EDUCATION

Undergraduate Degree

  • University of British Columbia , 1968 , Vancouver , British Columbia, Canada

Medical School

  • Boston University School of Medicine , 1978 , Boston , MA

Internship

  • Beth Israel Deaconess Medical Center , 1979 , Boston , MA

Residency

  • Massachusetts Eye and Ear Infirmary , 1982 , Boston , MA

Fellowship

  • Boston Children's Hospital , 1983 , Boston , MA

CERTIFICATIONS

  • American Board of Ophthalmology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Insulin-Like Growth Factor 1 in the Preterm Rabbit Pup: Characterization of Cerebrovascular Maturation following Administration of Recombinant Human Insulin-Like Growth Factor 1/Insulin-Like Growth Factor 1-Binding Protein 3. Dev Neurosci. 2021; 43(5):281-295. View abstract
  2. Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity. Br J Ophthalmol. 2021 May 12. View abstract
  3. Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 07; 1866(7):158939. View abstract
  4. Cellular senescence in pathologic retinal angiogenesis. Trends Endocrinol Metab. 2021 07; 32(7):415-416. View abstract
  5. Effect of Enteral Lipid Supplement on Severe Retinopathy of Prematurity: A Randomized Clinical Trial. JAMA Pediatr. 2021 Apr 01; 175(4):359-367. View abstract
  6. Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration. iScience. 2021 Apr 23; 24(4):102376. View abstract
  7. Decreased Platelet Counts and Serum Levels of VEGF-A, PDGF-BB, and BDNF in Extremely Preterm Infants Developing Severe ROP. Neonatology. 2021; 118(1):18-27. View abstract
  8. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2021 Feb 06; 62:100035. View abstract
  9. Vitreous metabolomics profiling of proliferative diabetic retinopathy. Diabetologia. 2021 01; 64(1):70-82. View abstract
  10. Notice of Withdrawal: Retinal Vasculature in Development and Diseases. Annu Rev Vis Sci. 2020 10 15; 0. View abstract
  11. Randomized Control Trial of Postnatal rhIGF-1/rhIGFBP-3 Replacement in Preterm Infants: Post-hoc Analysis of Its Effect on Brain Injury. Front Pediatr. 2020; 8:517207. View abstract
  12. An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis. J Vis Exp. 2020 08 06; (162). View abstract
  13. Association between low fatty acid levels and platelet count in infants with Retinopathy of Prematurity. Acta Paediatr. 2020 12; 109(12):2547-2548. View abstract
  14. Validation of the Retinopathy of Prematurity Activity Scale (ROP-ActS) using retrospective clinical data. Acta Ophthalmol. 2021 Mar; 99(2):201-206. View abstract
  15. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. View abstract
  16. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 03 23; 52(6):779-793.e7. View abstract
  17. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). View abstract
  18. Individual Risk Prediction for Sight-Threatening Retinopathy of Prematurity Using Birth Characteristics. JAMA Ophthalmol. 2020 01 01; 138(1):21-29. View abstract
  19. Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research. Ophthalmic Res. 2019; 62(4):196-202. View abstract
  20. Leucocytosis is associated with retinopathy of prematurity in extremely preterm infants. Acta Paediatr. 2019 07; 108(7):1357-1358. View abstract
  21. Tailored vs Static Oxygen Saturation Targets to Prevent Retinopathy of Prematurity. JAMA Ophthalmol. 2019 04 01; 137(4):423-424. View abstract
  22. Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials. JAMA Ophthalmol. 2019 03 01; 137(3):305-311. View abstract
  23. Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk. Acta Paediatr. 2019 06; 108(6):998-1007. View abstract
  24. Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. JAMA Ophthalmol. 2019 01 01; 137(1):91-95. View abstract
  25. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial. J Pediatr. 2019 03; 206:56-65.e8. View abstract
  26. Erythropoietin serum levels, versus anaemia as risk factors for severe retinopathy of prematurity. Pediatr Res. 2019 08; 86(2):276-282. View abstract
  27. Retinal Vasculature in Development and Diseases. Annu Rev Vis Sci. 2018 09 15; 4:101-122. View abstract
  28. A Dosing Study of Bevacizumab for Retinopathy of Prematurity: Late Recurrences and Additional Treatments. Ophthalmology. 2018 12; 125(12):1961-1966. View abstract
  29. Influence of Human Milk and Parenteral Lipid Emulsions on Serum Fatty Acid Profiles in Extremely Preterm Infants. JPEN J Parenter Enteral Nutr. 2019 01; 43(1):152-161. View abstract
