Orah Platt, MD

Chief, Department of Laboratory Medicine

Professor of Pediatrics, Harvard Medical School

  • Contact: 617-355-6347

  • Fax: 617-730-0383

Medical Services

Specialties

  • Thalassemia
  • Sickle Cell Anemia

Departments

  • Hematology / Oncology

Languages

  • English

Programs

  • Laboratory Medicine Research Center
To schedule an appointment: Call 617-355-6347

Experience and Education

Education

Medical School

Harvard Medical School,

Boston, MA

Internship

Massachusetts General Hospital,,

Boston, Ma

Residency

Massachusetts General Hospital,

Boston, Ma

Fellowship

Boston Children's Hospital,

Boston, Ma

Certifications

  • Pediatrics

Publications

Publications powered by Harvard Catalyst Profiles
  1. Jacquemont S, Reymond A, Zufferey F, Harewood L, Walters RG, Kutalik Z, Martinet D, Shen Y, Valsesia A, Beckmann ND, Thorleifsson G, Belfiore M, Bouquillon S, Campion D, de Leeuw N, de Vries BB, Esko T, Fernandez BA, Fernández-Aranda F, Fernández-Real JM, Gratacòs M, Guilmatre A, Hoyer J, Jarvelin MR, Kooy RF, Kurg A, Le Caignec C, Männik K, Platt OS, Sanlaville D, Van Haelst MM, Villatoro Gomez S, Walha F, Wu BL, Yu Y, Aboura A, Addor MC, Alembik Y, Antonarakis SE, Arveiler B, Barth M, Bednarek N, Béna F, Bergmann S, Beri M, Bernardini L, Blaumeiser B, Bonneau D, Bottani A, Boute O, Brunner HG, Cailley D, Callier P, Chiesa J, Chrast J, Coin L, Coutton C, Cuisset JM, Cuvellier JC, David A, de Freminville B, Delobel B, Delrue MA, Demeer B, Descamps D, Didelot G, Dieterich K, Disciglio V, Doco-Fenzy M, Drunat S, Duban-Bedu B, Dubourg C, El-Sayed Moustafa JS, Elliott P, Faas BH, Faivre L, Faudet A, Fellmann F, Ferrarini A, Fisher R, Flori E, Forer L, Gaillard D, Gerard M, Gieger C, Gimelli S, Gimelli G, Grabe HJ, Guichet A, Guillin O, Hartikainen AL, Heron D, Hippolyte L, Holder M, Homuth G, Isidor B, Jaillard S, Jaros Z, Jiménez-Murcia S, Helas GJ, Jonveaux P, Kaksonen S, Keren B, Kloss-Brandstätter A, Knoers NV, Koolen DA, Kroisel PM, Kronenberg F, Labalme A, Landais E, Lapi E, Layet V, Legallic S, Leheup B, Leube B, Lewis S, Lucas J, MacDermot KD, Magnusson P, Marshall C, Mathieu-Dramard M, McCarthy MI, Meitinger T, Mencarelli MA, Merla G, Moerman A, Mooser V, Morice-Picard F, Mucciolo M, Nauck M, Ndiaye NC, Nordgren A, Pasquier L, Petit F, Pfundt R, Plessis G, Rajcan-Separovic E, Ramelli GP, Rauch A, Ravazzolo R, Reis A, Renieri A, Richart C, Ried JS, Rieubland C, Roberts W, Roetzer KM, Rooryck C, Rossi M, Saemundsen E, Satre V, Schurmann C, Sigurdsson E, Stavropoulos DJ, Stefansson H, Tengström C, Thorsteinsdóttir U, Tinahones FJ, Touraine R, Vallée L, van Binsbergen E, Van der Aa N, Vincent-Delorme C, Visvikis-Siest S, Vollenweider P, Völzke H, Vulto-van Silfhout AT, Waeber G, Wallgren-Pettersson C, Witwicki RM, Zwolinksi S, Andrieux J, Estivill X, Gusella JF, Gustafsson O, Metspalu A, Scherer SW, Stefansson K, Blakemore AI, Beckmann JS, Froguel P. Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature. 2011 Oct 6; 478(7367):97-102.
  2. Yu Y, Zhu H, Miller DT, Gusella JF, Platt OS, Wu BL, Shen Y. Age- and gender-dependent obesity in individuals with 16p11.2 deletion. J Genet Genomics. 2011 Sep 20; 38(9):403-9.
  3. Siciliano A, Malpeli G, Platt OS, Lebouef C, Janin A, Scarpa A, Olivieri O, Amato E, Corrocher R, Beuzard Y, De Franceschi L. Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy. Haematologica. 2011 Jan; 96(1):24-32.
  4. Bunn HF, Nathan DG, Dover GJ, Hebbel RP, Platt OS, Rosse WF, Ware RE. Pulmonary hypertension and nitric oxide depletion in sickle cell disease. Blood. 2010 Aug 5; 116(5):687-92.
  5. Dai P, Stewart AK, Chebib F, Hsu A, Rozenfeld J, Huang D, Kang D, Lip V, Fang H, Shao H, Liu X, Yu F, Yuan H, Kenna M, Miller DT, Shen Y, Yang W, Zelikovic I, Platt OS, Han D, Alper SL, Wu BL. Distinct and novel SLC26A4/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss. Physiol Genomics. 2009 Aug 7; 38(3):281-90.
