• English



  • Georgetown University Medical Division, DC General Hospital , 1978 , Washington , DC

Medical School

  • University of Leiden , 1977 , Leiden , Netherlands


  • St. Francis Hospital and Medical Center , 1980 , Hartford , CT


  • New England Medical Center Hospital , 1983 , Boston , MA


  • American Board of Internal Medicine, Endocrinology, Hematology
  • American Board of Pathology, Blood Banking/Transfusion Medicine


Publications powered by Harvard Catalyst Profiles

  1. Kong NR, Bassal MA, Tan HK, Kurland JV, Yong KJ, Young JJ, Yang Y, Li F, Lee JD, Liu Y, Wu CS, Stein A, Luo HR, Silberstein LE, Bulyk ML, Tenen DG, Chai L. Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression. Cell Rep. 2021 Jan 05; 34(1):108574. View abstract
  2. Xie X, Shi Q, Wu P, Zhang X, Kambara H, Su J, Yu H, Park SY, Guo R, Ren Q, Zhang S, Xu Y, Silberstein LE, Cheng T, Ma F, Li C, Luo HR. Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection. Nat Immunol. 2020 09; 21(9):1119-1133. View abstract
  3. Park SY, Matte A, Jung Y, Ryu J, Anand WB, Han EY, Liu M, Carbone C, Melisi D, Nagasawa T, Locascio JJ, Lin CP, Silberstein LE, De Franceschi L. Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion. Blood. 2020 Jun 04; 135(23):2071-2084. View abstract
  4. Lane WJ, Westhoff CM, Gleadall NS, Aguad M, Smeland-Wagman R, Vege S, Simmons DP, Mah HH, Lebo MS, Walter K, Soranzo N, Di Angelantonio E, Danesh J, Roberts DJ, Watkins NA, Ouwehand WH, Butterworth AS, Kaufman RM, Rehm HL, Silberstein LE, Green RC. Automated typing of red blood cell and platelet antigens: a whole-genome sequencing study. Lancet Haematol. 2018 Jun; 5(6):e241-e251. View abstract
  5. Kambara H, Liu F, Zhang X, Liu P, Bajrami B, Teng Y, Zhao L, Zhou S, Yu H, Zhou W, Silberstein LE, Cheng T, Han M, Xu Y, Luo HR. Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death. Cell Rep. 2018 03 13; 22(11):2924-2936. View abstract
  6. Zhang X, Liu P, Zhang C, Chiewchengchol D, Zhao F, Yu H, Li J, Kambara H, Luo KY, Venkataraman A, Zhou Z, Zhou W, Zhu H, Zhao L, Sakai J, Chen Y, Ho YS, Bajrami B, Xu B, Silberstein LE, Cheng T, Xu Y, Ke Y, Luo HR. Positive Regulation of Interleukin-1ß Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation. Cell Rep. 2017 07 05; 20(1):224-235. View abstract
  7. Liu S, de Castro LF, Jin P, Civini S, Ren J, Reems JA, Cancelas J, Nayak R, Shaw G, O'Brien T, McKenna DH, Armant M, Silberstein L, Gee AP, Hei DJ, Hematti P, Kuznetsov SA, Robey PG, Stroncek DF. Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers. Sci Rep. 2017 04 27; 7:46731. View abstract
  8. Zhu H, Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Kambara H, Yu H, Chai L, Silberstein LE, Cheng T, Luo HR. Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis. J Immunol. 2017 04 01; 198(7):2854-2864. View abstract
  9. Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Park SY, Loison F, Sakai J, Xu Y, Silberstein LE, Luo HR. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016 09 19; 213(10):1999-2018. View abstract
  10. Manis JP, Silberstein LE. Platelet refractoriness: it's not the B-all and end-all. Blood. 2016 Apr 07; 127(14):1740-1. View abstract
  11. Lane WJ, Westhoff CM, Uy JM, Aguad M, Smeland-Wagman R, Kaufman RM, Rehm HL, Green RC, Silberstein LE. Comprehensive red blood cell and platelet antigen prediction from whole genome sequencing: proof of principle. Transfusion. 2016 Mar; 56(3):743-54. View abstract
  12. Ciuculescu MF, Park SY, Canty K, Mathieu R, Silberstein LE, Williams DA. Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo. Blood. 2015 May 14; 125(20):3105-13. View abstract
  13. Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR. Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20; 42(1):159-71. View abstract
