MEDICAL SERVICES

EDUCATION

Undergraduate Degree

  • Yale University , 1988 , New Haven , CT

Medical School

  • Harvard Medical School , 1993 , Boston , MA

Internship

  • Boston Children's Hospital , 1994 , Boston , MA

Residency

  • Boston Children's Hospital , 1996 , Boston , MA

Fellowship

  • Boston Children's Hospital , 1999 , Boston , MA

Philosophy of Care

I am committed to providing the highest quality care for pediatric patients with heart disease, and to advance their diagnosis and treatment through research and innovation.

PROFESSIONAL HISTORY

I grew up in upstate New York. From college at Yale through medical school at Harvard and training in pediatrics and pediatric cardiology at Boston Children’s, my passion has been to bring advances in science to bear on the problems faced by patients.

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Cardiology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Current and future treatment approaches for Barth syndrome. J Inherit Metab Dis. 2021 Oct 29. View abstract
  2. Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 Aug 19; 12(1):5105. View abstract
  3. Cardiac CIP protein regulates dystrophic cardiomyopathy. Mol Ther. 2021 Aug 14. View abstract
  4. Experimental models of Barth syndrome. J Inherit Metab Dis. 2021 Aug 09. View abstract
  5. Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 07 21; 12(1):4442. View abstract
  6. Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts. Elife. 2021 07 14; 10. View abstract
  7. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. Int J Mol Sci. 2021 Jun 22; 22(13). View abstract
  8. Calcific aortic valve disease: turning therapeutic discovery up a notch. Nat Rev Cardiol. 2021 05; 18(5):309-310. View abstract
  9. Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome. Circulation. 2021 May 11; 143(19):1894-1911. View abstract
  10. Two sides of the same coin: new insights into mechanisms of ventricular fibrillation. Cardiovasc Res. 2021 03 21; 117(4):983-984. View abstract
  11. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 May 18; 143(20):2007-2022. View abstract
  12. TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes. Cell Death Differ. 2021 Jul; 28(7):2045-2059. View abstract
  13. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 01 12; 118(2). View abstract
  14. AAV Gene Transfer to the Heart. Methods Mol Biol. 2021; 2158:269-280. View abstract
  15. Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Dev Cell. 2021 02 08; 56(3):292-309.e9. View abstract
  16. Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666. View abstract
  17. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678. View abstract
  18. Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21450-21458. View abstract
  19. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18; 32(7):108058. View abstract
  20. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 07 28; 32(4):107974. View abstract
  21. Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19254-19265. View abstract
  22. Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. Sci Adv. 2020 Jul; 6(30):eaba7606. View abstract
  23. Gene therapy for inherited arrhythmias. Cardiovasc Res. 2020 07 15; 116(9):1635-1650. View abstract
  24. The architecture and function of cardiac dyads. Biophys Rev. 2020 Aug; 12(4):1007-1017. View abstract
  25. Genetic and Epigenetic Control of Heart Development. Cold Spring Harb Perspect Biol. 2020 07 01; 12(7). View abstract
  26. Cardiomyocyte Maturation: New Phase in Development. Circ Res. 2020 04 10; 126(8):1086-1106. View abstract
  27. AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome. Circ Res. 2020 04 10; 126(8):1024-1039. View abstract
  28. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9. View abstract
  29. Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020 01 30; 11(1):75. View abstract
  30. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020 01; 3(1). View abstract
  31. Investigation of Streptococcus agalactiae using pcsB-based LAMP in milk, tilapia and vaginal swabs in Haikou, China. J Appl Microbiol. 2020 Mar; 128(3):784-793. View abstract
  32. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 10 28; 10(1):4907. View abstract
  33. Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification. Scand J Rheumatol. 2020 Mar; 49(2):146-153. View abstract
  34. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. View abstract
  35. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 07 30; 140(5):390-404. View abstract
  36. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II. Circulation. 2019 07 30; 140(5):405-419. View abstract
  37. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019 04 17; 10(1):1802. View abstract
  38. A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. Genome Res. 2019 02; 29(2):193-207. View abstract
  39. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 01 04; 124(1):161-169. View abstract
  40. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 11 20; 138(21):e653-e711. View abstract
  41. Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor. Nat Commun. 2018 09 21; 9(1):3837. View abstract
  42. Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review. Curr Hypertens Rep. 2018 08 07; 20(10):86. View abstract
  43. A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2018 12; 2(12):930-941. View abstract
