Joseph Majzoub MD

Joseph Majzoub, MD

Chief, Division of Endocrinology, Harvard Medical School; Senior Physician in Medicine

Professor of Pediatrics and Medicine, Harvard Medical School

  • Contact: Endocrine: 617-355-7476

  • Fax: 617-730-0194

Medical Services

Specialties

  • Neuroendocrinology

Departments

  • Endocrinology
  • Medicine

Programs

  • Endocrinology Program
To schedule an appointment: Call Endocrine: 617-355-7476 or Request an Appointment

Experience and Education

Education

Undergraduate

University of Michigan,

Ann Arbor, MI

Medical School

Stanford University School of Medicine, 1974

Stanford, CA

Adult Endocrinology Fellowship

Massachusetts General Hospital,

Boston, MA

Internal Medicine Internship

Brigham and Women's Hospital, 1975

Boston, MA

Internal Medicine Residency

Brigham and Women's Hospital, 1976

Boston, MA

Certifications

  • Internal Medicine, Adult Endocrinology

Publications

Publications powered by Harvard Catalyst
  1. Leviton A, Allred EN, Kuban KC, O'Shea TM, Paneth N, Majzoub J. Brain disorders associated with corticotropin-releasing hormone expression in the placenta among children born before the 28th week of gestation. Acta Paediatr. 2016 Jan; 105(1):e7-e11.
  2. Herold KC, Majzoub JA, Melmed S, Pendergrass M, Schlumberger M. Endocrinology research-reflecting on the past decade and looking to the next. Nat Rev Endocrinol. 2015 Nov; 11(11):672-80.
  3. Thomas JL, Rajapaksha M, Mack VL, DeMars GA, Majzoub JA, Bose HS. Regulation of human 3ß-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche. J Pharmacol Exp Ther. 2015 Jan; 352(1):67-76.
  4. Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzynski P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrecic L, Palandacic A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol. 2014; 15(3):R53.
  5. Freedman BD, Kempna PB, Carlone DL, Shah MS, Guagliardo NA, Barrett PQ, Gomez-Sanchez CE, Majzoub JA, Breault DT. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30; 26(6):666-73.
  6. Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, O'Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science. 2013 Jul 19; 341(6143):275-8.
  7. Sharara-Chami RI, Zhou Y, Ebert S, Pacak K, Ozcan U, Majzoub JA. Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice. Int J Biochem Cell Biol. 2012 Jun; 44(6):905-13.
  8. Trivedi S, Joachim M, McElrath T, Kliman HJ, Allred EN, Fichorova RN, Onderdonk A, Heitor F, Chaychi L, Leviton A, Majzoub JA. Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery. Am J Obstet Gynecol. 2012 Mar; 206(3):236.e1-8.
  9. Topor LS, Asai M, Dunn J, Majzoub JA. Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2. J Clin Endocrinol Metab. 2011 Jan; 96(1):E31-9.
  10. Dauber A, Feldman HA, Majzoub JA. Nocturnal Dexamethasone versus Hydrocortisone for the Treatment of Children with Congenital Adrenal Hyperplasia. Int J Pediatr Endocrinol. 2010; 2010.
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  12. Sharara-Chami RI, Joachim M, Mulcahey M, Ebert S, Majzoub JA. Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue. Mol Cell Endocrinol. 2010 Oct 26; 328(1-2):34-9.
  13. Dauber A, Kellogg M, Majzoub JA. Monitoring of therapy in congenital adrenal hyperplasia. Clin Chem. 2010 Aug; 56(8):1245-51.