  14. Nombela-Arrieta C, Silberstein LE. The science behind the hypoxic niche of hematopoietic stem and progenitors. Hematology Am Soc Hematol Educ Program. 2014 Dec 05; 2014(1):542-7. View abstract
  15. Lindblad RW, Ibenana L, Wagner JE, McKenna DH, Hei DJ, Hematti P, Couture LA, Silberstein LE, Armant M, Rooney CM, Gee AP, Welniak LA, Heath Mondoro T, Wood DA, Styers D. Cell therapy product administration and safety: data capture and analysis from the Production Assistance for Cellular Therapies (PACT) program. Transfusion. 2015 Mar; 55(3):674-9. View abstract
  16. Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, De Oliveira S, Fernández KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot F, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD, Fischer A, Kohn DB, Filipovich AH, Notarangelo LD, Cavazzana M, Williams DA, Thrasher AJ. A modified ?-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med. 2014 Oct 09; 371(15):1407-17. View abstract
  17. Gazit R, Mandal PK, Ebina W, Ben-Zvi A, Nombela-Arrieta C, Silberstein LE, Rossi DJ. Fgd5 identifies hematopoietic stem cells in the murine bone marrow. J Exp Med. 2014 Jun 30; 211(7):1315-31. View abstract
  18. Wood D, Wesselschmidt R, Hematti P, Gee AP, Rooney C, Silberstein L, Armant M, Couture L, Wagner JE, McKenna DH, Hei D, Mondoro TH, Welniak L, Lindblad R. An update from the United States National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) program: a decade of cell therapy. Clin Transl Sci. 2014 Apr; 7(2):93-9. View abstract
  19. Ueno S, Lu J, He J, Li A, Zhang X, Ritz J, Silberstein LE, Chai L. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol. 2014 Apr; 42(4):307-316.e8. View abstract
  20. Silberstein LE, Lin CP. A new image of the hematopoietic stem cell vascular niche. Cell Stem Cell. 2013 Nov 07; 13(5):514-6. View abstract
  21. Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81. View abstract
  22. Luckey CJ, Silberstein LE. A mouse model of hemolytic disease of the newborn. Blood. 2013 Aug 22; 122(8):1334-5. View abstract
  23. Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol. 2013 Aug 1; 15(8):1016. View abstract
  24. Sanchez R, Silberstein LE, Lindblad RW, Welniak LA, Mondoro TH, Wagner JE. Strategies for more rapid translation of cellular therapies for children: a US perspective. Pediatrics. 2013 Aug; 132(2):351-8. View abstract
  25. Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR. Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment. Dev Cell. 2013 May 28; 25(4):333-49. View abstract
  26. Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013 May 23; 153(5):1025-35. View abstract
  27. Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol. 2013 May; 15(5):533-43. View abstract
  28. Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell. 2013 Mar 07; 49(5):934-46. View abstract
  29. Mollova M, Bersell K, Walsh S, Savla J, Das LT, Park SY, Silberstein LE, Dos Remedios CG, Graham D, Colan S, Kühn B. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1446-51. View abstract
  30. Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE. Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J Immunol. 2013 Feb 01; 190(3):1094-102. View abstract
  31. Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2013 Feb 21; 121(8):1255-64. View abstract
  32. Gao H, Wu X, Sun Y, Zhou S, Silberstein LE, Zhu Z. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012 Aug 24; 287(35):29979-87. View abstract
  33. Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3. View abstract
  34. Li Y, Prasad A, Jia Y, Roy SG, Loison F, Mondal S, Kocjan P, Silberstein LE, Ding S, Luo HR. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16; 117(24):6702-13. View abstract