  30. Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants. Neonatology. 2018; 114(1):46-52. View abstract
  31. Long-chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation. Acta Paediatr. 2018 06; 107(6):1020-1027. View abstract
  32. Association of Retinopathy of Prematurity With Low Levels of Arachidonic Acid: A Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol. 2018 03 01; 136(3):271-277. View abstract
  33. Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity: A Randomized Clinical Trial. JAMA Pediatr. 2018 03 01; 172(3):278-286. View abstract
  34. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. View abstract
  35. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. View abstract
  36. Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity. Growth Horm IGF Res. 2018 04; 39:19-24. View abstract
  37. Implementing higher oxygen saturation targets reduced the impact of poor weight gain as a predictor for retinopathy of prematurity. Acta Paediatr. 2018 05; 107(5):767-773. View abstract
  38. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. View abstract
  39. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. View abstract
  40. Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage? Transl Stroke Res. 2017 Jun 10. View abstract
  41. Assessment of Lower Doses of Intravitreous Bevacizumab for Retinopathy of Prematurity: A Phase 1 Dosing Study. JAMA Ophthalmol. 2017 06 01; 135(6):654-656. View abstract
  42. Effects of a lipid emulsion containing fish oil on polyunsaturated fatty acid profiles, growth and morbidities in extremely premature infants: A randomized controlled trial. Clin Nutr ESPEN. 2017 Aug; 20:17-23. View abstract
  43. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. View abstract
  44. Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative. Ophthalmology. 2017 07; 124(7):926-934. View abstract
  45. Sema3f Protects Against Subretinal Neovascularization In Vivo. EBioMedicine. 2017 Apr; 18:281-287. View abstract
  46. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. View abstract
  47. IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development. Curr Pharm Des. 2017; 23(38):5964-5970. View abstract
  48. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. View abstract
  49. IGF-I in the clinics: Use in retinopathy of prematurity. Growth Horm IGF Res. 2016 Oct - Dec; 30-31:75-80. View abstract
  50. IGF-1 in retinopathy of prematurity, a CNS neurovascular disease. Early Hum Dev. 2016 11; 102:13-19. View abstract
  51. Aggressive Posterior Retinopathy of Prematurity Is Associated with Multiple Infectious Episodes and Thrombocytopenia. Neonatology. 2017; 111(1):79-85. View abstract
  52. Role of Insulinlike Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants. Am J Perinatol. 2016 09; 33(11):1067-71. View abstract
  53. Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. . 2016 09 01; 311(3):H738-49. View abstract
  54. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. View abstract
  55. Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 06 07; 22(6):692. View abstract
  56. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. View abstract
  57. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View abstract
  58. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016 Jun; 105(6):576-86. View abstract
  59. The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. Am J Pathol. 2016 Mar; 186(3):568-78. View abstract
  60. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View abstract
  61. Serum concentrations of vascular endothelial growth factor in relation to retinopathy of prematurity. Pediatr Res. 2016 Jan; 79(1-1):70-5. View abstract
  62. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View abstract
  63. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct; 18(4):449-62. View abstract
  64. Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PLoS One. 2015; 10(5):e0125548. View abstract
  65. Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles. Neonatology. 2015; 108(1):16-22. View abstract
  66. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View abstract
  67. Low birth weight is a risk factor for severe retinopathy of prematurity depending on gestational age. PLoS One. 2014; 9(10):e109460. View abstract
  68. Insulin-like growth factor-1 and anti-vascular endothelial growth factor in retinopathy of prematurity: has the time come? Neonatology. 2014; 106(3):254-60. View abstract