  44. Exercising engineered heart muscle to maturity. Nat Rev Cardiol. 2018 07; 15(7):383-384. View abstract
  45. Genetic Mosaics for Greater Precision in Cardiovascular Research. Circ Res. 2018 06 22; 123(1):27-29. View abstract
  46. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec; 23(12):1488-1498. View abstract
  47. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 01 05; 122(1):74-87. View abstract
  48. CASAAV: A CRISPR-Based Platform for Rapid Dissection of Gene Function In Vivo. Curr Protoc Mol Biol. 2017 10 02; 120:31.11.1-31.11.14. View abstract
  49. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. View abstract
  50. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun. 2017 07 20; 8(1):87. View abstract
  51. Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng. 2017; 1. View abstract
  52. The complex genetics of hypoplastic left heart syndrome. Nat Genet. 2017 Jul; 49(7):1152-1159. View abstract
  53. Divergent Requirements for EZH1 in Heart Development Versus Regeneration. Circ Res. 2017 Jul 07; 121(2):106-112. View abstract
  54. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. View abstract
  55. Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 04 13; 8(4):e2744. View abstract
  56. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017 04 10; 6. View abstract
  57. Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 09; 120(12):1874-1888. View abstract
  58. Cardiac Regeneration: Lessons From Development. Circ Res. 2017 Mar 17; 120(6):941-959. View abstract
  59. Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq. Elife. 2017 01 25; 6. View abstract
  60. Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts. J Vis Exp. 2016 12 17; (118). View abstract
  61. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nat Protoc. 2017 Jan; 12(1):88-103. View abstract
  62. Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ J. 2016 Dec 22; 81(1):12-21. View abstract
  63. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. View abstract
  64. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res. 2016 Nov 01; 112(2):543-554. View abstract
  65. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. View abstract
  66. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016 11 21; 39(4):466-479. View abstract
  67. Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types. Genome Biol. 2016 06 03; 17(1):120. View abstract
  68. Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Dev Biol. 2016 05 15; 413(2):153-159. View abstract
  69. GATA4 regulates Fgf16 to promote heart repair after injury. Development. 2016 Mar 15; 143(6):936-49. View abstract
  70. Recounting Cardiac Cellular Composition. Circ Res. 2016 Feb 05; 118(3):368-70. View abstract
  71. Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):222-30. View abstract
  72. Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia. Psychol Med. 2016 Apr; 46(6):1211-24. View abstract
  73. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34. View abstract
  74. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View abstract
  75. Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015; 10(9):e0136025. View abstract
  76. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. View abstract
  77. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul; 47(7):776-83. View abstract
  78. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015; 10(5):e0128105. View abstract
  79. Cellular origin and developmental program of coronary angiogenesis. Circ Res. 2015 Jan 30; 116(3):515-30. View abstract
  80. Releasing YAP from an a-catenin trap increases cardiomyocyte proliferation. Circ Res. 2015 Jan 02; 116(1):9-11. View abstract
  81. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun. 2014 Nov 26; 5:5507. View abstract
  82. Introduction to the special issue on heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):521-2. View abstract
  83. Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harb Perspect Med. 2014 Oct 01; 4(10). View abstract
  84. Epicardium-to-fat transition in injured heart. Cell Res. 2014 Nov; 24(11):1367-9. View abstract
  85. Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nat Commun. 2014 Sep 24; 5:4907. View abstract
  86. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015 Jan 02; 116(1):35-45. View abstract
  87. Optimization of genome engineering approaches with the CRISPR/Cas9 system. PLoS One. 2014; 9(8):e105779. View abstract
  88. Ultrasound-guided transthoracic intramyocardial injection in mice. J Vis Exp. 2014 Aug 05; (90):e51566. View abstract
  89. Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 04; 345(6192):90-4. View abstract
  90. Strategies for cardiac regeneration and repair. Sci Transl Med. 2014 Jun 04; 6(239):239rv1. View abstract
  91. GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27. Biochim Biophys Acta. 2014 Nov; 1839(11):1273-82. View abstract
  92. Notching up vascular regeneration. Cell Res. 2014 Jul; 24(7):777-8. View abstract
  93. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014 Jul 18; 115(3):354-63. View abstract
  94. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014 Jul 04; 289(27):18681-92. View abstract
  95. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. View abstract
  96. Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):571-81. View abstract