  35. Lu J, Ma Y, Kong N, Alipio Z, Gao C, Krause DS, Silberstein LE, Chai L. Dissecting the role of SALL4, a newly identified stem cell factor, in chronic myelogenous leukemia. Leukemia. 2011 Jul; 25(7):1211-3. View abstract
  36. Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6486-91. View abstract
  37. Nombela-Arrieta C, Ritz J, Silberstein LE. The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol. 2011 02; 12(2):126-31. View abstract
  38. Jo H, Loison F, Hattori H, Silberstein LE, Yu H, Luo HR. Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One. 2010 Apr 23; 5(4):e10318. View abstract
  39. Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR. Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN. Leukemia. 2010 May; 24(5):1077-80. View abstract
  40. Gao H, Le Y, Wu X, Silberstein LE, Giese RW, Zhu Z. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res. 2010 Jan 01; 70(1):202-11. View abstract
  41. Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR. Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol. 2009 Jul 15; 183(2):1032-43. View abstract
  42. Sarraj B, Massberg S, Li Y, Kasorn A, Subramanian K, Loison F, Silberstein LE, von Andrian U, Luo HR. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol. 2009 Jun 01; 182(11):7190-200. View abstract
  43. Lu J, Jeong HW, Jeong H, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Chai L. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One. 2009; 4(5):e5577. View abstract
  44. Le Y, Xu L, Lu J, Fang J, Nardi V, Chai L, Silberstein LE. FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells. Am J Hematol. 2009 May; 84(5):273-8. View abstract
  45. Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60. View abstract
  46. Steigman SA, Armant M, Bayer-Zwirello L, Kao GS, Silberstein L, Ritz J, Fauza DO. Preclinical regulatory validation of a 3-stage amniotic mesenchymal stem cell manufacturing protocol. J Pediatr Surg. 2008 Jun; 43(6):1164-9. View abstract
  47. Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44. View abstract
  48. Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE. SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity. 2007 Nov; 27(5):811-23. View abstract
  49. Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia. 2007 Aug; 21(8):1723-32. View abstract
  50. Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10494-9. View abstract
  51. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar; 47(3):442-51. View abstract
  52. Zhu D, Hattori H, Jo H, Jia Y, Subramanian KK, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo HR. Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14836-41. View abstract
  53. Honczarenko M, Glodek AM, Swierkowski M, Na IK, Silberstein LE. Developmental stage-specific shift in responsiveness to chemokines during human B-cell development. Exp Hematol. 2006 Aug; 34(8):1093-100. View abstract
  54. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells. 2006 Apr; 24(4):1030-41. View abstract
  55. Honczarenko M, Ratajczak MZ, Nicholson-Weller A, Silberstein LE. Complement C3a enhances CXCL12 (SDF-1)-mediated chemotaxis of bone marrow hematopoietic cells independently of C3a receptor. J Immunol. 2005 Sep 15; 175(6):3698-706. View abstract
  56. Honczarenko M, Lu B, Nicholson-Weller A, Gerard NP, Silberstein LE, Gerard C. C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Leukemia. 2005 Sep; 19(9):1682-3; author reply 1684-5. View abstract
  57. Le Y, Honczarenko M, Glodek AM, Ho DK, Silberstein LE. CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells. J Immunol. 2005 Mar 01; 174(5):2582-90. View abstract
  58. Mazo IB, Honczarenko M, Leung H, Cavanagh LL, Bonasio R, Weninger W, Engelke K, Xia L, McEver RP, Koni PA, Silberstein LE, von Andrian UH. Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity. 2005 Feb; 22(2):259-70. View abstract
