MEDICAL SERVICES

EDUCATION

Medical School

  • Dalhousie University , 2008 , Halifax , Nova Scotia, Canada

Residency

  • University of Manitoba , 2012 , Winnipeg , Manitoba, Canada

Fellowship

  • Boston Children's Hospital , 2016 , Boston , MA

PROFESSIONAL HISTORY

Dr. Silvester completed her PhD in Biology at the University of Cambridge, Cambridge, England, prior to studying medicine at Dalhousie University in Halifax, Nova Scotia, Canada. She completed her residency at the University of Manitoba in Winnipeg, Canada and her Fellowship in Gastroenterology, Hepatology and Nutrition at Boston Children’s Hospital. Dr. Silvester continues to work as a general pediatrician in remote regions of Northern Canada as well as at Boston Children’s Hospital. Her research interests include the diagnosis and management of celiac disease.


CERTIFICATIONS

  • American Board of Pediatrics, General Pediatrics
  • American Board of Pediatrics, Pediatric Gastroenterology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease. Nat Rev Gastroenterol Hepatol. 2021 Sep 15. View abstract
  2. Clinical classification and long-term outcomes of seronegative coeliac disease: a 20-year multicentre follow-up study. Aliment Pharmacol Ther. 2021 Sep 08. View abstract
  3. Prevalence of Celiac Disease in China: Meta-analysis and Serological Survey in High-risk Populations. J Dig Dis. 2021 Sep 05. View abstract
  4. Patient Perspectives on the Long-term Management of Celiac Disease. J Clin Gastroenterol. 2021 Jul 30. View abstract
  5. Celiac Disease: Fallacies and Facts. Am J Gastroenterol. 2021 06 01; 116(6):1148-1155. View abstract
  6. Non-responsive celiac disease in children on a gluten free diet. World J Gastroenterol. 2021 Apr 07; 27(13):1311-1320. View abstract
  7. Editorial: Advances in Gastrointestinal Immunology. Curr Opin Gastroenterol. 2020 11; 36(6):463. View abstract
  8. Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial. Gastroenterology. 2021 02; 160(3):720-733.e8. View abstract
  9. The Gluten-Free Family Ripple Effect: The Tides that Bond and the Tides that Divide. Dig Dis Sci. 2020 10; 65(10):2754-2755. View abstract
  10. Safety of a GFD in Pregnant Women Without Celiac Disease: Investigating Ingrained Habits. Dig Dis Sci. 2020 10; 65(10):2751-2753. View abstract
  11. Exposure sources, amounts and time course of gluten ingestion and excretion in patients with coeliac disease on a gluten-free diet. Aliment Pharmacol Ther. 2020 11; 52(9):1469-1479. View abstract
  12. Reply. Gastroenterology. 2020 09; 159(3):1189-1190. View abstract
  13. Enteric-Release Budesonide May Be Useful in the Management of Non-Responsive Celiac Disease. Dig Dis Sci. 2021 06; 66(6):1989-1997. View abstract
  14. The Utility of IgA-Based Serologic Markers in Diagnosing Celiac Disease in Children 24 Months of Age or Younger. J Pediatr. 2020 09; 224:158-161.e2. View abstract
  15. Development of the Dietitian Integrated Evaluation Tool for Gluten-free Diets (DIET-GFD). Nutrition. 2020 10; 78:110819. View abstract
  16. A Quantitative Assessment of Gluten Cross-contact in the School Environment for Children With Celiac Disease. J Pediatr Gastroenterol Nutr. 2020 03; 70(3):289-294. View abstract
  17. Can individuals with celiac disease identify gluten-free foods correctly? Clin Nutr ESPEN. 2020 04; 36:82-90. View abstract
  18. Assessing the association between dipeptidyl peptidase-4 inhibitors use and celiac disease through drug adverse event reporting. Ther Adv Chronic Dis. 2020; 11:2040622320904301. View abstract
  19. Celiac Disease: Extraintestinal Manifestations and Associated Conditions. J Clin Gastroenterol. 2020 01; 54(1):8-21. View abstract
  20. Most Patients With Celiac Disease on Gluten-Free Diets Consume Measurable Amounts of Gluten. Gastroenterology. 2020 04; 158(5):1497-1499.e1. View abstract
  21. Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease. PLoS One. 2019; 14(10):e0222952. View abstract
  22. Preparation of Gluten-Free Foods Alongside Gluten-Containing Food May Not Always Be as Risky for Celiac Patients as Diet Guides Suggest. Gastroenterology. 2020 01; 158(1):273-275. View abstract
  23. Inter- and Intra-assay Variation in the Diagnostic Performance of Assays for Anti-tissue Transglutaminase in 2 Populations. Clin Gastroenterol Hepatol. 2020 10; 18(11):2628-2630. View abstract