  6. Dai P, Li Q, Huang D, Yuan Y, Kang D, Miller DT, Shao H, Zhu Q, He J, Yu F, Liu X, Han B, Yuan H, Platt OS, Han D, Wu BL. SLC26A4 c.919-2A&gtG varies among Chinese ethnic groups as a cause of hearing loss. Genet Med. 2008 Aug; 10(8):586-92.
  7. Platt OS. Hydroxyurea for the treatment of sickle cell anemia. N Engl J Med. 2008 Mar 27; 358(13):1362-9.
  8. De Franceschi L, Platt OS, Malpeli G, Janin A, Scarpa A, Leboeuf C, Beuzard Y, Payen E, Brugnara C. Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice. FASEB J. 2008 Jun; 22(6):1849-60.
  9. Weiss LA, Shen Y, Korn JM, Arking DE, Miller DT, Fossdal R, Saemundsen E, Stefansson H, Ferreira MA, Green T, Platt OS, Ruderfer DM, Walsh CA, Altshuler D, Chakravarti A, Tanzi RE, Stefansson K, Santangelo SL, Gusella JF, Sklar P, Wu BL, Daly MJ. Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med. 2008 Feb 14; 358(7):667-75.
  10. Shen Y, Irons M, Miller DT, Cheung SW, Lip V, Sheng X, Tomaszewicz K, Shao H, Fang H, Tang HS, Irons M, Walsh CA, Platt O, Gusella JF, Wu BL. Development of a focused oligonucleotide-array comparative genomic hybridization chip for clinical diagnosis of genomic imbalance. Clin Chem. 2007 Dec; 53(12):2051-9.
  11. Show all
  12. Bertin A, Mahaney MC, Cox LA, Rogers J, VandeBerg JL, Brugnara C, Platt OS. Quantitative trait loci for peripheral blood cell counts: a study in baboons. Mamm Genome. 2007 May; 18(5):361-72.
  13. Peters LL, Lambert AJ, Zhang W, Churchill GA, Brugnara C, Platt OS. Quantitative trait loci for baseline erythroid traits. Mamm Genome. 2006 Apr; 17(4):298-309.
  14. Platt OS. Prevention and management of stroke in sickle cell anemia. Hematology Am Soc Hematol Educ Program. 2006; 54-7.
  15. Platt OS. Preventing stroke in sickle cell anemia. N Engl J Med. 2005 Dec 29; 353(26):2743-5.
  16. Peters LL, Zhang W, Lambert AJ, Brugnara C, Churchill GA, Platt OS. Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume. Mamm Genome. 2005 Oct; 16(10):749-63.
  17. Mahaney MC, Brugnara C, Lease LR, Platt OS. Genetic influences on peripheral blood cell counts: a study in baboons. Blood. 2005 Aug 15; 106(4):1210-4.
  18. Fukuda JT, Sonis AL, Platt OS, Kurth S. Acquisition of mutans streptococci and caries prevalence in pediatric sickle cell anemia patients receiving long-term antibiotic therapy. Pediatr Dent. 2005 May-Jun; 27(3):186-90.
  19. Wu BL, Kenna M, Lip V, Irons M, Platt O. Use of a multiplex PCR/sequencing strategy to detect both connexin 30 (GJB6) 342 kb deletion and connexin 26 (GJB2) mutations in cases of childhood deafness. Am J Med Genet A. 2003 Aug 30; 121A(2):102-8.
  20. Zhang Y, Manning LR, Falcone J, Platt O, Manning JM. Human erythrocyte membrane band 3 protein influences hemoglobin cooperativity. Possible effect on oxygen transport. J Biol Chem. 2003 Oct 10; 278(41):39565-71.
  21. Wu BL, Lindeman N, Lip V, Adams A, Amato RS, Cox G, Irons M, Kenna M, Korf B, Raisen J, Platt O. Effectiveness of sequencing connexin 26 (GJB2) in cases of familial or sporadic childhood deafness referred for molecular diagnostic testing. Genet Med. 2002 Jul-Aug; 4(4):279-88.
  22. Platt OS. Sickle cell anemia as an inflammatory disease. J Clin Invest. 2000 Aug; 106(3):337-8.
  23. Platt OS. The acute chest syndrome of sickle cell disease. N Engl J Med. 2000 Jun 22; 342(25):1904-7.
  24. Chen W, Dumoulin A, Li X, Padovan JC, Chait BT, Buonopane R, Platt OS, Manning LR, Manning JM. Transposing sequences between fetal and adult hemoglobins indicates which subunits and regulatory molecule interfaces are functionally related. Biochemistry. 2000 Apr 4; 39(13):3774-81.