  59. Burger M, Glodek A, Hartmann T, Schmitt-Gräff A, Silberstein LE, Fujii N, Kipps TJ, Burger JA. Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Oncogene. 2003 Nov 06; 22(50):8093-101. View abstract
  60. Glodek AM, Honczarenko M, Le Y, Campbell JJ, Silberstein LE. Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis. J Exp Med. 2003 Feb 17; 197(4):461-73. View abstract
  61. Honczarenko M, Le Y, Glodek AM, Majka M, Campbell JJ, Ratajczak MZ, Silberstein LE. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. Blood. 2002 Oct 01; 100(7):2321-9. View abstract
  62. Zubair AC, Silberstein L, Ritz J. Adult hematopoietic stem cell plasticity. Transfusion. 2002 Aug; 42(8):1096-101. View abstract
  63. Westhoff CM, Silberstein LE, Wylie DE, Skavdahl M, Reid ME. 16Cys encoded by the RHce gene is associated with altered expression of the e antigen and is frequent in the R0 haplotype. Br J Haematol. 2001 Jun; 113(3):666-71. View abstract
  64. Silberstein LE, Toy P. Research opportunities in transfusion medicine. JAMA. 2001 Feb 07; 285(5):577-80. View abstract
  65. Majewski M, Korecka M, Kossev P, Li S, Goldman J, Moore J, Silberstein LE, Nowell PC, Schuler W, Shaw LM, Wasik MA. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4285-90. View abstract
  66. Westhoff CM, Silberstein LE, Wylie DE. Evidence supporting the requirement for two proline residues for expression of c. Transfusion. 2000 Mar; 40(3):321-4. View abstract
  67. Cunto-Amesty G, Przybylski G, Honczarenko M, Monroe JG, Silberstein LE. Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens. Blood. 2000 Feb 15; 95(4):1393-9. View abstract
  68. Majka M, Ratajczak J, Lee B, Honczarenko M, Douglas R, Kowalska MA, Silberstein L, Gewirtz AM, Ratajczak MZ. The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro. Stem Cells. 2000; 18(2):128-38. View abstract
  69. Dzik S, Aubuchon J, Jeffries L, Kleinman S, Manno C, Murphy MF, Popovsky MA, Sayers M, Silberstein LE, Slichter SJ, Vamvakas EC. Leukocyte reduction of blood components: public policy and new technology. Transfus Med Rev. 2000 Jan; 14(1):34-52. View abstract
  70. Stadtmauer EA, Tsai DE, Sickles CJ, Mick R, Luger SM, Porter DL, Mangan PA, Schuchter LM, Schuster SJ, Loh EY, Magee DA, Sachs RA, Wall ME, Moore J, Buzby GP, Zaleta E, Kamoun M, Silberstein LE. Stem cell transplantation for metastatic breast cancer: analysis of tumor contamination. Med Oncol. 1999 Dec; 16(4):279-88. View abstract
  71. Majka M, Rozmyslowicz T, Lee B, Murphy SL, Pietrzkowski Z, Gaulton GN, Silberstein L, Ratajczak MZ. Bone marrow CD34(+) cells and megakaryoblasts secrete beta-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. J Clin Invest. 1999 Dec; 104(12):1739-49. View abstract
  72. Honczarenko M, Douglas RS, Mathias C, Lee B, Ratajczak MZ, Silberstein LE. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells. Blood. 1999 Nov 01; 94(9):2990-8. View abstract
  73. Rao SP, Riggs JM, Friedman DF, Scully MS, LeBien TW, Silberstein LE. Biased VH gene usage in early lineage human B cells: evidence for preferential Ig gene rearrangement in the absence of selection. J Immunol. 1999 Sep 01; 163(5):2732-40. View abstract
  74. Moore HC, Mick R, Solin LJ, Sickles C, Mangan PA, Luger SM, Fox KR, Schuchter LM, Loh E, Porter DL, Schuster S, Buzby GP, Glatstein E, Silberstein LE, Stadtmauer EA. Autologous stem-cell transplant after conventional dose adjuvant chemotherapy for high-risk breast cancer: impact on the delivery of local-regional radiation therapy. Ann Oncol. 1999 Aug; 10(8):929-36. View abstract
  75. Westhoff CM, Schultze A, From A, Wylie DE, Silberstein LE. Characterization of the mouse Rh blood group gene. Genomics. 1999 May 01; 57(3):451-4. View abstract