  14. Sharara-Chami RI, Joachim M, Pacak K, Majzoub JA. Glucocorticoid treatment--effect on adrenal medullary catecholamine production. Shock. 2010 Feb; 33(2):213-7.
  15. Shaw ND, Majzoub JA. Permanent Neonatal Diabetes in a Patient with a KCNJ11/Q52R Mutation Accompanied by Intermittent Hypoglycemia and Liver Failure. Int J Pediatr Endocrinol. 2009; 2009:453240.
  16. Annesley T, Majzoub J, Hsing A, Wu A, Rockwood A, Mason D. Mass spectrometry in the clinical laboratory: how have we done, and where do we need to be? Clin Chem. 2009 Jun; 55(6):1236-9.
  17. Fasting MH, Oken E, Mantzoros CS, Rich-Edwards JW, Majzoub JA, Kleinman K, Rifas-Shiman SL, Vik T, Gillman MW. Maternal levels of corticotropin-releasing hormone during pregnancy in relation to adiponectin and leptin in early childhood. J Clin Endocrinol Metab. 2009 Apr; 94(4):1409-15.
  18. Scribner KB, Pawlak DB, Aubin CM, Majzoub JA, Ludwig DS. Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice. Am J Physiol Endocrinol Metab. 2008 Nov; 295(5):E1126-31.
  19. Morra M, Geigenmuller U, Curran J, Rainville IR, Brennan T, Curtis J, Reichert V, Hovhannisyan H, Majzoub J, Miller DT. Genetic diagnosis of primary immune deficiencies. Immunol Allergy Clin North Am. 2008 May; 28(2):387-412, x.
  20. Rich-Edwards JW, Mohllajee AP, Kleinman K, Hacker MR, Majzoub J, Wright RJ, Gillman MW. Elevated midpregnancy corticotropin-releasing hormone is associated with prenatal, but not postpartum, maternal depression. J Clin Endocrinol Metab. 2008 May; 93(5):1946-51.
  21. Linhart KB, Majzoub JA. Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin. Endocrinology. 2008 Feb; 149(2):681-6.
  22. Majzoub JA, Srivatsa A. Diabetes insipidus: clinical and basic aspects. Pediatr Endocrinol Rev. 2006 Dec; 4 Suppl 1:60-5.
  23. Gillman MW, Rich-Edwards JW, Huh S, Majzoub JA, Oken E, Taveras EM, Rifas-Shiman SL. Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity. Obesity (Silver Spring). 2006 Sep; 14(9):1647-53.
  24. Strong EF, Kleinman KP, Gillman MW, Clark I, Emanuel RL, Majzoub JA, Rich-Edwards JW. Measuring corticotropin-releasing hormone in pregnant women - comparing blood collection protocols for epidemiological studies. Paediatr Perinat Epidemiol. 2006 Jan; 20(1):67-71.
  25. Silverman ES, Breault DT, Vallone J, Subramanian S, Yilmaz AD, Mathew S, Subramaniam V, Tantisira K, Pacák K, Weiss ST, Majzoub JA. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol. 2004 Oct; 114(4):747-54.
  26. McElhinney DB, Colan SD, Moran AM, Wypij D, Lin M, Majzoub JA, Crawford EC, Bartlett JM, McGrath EA, Newburger JW. Recombinant human growth hormone treatment for dilated cardiomyopathy in children. Pediatrics. 2004 Oct; 114(4):e452-8.
  27. Wise-Faberowski L, Soriano SG, Ferrari L, McManus ML, Wolfsdorf JI, Majzoub J, Scott RM, Truog R, Rockoff MA. Perioperative management of diabetes insipidus in children. J Neurosurg Anesthesiol. 2004 Jul; 16(3):220-5.
  28. Kubovcakova L, Tybitanclova K, Sabban EL, Majzoub J, Zorad S, Vietor I, Wagner EF, Krizanova O, Kvetnansky R. Catecholamine synthesizing enzymes and their modulation by immobilization stress in knockout mice. Ann N Y Acad Sci. 2004 Jun; 1018:458-65.
  29. Venihaki M, Sakihara S, Subramanian S, Dikkes P, Weninger SC, Liapakis G, Graf T, Majzoub JA. Urocortin III, a brain neuropeptide of the corticotropin-releasing hormone family: modulation by stress and attenuation of some anxiety-like behaviours. J Neuroendocrinol. 2004 May; 16(5):411-22.