  25. Kinney TR, Helms RW, O'Branski EE, Ohene-Frempong K, Wang W, Daeschner C, Vichinsky E, Redding-Lallinger R, Gee B, Platt OS, Ware RE. Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. Blood. 1999 Sep 1; 94(5):1550-4.
  26. Brugnara C, Zurakowski D, DiCanzio J, Boyd T, Platt O. Reticulocyte hemoglobin content to diagnose iron deficiency in children. JAMA. 1999 Jun 16; 281(23):2225-30.
  27. Kinney TR, Sleeper LA, Wang WC, Zimmerman RA, Pegelow CH, Ohene-Frempong K, Wethers DL, Bello JA, Vichinsky EP, Moser FG, Gallagher DM, DeBaun MR, Platt OS, Miller ST. Silent cerebral infarcts in sickle cell anemia: a risk factor analysis. The Cooperative Study of Sickle Cell Disease. Pediatrics. 1999 Mar; 103(3):640-5.
  28. De Franceschi L, Bachir D, Galacteros F, Tchernia G, Cynober T, Alper S, Platt O, Beuzard Y, Brugnara C. Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1997 Oct 1; 100(7):1847-52.
  29. Brugnara C, Zelmanovic D, Sorette M, Ballas SK, Platt O. Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity. Am J Clin Pathol. 1997 Aug; 108(2):133-42.
  30. Platt OS. The febrile child with sickle cell disease: a pediatrician's quandary. J Pediatr. 1997 May; 130(5):693-4.
  31. Platt OS, Guinan EC. Bone marrow transplantation in sickle cell anemia--the dilemma of choice. N Engl J Med. 1996 Aug 8; 335(6):426-8.
  32. Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS. Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 1; 97(5):1227-34.
  33. Rifai N, Sakamoto M, Platt O, Brugnara C. A high-performance liquid chromatographic assay for the determination of itraconazole concentration using solid-phase extraction and small sample volume. Ther Drug Monit. 1995 Oct; 17(5):522-5.
  34. Platt OS, Falcone JF. Membrane protein interactions in sickle red blood cells: evidence of abnormal protein 3 function. Blood. 1995 Sep 1; 86(5):1992-8.
  35. Brugnara C, De Franceschi L, Armsby CC, Saadane N, Trudel M, Beuzard Y, Rittenhouse A, Rifai N, Platt O, Alper SL. A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole. Ann N Y Acad Sci. 1995 Jul 12; 763:262-71.
  36. Brugnara C, Armsby CC, Sakamoto M, Rifai N, Alper SL, Platt O. Oral administration of clotrimazole and blockade of human erythrocyte Ca(++)-activated K+ channel: the imidazole ring is not required for inhibitory activity. J Pharmacol Exp Ther. 1995 Apr; 273(1):266-72.
  37. Platt OS. Sickle cell paths converge on hydroxyurea. Nat Med. 1995 Apr; 1(4):307-8.
  38. Rifai N, Sakamoto M, Law T, Platt O, Mikati M, Armsby CC, Brugnara C. HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clin Chem. 1995 Mar; 41(3):387-91.
  39. Gee BE, Platt OS. Sickle reticulocytes adhere to VCAM-1. Blood. 1995 Jan 1; 85(1):268-74.
  40. Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, Klug PP. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med. 1994 Jun 9; 330(23):1639-44.
  41. Brugnara C, Laufer MR, Friedman AJ, Bridges K, Platt O. Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy. Blood. 1994 May 15; 83(10):3100-1.
  42. Platt OS. Easing the suffering caused by sickle cell disease. N Engl J Med. 1994 Mar 17; 330(11):783-4.
  43. Rosenblum ND, Wetzel M, Platt O, Daniels S, Crawford J, Rosenthal R. Predicting medical student success in a clinical clerkship by rating students' nonverbal behavior. Arch Pediatr Adolesc Med. 1994 Feb; 148(2):213-9.
  44. Platt OS, Lux SE, Falcone JF. A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin. J Biol Chem. 1993 Nov 15; 268(32):24421-6.
  45. Rosenblum ND, Platt O, Wetzel M, Rosenthal R. Effect of context on the rating of students by faculty and housestaff in a clinical clerkship. Acad Med. 1992 Jul; 67(7):485.
  46. Charache S, Dover GJ, Moore RD, Eckert S, Ballas SK, Koshy M, Milner PF, Orringer EP, Phillips G, Platt OS, et al. Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia. Blood. 1992 May 15; 79(10):2555-65.