  76. Hillyer CD, Lankford KV, Roback JD, Gillespie TW, Silberstein LE. Transfusion of the HIV-seropositive patient: immunomodulation, viral reactivation, and limiting exposure to EBV (HHV-4), CMV (HHV-5), and HHV-6, 7, and 8. Transfus Med Rev. 1999 Jan; 13(1):1-17. View abstract
  77. Shan H, Goldman J, Cunto G, Manuppello J, Chaiken I, Cines DB, Silberstein LE. Heterogeneity of anti-phospholipid and anti-endothelial cell antibodies. J Autoimmun. 1998 Dec; 11(6):651-60. View abstract
  78. Silberstein LE, Rao SP. VH-mediated mechanisms in normal and neoplastic B cell development. Immunol Res. 1998; 17(1-2):253-9. View abstract
  79. Kraj P, Rao SP, Glas AM, Hardy RR, Milner EC, Silberstein LE. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J Immunol. 1997 Jun 15; 158(12):5824-32. View abstract
  80. Rose NC, Hurwitz C, Silberstein L, Andovalu R, Stoerker J. Prenatal analysis of rhesus CcDEe blood groups by heteroduplex generator. Am J Obstet Gynecol. 1997 May; 176(5):1084-9. View abstract
  81. Przybylski GK, Goldman J, Ng VL, McGrath MS, Herndier BG, Schenkein DP, Monroe JG, Silberstein LE. Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma. Blood. 1996 Dec 15; 88(12):4620-9. View abstract
  82. Dighiero G, Kipps T, Schroeder HW, Chiorazzi N, Stevenson F, Silberstein LE, Caligaris-Cappio F, Ferrarini M. What is the CLL B-lymphocyte? Leuk Lymphoma. 1996 Oct; 22 Suppl 2:13-39. View abstract
  83. Bird JM, Luger S, Mangan P, Edelstein M, Silberstein L, Powlis W, Ball J, Schultz DJ, Stadtmauer EA. 4-Hydroperoxycyclophosphamide purged autologous bone marrow transplantation in non-Hodgkin's lymphoma patients at high risk of bone marrow involvement. Bone Marrow Transplant. 1996 Aug; 18(2):309-13. View abstract
  84. Silberstein LE, Jefferies LC. Placental-blood banking--a new frontier in transfusion medicine. N Engl J Med. 1996 Jul 18; 335(3):199-201. View abstract
  85. Stoerker J, Hurwitz C, Rose NC, Silberstein LE, Highsmith WE. Heteroduplex generator in analysis of Rh blood group alleles. Clin Chem. 1996 Mar; 42(3):356-60. View abstract
  86. Silberstein LE, George A, Durdik JM, Kipps TJ. The V4-34 encoded anti-i autoantibodies recognize a large subset of human and mouse B-cells. Blood Cells Mol Dis. 1996; 22(2):126-38. View abstract
  87. Friedman DF, Kraj P, Silberstein LE. VH4.21 expression in the normal human B-cell repertoire. Ann N Y Acad Sci. 1995 Sep 29; 764:285-92. View abstract
  88. Jefferies LC, Carchidi CM, Silberstein LE. Immunoglobulin gene use by naturally occurring cold agglutinins. Ann N Y Acad Sci. 1995 Sep 29; 764:433-5. View abstract
  89. Moore JS, Friedman DF, Silberstein LE, Besa EC, Nowell PC. Clinical heterogeneity reflects biologic diversity in chronic lymphocytic leukemia. Crit Rev Oncol Hematol. 1995 Aug; 20(1-2):141-64. View abstract
  90. Kraj P, Friedman DF, Stevenson F, Silberstein LE. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J Immunol. 1995 Jun 15; 154(12):6406-20. View abstract
  91. Stadtmauer EA, Schneider CJ, Silberstein LE. Peripheral blood progenitor cell generation and harvesting. Semin Oncol. 1995 Jun; 22(3):291-300. View abstract
  92. Monroe JG, Silberstein LE. HIV-mediated B-lymphocyte activation and lymphomagenesis. J Clin Immunol. 1995 Mar; 15(2):61-8. View abstract
  93. Biggs DD, Kraj P, Goldman J, Jefferies L, Carchidi C, Anderson K, Silberstein LE. Immunoglobulin gene sequence analysis to further assess B-cell origin of multiple myeloma. Clin Diagn Lab Immunol. 1995 Jan; 2(1):44-52. View abstract
  94. Parr TB, Johnson TA, Silberstein LE, Kipps TJ. Anti-B cell autoantibodies encoded by VH 4-21 genes in human fetal spleen do not require in vivo somatic selection. Eur J Immunol. 1994 Dec; 24(12):2941-9. View abstract