  69. Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration. Am J Ophthalmol. 2014 Nov; 158(5):1071-78. View abstract
  70. Weight at first detection of retinopathy of prematurity predicts disease severity. Br J Ophthalmol. 2014 Nov; 98(11):1565-9. View abstract
  71. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. View abstract
  72. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One. 2014; 9(1):e85031. View abstract
  73. WINROP identifies severe retinopathy of prematurity at an early stage in a nation-based cohort of extremely preterm infants. PLoS One. 2013; 8(9):e73256. View abstract
  74. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013 Oct; 16(4):985-92. View abstract
  75. Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. PLoS One. 2013; 8(7):e69552. View abstract
  76. Retinopathy of prematurity. Lancet. 2013 Oct 26; 382(9902):1445-57. View abstract
  77. The biology of retinopathy of prematurity: how knowledge of pathogenesis guides treatment. Clin Perinatol. 2013 Jun; 40(2):201-14. View abstract
  78. Semaphorin 3F forms an anti-angiogenic barrier in outer retina. FEBS Lett. 2013 Jun 05; 587(11):1650-5. View abstract
  79. Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration. Cell Metab. 2013 Apr 02; 17(4):471-2. View abstract
  80. Nutrition, insulin-like growth factor-1 and retinopathy of prematurity. Semin Fetal Neonatal Med. 2013 Jun; 18(3):136-142. View abstract
  81. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ?-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. PLoS One. 2013; 8(1):e53155. View abstract
  82. Author response: Different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mouse strains? Invest Ophthalmol Vis Sci. 2012 Nov 19; 53(12):7728-9. View abstract
  83. Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants: pharmacokinetics and short-term safety. Pediatr Res. 2013 Jan; 73(1):68-74. View abstract
  84. Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants: a multicenter study analyzing weight velocity deviations for the prediction of retinopathy of prematurity. Arch Ophthalmol. 2012 Aug; 130(8):992-9. View abstract
  85. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One. 2012; 7(7):e41596. View abstract
  86. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood. 2012 Oct 04; 120(14):2925-9. View abstract
  87. Propranolol inhibition of ß-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):2968-77. View abstract
  88. Protective inflammasome activation in AMD. Nat Med. 2012 May 04; 18(5):658-60. View abstract
  89. Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. PLoS One. 2012; 7(1):e30203. View abstract
  90. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25; 124(17):1871-81. View abstract
  91. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. View abstract
  92. Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Invest Ophthalmol Vis Sci. 2011 Jul 23; 52(8):5376-86. View abstract
  93. Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity. Acta Paediatr. 2011 Dec; 100(12):1528-33. View abstract
  94. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2809-16. View abstract
  95. Current update on retinopathy of prematurity: screening and treatment. Curr Opin Pediatr. 2011 Apr; 23(2):173-8. View abstract
  96. Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. Br J Ophthalmol. 2011 Nov; 95(11):1496-501. View abstract
  97. Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood. 2011 Jun 02; 117(22):6024-35. View abstract
  98. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 09; 3(69):69ra12. View abstract
  99. Analysis of candidate genes for macular telangiectasia type 2. Mol Vis. 2010 Dec 14; 16:2718-26. View abstract
  100. Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol. 2010 Dec; 177(6):2715-23. View abstract
  101. Predicting proliferative retinopathy in a Brazilian population of preterm infants with the screening algorithm WINROP. Arch Ophthalmol. 2010 Nov; 128(11):1432-6. View abstract
  102. Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. Retina. 2010 Oct; 30(9):1524-9. View abstract
  103. Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion. Biochim Biophys Acta. 2011 Apr; 1812(4):549-57. View abstract
  104. Moderate GSK-3ß inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy. Angiogenesis. 2010 Sep; 13(3):269-77. View abstract
  105. An eye for discovery. J Clin Invest. 2010 Sep; 120(9):3008-11. View abstract