  97. Hippo activation in arrhythmogenic cardiomyopathy. Circ Res. 2014 Jan 31; 114(3):402-5. View abstract
  98. Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. PLoS One. 2013; 8(11):e80857. View abstract
  99. WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14; 27(1):5-18. View abstract
  100. Developing insights into cardiac regeneration. Development. 2013 Oct; 140(19):3933-7. View abstract
  101. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. View abstract
  102. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15395-400. View abstract
  103. HCN4 charges up the first heart field. Circ Res. 2013 Aug 02; 113(4):350-1. View abstract
  104. The mysterious origins of coronary vessels. Cell Res. 2013 Sep; 23(9):1063-4. View abstract
  105. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14. View abstract
  106. A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Res. 2013 Jun; 23(6):917-27. View abstract
  107. A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. Sci Rep. 2013; 3:2243. View abstract
  108. GATA factors promote ER integrity and ß-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan; 28(1):28-39. View abstract
  109. Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles. Circ Res. 2012 Nov 09; 111(11):e276-80. View abstract
  110. Myocardial regeneration: expanding the repertoire of thymosin ß4 in the ischemic heart. Ann N Y Acad Sci. 2012 Oct; 1269:92-101. View abstract
  111. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14035-40. View abstract
  112. Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2. Circ Res. 2012 Jul 06; 111(2):162-4. View abstract
  113. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11306-11. View abstract
  114. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ Res. 2012 Jun 08; 110(12):1628-45. View abstract
  115. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012; 8(5):e1002690. View abstract
  116. Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Angiogenesis. 2012 Sep; 15(3):443-55. View abstract
  117. Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 2012 May; 32(10):1830-43. View abstract
  118. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16; 110(6):818-30. View abstract
  119. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2394-9. View abstract
  120. Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. J Biol Chem. 2012 Mar 23; 287(13):9827-9834. View abstract
  121. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 01; 26(1):37-42. View abstract
  122. Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells. Methods Mol Biol. 2012; 843:155-68. View abstract
  123. Regulation of GATA4 transcriptional activity in cardiovascular development and disease. Curr Top Dev Biol. 2012; 100:143-69. View abstract
  124. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 03; 110(3):406-15. View abstract
  125. Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell. 2011 Dec 02; 9(6):527-40. View abstract
  126. Epicardial epithelial-to-mesenchymal transition in injured heart. J Cell Mol Med. 2011 Dec; 15(12):2781-3. View abstract
  127. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):43-7. View abstract
  128. miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. J Biol Chem. 2011 Oct 14; 286(41):35339-35346. View abstract
  129. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12331-6. View abstract
  130. De novo cardiomyocytes from within the activated adult heart after injury. Nature. 2011 Jun 08; 474(7353):640-4. View abstract
  131. WT1 regulates epicardial epithelial to mesenchymal transition through ß-catenin and retinoic acid signaling pathways. Dev Biol. 2011 Aug 15; 356(2):421-31. View abstract
  132. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May; 121(5):1894-904. View abstract
  133. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr; 121(4):1585-95. View abstract
  134. Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5632-7. View abstract
  135. Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation. Dev Biol. 2011 May 15; 353(2):229-41. View abstract
  136. Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4006-11. View abstract
  137. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. View abstract
  138. Reprogramming fibroblasts into cardiomyocytes. N Engl J Med. 2011 Jan 13; 364(2):177-8. View abstract
  139. CompleteMOTIFs: DNA motif discovery platform for transcription factor binding experiments. Bioinformatics. 2011 Mar 01; 27(5):715-7. View abstract
  140. Genome-wide location analysis by pull down of in vivo biotinylated transcription factors. Curr Protoc Mol Biol. 2010 Oct; Chapter 21:Unit 21.20. View abstract
  141. Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol. 2010 Nov; 49(5):841-50. View abstract
  142. Expression and function of microRNAs in heart disease. Curr Drug Targets. 2010 Aug; 11(8):913-25. View abstract
  143. Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine. Gut. 2010 Jul; 59(7):888-95. View abstract
  144. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol. 2010 Jun 22; 6:381. View abstract
  145. Heart failure-associated changes in RNA splicing of sarcomere genes. Circ Cardiovasc Genet. 2010 Apr; 3(2):138-46. View abstract
  146. Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis. 2010 Jan; 48(1):63-72. View abstract
  147. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol. 2010 Feb 15; 338(2):251-61. View abstract