  95. Siegel DL, Silberstein LE. Expression and characterization of recombinant anti-Rh(D) antibodies on filamentous phage: a model system for isolating human red blood cell antibodies by repertoire cloning. Blood. 1994 Apr 15; 83(8):2334-44. View abstract
  96. Silberstein LE. B-cell origin of cold agglutinins. Adv Exp Med Biol. 1994; 347:193-205. View abstract
  97. Biggs D, Stadtmauer E, Mangan P, Edelstein M, Powlis W, Buzby G, Magee D, Sachs B, Silberstein L. 4-Hydroperoxycyclophosphamide purged autologous bone marrow transplantation of relapsed, responding non-Hodgkin's lymphoma with granulocyte colony stimulating factor support results in reliable hematopoietic recovery. Prog Clin Biol Res. 1994; 389:9-15. View abstract
  98. Stadtmauer EA, Hodi FS, Sickles C, Biggs DD, Mangan P, Buzby G, Zaleta E, Silberstein L. High-dose therapy and growth factor mobilized peripheral blood progenitor cell support for responding patients with metastatic breast cancer. Prog Clin Biol Res. 1994; 389:487-95. View abstract
  99. Schutte ME, van Es JH, Silberstein LE, Logtenberg T. VH4.21-encoded natural autoantibodies with anti-i specificity mirror those associated with cold hemagglutinin disease. J Immunol. 1993 Dec 01; 151(11):6569-76. View abstract
  100. Jefferies LC, Carchidi CM, Silberstein LE. Naturally occurring anti-i/I cold agglutinins may be encoded by different VH3 genes as well as the VH4.21 gene segment. J Clin Invest. 1993 Dec; 92(6):2821-33. View abstract
  101. Goodnough LT, Anderson KC, Kurtz S, Lane TA, Pisciotto PT, Sayers MH, Silberstein LE. Indications and guidelines for the use of hematopoietic growth factors. Transfusion. 1993 Nov-Dec; 33(11):944-59. View abstract
  102. Pisciotto PT, Anderson KC, Goodnough LT, Kurtz SR, Lane TA, Sayers MH, Silberstein LE. Current trends: evolving concepts in transfusion medicine. The need for standardization of cryoprecipitate-derived fibrin adhesive. Transfus Sci. 1993 Jul; 14(3):291-4. View abstract
  103. Stevenson FK, Spellerberg MB, Treasure J, Chapman CJ, Silberstein LE, Hamblin TJ, Jones DB. Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. Blood. 1993 Jul 01; 82(1):224-30. View abstract
  104. Konrad RJ, Kricka LJ, Goodman DB, Goldman J, Silberstein LE. Brief report: myeloma-associated paraprotein directed against the HIV-1 p24 antigen in an HIV-1-seropositive patient. N Engl J Med. 1993 Jun 24; 328(25):1817-9. View abstract
  105. Silberstein LE. Natural and pathologic human autoimmune responses to carbohydrate antigens on red blood cells. Springer Semin Immunopathol. 1993; 15(2-3):139-53. View abstract
  106. Jefferies LC, Silverman GJ, Carchidi CM, Silberstein LE. Idiotypic heterogeneity of VKIII autoantibodies to red blood cell antigens. Clin Immunol Immunopathol. 1992 Nov; 65(2):119-28. View abstract
  107. Friedman DF, Moore JS, Erikson J, Manz J, Goldman J, Nowell PC, Silberstein LE. Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia. Blood. 1992 Nov 01; 80(9):2287-97. View abstract
  108. Lane TA, Anderson KC, Goodnough LT, Kurtz S, Moroff G, Pisciotto PT, Sayers M, Silberstein LE. Leukocyte reduction in blood component therapy. Ann Intern Med. 1992 Jul 15; 117(2):151-62. View abstract
  109. Grillot-Courvalin C, Brouet JC, Piller F, Rassenti LZ, Labaume S, Silverman GJ, Silberstein L, Kipps TJ. An anti-B cell autoantibody from Wiskott-Aldrich syndrome which recognizes i blood group specificity on normal human B cells. Eur J Immunol. 1992 Jul; 22(7):1781-8. View abstract
  110. Sayers MH, Anderson KC, Goodnough LT, Kurtz SR, Lane TA, Pisciotto P, Silberstein LE. Reducing the risk for transfusion-transmitted cytomegalovirus infection. Ann Intern Med. 1992 Jan 01; 116(1):55-62. View abstract