  30. Pagan YL, Hirschhorn J, Yang B, D'Souza-Li L, Majzoub JA, Hendy GN. Maternal activating mutation of the calcium-sensing receptor: implications for calcium metabolism in the neonate. J Pediatr Endocrinol Metab. 2004 Apr; 17(4):673-7.
  31. Jeong KH, Sakihara S, Widmaier EP, Majzoub JA. Impaired leptin expression and abnormal response to fasting in corticotropin-releasing hormone-deficient mice. Endocrinology. 2004 Jul; 145(7):3174-81.
  32. Wise-Faberowski L, Soriano SG, Ferrari L, McManus ML, Wolfsdorf JI, Majzoub J, Scott RM, Truog R, Rockoff MA. Perioperative management of diabetes insipidus in children [corrected]. J Neurosurg Anesthesiol. 2004 Jan; 16(1):14-9.
  33. Brewer JA, Bethin KE, Schaefer ML, Muglia LM, Vogt SK, Weninger SC, Majzoub JA, Muglia LJ. Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice. Stress. 2003 Jun; 6(2):121-5.
  34. Venihaki M, Majzoub J. Lessons from CRH knockout mice. Neuropeptides. 2002 Apr-Jun; 36(2-3):96-102.
  35. Gordon CM, Dougherty DD, Fischman AJ, Emans SJ, Grace E, Lamm R, Alpert NM, Majzoub JA, Rauch SL. Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomography. J Pediatr. 2001 Jul; 139(1):51-7.
  36. Rich-Edwards J, Krieger N, Majzoub J, Zierler S, Lieberman E, Gillman M. Maternal experiences of racism and violence as predictors of preterm birth: rationale and study design. Paediatr Perinat Epidemiol. 2001 Jul; 15 Suppl 2:124-35.
  37. Muglia LJ, Jacobson L, Weninger SC, Karalis KP, Jeong K, Majzoub JA. The physiology of corticotropin-releasing hormone deficiency in mice. Peptides. 2001 May; 22(5):725-31.
  38. Seth KA, Majzoub JA. Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. J Biol Chem. 2001 Apr 27; 276(17):13917-23.
  39. Moran AM, Colan SD, Majzoub JA, Newburger JW. Exogenous growth hormone: a new therapy for dilated cardiomyopathy. Prog Pediatr Cardiol. 2000 Nov 4; 12(1):125-132.
  40. Muglia LJ, Bethin KE, Jacobson L, Vogt SK, Majzoub JA. Pituitary-adrenal axis regulation in CRH-deficient mice. Endocr Res. 2000 Nov; 26(4):1057-66.
  41. Wohl ME, Majzoub JA. Asthma, steroids, and growth. N Engl J Med. 2000 Oct 12; 343(15):1113-4.
  42. Gordon CM, Emans SJ, DuRant RH, Mantzoros C, Grace E, Harper GP, Majzoub JA. Endocrinologic and psychological effects of short-term dexamethasone in anorexia nervosa. Eat Weight Disord. 2000 Sep; 5(3):175-82.
  43. Iwasaki Y, Oiso Y, Saito H, Majzoub JA. Effects of various mutations in the neurophysin/glycopeptide portion of the vasopressin gene on vasopressin expression in vitro. Tohoku J Exp Med. 2000 Aug; 191(4):187-202.
  44. Venihaki M, Carrigan A, Dikkes P, Majzoub JA. Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7336-41.
  45. Muglia LJ, Jacobson L, Luedke C, Vogt SK, Schaefer ML, Dikkes P, Fukuda S, Sakai Y, Suda T, Majzoub JA. Corticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency. J Clin Invest. 2000 May; 105(9):1269-77.
  46. Gordon CM, Dougherty DD, Rauch SL, Emans SJ, Grace E, Lamm R, Alpert NM, Majzoub JA, Fischman AJ. Neuroanatomy of human appetitive function: A positron emission tomography investigation. Int J Eat Disord. 2000 Mar; 27(2):163-71.
  47. Jeong KH, Jacobson L, Pacák K, Widmaier EP, Goldstein DS, Majzoub JA. Impaired basal and restraint-induced epinephrine secretion in corticotropin-releasing hormone-deficient mice. Endocrinology. 2000 Mar; 141(3):1142-50.
