EDUCATION

Undergraduate Degree

  • Marquette University , 1974 , Milwaukee , WI

Medical School

  • University of Wisconsin Medical School , 1978 , Madison , WI

Internship

Pediatrics
  • University of California at Irvine Medical Center , 1980 , Irvine , CA

Residency

Pediatrics
  • University of California at San Francisco Medical Center , 1981 , San Francisco , CA

Fellowship

Pulmonary Medicine
  • Boston Children's Hospital , 1986 , Boston , MA

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Pulmonology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures. Nat Genet. 2014 Jan; 46(1):82-7. View abstract
  2. Mechanisms of acute respiratory distress syndrome in children and adults: a review and suggestions for future research. Pediatr Crit Care Med. 2013 Jul; 14(6):631-43. View abstract
  3. The Fas/FasL pathway impairs the alveolar fluid clearance in mouse lungs. . 2013 Sep; 305(5):L377-88. View abstract
  4. Phenazine content in the cystic fibrosis respiratory tract negatively correlates with lung function and microbial complexity. Am J Respir Cell Mol Biol. 2012 Dec; 47(6):738-45. View abstract
  5. Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. J Infect Dis. 2012 Jun; 205(11):1709-18. View abstract
  6. Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):196-202. View abstract
  7. Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol. 2011 Oct 15; 187(8):4245-55. View abstract
  8. Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice. . 2011 Oct; 301(4):L451-60. View abstract
  9. The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region. J Clin Invest. 2011 Mar; 121(3):1174-90. View abstract
  10. Clinically useful spirometry in preschool-aged children: evaluation of the 2007 American Thoracic Society Guidelines. J Asthma. 2010 Sep; 47(7):762-7. View abstract
  11. Febrile-range hyperthermia augments lipopolysaccharide-induced lung injury by a mechanism of enhanced alveolar epithelial apoptosis. J Immunol. 2010 Apr 01; 184(7):3801-13. View abstract
  12. Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa. Environ Microbiol. 2010 May; 12(5):1293-303. View abstract
  13. Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs. J Immunol. 2010 Mar 01; 184(5):2677-85. View abstract
  14. Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):475-86. View abstract
  15. Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. . 2009 Feb; 296(2):L198-209. View abstract
  16. Animal models of acute lung injury. . 2008 Sep; 295(3):L379-99. View abstract
  17. Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin. Exp Lung Res. 2008 Jun; 34(5):225-43. View abstract
  18. Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):210-21. View abstract
  19. The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation. J Immunol. 2006 Dec 01; 177(11):8086-94. View abstract
  20. Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia. Lab Invest. 2006 Aug; 86(8):790-9. View abstract
  21. Inflammatory cells as a source of airspace extracellular superoxide dismutase after pulmonary injury. Am J Respir Cell Mol Biol. 2006 Feb; 34(2):226-32. View abstract
  22. Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung. J Immunol. 2005 Sep 15; 175(6):4069-75. View abstract
  23. Sweat testing infants detected by cystic fibrosis newborn screening. J Pediatr. 2005 Sep; 147(3 Suppl):S69-72. View abstract
  24. Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. J Immunol. 2005 Sep 01; 175(5):3369-76. View abstract
  25. Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. J Immunol. 2005 Aug 15; 175(4):2570-8. View abstract
  26. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. . 2005 Nov; 289(5):L731-8. View abstract
  27. Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia. Anesthesiology. 2005 Feb; 102(2):331-9. View abstract
  28. Blockade of the Fas/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen. J Infect Dis. 2005 Feb 15; 191(4):596-606. View abstract
  29. Clinical issues and research in respiratory failure from severe acute respiratory syndrome. Am J Respir Crit Care Med. 2005 Mar 01; 171(5):518-26. View abstract
  30. Direct lung injury by bacteria: clarifying the tools of the trade. Crit Care Med. 2004 Nov; 32(11):2360-1. View abstract
  31. Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. . 2004 Jun; 286(6):L1114-21. View abstract
  32. Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. J Immunol. 2003 May 15; 170(10):5244-51. View abstract
  33. Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription. Respir Physiol Neurobiol. 2002 Aug 30; 132(2):191-203. View abstract
  34. Tissue-specific mechanisms control the retention of IL-8 in lungs and skin. J Immunol. 2002 Apr 01; 168(7):3550-6. View abstract
