EDUCATION

Graduate Degree

  • Keio University , 1989 , Tokyo , Japan

Medical School

  • Keio University School of Medicine , 1993 , Tokyo , Japan

Internship

  • Keio University , 1995 , Tokyo , Japan

Residency

  • Massachusetts General Hospital , 1998 , Boston , MA

Fellowship

  • Boston Children's Hospital , 2000 , Boston , MA

CERTIFICATIONS

  • American Board of Psychiatry and Neurology, Child and Adolescent Neurology
  • American Board of Clinical Neurophysiology
  • American Board of Psychiatry and Neurology, Epilepsy

PUBLICATIONS

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  1. Mortality in infantile spasms: A hospital-based study. Epilepsia. 2020 04; 61(4):702-713. View abstract
  2. Neuroimaging in Pediatric Epilepsy. Brain Sci. 2019 Aug 07; 9(8). View abstract
  3. Yield of Emergent Neuroimaging in Patients With Sturge-Weber Syndrome Presenting With Acute Neurologic Symptoms. J Child Neurol. 2019 01; 34(1):17-21. View abstract
  4. Transient regional cerebral hypoperfusion during a paroxysmal hemiplegic event in GLUT1 deficiency syndrome. Eur J Paediatr Neurol. 2018 May; 22(3):544-547. View abstract
  5. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 03; 60(3):283-289. View abstract
  6. Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. Pediatr Neurol. 2017 Nov; 76:47-53. View abstract
  7. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar; 81(3):419-429. View abstract
  8. Compound heterozygosity with PRRT2: Pushing the phenotypic envelope in genetic epilepsies. Epilepsy Behav Case Rep. 2019; 11:125-128. View abstract
  9. Sturge-Weber Syndrome: Brain Magnetic Resonance Imaging and Neuropathology Findings. Pediatr Neurol. 2016 05; 58:25-30. View abstract
  10. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov; 52(Pt A):200-4. View abstract
  11. Pediatric anti-Hu-associated encephalitis with clinical features of Rasmussen encephalitis. Neurol Neuroimmunol Neuroinflamm. 2015 Oct; 2(5):e150. View abstract
  12. Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. J Neuroimaging. 2015 Sep-Oct; 25(5):824-31. View abstract
  13. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View abstract
  14. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View abstract
  15. Surgery for intractable epilepsy due to unilateral brain disease: a retrospective study comparing hemispherectomy techniques. Pediatr Neurol. 2014 Sep; 51(3):336-43. View abstract
  16. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View abstract
  17. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View abstract
  18. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View abstract
  19. Predictors of seizure occurrence in children undergoing pre-surgical monitoring. Seizure. 2013 Oct; 22(8):640-6. View abstract
  20. Perfusion Imaging of Focal Cortical Dysplasia Using Arterial Spin Labeling: Correlation With Histopathological Vascular Density. J Child Neurol. 2013 Nov; 28(11):1474-1482. View abstract
  21. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 Nov 27; 79(22):2218; author reply 2218-9. View abstract
  22. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View abstract
  23. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View abstract
  24. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View abstract
  25. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9. View abstract
  26. Benign rolandic epileptiform discharges are associated with mood and behavior problems. Epilepsy Behav. 2011 Oct; 22(2):298-303. View abstract
  27. Electroencephalography in clinical epilepsy research. Epilepsy Behav. 2011 Sep; 22(1):126-33. View abstract
  28. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol. 2011 Jun; 44(6):414-9. View abstract
  29. A novel mutation in the aristaless domain of the ARX gene leads to Ohtahara syndrome, global developmental delay, and ambiguous genitalia in males and neuropsychiatric disorders in females. Epilepsia. 2011 May; 52(5):984-92. View abstract
  30. Rufinamide for the treatment of epileptic spasms. Epilepsy Behav. 2011 Feb; 20(2):344-8. View abstract
  31. Experience with rufinamide in a pediatric population: a single center's experience. Pediatr Neurol. 2010 Sep; 43(3):155-8. View abstract
  32. Exercise effects on methylation of ASC gene. Int J Sports Med. 2010 Sep; 31(9):671-5. View abstract
  33. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia. 2010 Jul; 51(7):1319-22. View abstract
  34. Reversible uncal herniation in a neonate with a large MCA infarct. Brain Dev. 2009 Nov; 31(10):763-5. View abstract
  35. Repetitive transcranial magnetic stimulation in the treatment of epilepsia partialis continua. Epilepsy Behav. 2009 Jan; 14(1):253-7. View abstract
  36. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet. 2009 Apr; 46(4):242-8. View abstract
  37. Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis. Epilepsy Behav. 2008 Jul; 13(1):260-2. View abstract
  38. Present status of surgical intervention for children with intractable seizures. Curr Neurol Neurosci Rep. 2008 Mar; 8(2):123-9. View abstract
  39. Oxcarbazepine in children with nocturnal frontal-lobe epilepsy. Pediatr Neurol. 2007 Nov; 37(5):345-9. View abstract
  40. Focal cortical malformations can show asymmetrically higher uptake on interictal fluorine-18 fluorodeoxyglucose positron emission tomography (PET). J Child Neurol. 2007 Feb; 22(2):232-7. View abstract
  41. Focal status epilepticus as atypical presentation of pyridoxine-dependent epilepsy. J Child Neurol. 2005 Aug; 20(8):696-8. View abstract
  42. A distinct asymmetrical pattern of cortical malformation: large unilateral malformation of cortical development with contralateral periventricular nodular heterotopia in three pediatric cases. Epilepsia. 2005 Aug; 46(8):1317-21. View abstract
  43. Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain. 2005 Jan; 128(Pt 1):213-26. View abstract
  44. Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome. Neurology. 2004 Oct 12; 63(7):1289-92. View abstract
  45. FK506-associated limbic injury following umbilical cord blood transplantation. Bone Marrow Transplant. 2003 Sep; 32(5):523-5. View abstract
  46. Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanoma. Br J Dermatol. 2003 May; 148(5):971-80. View abstract
  47. MRI volumetric analysis in rasmussen encephalitis: a longitudinal study. Epilepsia. 2003 Feb; 44(2):247-51. View abstract
  48. Abnormal asymmetry in language association cortex in autism. Ann Neurol. 2002 Nov; 52(5):588-96. View abstract
  49. Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy. Epilepsia. 2002 Sep; 43(9):1072-5. View abstract
  50. Infectious and inflammatory disorders of the circulatory system and stroke in childhood. Curr Opin Neurol. 2002 Apr; 15(2):159-64. View abstract
  51. Diffusion-weighted images in neonatal cerebral hypoxic-ischemic injury. Pediatr Neurol. 2002 Apr; 26(4):274-81. View abstract
  52. Diffusion-weighted imaging in moyamoya disease. J Child Neurol. 2001 Jul; 16(7):526-30. View abstract
  53. Topiramate and metabolic acidosis in pediatric epilepsy. Epilepsia. 2001 Mar; 42(3):387-92. View abstract
  54. Carbamyl phosphate synthetase 1 deficiency: a destructive encephalopathy. Pediatr Neurol. 2001 Mar; 24(3):193-9. View abstract
  55. Diffusion-weighted imaging in neonatal cerebral infarction: clinical utility and follow-up. J Child Neurol. 2000 Sep; 15(9):592-602. View abstract
  56. Fosphenytoin in infants. J Child Neurol. 1998 Nov; 13(11):537-40. View abstract
  57. Petroclival meningioma presenting with pathological laughter. Neurology. 1998 Jun; 50(6):1918-9. View abstract