  48. Jacobson L, Muglia LJ, Weninger SC, Pacák K, Majzoub JA. CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors. Neuroendocrinology. 2000 Feb; 71(2):79-87.
  49. Weninger SC, Peters LL, Majzoub JA. Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency. Endocrinology. 2000 Jan; 141(1):256-63.
  50. Arbiser JL, Karalis K, Viswanathan A, Koike C, Anand-Apte B, Flynn E, Zetter B, Majzoub JA. Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin. J Invest Dermatol. 1999 Nov; 113(5):838-42.
  51. Gudmundsson K, Majzoub JA, Bradwin G, Mandel S, Rifai N. Virilising 21-hydroxylase deficiency: timing of newborn screening and confirmatory tests can be crucial. J Pediatr Endocrinol Metab. 1999 Nov-Dec; 12(6):895-901.
  52. Weninger SC, Muglia LJ, Jacobson L, Majzoub JA. CRH-deficient mice have a normal anorectic response to chronic stress. Regul Pept. 1999 Oct 22; 84(1-3):69-74.
  53. Weninger SC, Dunn AJ, Muglia LJ, Dikkes P, Miczek KA, Swiergiel AH, Berridge CW, Majzoub JA. Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH. Proc Natl Acad Sci U S A. 1999 Jul 6; 96(14):8283-8.
  54. Zurakowski D, Di Canzio J, Majzoub JA. Pediatric reference intervals for serum thyroxine, triiodothyronine, thyrotropin, and free thyroxine. Clin Chem. 1999 Jul; 45(7):1087-91.
  55. Karalis KP, Kontopoulos E, Muglia LJ, Majzoub JA. Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):7093-7.
  56. Wölfl S, Martinez C, Majzoub JA. Inducible binding of cyclic adenosine 3',5'-monophosphate (cAMP)-responsive element binding protein (CREB) to a cAMP-responsive promoter in vivo. Mol Endocrinol. 1999 May; 13(5):659-69.
  57. Jeong KH, Jacobson L, Widmaier EP, Majzoub JA. Normal suppression of the reproductive axis following stress in corticotropin-releasing hormone-deficient mice. Endocrinology. 1999 Apr; 140(4):1702-8.
  58. Venihaki M, Majzoub JA. Animal models of CRH deficiency. Front Neuroendocrinol. 1999 Apr; 20(2):122-45.
  59. Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics. 1999 Mar; 103(3):E26.
  60. Lopez MF, Dikkes P, Zurakowski D, Villa-Komaroff L, Majzoub JA. Regulation of hepatic glycogen in the insulin-like growth factor II-deficient mouse. Endocrinology. 1999 Mar; 140(3):1442-8.
  61. Muglia LJ, Bae DS, Brown TT, Vogt SK, Alvarez JG, Sunday ME, Majzoub JA. Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice. Am J Respir Cell Mol Biol. 1999 Feb; 20(2):181-8.
  62. Majzoub JA, Karalis KP. Placental corticotropin-releasing hormone: function and regulation. Am J Obstet Gynecol. 1999 Jan; 180(1 Pt 3):S242-6.
  63. Majzoub JA, McGregor JA, Lockwood CJ, Smith R, Taggart MS, Schulkin J. A central theory of preterm and term labor: putative role for corticotropin-releasing hormone. Am J Obstet Gynecol. 1999 Jan; 180(1 Pt 3):S232-41.
  64. Grant FD, Ahmadi A, Hosley CM, Majzoub JA. Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant. J Clin Endocrinol Metab. 1998 Nov; 83(11):3958-64.
  65. Hanley K, Feingold KR, Kömüves LG, Elias PM, Muglia LJ, Majzoub JA, Williams ML. Glucocorticoid deficiency delays stratum corneum maturation in the fetal mouse. J Invest Dermatol. 1998 Sep; 111(3):440-4.
  66. Emanuel RL, Iwasaki Y, Arbiser ZK, Velez EM, Emerson CH, Majzoub JA. Vasopressin messenger ribonucleic acid regulation via the protein kinase A pathway. Endocrinology. 1998 Jun; 139(6):2831-7.