  106. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. View abstract
  107. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010 Aug 20; 107(4):495-500. View abstract
  108. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2813-26. View abstract
  109. High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis. Pediatrics. 2010 Jun; 125(6):e1483-92. View abstract
  110. Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity. Arch Ophthalmol. 2010 Apr; 128(4):443-7. View abstract
  111. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4(11):1565-73. View abstract
  112. A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants. Pediatr Res. 2009 May; 65(5):574-9. View abstract
  113. Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I. Arch Ophthalmol. 2009 May; 127(5):622-7. View abstract
  114. Early weight gain predicts retinopathy in preterm infants: new, simple, efficient approach to screening. Pediatrics. 2009 Apr; 123(4):e638-45. View abstract
  115. Retinopathy of prematurity: current concepts in molecular pathogenesis. Semin Ophthalmol. 2009 Mar-Apr; 24(2):77-81. View abstract
  116. Emerging treatments for retinopathy of prematurity. Semin Ophthalmol. 2009 Mar-Apr; 24(2):82-6. View abstract
  117. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8. View abstract
  118. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1831-7. View abstract
  119. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1329-35. View abstract
  120. Use of Bayesian networks to probabilistically model and improve the likelihood of validation of microarray findings by RT-PCR. J Biomed Inform. 2009 Apr; 42(2):287-95. View abstract
  121. Through the eyes of a child: understanding retinopathy through ROP the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5177-82. View abstract
  122. A double-edged sword: erythropoietin eyed in retinopathy of prematurity. J AAPOS. 2008 Jun; 12(3):221-2. View abstract
  123. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb; 118(2):526-33. View abstract
  124. Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. J Clin Invest. 2007 Oct; 117(10):2758-62. View abstract
  125. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-873. View abstract
  126. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10589-94. View abstract
  127. Retinopathy of prematurity. Angiogenesis. 2007; 10(2):133-40. View abstract
  128. Longitudinal postnatal weight and insulin-like growth factor I measurements in the prediction of retinopathy of prematurity. Arch Ophthalmol. 2006 Dec; 124(12):1711-8. View abstract
  129. Postnatal head growth deficit among premature infants parallels retinopathy of prematurity and insulin-like growth factor-1 deficit. Pediatrics. 2006 Jun; 117(6):1930-8. View abstract
  130. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. View abstract
  131. A radically twisted lipid regulates vascular death. Nat Med. 2005 Dec; 11(12):1275-6. View abstract
  132. Quantitative multi-gene transcriptional profiling using real-time PCR with a master template. Exp Mol Pathol. 2005 Aug; 79(1):14-22. View abstract
  133. Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia. Invest Ophthalmol Vis Sci. 2005 Aug; 46(8):2736-47. View abstract
  134. IGF-1 and retinopathy of prematurity in the preterm infant. Biol Neonate. 2005; 88(3):237-44. View abstract
  135. Periorbital lymphatic malformation: clinical course and management in 42 patients. Plast Reconstr Surg. 2005 Jan; 115(1):22-30. View abstract
  136. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics. 2004 Dec 15; 20(1):36-44. View abstract
  137. Bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa. J Clin Invest. 2004 Sep; 114(6):755-7. View abstract
  138. Can we restore aspects of the in utero environment in premature infants to prevent disease? Pediatrics. 2004 Aug; 114(2):491. View abstract
  139. Pathogenesis of retinopathy of prematurity. Growth Horm IGF Res. 2004 Jun; 14 Suppl A:S140-4. View abstract
  140. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15859-64. View abstract
  141. Pathogenesis of retinopathy of prematurity. Semin Neonatol. 2003 Dec; 8(6):469-73. View abstract
  142. Adipose tissue growth and regression are regulated by angiopoietin-1. Biochem Biophys Res Commun. 2003 Nov 21; 311(3):563-71. View abstract
  143. Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics. 2003 Nov; 112(5):1016-20. View abstract