  35. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1479-84. View abstract
  36. Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 1):1896-903. View abstract
  37. Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: potential role for a gut-lung axis of inflammation. J Immunol. 2000 Dec 01; 165(11):6612-9. View abstract
  38. CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2000 Nov; 23(5):646-51. View abstract
  39. Effect of CD14 blockade in rabbits with Escherichia coli pneumonia and sepsis. J Immunol. 2000 May 15; 164(10):5439-45. View abstract
  40. Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice. Am J Respir Crit Care Med. 1999 Oct; 160(4):1150-6. View abstract
  41. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999 Jun; 103(12):1737-43. View abstract
  42. Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice. J Appl Physiol (1985). 1999 Jan; 86(1):202-10. View abstract
  43. The role of leukocyte emigration and IL-8 on the development of lipopolysaccharide-induced lung injury in rabbits. J Immunol. 1998 Nov 15; 161(10):5704-9. View abstract
  44. Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood. 1998 Oct 01; 92(7):2571-80. View abstract
  45. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest. 1998 Apr 15; 101(8):1614-22. View abstract
  46. Persistence of pulmonary pathology and abnormal lung function in IL-3/GM-CSF/IL-5 beta c receptor-deficient mice despite correction of alveolar proteinosis after BMT. Bone Marrow Transplant. 1997 Oct; 20(8):657-62. View abstract
  47. Pulmonary and systemic inflammatory responses in rabbits with gram-negative pneumonia. Am J Respir Crit Care Med. 1997 Jun; 155(6):2030-40. View abstract
  48. Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). J Exp Med. 1997 May 05; 185(9):1533-40. View abstract
  49. T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. Nat Med. 1997 Apr; 3(4):460-2. View abstract
  50. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest. 1997 Mar 01; 99(5):901-14. View abstract
  51. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1344-9. View abstract
  52. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 1996 Oct 15; 88(8):3230-9. View abstract
  53. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet. 1995 Oct; 11(2):150-4. View abstract
  54. Effects of endotoxin in the lungs of neonatal rats: age-dependent impairment of the inflammatory response. J Infect Dis. 1995 Jan; 171(1):134-44. View abstract
  55. Active anaphylaxis in IgE-deficient mice. Nature. 1994 Aug 04; 370(6488):367-70. View abstract
  56. Serotonin-induced pulmonary responses are mediated by the 5-HT2 receptor in the mouse. J Pharmacol Exp Ther. 1994 Jan; 268(1):104-9. View abstract
  57. Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice. J Immunol. 1993 Jul 01; 151(1):367-76. View abstract
  58. Mast cell activation enhances airway responsiveness to methacholine in the mouse. J Clin Invest. 1993 Mar; 91(3):1176-82. View abstract
  59. Recombinant murine interferon-gamma reversibly activates rat alveolar macrophages to kill Legionella pneumophila. J Infect Dis. 1992 Dec; 166(6):1354-61. View abstract
  60. The effect of type-specific polysaccharide capsule on the clearance of group B streptococci from the lungs of infant and adult rats. J Infect Dis. 1992 Feb; 165(2):306-14. View abstract
  61. Alveolar macrophage function in rats with severe protein calorie malnutrition. Arachidonic acid metabolism, cytokine release, and antimicrobial activity. J Immunol. 1990 Feb 01; 144(3):1052-61. View abstract
  62. The trachea and esophagus after repair of esophageal atresia and distal fistula: computed tomographic observations. Pediatr Radiol. 1990; 20(6):447-50. View abstract
  63. Impaired clearance of aerosolized Legionella pneumophila in corticosteroid-treated rats: a model of Legionnaires' disease in the compromised host. J Infect Dis. 1989 Aug; 160(2):261-73. View abstract
  64. Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. J Clin Invest. 1989 Apr; 83(4):1375-83. View abstract
  65. Relationship between maximal expiratory flows and lung volumes in growing humans. J Appl Physiol (1985). 1988 Aug; 65(2):822-8. View abstract
  66. Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol (1985). 1988 Jun; 64(6):2318-23. View abstract
  67. Lung antibacterial defense mechanisms in infant and adult rats: implications for the pathogenesis of group B streptococcal infections in the neonatal lung. J Infect Dis. 1988 Jan; 157(1):91-100. View abstract
  68. Controlled clinical trial of methylprednisolone in patients with chronic bronchitis and acute respiratory insufficiency. Ann Intern Med. 1980 Jun; 92(6):753-8. View abstract