  67. Gordon Cm, Majzoub JA, Marsh DJ, Mulliken JB, Ponder BA, Robinson BG, Eng C. Four cases of mucosal neuroma syndrome: multiple endocrine neoplasm 2B or not 2B? J Clin Endocrinol Metab. 1998 Jan; 83(1):17-20.
  68. Iwasaki Y, Oiso Y, Saito H, Majzoub JA. Positive and negative regulation of the rat vasopressin gene promoter. Endocrinology. 1997 Dec; 138(12):5266-74.
  69. Fraefel C, Jacoby DR, Lage C, Hilderbrand H, Chou JY, Alt FW, Breakefield XO, Majzoub JA. Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Mol Med. 1997 Dec; 3(12):813-25.
  70. Gordon MS, Majzoub JA, Williams GH, Gordon MB. Sodium balance modulates thirst in normal man. Endocr Res. 1997 Nov; 23(4):377-92.
  71. Muglia LJ, Jacobson L, Weninger SC, Luedke CE, Bae DS, Jeong KH, Majzoub JA. Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice. J Clin Invest. 1997 Jun 15; 99(12):2923-9.
  72. Jacobson L, Zurakowski D, Majzoub JA. Protein malnutrition increases plasma adrenocorticotropin and anterior pituitary proopiomelanocortin messenger ribonucleic acid in the rat. Endocrinology. 1997 Mar; 138(3):1048-57.
  73. Karalis K, Muglia LJ, Bae D, Hilderbrand H, Majzoub JA. CRH and the immune system. J Neuroimmunol. 1997 Feb; 72(2):131-6.
  74. Hill AG, Jacobson L, Gonzalez J, Rounds J, Majzoub JA, Wilmore DW. Chronic central nervous system exposure to interleukin-1 beta causes catabolism in the rat. Am J Physiol. 1996 Nov; 271(5 Pt 2):R1142-8.
  75. Karalis K, Goodwin G, Majzoub JA. Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Nat Med. 1996 May; 2(5):556-60.
  76. Wölfl S, Martinez C, Rich A, Majzoub JA. Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3664-8.
  77. Majzoub JA, Muglia LJ. Knockout mice. N Engl J Med. 1996 Apr 4; 334(14):904-7.
  78. Muglia L, Jacobson L, Majzoub JA. Production of corticotropin-releasing hormone-deficient mice by targeted mutation in embryonic stem cells. Ann N Y Acad Sci. 1996 Mar 22; 780:49-59.
  79. Karalis K, Majzoub JA. Regulation of placental corticotropin-releasing hormone by steroids. Possible implications in labor initiation. Ann N Y Acad Sci. 1995 Dec 29; 771:551-5.
  80. Majzoub JA, Muglia LJ, Martinez C, Jacobson L. Molecular and transgenic studies of the corticotropin-releasing hormone gene. Ann N Y Acad Sci. 1995 Dec 29; 771:293-300.
  81. Muglia L, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995 Feb 2; 373(6513):427-32.
  82. Muglia LJ, Jenkins NA, Gilbert DJ, Copeland NG, Majzoub JA. Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells. J Clin Invest. 1994 May; 93(5):2066-72.
  83. Arbiser JL, Martinez C, Arbiser ZK, Adler GK, Rosen LB, Majzoub JA. Regulation of the ectopically expressed human glycoprotein alpha-subunit gene in the human hepatoma cell line NPLC. Endocrinology. 1994 Feb; 134(2):582-7.
  84. Emanuel RL, Robinson BG, Seely EW, Graves SW, Kohane I, Saltzman D, Barbieri R, Majzoub JA. Corticotrophin releasing hormone levels in human plasma and amniotic fluid during gestation. Clin Endocrinol (Oxf). 1994 Feb; 40(2):257-62.
  85. Arbiser JL, Arbiser ZK, Majzoub JA. Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma. J Endocrinol Invest. 1993 Dec; 16(11):849-56.
  86. Hirsch AT, Majzoub JA, Ren CJ, Scales KM, Creager MA. Contribution of vasopressin to blood pressure regulation during hypovolemic hypotension in humans. J Appl Physiol (1985). 1993 Nov; 75(5):1984-8.