  148. Identification of a cardiac disease modifier gene using forward genetics in the mouse. PLoS Genet. 2009 Sep; 5(9):e1000643. View abstract
  149. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun; 119(6):1462-76. View abstract
  150. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009 Apr; 29(8):2193-204. View abstract
  151. Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res. 2008 Dec 05; 103(12):1393-401. View abstract
  152. More than a cover: epicardium as a novel source of cardiac progenitor cells. Regen Med. 2008 Sep; 3(5):633-5. View abstract
  153. Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol. 2008 Nov 01; 323(1):98-104. View abstract
  154. Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):450-3. View abstract
  155. GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol. 2008 Sep; 28(17):5420-31. View abstract
  156. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 03; 454(7200):109-13. View abstract
  157. Altered microRNA expression in human heart disease. Physiol Genomics. 2007 Nov 14; 31(3):367-73. View abstract
  158. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 2007 Aug; 13(8):952-61. View abstract
  159. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007 Dec; 43(6):677-85. View abstract
  160. Therapeutic neovascularization for peripheral arterial diseases: advances and perspectives. Histol Histopathol. 2007 06; 22(6):677-86. View abstract
  161. Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes. . 2007 Jul; 293(1):H829-35. View abstract
  162. Mesenchymal stem/stromal cells (MSC) transfected with stromal derived factor 1 (SDF-1) for therapeutic neovascularization: enhancement of cell recruitment and entrapment. Med Hypotheses. 2007; 68(6):1268-71. View abstract
  163. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 2007 Jan 15; 301(2):602-14. View abstract
  164. Chaperoning of estrogen receptor and induction of mammary gland proliferation by neuronal protein synuclein gamma. Oncogene. 2007 Mar 29; 26(14):2115-25. View abstract
  165. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14471-6. View abstract
  166. Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol. 2006 Dec; 26(23):9060-70. View abstract
  167. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development. 2006 Sep; 133(18):3607-18. View abstract
  168. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure . Proc. Natl. Acad. Sci USA. 2006; 103:14471-14476. View abstract
  169. A multivariate approach for integrating genome-wide expression data and biological knowledge. Bioinformatics. 2006 Oct 01; 22(19):2373-80. View abstract
  170. Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circ Res. 2006 Aug 18; 99(4):415-23. View abstract
  171. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 2006 Jun; 12(5):392-8. View abstract
  172. Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. FASEB J. 2006 Apr; 20(6):800-2. View abstract
  173. Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest. 2005 Jun; 115(6):1522-31. View abstract
  174. GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol. 2004 Nov 01; 275(1):235-44. View abstract
  175. Molecular Basis of Heart Failure. Heart Failure: A Companion to Braunwald's Heart Disease (D. L. Mann, ed.). 2004; 10-40. View abstract
  176. Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos. Circ Res. 2003 Oct 31; 93(9):857-65. View abstract
  177. NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro. Circ Res. 2003 Apr 18; 92(7):725-31. View abstract
  178. Structural characterization of the mouse Girk genes. Gene. 2002 Feb 06; 284(1-2):241-50. View abstract
  179. Transcription factors and heart failure: does the stressed heart need a hand? J Mol Cell Cardiol. 2001 Oct; 33(10):1765-7. View abstract
  180. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol. 2001 Jun 15; 37(8):2136-43. View abstract
  181. [Diagnostic and differential diagnostic potential of mitochondrial DNA assessment in patients with Leber's hereditary optic neuropathy]. Zhonghua Yan Ke Za Zhi. 2001 May; 37(3):174-7. View abstract
  182. Diagnostic potential of mitochondrial DNA assessment in patients with optic neuropathy. Chin Med J (Engl). 2000 Aug; 113(8):743-6. View abstract
  183. ICln is essential for cellular and early embryonic viability. J Biol Chem. 2000 Apr 28; 275(17):12363-6. View abstract
  184. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol. 1999 Jun; 19(6):4113-20. View abstract
  185. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J Biol Chem. 1998 May 01; 273(18):10811-4. View abstract
  186. [An experimental study on effects of biomembrane on prevention of filtering bleb adhesion in trabeculectomy]. Zhonghua Yan Ke Za Zhi. 1998 Jan; 34(1):68-70. View abstract
  187. Diagnosis and management of agenesis of the right lung and left pulmonary artery sling. Am J Cardiol. 1996 Sep 15; 78(6):723-7. View abstract
  188. Dimerization of leucine zippers analyzed by random selection. Nucleic Acids Res. 1993 Sep 11; 21(18):4348-55. View abstract
  189. Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2007-11. View abstract
  190. Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. Nucleic Acids Res. 1992 Feb 25; 20(4):771-5. View abstract
  191. Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol. 1991 Oct; 11(10):4918-26. View abstract
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