  47. Platt OS, Thorington BD, Brambilla DJ, Milner PF, Rosse WF, Vichinsky E, Kinney TR. Pain in sickle cell disease. Rates and risk factors. N Engl J Med. 1991 Jul 4; 325(1):11-6.
  48. Guay-Woodford LM, Platt O, Harris HW. Toad urinary bladder epithelial cells contain an analogue of cytoskeletal protein 4.1. Am J Physiol. 1991 Jun; 260(6 Pt 1):C1308-14.
  49. Platt OS. Pathology of membrane proteins in sickle erythrocytes. Ann N Y Acad Sci. 1989; 565:83-5.
  50. Platt OS. Is there treatment for sickle cell anemia? N Engl J Med. 1988 Dec 1; 319(22):1479-80.
  51. Platt OS, Falcone JF. Membrane protein lesions in erythrocytes with Heinz bodies. J Clin Invest. 1988 Sep; 82(3):1051-8.
  52. Miller BA, Platt O, Hope S, Dover G, Nathan DG. Influence of hydroxyurea on fetal hemoglobin production in vitro. Blood. 1987 Dec; 70(6):1824-9.
  53. Joiner CH, Platt OS, Lux SE. Cation depletion by the sodium pump in red cells with pathologic cation leaks. Sickle cells and xerocytes. J Clin Invest. 1986 Dec; 78(6):1487-96.
  54. Muller-Soyano A, Platt O, Glader BE. Pyruvate kinase deficiency in dog and human erythrocytes: effects of energy depletion on cation composition and cellular hydration. Am J Hematol. 1986 Nov; 23(3):217-21.
  55. Newburger PE, Luscinskas FW, Ryan T, Beard CJ, Wright J, Platt OS, Simons ER, Tauber AI. Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection. Blood. 1986 Oct; 68(4):914-9.
  56. Platt OS. Chemotherapy to increase fetal hemoglobin in patients with sickle cell anemia. Am J Pediatr Hematol Oncol. 1985; 7(3):258-60.
  57. Patel VP, Ciechanover A, Platt O, Lodish HF. Loss of adhesion of erythrocyte precursors to fibronectin during erythroid differentiation. Prog Clin Biol Res. 1985; 184:355-68.
  58. Patel VP, Ciechanover A, Platt O, Lodish HF. Mammalian reticulocytes lose adhesion to fibronectin during maturation to erythrocytes. Proc Natl Acad Sci U S A. 1985 Jan; 82(2):440-4.
  59. Platt OS, Falcone JF, Lux SE. Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles. J Clin Invest. 1985 Jan; 75(1):266-71.
  60. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest. 1984 Aug; 74(2):652-6.
  61. Platt OS, Rosenstock W, Espeland MA. Influence of sickle hemoglobinopathies on growth and development. N Engl J Med. 1984 Jul 5; 311(1):7-12.
  62. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. Trans Assoc Am Physicians. 1984; 97:268-74.
  63. Platt OS. Exercise-induced hemolysis in sickle cell anemia: shear sensitivity and erythrocyte dehydration. Blood. 1982 May; 59(5):1055-60.
  64. Platt OS, Lux SE, Nathan DG. Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. J Clin Invest. 1981 Sep; 68(3):631-8.
  65. Sosenko JM, Flückiger R, Platt OS, Gabbay KH. Glycosylation of variant hemoglobins in normal and diabetic subjects. Diabetes Care. 1980 Sep-Oct; 3(5):590-3.
  66. Wason S, Detsky AS, Platt OS, Lovejoy FH. Isobutyl nitrite toxicity by ingestion. Ann Intern Med. 1980 May; 92(5):637-8.
  67. Wall MA, Platt OS, Strieder DJ. Lung function in children with sickle cell anemia. Am Rev Respir Dis. 1979 Jul; 120(1):210-4.
  68. Platt OS. Newborn bleeding disorders: a practical approach. Pediatr Ann. 1979 Jun; 8(6):55-67.
  69. Glader BE, Lux SE, Muller-Soyano A, Platt OS, Propper RD, Nathan DG. Energy reserve and cation composition of irreversibly sickled cells in vivo. Br J Haematol. 1978 Dec; 40(4):527-32.
  70. Glader BE, McCrimmons D, Müller-Soyano A, Platt O. Red blood cell size and glycolytic enzyme activity: relationship to number of intramedullary cell divisions. Pediatr Res. 1978 Apr; 12(4 Pt 1):308-9.
  71. Glader BE, Platt O. Haemolytic disorders of infancy. Clin Haematol. 1978 Feb; 7(1):35-61.
To schedule an appointment: Call 617-355-6347

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