  87. Grant FD, Reventos J, Kawabata S, Miller M, Gordon JW, Majzoub JA. Transgenic mouse models of vasopressin expression. Hypertension. 1993 Oct; 22(4):640-5.
  88. Grant FD, Reventos J, Gordon JW, Kawabata S, Miller M, Majzoub JA. Tissue-specific expression and osmotic regulation of a rat vasopressin gene in transgenic mice. Ann N Y Acad Sci. 1993 Jul 22; 689:530-3.
  89. Grant FD, Reventos J, Gordon JW, Kawabata S, Miller M, Majzoub JA. Expression of the rat arginine vasopressin gene in transgenic mice. Mol Endocrinol. 1993 May; 7(5):659-67.
  90. Arbiser JL, Arbiser ZK, Majzoub JA. Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitors. Endocr J. 1993 Apr; 40(2):263-8.
  91. Majzoub JA, Emanuel R, Adler G, Martinez C, Robinson B, Wittert G. Second messenger regulation of mRNA for corticotropin-releasing factor. Ciba Found Symp. 1993; 172:30-43; discussion 43-58.
  92. Emanuel RL, Girard DM, Thull DL, Majzoub JA. Regulated expression of vasopressin gene by cAMP and phorbol ester in primary rat fetal hypothalamic cultures. Mol Cell Endocrinol. 1992 Jul; 86(1-2):29-36.
  93. Rosen LB, Majzoub JA, Adler GK. Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells. Endocrinology. 1992 Apr; 130(4):2237-44.
  94. Adler GK, Rosen LB, Fiandaca MJ, Majzoub JA. Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells. Mol Endocrinol. 1992 Mar; 6(3):476-84.
  95. Robinson BG, Mealy K, Wilmore DW, Majzoub JA. The effect of insulin-induced hypoglycemia on gene expression in the hypothalamic-pituitary-adrenal axis of the rat. Endocrinology. 1992 Feb; 130(2):920-5.
  96. Arbiser JL, Arbiser ZK, Majzoub JA. Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea. Endocrinology. 1991 Feb; 128(2):972-8.
  97. Michie HR, Majzoub JA, O'Dwyer ST, Revhaug A, Wilmore DW. Both cyclooxygenase-dependent and cyclooxygenase-independent pathways mediate the neuroendocrine response in humans. Surgery. 1990 Aug; 108(2):254-9; discussion 259-61.
  98. Emanuel RL, Girard DM, Thull DL, Majzoub JA. Second messengers involved in the regulation of corticotropin-releasing hormone mRNA and peptide in cultured rat fetal hypothalamic primary cultures. Endocrinology. 1990 Jun; 126(6):3016-21.
  99. Adler GK, Smas CM, Fiandaca M, Frim DM, Majzoub JA. Regulated expression of the human corticotropin releasing hormone gene by cyclic AMP. Mol Cell Endocrinol. 1990 Apr 17; 70(2):165-74.
  100. Frim DM, Robinson BG, Pasieka KB, Majzoub JA. Differential regulation of corticotropin-releasing hormone mRNA in rat brain. Am J Physiol. 1990 Apr; 258(4 Pt 1):E686-92.
  101. Mealy K, Robinson B, Millette CF, Majzoub J, Wilmore DW. The testicular effects of tumor necrosis factor. Ann Surg. 1990 Apr; 211(4):470-5.
  102. Emanuel RL, Thull DL, Girard DM, Majzoub JA. Developmental expression of corticotropin releasing hormone messenger RNA and peptide in rat hypothalamus. Peptides. 1989 Nov-Dec; 10(6):1165-9.
  103. Hirsch AT, Dzau VJ, Majzoub JA, Creager MA. Vasopressin-mediated forearm vasodilation in normal humans. Evidence for a vascular vasopressin V2 receptor. J Clin Invest. 1989 Aug; 84(2):418-26.
  104. Graves SW, Adler G, Stuenkel C, Sharma K, Brena A, Majzoub J. Increases in plasma digitalis-like factor activity during insulin-induced hypoglycemia. Neuroendocrinology. 1989 Jun; 49(6):586-91.
