoplastic left heart syndrome. Ultrasound Med Biol. 2010 Jan; 36(1):29-37. View abstract
  68. Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation. 2010 Jan 05; 121(1):26-33. View abstract
  69. Reversible ductus arteriosus constriction due to maternal indomethacin after fetal intervention for hypoplastic left heart syndrome with intact/restrictive atrial septum. Fetal Diagn Ther. 2010; 27(1):40-5. View abstract
  70. Postnatal angiographic appearance of left ventricular myocardium in fetal patients with aortic stenosis having in-utero aortic valvuloplasty. Am J Cardiol. 2009 Nov 01; 104(9):1271-5. View abstract
  71. Primary left ventricular rehabilitation is effective in maintaining two-ventricle physiology in the borderline left heart. J Thorac Cardiovasc Surg. 2009 Dec; 138(6):1276-82. View abstract
  72. Predictors of technical success and postnatal biventricular outcome after in utero aortic valvuloplasty for aortic stenosis with evolving hypoplastic left heart syndrome. Circulation. 2009 Oct 13; 120(15):1482-90. View abstract
  73. In utero valvuloplasty for pulmonary atresia with hypoplastic right ventricle: techniques and outcomes. Pediatrics. 2009 Sep; 124(3):e510-8. View abstract
  74. Association of socioeconomic position and medical insurance with fetal diagnosis of critical congenital heart disease. Circ Cardiovasc Qual Outcomes. 2009 Jul; 2(4):354-60. View abstract
  75. Cardiac anomalies in the fetus. Clin Perinatol. 2009 Jun; 36(2):439-49, xi. View abstract
  76. Truncus arteriosus: diagnostic accuracy, outcomes, and impact of prenatal diagnosis. Pediatr Cardiol. 2009 Apr; 30(3):256-61. View abstract
  77. Results of in utero atrial septoplasty in fetuses with hypoplastic left heart syndrome. Prenat Diagn. 2008 Nov; 28(11):1023-8. View abstract
  78. A vision for an International Society for Fetal and Perinatal Cardiovascular Disease. Curr Opin Pediatr. 2008 Oct; 20(5):532-7. View abstract
  79. Outcome of fetuses and infants with double inlet single left ventricle. Am J Cardiol. 2008 Jun 01; 101(11):1652-6. View abstract
  80. Matrix-array 3-dimensional echocardiographic assessment of volumes, mass, and ejection fraction in young pediatric patients with a functional single ventricle: a comparison study with cardiac magnetic resonance. Circulation. 2008 Apr 08; 117(14):1842-8. View abstract
  81. Fast block flow tracking of atrial septal defects in 4D echocardiography. Med Image Anal. 2008 Aug; 12(4):397-412. View abstract
  82. Changes in left heart hemodynamics after technically successful in-utero aortic valvuloplasty. Ultrasound Obstet Gynecol. 2007 Oct; 30(5):715-20. View abstract
  83. Pathophysiology, management, and outcomes of fetal hemodynamic instability during prenatal cardiac intervention. Pediatr Res. 2007 Sep; 62(3):325-30. View abstract
  84. Hypoplastic left heart syndrome with intact or highly restrictive atrial septum: surgical experience from a single center. Ann Thorac Surg. 2007 Aug; 84(2):581-5; discussion 586. View abstract
  85. Outcome after prenatal diagnosis of tricuspid atresia: a multicenter experience. Am Heart J. 2007 May; 153(5):772-8. View abstract
  86. Fetal tricuspid valve size and growth as predictors of outcome in pulmonary atresia with intact ventricular septum. Pediatrics. 2006 Aug; 118(2):e415-20. View abstract
  87. Factors affecting technical success of fetal aortic valve dilation. Ultrasound Obstet Gynecol. 2006 Jul; 28(1):47-52. View abstract
  88. Fetal aortic valve stenosis and the evolution of hypoplastic left heart syndrome: patient selection for fetal intervention. Circulation. 2006 Mar 21; 113(11):1401-5. View abstract
  89. Usefulness of magnetic resonance imaging of left ventricular endocardial fibroelastosis in infants after fetal intervention for aortic valve stenosis. Am J Cardiol. 2005 Dec 01; 96(11):1568-70. View abstract
  90. In-utero intervention for hypoplastic left heart syndrome--a perinatologist's perspective. Ultrasound Obstet Gynecol. 2005 Oct; 26(5):481-6. View abstract
  91. Aortic valvuloplasty in the fetus: technical characteristics of successful balloon dilation. J Pediatr. 2005 Oct; 147(4):535-9. View abstract
  92. Improving outcomes in fetuses and neonates with congenital displacement (Ebstein's malformation) or dysplasia of the tricuspid valve. Am J Cardiol. 2005 Aug 15; 96(4):582-6. View abstract
  93. Fetal interventions for cardiac defects. Pediatr Clin North Am. 2004 Dec; 51(6):1503-13, vii. View abstract
  94. Balloon dilation of severe aortic stenosis in the fetus: potential for prevention of hypoplastic left heart syndrome: candidate selection, technique, and results of successful intervention. Circulation. 2004 Oct 12; 110(15):2125-31. View abstract
  95. Creation of an atrial septal defect in utero for fetuses with hypoplastic left heart syndrome and intact or highly restrictive atrial septum. Circulation. 2004 Jul 20; 110(3):253-8. View abstract
  96. Pulmonary venous pathway obstruction from recurrent restriction at atrial septum late after Fontan procedure. J Thorac Cardiovasc Surg. 2004 Jan; 127(1):281-3. View abstract
  97. Balloon valvuloplasty for congenital heart disease in the fetus. Clin Perinatol. 2003 Sep; 30(3):541-50. View abstract
  98. Association between cardiac tumors and tuberous sclerosis in the fetus and neonate. Am J Cardiol. 2003 Aug 15; 92(4):487-9. View abstract
  99. Effects of losartan in patients with a systemically functioning morphologic right ventricle after atrial repair of transposition of the great arteries. Am J Cardiol. 2001 Dec 01; 88(11):1314-6. View abstract
  100. Improved surgical outcome after fetal diagnosis of hypoplastic left heart syndrome. Circulation. 2001 Mar 06; 103(9):1269-73. View abstract
  101. Inhaled nitric oxide in neonates with persistent pulmonary hypertension. Lancet. 2001 Jan 13; 357(9250):118-20. View abstract
  102. Balloon arterioplasty of recurrent coarctation after the modified Norwood procedure in infants. Catheter Cardiovasc Interv. 2000 May; 50(1):54-8. View abstract
  103. Incidence and implications of systemic to pulmonary collaterals after bidirectional cavopulmonary anastomosis. Ann Thorac Surg. 2000 Apr; 69(4):1222-8. View abstract
  104. Issues and outcomes in the management of supravalvar aortic stenosis. Ann Thorac Surg. 2000 Feb; 69(2):562-7. View abstract
  105. Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects. J Am Coll Cardiol. 2000 Feb; 35(2):463-7. View abstract
  106. Congenital obstructive lesions of the right aortic arch. Ann Thorac Surg. 1999 Apr; 67(4):1194-202. View abstract
  107. Echocardiographic diagnosis alone for the complete repair of major congenital heart defects. J Am Coll Cardiol. 1999 Jan; 33(1):228-33. View abstract
  108. Multiple ventricular septal defects: how and when should they be repaired? J Thorac Cardiovasc Surg. 1999 Jan; 117(1):134-9; discussion 39-40. View abstract
  109. Early and late results after repair of aortopulmonary septal defect and associated anomalies in infants <6 months of age. Am J Cardiol. 1998 Jan 15; 81(2):195-201. View abstract