  111. Stadtmauer EA, Edelstein M, Lin E, Spitalnik S, Silberstein L, Cassileth PA. Autologous bone marrow transplantation with in vitro chemotherapy purge in first remission of acute myeloid leukemia. Prog Clin Biol Res. 1992; 377:273-9. View abstract
  112. Reidl LS, Friedman DF, Goldman J, Hardy RR, Jefferies LC, Silberstein LE. Structural basis of a conserved idiotope expressed by an autoreactive human B cell lymphoma. Evidence that a VH CDR3 mutation alters idiotypy and specificity. J Immunol. 1991 Nov 15; 147(10):3623-31. View abstract
  113. Silberstein LE, Jefferies LC, Goldman J, Friedman D, Moore JS, Nowell PC, Roelcke D, Pruzanski W, Roudier J, Silverman GJ. Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood. 1991 Nov 01; 78(9):2372-86. View abstract
  114. Friedman DF, Cho EA, Goldman J, Carmack CE, Besa EC, Hardy RR, Silberstein LE. The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma. J Exp Med. 1991 Sep 01; 174(3):525-37. View abstract
  115. Anderson KC, Goodnough LT, Sayers M, Pisciotto PT, Kurtz SR, Lane TA, Anderson CS, Silberstein LE. Variation in blood component irradiation practice: implications for prevention of transfusion-associated graft-versus-host disease. Blood. 1991 May 15; 77(10):2096-102. View abstract
  116. Andrzejewski C, Young PJ, Cines DB, Silberstein LE. Heterogeneity of human red cell autoantibodies assessed by isoelectric focusing. Transfusion. 1991 Mar-Apr; 31(3):236-44. View abstract
  117. Eshleman JR, Silberstein LE. The development of selective plasmapheresis as a means for specific therapeutic intervention. Transfusion. 1991 Feb; 31(2):96-8. View abstract
  118. Goodnough LT, Johnston MF, Ramsey G, Sayers MH, Eisenstadt RS, Anderson KC, Rutman RC, Silberstein LE. Guidelines for transfusion support in patients undergoing coronary artery bypass grafting. Transfusion Practices Committee of the American Association of Blood Banks. Ann Thorac Surg. 1990 Oct; 50(4):675-83. View abstract
  119. Jefferies LC, Stevenson FK, Goldman J, Bennett IM, Spitalnik SL, Silberstein LE. Anti-idiotypic antibodies specific for a pathologic anti-Pr2 cold agglutinin. Transfusion. 1990 Jul-Aug; 30(6):495-502. View abstract
  120. Judd WJ, Luban NL, Ness PM, Silberstein LE, Stroup M, Widmann FK. Prenatal and perinatal immunohematology: recommendations for serologic management of the fetus, newborn infant, and obstetric patient. Transfusion. 1990 Feb; 30(2):175-83. View abstract
  121. Silberstein LE, Kruskall MS, Stehling LC, Johnston MF, Rutman RC, Samia CT, Ramsey G, Eisenstaedt RS. Strategies for the review of transfusion practices. JAMA. 1989 Oct 13; 262(14):1993-7. View abstract
  122. Silberstein LE, Litwin S, Carmack CE. Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies. J Exp Med. 1989 May 01; 169(5):1631-43. View abstract
  123. Andrzejewski C, Young PJ, Goldman J, Spitalnik SL, Silberstein LE. Production of human warm-reacting red cell monoclonal autoantibodies by Epstein-Barr virus transformation. Transfusion. 1989 Mar-Apr; 29(3):196-200. View abstract
  124. Silberstein LE, Jefferies LC, Goldman J, Spitalnik SL. Production of carbohydrate-specific human monoclonal antibodies in vitro. Methods Enzymol. 1989; 179:299-304. View abstract
  125. Silberstein LE, Williams LJ, Hughlett MA, Magee DA, Weisman RA. An autologous fibrinogen-based adhesive for use in otologic surgery. Transfusion. 1988 Jul-Aug; 28(4):319-21. View abstract
  126. Silberstein LE, Goldman J, Kant JA, Spitalnik SL. Comparative biochemical and genetic characterization of clonally related human B-cell lines secreting pathogenic anti-Pr2 cold agglutinins. Arch Biochem Biophys. 1988 Jul; 264(1):244-52. View abstract