  105. Robinson BG, Arbiser JL, Emanuel RL, Majzoub JA. Species-specific placental corticotropin releasing hormone messenger RNA and peptide expression. Mol Cell Endocrinol. 1989 Apr; 62(2):337-41.
  106. Robinson BG, D'Angio LA, Pasieka KB, Majzoub JA. Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing. Mol Cell Endocrinol. 1989 Feb; 61(2):175-80.
  107. Robinson BG, Frim DM, Schwartz WJ, Majzoub JA. Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length. Science. 1988 Jul 15; 241(4863):342-4.
  108. Robinson BG, Emanuel RL, Frim DM, Majzoub JA. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5244-8.
  109. Frim DM, Emanuel RL, Robinson BG, Smas CM, Adler GK, Majzoub JA. Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta. J Clin Invest. 1988 Jul; 82(1):287-92.
  110. Carrazana EJ, Pasieka KB, Majzoub JA. The vasopressin mRNA poly(A) tract is unusually long and increases during stimulation of vasopressin gene expression in vivo. Mol Cell Biol. 1988 Jun; 8(6):2267-74.
  111. Caulfield MP, Duong LT, O'Brien R, Majzoub JA, Rosenblatt M. A chemically synthesized radiolabeled signal peptide: design, preparation, and biological evaluation of an iodinated analog of preproparathyroid hormone. Mol Endocrinol. 1988 May; 2(5):452-8.
  112. Adler GK, Smas CM, Majzoub JA. Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line. J Biol Chem. 1988 Apr 25; 263(12):5846-52.
  113. Arbiser JL, Morton CC, Bruns GA, Majzoub JA. Human corticotropin releasing hormone gene is located on the long arm of chromosome 8. Cytogenet Cell Genet. 1988; 47(3):113-6.
  114. Nabel EG, Colucci WS, Lilly LS, Cutler SS, Majzoub JA, St John Sutton MG, Dzau VJ, Creager MA. Relationship of cardiac chamber volume to baroreflex activity in normal humans. J Clin Endocrinol Metab. 1987 Sep; 65(3):475-81.
  115. Adler GK, Majzoub JA. Influence of infused hypertonic saline on the response to insulin-induced hypoglycemia in man. J Clin Endocrinol Metab. 1987 Jul; 65(1):116-21.
  116. Majzoub JA, Carrazana EJ, Shulman JS, Baker KJ, Emanuel RL. Defective regulation of vasopressin gene expression in Brattleboro rats. Am J Physiol. 1987 May; 252(5 Pt 1):E637-42.
  117. Majzoub JA, Pappey A, Burg R, Habener JF. Vasopressin gene is expressed at low levels in the hypothalamus of the Brattleboro rat. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5296-9.
  118. Majzoub JA, Rich A, van Boom J, Habener JF. Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides. J Biol Chem. 1983 Dec 10; 258(23):14061-4.
  119. Majzoub JA, Dee PC, Habener JF. Cellular and cell-free processing of parathyroid secretory proteins. J Biol Chem. 1982 Apr 10; 257(7):3581-8.
  120. Majzoub JA, Rosenblatt M, Fennick B, Maunus R, Kronenberg HM, Potts JT, Habener JF. Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones. J Biol Chem. 1980 Dec 10; 255(23):11478-83.
  121. Kronenberg HM, McDevitt BE, Majzoub JA, Nathans J, Sharp PA, Potts JT, Rich A. Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):4981-5.
  122. Majzoub JA, Kronenberg HM, Potts JT, Rich A, Habener JF. Identification and cell-free translation of mRNA coding for a precursor of parathyroid secretory protein. J Biol Chem. 1979 Aug 10; 254(15):7449-55.
  123. Graboys TB, Majzoub JA. Letter: "Smudge" ECG. N Engl J Med. 1975 Jan 2; 292(1):50.
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