  24. Can We Ignore the Utility of Deamidated Gliadin Peptide in the Diagnosis of Celiac Disease in Children? J Pediatr Gastroenterol Nutr. 2019 07; 69(1):e23. View abstract
  25. Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten-free diet. Aliment Pharmacol Ther. 2019 06; 49(12):1484-1492. View abstract
  26. Efficacy of Enteric-Release Oral Budesonide in Treatment of Acute Reactions to Gluten in Patients With Celiac Disease. Clin Gastroenterol Hepatol. 2020 01; 18(1):254-256. View abstract
  27. Sequence of acquisition of self-management skills to follow a gluten-free diet by adults with celiac disease. Dig Liver Dis. 2019 08; 51(8):1096-1100. View abstract
  28. Red Spot Lesions in the Duodenal Bulb Are a Highly Specific Endoscopic Sign of Celiac Disease: A Prospective Study. J Pediatr Gastroenterol Nutr. 2019 02; 68(2):251-255. View abstract
  29. Serum zonulin is elevated in IBS and correlates with stool frequency in IBS-D. United European Gastroenterol J. 2019 06; 7(5):709-715. View abstract
  30. Lack of Follow-up of Pediatric Patients With Celiac Disease. Clin Gastroenterol Hepatol. 2019 11; 17(12):2603-2604. View abstract
  31. (Outcome) Measure for (Intervention) Measures: A Guide to Choosing the Appropriate Noninvasive Clinical Outcome Measure for Intervention Studies in Celiac Disease. Gastroenterol Clin North Am. 2019 03; 48(1):85-99. View abstract
  32. Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1570-E1577. View abstract
  33. Symptoms of Functional Intestinal Disorders Are Common in Patients with Celiac Disease Following Transition to a Gluten-Free Diet. Dig Dis Sci. 2017 09; 62(9):2449-2454. View abstract
  34. Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis. Gastroenterology. 2017 09; 153(3):689-701.e1. View abstract
  35. Value of IgA tTG in Predicting Mucosal Recovery in Children With Celiac Disease on a Gluten-Free Diet. J Pediatr Gastroenterol Nutr. 2017 02; 64(2):286-291. View abstract
  36. Is Autoimmunity Infectious? The Effect of Gastrointestinal Viral Infections and Vaccination on Risk of Celiac Disease Autoimmunity. Clin Gastroenterol Hepatol. 2017 05; 15(5):703-705. View abstract
  37. Information seeking and anxiety among colonoscopy-naïve adults: Direct-to-colonoscopy vs traditional consult-first pathways. World J Gastrointest Endosc. 2016 Nov 16; 8(19):701-708. View abstract
  38. Symptomatic suspected gluten exposure is common among patients with coeliac disease on a gluten-free diet. Aliment Pharmacol Ther. 2016 09; 44(6):612-9. View abstract
  39. Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods. Nutrition. 2016 Jul-Aug; 32(7-8):777-83. View abstract
  40. The Potential for Treatment of Potential Celiac Disease. Clin Gastroenterol Hepatol. 2016 May; 14(5):694-5. View abstract
  41. Recent Advances in Celiac Disease from TTG to Gluten in Pee. Clin Transl Gastroenterol. 2015 Nov 12; 6:e125. View abstract
  42. Living gluten-free: adherence, knowledge, lifestyle adaptations and feelings towards a gluten-free diet. J Hum Nutr Diet. 2016 Jun; 29(3):374-82. View abstract
  43. Five things to know about...celiac disease. CMAJ. 2013 Jan 08; 185(1):60. View abstract
  44. The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene. 2012 Feb 16; 31(7):884-96. View abstract
  45. Long-term management of patients with celiac disease: current practices of gastroenterologists in Canada. Can J Gastroenterol. 2010 Aug; 24(8):499-509. View abstract
  46. Long-term follow-up of individuals with celiac disease: an evaluation of current practice guidelines. Can J Gastroenterol. 2007 Sep; 21(9):557-64. View abstract
  47. On the structure of the stator of the mitochondrial ATP synthase. EMBO J. 2006 Jun 21; 25(12):2911-8. View abstract
  48. The expression, purification, crystallization and preliminary X-ray analysis of a subcomplex of the peripheral stalk of ATP synthase from bovine mitochondria. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 01; 62(Pt 6):530-3. View abstract
  49. Solution structure of subunit F(6) from the peripheral stalk region of ATP synthase from bovine heart mitochondria. J Mol Biol. 2004 Sep 10; 342(2):593-603. View abstract
  50. An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart. Br J Pharmacol. 1999 Jul; 127(6):1518-24. View abstract