  127. Kruskall MS, Mintz PD, Bergin JJ, Johnston MF, Klein HG, Miller JD, Rutman R, Silberstein L. Transfusion therapy in emergency medicine. Ann Emerg Med. 1988 Apr; 17(4):327-35. View abstract
  128. Webster C, Silberstein L, Hays AP, Blau HM. Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy. Cell. 1988 Feb 26; 52(4):503-13. View abstract
  129. Lichtin AE, Schreiber AD, Hurwitz S, Willoughby TL, Silberstein LE. Efficacy of intensive plasmapheresis in thrombotic thrombocytopenic purpura. Arch Intern Med. 1987 Dec; 147(12):2122-6. View abstract
  130. Silberstein LE, Abrahm J, Shattil SJ. The efficacy of intensive plasma exchange in acquired von Willebrand's disease. Transfusion. 1987 May-Jun; 27(3):234-7. View abstract
  131. Silberstein LE, Berkman EM, Schreiber AD. Cold hemagglutinin disease associated with IgG cold-reactive antibody. Ann Intern Med. 1987 Feb; 106(2):238-42. View abstract
  132. White KK, Silberstein LE. Quality control in the blood bank. Clin Lab Med. 1986 Dec; 6(4):689-96. View abstract
  133. Silberstein L, Webster SG, Travis M, Blau HM. Developmental progression of myosin gene expression in cultured muscle cells. Cell. 1986 Sep 26; 46(7):1075-81. View abstract
  134. Cameron PM, Limjuco GA, Chin J, Silberstein L, Schmidt JA. Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1. J Exp Med. 1986 Jul 01; 164(1):237-50. View abstract
  135. Silberstein LE, Robertson GA, Harris AC, Moreau L, Besa E, Nowell PC. Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B cell clone. Blood. 1986 Jun; 67(6):1705-9. View abstract
  136. Lichtin AE, Silberstein LE, Schreiber AD. Thrombotic thrombocytopenic purpura with colitis in an elderly woman. JAMA. 1986 Mar 21; 255(11):1435-6. View abstract
  137. Silberstein LE, Naryshkin S, Haddad JJ, Strauss JF. Calcium homeostasis during therapeutic plasma exchange. Transfusion. 1986 Mar-Apr; 26(2):151-5. View abstract
  138. Silberstein LE, Shaw LM. Effect of plasma exchange on phenytoin plasma concentration. Ther Drug Monit. 1986; 8(2):172-6. View abstract
  139. Silberstein LE, Shoenfeld Y, Schwartz RS, Berkman EM. A combination of IgG and IgM autoantibodies in chronic cold agglutinin disease: immunologic studies and response to splenectomy. Vox Sang. 1985; 48(2):105-9. View abstract
  140. Silberstein LE, Duggan D, Berkman EM. Therapeutic trial of plasma exchange in osteosclerotic myeloma associated with the POEMS syndrome. J Clin Apher. 1985; 2(3):253-7. View abstract
  141. Sherman LA, Silberstein LE, Berkman EM. Altered blood group expression in a patient with congenital rubella infection. Transfusion. 1984 May-Jun; 24(3):267-9. View abstract
  142. Inestrosa NC, Miller JB, Silberstein L, Ziskind-Conhaim L, Hall ZW. Developmental regulation of 16S acetylcholinesterase and acetylcholine receptors in a mouse muscle cell line. Exp Cell Res. 1983 Sep; 147(2):393-405. View abstract
  143. Silberstein LE, Berkman EM, Fanburg BL. Angiotensin-1-converting enzyme (ACE) activity in human serum following plasma exchange. . 1983 Jun; 173(2):222-6. View abstract
  144. Silberstein LE, Berkman EM. Plasma exchange in autoimmune hemolytic anemia (AIHA). J Clin Apher. 1983; 1(4):238-42. View abstract
  145. Shoenfeld Y, Hsu-Lin SC, Gabriels JE, Silberstein LE, Furie BC, Furie B, Stollar BD, Schwartz RS. Production of autoantibodies by human-human hybridomas. J Clin Invest. 1982 Jul; 70(1):205-8. View abstract
  146. Inestrosa NC, Silberstein L, Hall ZW. Association of the synaptic form of acetylcholinesterase with extracellular matrix in cultured mouse muscle cells. Cell. 1982 May; 29(1):71-9. View abstract
  147. Reuveny S, Silberstein L, Shahar A, Freeman E, Mizrahi A. DE-52 and DE-53 cellulose microcarriers. I. Growth of primary and established anchorage-dependent cells. In Vitro. 1982 Feb; 18(2):92-8. View abstract