  144. Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity. J Clin Invest. 2003 Jul; 112(1):50-7. View abstract
  145. Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatin. Int J Cancer. 2002 Sep 20; 101(3):224-34. View abstract
  146. Stem cells go for the eyes. Nat Med. 2002 Sep; 8(9):932-4. View abstract
  147. IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab. 2002 Jul; 87(7):3413-6. View abstract
  148. Molecular profiling of angiogenesis markers. Am J Pathol. 2002 Jul; 161(1):35-41. View abstract
  149. RP-forme fruste. J Perinatol. 2002 Apr-May; 22(3):257; author reply 257-8. View abstract
  150. Pathogenesis of retinopathy of prematurity. Acta Paediatr Suppl. 2002; 91(437):26-8. View abstract
  151. Heat shock protein 90 in retinal ganglion cells: association with axonally transported proteins. Vis Neurosci. 2001 May-Jun; 18(3):429-36. View abstract
  152. Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development. FASEB J. 2001 May; 15(7):1215-7. View abstract
  153. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5804-8. View abstract
  154. Angiogenesis as a potential biomarker in prostate cancer chemoprevention trials. Urology. 2001 Apr; 57(4 Suppl 1):143-7. View abstract
  155. Oligonucleotide-based inhibition of embryonic gene expression. Nat Biotechnol. 1999 Dec; 17(12):1184-7. View abstract
  156. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med. 1999 Dec; 5(12):1390-5. View abstract
  157. Progressive juvenile onset punctate cataracts caused by mutation of the gamma D crystalline gene. Proc Natl Acad Sci USA. 1999; 96(3):1008-1012. View abstract
  158. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 1997 Sep; 46(9):1473-80. View abstract
  159. Essential role of growth hormone in ischemia-induced retinal neovascularization. Science. 1997 Jun 13; 276(5319):1706-9. View abstract
  160. Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity. J AAPOS. 1997 Jun; 1(2):105-10. View abstract
  161. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol. 1996 Oct; 114(10):1219-28. View abstract
  162. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4851-6. View abstract
  163. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A. 1995 Nov 07; 92(23):10457-61. View abstract
  164. Enamel hypoplasia, bilateral cataracts, and aqueductal stenosis: a new syndrome? Am J Med Genet. 1995 Sep 25; 58(4):371-3. View abstract
  165. Conjunctival biopsy in patients with Kawasaki disease. Pediatr Pathol Lab Med. 1995 Jul-Aug; 15(4):547-53. View abstract
  166. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):905-9. View abstract
  167. Effect of light on oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994 Jan; 35(1):112-9. View abstract
  168. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994 Jan; 35(1):101-11. View abstract
  169. Microscopic visualization of the retina by angiography with high-molecular-weight fluorescein-labeled dextrans in the mouse. Microvasc Res. 1993 Sep; 46(2):135-42. View abstract
  170. Alterations in endothelial superoxide dismutase levels as a function of growth state in vitro. Invest Ophthalmol Vis Sci. 1992 Jan; 33(1):36-41. View abstract
  171. Kawasaki Syndrome in the Eye. Pediatric Infectious Disease Journal. 1989; 8:116-118. View abstract
  172. Characterization of vascular development in the mouse retina. Microvasc Res. 1988 Nov; 36(3):275-90. View abstract
  173. Ophthalmic evaluation of survivors of acute lymphoblastic leukemia. Ophthalmology. 1988 Feb; 95(2):151-5. View abstract
  174. Neuroanatomy of the human visual system: part II- Retinal projections to the superior colliculus and pulvinar. Neuro-ophthalmology. 1986; 6(6):362-370. View abstract
  175. A retinohypothalamic pathway in man: light mediation of circadian rhythms. Brain Res. 1984 Jun 08; 302(2):371-7. View abstract
  176. Paraphenylenediamine: a new method for tracing human visual pathways. J Neuropathol Exp Neurol. 1983 Mar; 42(2):200-6. View abstract
  177. Direct demonstration of transsynaptic degeneration in the human visual system. Journal of Neurology Neurosurgery Psychiatry. 1982; 45:143. View abstract
  178. Alpha-secondary tritium isotope effects in the aqueous hydrolysis of glycopyranosides of N-acetyl-beta-D-glucosamine. Arch Biochem Biophys. 1973 Nov; 159(1):505-11. View abstract
  179. Mechanism for lysozyme-catalyzed hydrolysis. J Am Chem Soc. 1973 Oct 31; 95(22):7497-7500. View abstract